Abstract:
:The effects of beclomethasone, dipropionate aerosol (DBA) (400 microgram/day) on clinical course, pulmonary function, and pituitary-adrenal function was studied in 34 steroid-dependent asthmatic children. Asthma severity was assessed by daily symptom and medication scores, peak flow measured three times a day, and weekly spirometry. Pituitary-adrenal function was evaluated by diurnal cortisol levels, cortisol responses to intravenous (IV) corticotropin (ACTH), and steroid responses to IV metyrapone. After 12 weeks of BDA therapy, 30 of 34 patients no longer required prednisone. Mean weekly symptom and medication scores and the number of attacks decreased significantly (P less than .01)). A significant improvement was demonstrated in the patients' peak flow (P less than .01), forced expiratory volume in one second, and maximum midexpiratory flow rates (P less than .01). Thirty of the 34 patients initially had abnormal metyrapone responses, 28 had abnormal diurnal cortisol levels, whereas only 14 had abnormal IV ACTH response tests. Although significant improvement was noted in the mean metyrapone and diurnal cortisol tests, only partial recovery of pituitary-adrenal function was observed in 20 patients, complete recovery in 5, and no change in 9. BDA was found to be therapeutically superior to oral steroids in the group of steroid-dependent asthmatic children and produced no serious adverse effects.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Kershnar H,Klein R,Waldman D,Berger W,Rachelefsky G,Katz R,Siegel Ssubject
Has Abstractpub_date
1978-08-01 00:00:00pages
189-97issue
2eissn
0031-4005issn
1098-4275journal_volume
62pub_type
临床试验,杂志文章相关文献
PEDIATRICS文献大全abstract:BACKGROUND:Stroke is often a devastating complication of sickle cell disease (SCD). Most children with SCD-related stroke have stenotic and occlusive disease of cerebral blood vessels due to intimal hyperplasia. This hyperplasia is hypothesized to result from an inflammatory response similar to that in atherosclerosis ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.4.e318
更新日期:2004-04-01 00:00:00
abstract::Many women whose premature infants are hospitalized in a newborn intensive care unit choose to express breast milk for their babies. Yet anxiety, fatigue, and emotional stress are powerful inhibitors of lactation. To facilitate the breast-feeding experience, intervention mothers were given a 20-minute audio cassette t...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:Preterm infants are frequently discharged from the hospital growth retarded and show reduced growth throughout childhood. In a large efficacy and safety trial, we tested the hypothesis that nutritional intervention in the first 9 months postterm would reverse postdischarge growth deficits and improve neurode...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.108.3.703
更新日期:2001-09-01 00:00:00
abstract::Decision-making is important in the context of pediatric chronic illness because children and families need to make decisions about burdensome and complex treatments on a regular basis, and children must eventually learn how to make such decisions independently. Research related to children's decision-making in medica...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-0516D
更新日期:2018-11-01 00:00:00
abstract::Aerosolized racemic epinephrine, but not L-epinephrine, is commonly used in treating croup. The efficacy and adverse effects of nebulized racemic and L-epinephrine in the treatment of laryngotracheitis were compared. Children 6 months to 6 years of age with a croup score of 6 or above were assigned in a randomized dou...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Little published information is available regarding the proportion of hospitals that offer pediatric services at specified levels, or the actual utilization of such services. OBJECTIVE:To determine if an existing national accreditation process created for educational purposes identifies hospitals with a dis...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.5.1068
更新日期:2003-05-01 00:00:00
abstract::Simultaneous serum concentrations of dehydroepiandrosterone sulfate (DHEA-S) and 17-hydroxyprogesterone (17-OHP) were compared with urinary 17-ketosteroid (17-KS) and pregnanetriol (PT) excretion during therapy in 18 prepubertal patients with the 21-hydroxylase deficiency form of congenital adrenal hyperplasia (CAH). ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-06-01 00:00:00
abstract::Arterial blood gases and regional lung function, measured with a 133xenon technique, were used to evalute the physiological defects and follow the natural history of 16 infants with lobar hyperinflation ("emphysema"). Hypoxemia was due to V/Q inequality at rest. Worsening of hypoxemia (mean Pao2 delta--26 mm Hg) with ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::Partial nasal obstruction in preterm infants increases the airway resistance. In spite of this, nasal feeding tubes are often used, if only because oral tubes are difficult to secure. A palatal appliance has been devised that maintains the position of oroenteric feeding tube(s) and is not associated with local complic...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVES:To describe the contribution of whole fruit, including discrete types of fruit, to total fruit consumption and to investigate differences in consumption by sociodemographic characteristics. METHODS:We analyzed data from 3129 youth aged 2 to 19 years from the National Health and Nutrition Examination Survey,...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-1709
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To determine the lowest dose of concentrated (U100) insulin that can be reproducibly delivered. METHODS:A telephone survey was used to determine current practices in major pediatric hospitals regarding the administration of low doses of concentrated insulin. A sensitive gravitometric technique was used to de...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:We describe patient characteristics and postoperative morbidity and mortality rates for patients with Down syndrome undergoing congenital heart disease surgery. METHODS:This retrospective cohort study used the Society of Thoracic Surgeons Congenital Heart Surgery Database to compare patient characteristics a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-3245
更新日期:2010-08-01 00:00:00
abstract::Two different tetravalent polysaccharide vaccines against group A, C, Y, and W135 meningococci were given to 118 infants aged 6 to 23 months; the same vaccines were administered in a second dose 12 months later to those infants aged 6 to 11 months at first vaccination. Forty of the infants received vaccine containing ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1985-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of a "walking school bus" program on children's rates of active commuting to school and physical activity. METHODS:We conducted a pilot cluster randomized controlled trial among 4th-graders from 8 schools in Houston, Texas (N = 149). Random allocation to treatment or control conditions...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2010-3486
更新日期:2011-09-01 00:00:00
abstract::With a randomized clinical trial, the possibility was assessed that a tracheal instillation of pulmonary surfactant prior to the first breath might prevent the development of some of the signs of neonatal respiratory distress syndrome. Of the 72 infants in the trial, all born at a gestational age of less than 30 weeks...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1985-08-01 00:00:00
abstract::Age at diagnosis is a modifiable risk factor in outcomes after hepatoportoenterostomy in biliary atresia; however, distinguishing biliary atresia from other more common causes of prolonged neonatal jaundice can be difficult. To focus attention on diagnosis of biliary atresia, we analyzed secular trends in the age at d...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-2709
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:The Neonatal Individualized Developmental Care Program (NIDCAP) for very low birth weight (VLBW) preterm infants has been suggested by Als et al to improve several medical outcome variables such as time on ventilator, time to nipple feed, the duration of hospital stay, better behavioral performance on Assessm...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.100.6.e9
更新日期:1997-12-01 00:00:00
abstract::Several recommendations in the American Academy of Pediatrics policy statement "The Pediatrician's Role in Community Pediatrics" underscore the essential role of research as an agent of change to promote the health and well-being of children. This article provides (1) a framework for thinking about research in communi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2825T
更新日期:2005-04-01 00:00:00
abstract::As part of a multicenter collaborative study, M-mode echocardiograms were obtained shortly after birth on 3,559 premature infants with birth weight less than or equal to 1,750 g. Of these infants, 1,496 did not develop a cardiac murmur or other signs of a "hemodynamically significant" patent ductus arteriosus (PDA). E...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:Pediatric emergency department (PED) overcrowding and prolonged boarding times (admission order to PED departure) decrease quality of care. Timely transfer of patients from the PED to inpatient units is a key driver that relieves overcrowding. In 2015, PED boarding time at our hospital was 10% longer than th...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-1477
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:The objective of this amplitude-integrated electroencephalography (aEEG) study was to evaluate the influence of perinatal hypoxia-ischemia on sleep-wake cycling (SWC) in term newborns and assess whether characteristics of SWC are of predictive value for neurodevelopmental outcome. METHODS:From a consecutive ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:10.1542/peds.2004-0863
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:Long-term follow-up studies of patients with epilepsy have revealed an increased mortality risk compared with the general population. Mortality of children who have epilepsy in modern times is as yet unknown. Therefore, the objective of this study was to determine mortality of children who have epilepsy in co...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.6.1259
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:Evaluate safety and efficacy of filtered-sunlight phototherapy (FS-PT). METHODS:Term/late preterm infants #14 days old with clinically significant jaundice, assessed by total bilirubin (TB) levels, were recruited from a maternity hospital in Lagos, Nigeria. Sunlight was filtered with commercial window-tinti...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-3500
更新日期:2014-06-01 00:00:00
abstract::Psychosocial problems of children have received increasing attention in the pediatric literature, but it remains unclear to what extent psychiatric services are available and used for the treatment of these problems. This paper examines the utilization of psychiatric services by children over an 18-year period in Monr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:Current federal regulations of potentially carcinogenic environmental chemicals are based on the assumption that risks for humans can be extrapolated from the effects of chronic high-dose exposure of rodents. It is assumed that all chemicals induce cancer by a genotoxic mechanism (direct interaction with DNA)...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1993-09-01 00:00:00
abstract::Alcohol use continues to be problematic for youth and young adults in the United States. Understanding of neurobiology and neuroplasticity continues to highlight the potential adverse impact of underage drinking on the developing brain. This policy statement provides the position of the American Academy of Pediatrics ...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2019-1356
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Clinical evidence indicates newborn critical congenital heart disease (CCHD) screening through pulse oximetry is lifesaving. In 2011, CCHD was added to the US Recommended Uniform Screening Panel for newborns. Several states have implemented or are considering screening mandates. This study aimed to estimate ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0332
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Depression, impulsivity, and aggression during adolescence have been associated with both adoption and suicidal behavior. Studies of adopted adults suggest that impulsivity, even more than depression, may be an inherited factor that mediates suicidal behavior. However, the association between adoption and ado...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.2.e30
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Despite high per capita health care expenditure, the United States has crude infant survival rates that are lower than similarly developed nations. Although differences in vital recording and socioeconomic risk have been studied, a systematic, cross-national comparison of perinatal health care systems is lac...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.109.6.1036
更新日期:2002-06-01 00:00:00
abstract::Parents, educators, law enforcement officials, and health professionals are all concerned about the violent radicalization of adolescents. Health professionals may be called on to assess teenagers regarding the risk that they will become dangerous. We present a case in which a psychiatrist is asked to do a forensic ev...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-0685
更新日期:2017-10-01 00:00:00