Evaluation of two tetravalent (ACYW135) meningococcal vaccines in infants and small children: a clinical study comparing immunogenicity of O-acetyl-negative and O-acetyl-positive group C polysaccharides.

Abstract:

:Two different tetravalent polysaccharide vaccines against group A, C, Y, and W135 meningococci were given to 118 infants aged 6 to 23 months; the same vaccines were administered in a second dose 12 months later to those infants aged 6 to 11 months at first vaccination. Forty of the infants received vaccine containing the nonacetylated group C polysaccharide C(OAc-) and 78 the acetylated group C polysaccharide C(OAc+) together with group A, Y, and W135 polysaccharides. All polysaccharides, at a dose of 30 micrograms, induced antibody responses after administration of both vaccines in all age groups although the responses were better in the older infants. Acetylation of the sialic acid of the group C polysaccharide did not significantly influence the response. Rapid decreases in the antibody titers after the first vaccination stressed the need for one or more revaccinations. Vaccination elicited mild local and systemic reactions. Elevated temperatures were more common in the youngest infants but only four developed fever exceeding 38.5 degrees C (101.3 degrees F). We conclude that tetravalent (ACYW135) meningococcal vaccine is safe and immunologically effective in children younger than age 2 years. However, revaccinations may be required to maintain immunity.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Peltola H,Safary A,Käyhty H,Karanko V,André FE

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

91-6

issue

1

eissn

0031-4005

issn

1098-4275

journal_volume

76

pub_type

临床试验,杂志文章,随机对照试验
  • Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial.

    abstract:OBJECTIVE:To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN:Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING:National Women's Hospital (Auckland, New Zealand)...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-0196

    authors: Dalziel SR,Liang A,Parag V,Rodgers A,Harding JE

    更新日期:2004-09-01 00:00:00

  • Psychological problems in children with daytime wetting.

    abstract:OBJECTIVE:This population-based study investigated the psychological problems associated with daytime wetting in children. METHODS:A sample of 8213 children (age range: 7 years 6 months to 9 years 3 months) who were enrolled in the population-based Avon Longitudinal Study of Parents and Children participated in this s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0894

    authors: Joinson C,Heron J,von Gontard A

    更新日期:2006-11-01 00:00:00

  • Prepregnant overweight and obesity diminish the prolactin response to suckling in the first week postpartum.

    abstract:OBJECTIVE:The population subgroups with the highest proportion of overweight and obese women often are characterized by the lowest rates of initiation and shortest durations of breastfeeding. We previously documented that these 2 population-level trends may be related. In a population of white women who lived in a rura...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.5.e465

    authors: Rasmussen KM,Kjolhede CL

    更新日期:2004-05-01 00:00:00

  • Diabetic autoimmune markers in children and adolescents with type 2 diabetes.

    abstract:BACKGROUND:There is an increase in the incidence of type 2 diabetes in children and adolescents. Absence of known diabetes autoimmune markers is sometimes required to confirm the diagnosis. OBJECTIVE:To identify clinical and autoimmune characteristics of type 2 diabetes in a pediatric population. METHOD:We report an ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.6.e102

    authors: Hathout EH,Thomas W,El-Shahawy M,Nahab F,Mace JW

    更新日期:2001-06-01 00:00:00

  • Suicide Attempts and Childhood Maltreatment Among Street Youth: A Prospective Cohort Study.

    abstract:BACKGROUND:Although suicide is a known leading cause of death among street youth, few prospective studies have explored childhood experiences as risk factors for future suicide attempt in this population. We examined the risk of attempted suicide in relation to childhood maltreatment among street youth. METHODS:From S...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-1108

    authors: Hadland SE,Wood E,Dong H,Marshall BD,Kerr T,Montaner JS,DeBeck K

    更新日期:2015-09-01 00:00:00

  • Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant: a randomized clinical trial.

    abstract::With a randomized clinical trial, the possibility was assessed that a tracheal instillation of pulmonary surfactant prior to the first breath might prevent the development of some of the signs of neonatal respiratory distress syndrome. Of the 72 infants in the trial, all born at a gestational age of less than 30 weeks...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Enhorning G,Shennan A,Possmayer F,Dunn M,Chen CP,Milligan J

    更新日期:1985-08-01 00:00:00

  • Prenatal Exposure to Acetaminophen and Risk of ADHD.

    abstract:OBJECTIVES:To estimate the association between maternal use of acetaminophen during pregnancy and of paternal use before pregnancy with attention-deficit/hyperactivity disorder (ADHD) in offspring while adjusting for familial risk for ADHD and indications of acetaminophen use. METHODS:Diagnoses were obtained from the ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-3840

    authors: Ystrom E,Gustavson K,Brandlistuen RE,Knudsen GP,Magnus P,Susser E,Davey Smith G,Stoltenberg C,Surén P,Håberg SE,Hornig M,Lipkin WI,Nordeng H,Reichborn-Kjennerud T

    更新日期:2017-11-01 00:00:00

  • Phototherapy for neonatal hyperbilirubinemia in "healthy" and "ill" infants.

    abstract::The effectiveness of phototherapy for nonhemolytic hyperbilirubinemia was evaluated in two groups of closely matched newborns, one group consisting of "healthy" and the other "ill" infants. Phototherapy was equally effective in reducing bilirubin levels in both groups of infants. It would seem to be the treatment of c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Tan KL

    更新日期:1976-06-01 00:00:00

  • Use of a telephone nursing line in a pediatric neurology clinic: one approach to the shortage of subspecialists.

    abstract:OBJECTIVE:There are not enough pediatric neurologists to meet the many needs of pediatric neurology patients. The Hospital for Sick Children has responded by expanding the nursing role in the pediatric neurology outpatient clinic. The objective of this study was to examine the use of a telephone nursing line in this ho...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.5.1083

    authors: Letourneau MA,MacGregor DL,Dick PT,McCabe EJ,Allen AJ,Chan VW,MacMillan LJ,Golomb MR

    更新日期:2003-11-01 00:00:00

  • Hypertension screening in schools: results of the Dallas study.

    abstract::The purpose of this study was to determine the prevalence of persistent blood pressure elevations in an eighth-grade population composed of three ethnic groups, and to determine the feasibility of using school health facilities for hypertension screening. Blood pressure was recorded in 10,641 subjects (90% of the tota...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fixler DE,Laird WP,Fitzgerald V,Stead S,Adams R

    更新日期:1979-01-01 00:00:00

  • Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys.

    abstract:OBJECTIVE:Exercise can enhance growth and development in children, but recent investigations have revealed an intriguing paradox. Namely, the early (4-5 weeks) response to training programs in children lead to a catabolic, growth hormone (GH)-resistant state rather than the expected anabolic activation of the GH-->insu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.4.681

    authors: Nemet D,Oh Y,Kim HS,Hill M,Cooper DM

    更新日期:2002-10-01 00:00:00

  • Community physician's role in case management of children with chronic illnesses.

    abstract::There is general agreement that case management should be provided to children with chronic illnesses, yet it is not clear who should provide this service. A survey of physicians and parents of children with chronic illnesses was conducted to evaluate the practice and views of pediatricians and compare their assessmen...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Liptak GS,Revell GM

    更新日期:1989-09-01 00:00:00

  • Post-varicella epiglottitis and necrotizing fasciitis.

    abstract::Varicella is a nearly ubiquitous acquired childhood disease. Infectious complications of varicella can be life- or limb-threatening. These complications appear 3 to 4 days after the appearance of varicella exanthem and are heralded by fever, pain, and erythema of the overlying skin. Airway complications of varicella a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.1.e13

    authors: Slack CL,Allen GC,Morrison JE,Garren KC,Roback MG

    更新日期:2000-01-01 00:00:00

  • Pituitary gland gumma in congenital syphilis after failed maternal treatment: a case report.

    abstract::A preterm, very low birth weight infant was born to a mother with early latent syphilis who was treated 10 days and 3 days before delivery with 2.4 mU of benzathine penicillin. The infant had clinical, laboratory, and radiographic abnormalities consistent with congenital syphilis, ie, a Venereal Disease Research Labor...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.104.1.e4

    authors: Benzick AE,Wirthwein DP,Weinberg A,Wendel GD Jr,Alsaadi R,Leos NK,Zeray F,Sánchez PJ

    更新日期:1999-07-01 00:00:00

  • Usefulness of the serum electrolyte panel in the management of pediatric dehydration treated with intravenously administered fluids.

    abstract:BACKGROUND:The serum electrolyte panel (SEP) is a frequently ordered laboratory test, but it has unproven usefulness in the treatment of dehydrated pediatric patients. Our study purpose was to evaluate the usefulness of routinely ordering a SEP in the treatment of dehydrated pediatric patients receiving intravenous flu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-0457

    authors: Wathen JE,MacKenzie T,Bothner JP

    更新日期:2004-11-01 00:00:00

  • Pediatric Psychopharmacology for Treatment of ADHD, Depression, and Anxiety.

    abstract::The pediatric practitioner is often the first point-of-contact for children and adolescents suffering from mental illness. Part of the treatment planning for psychiatric diagnoses includes consideration of medication. Attention-deficit/hyperactivity disorder, one of the most common diagnoses, is very responsive to sti...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-1581

    authors: Southammakosane C,Schmitz K

    更新日期:2015-08-01 00:00:00

  • A Multifaceted Approach to Improving Outcomes in the NICU: The Pediatrix 100 000 Babies Campaign.

    abstract:BACKGROUND AND OBJECTIVE:Despite advances in neonatal medicine, infants requiring neonatal intensive care continue to experience substantial morbidity and mortality. The purpose of this initiative was to generate large-scale simultaneous improvements in multiple domains of care in a large neonatal network through a pro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-0389

    authors: Ellsbury DL,Clark RH,Ursprung R,Handler DL,Dodd ED,Spitzer AR

    更新日期:2016-04-01 00:00:00

  • Spontaneous Closure of Patent Ductus Arteriosus in Infants ≤1500 g.

    abstract:OBJECTIVES:Patent ductus arteriosus (PDA) remains a challenging issue in very low birth weight (VLBW) infants, and its management varies widely. Our aim in this study was to document the natural course of ductus arteriosus in a cohort of VLBW infants who underwent conservative PDA management with no medical or surgical...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-4258

    authors: Semberova J,Sirc J,Miletin J,Kucera J,Berka I,Sebkova S,O'Sullivan S,Franklin O,Stranak Z

    更新日期:2017-08-01 00:00:00

  • Herpes simplex virus central nervous system relapse during treatment of infantile spasms with corticotropin.

    abstract::Here we report an infant who had herpes simplex virus (HSV) encephalitis and sustained severe bilateral damage to the posterior frontal lobes, postcentral gyri, and the thalami despite intravenous acyclovir treatment. At 7 months of age, the patient developed infantile spasms and was treated with corticotropin injecti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1867

    authors: Bonkowsky JL,Filloux FM,Byington CL

    更新日期:2006-05-01 00:00:00

  • In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children.

    abstract:OBJECTIVE:We investigated the relationship between prenatal exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment of Mexican farm-workers' children in California. METHODS:Participants from the Center for the Health Assessment of Mothers and Children of Salina...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-3117

    authors: Eskenazi B,Marks AR,Bradman A,Fenster L,Johnson C,Barr DB,Jewell NP

    更新日期:2006-07-01 00:00:00

  • Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants.

    abstract:BACKGROUND:Although caffeine use for apnea of prematurity is well studied, the long-term safety and benefit of routine early caffeine administration has not been explored. Our objective was to determine the association between early (within 2 days of birth) versus late caffeine exposure and neurodevelopmental outcomes ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-1348

    authors: Lodha A,Entz R,Synnes A,Creighton D,Yusuf K,Lapointe A,Yang J,Shah PS,investigators of the Canadian Neonatal Network (CNN) and the Canadian Neonatal Follow-up Network (CNFUN).

    更新日期:2019-01-01 00:00:00

  • Pediatric residents' continuity clinics: how are we really doing?

    abstract::The Accreditation Council for Graduate Medical Education (ACGME) established guidelines in 1989 requiring pediatric residents to attend a continuity clinic (CC) one half-day per week. OBJECTIVE. To assess pediatric residents' CCs, with an emphasis on those factors potentially affecting house staff education and patien...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Dumont-Driscoll MC,Barbian LT,Pollock BH

    更新日期:1995-10-01 00:00:00

  • Effect of ampicillin and chloramphenicol against Haemophilus influenzae.

    abstract::Synergy, determined by isobolograms constructed from the minimal inhibitory concentrations of combinations of ampicillin and chloramphenicol, was observed against six of 13 ampicillin-susceptible Haemophilus influenzae type b isolates and against five of eight ampicillin-resistant strains by using a small inoculum of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.406

    authors: Feldman WE

    更新日期:1978-03-01 00:00:00

  • Recent trends in waist circumference and waist-height ratio among US children and adolescents.

    abstract:OBJECTIVES:Abdominal obesity may be a better predictor than overall obesity for the risk of cardiovascular disease and type 2 diabetes. Waist circumference and waist-height ratio are 2 simple, yet effective, surrogate measures of abdominal obesity. We sought to examine the recent trends in mean waist circumference and ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1062

    authors: Li C,Ford ES,Mokdad AH,Cook S

    更新日期:2006-11-01 00:00:00

  • Disaster Preparedness in Neonatal Intensive Care Units.

    abstract::Disasters disproportionally affect vulnerable, technology-dependent people, including preterm and critically ill newborn infants. It is important for health care providers to be aware of and prepared for the potential consequences of disasters for the NICU. Neonatal intensive care personnel can provide specialized exp...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0507

    authors: Barfield WD,Krug SE,COMMITTEE ON FETUS AND NEWBORN.,DISASTER PREPAREDNESS ADVISORY COUNCIL.

    更新日期:2017-05-01 00:00:00

  • Circulating pro- and counterinflammatory cytokine levels and severity in necrotizing enterocolitis.

    abstract:OBJECTIVES:To evaluate the relationship between the severity of necrotizing enterocolitis (NEC) and circulating concentrations of proinflammatory cytokines interleukin (IL)-1beta and IL-8 and counterinflammatory cytokines IL-1 receptor antagonist (IL-1ra) and IL-10. These cytokines have been associated with bowel injur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.4.766

    authors: Edelson MB,Bagwell CE,Rozycki HJ

    更新日期:1999-04-01 00:00:00

  • Apparent Cause Analysis: A Safety Tool.

    abstract::Causal analysis is a core function of safety programs. Although established protocols exist for conducting root cause analysis for serious safety events, there is limited guidance for apparent cause analysis (ACA) in health care. At our institution, through a novel facilitated ACA approach, we aim to improve safety cu...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2019-1819

    authors: Parikh K,Hochberg E,Cheng JJ,Lavette LB,Merkeley K,Fahey L,Shah RK

    更新日期:2020-05-01 00:00:00

  • Ostensible versus actual reasons for seeking pediatric attention: another look at the parental ticket of admission.

    abstract::The presentation of parental anxiety that appears excessive in view of the nature of the child's "chief complaint" is a frequent occurrence in pediatric practice. This study reviews 370 sick-patient visits in one pediatric office during a three-month period. Additional questioning in the area of parental anxieties con...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bass LW,Cohen RL

    更新日期:1982-12-01 00:00:00

  • Long-term follow-up care for pediatric cancer survivors.

    abstract::Progress in therapy has made survival into adulthood a reality for most children, adolescents, and young adults diagnosed with cancer today. Notably, this growing population remains vulnerable to a variety of long-term therapy-related sequelae. Systematic ongoing follow-up of these patients, therefore, is important fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3688

    authors: American Academy of Pediatrics Section on Hematology\/Oncology Children's Oncology Group.

    更新日期:2009-03-01 00:00:00

  • Improving Access to Care at Autism Treatment Centers: A System Analysis Approach.

    abstract:OBJECTIVE:The prevalence of autism spectrum disorder is steadily increasing and placing more demands on already overburdened diagnostic and treatment systems. A thoughtful, systematic reorganization of autism service delivery may reduce delays and better meet the growing need. METHODS:Two clinical centers in the Autis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2851M

    authors: Austin J,Manning-Courtney P,Johnson ML,Weber R,Johnson H,Murray D,Ratliff-Schaub K,Tadlock AM,Murray M

    更新日期:2016-02-01 00:00:00