Abstract:
BACKGROUND:Although caffeine use for apnea of prematurity is well studied, the long-term safety and benefit of routine early caffeine administration has not been explored. Our objective was to determine the association between early (within 2 days of birth) versus late caffeine exposure and neurodevelopmental outcomes in preterm infants. METHODS:Infants of <29 weeks' gestation born between April 2009 and September 2011 and admitted to Canadian Neonatal Network units and then assessed at Canadian Neonatal Follow-up Network centers were studied. Neonates who received caffeine were divided into early- (received within 2 days of birth) and late-caffeine (received after 2 days of birth) groups. The primary outcome was significant neurodevelopmental impairment, defined as cerebral palsy, or a Bayley Scales of Infant and Toddler Development, Third Edition composite score of <70 on any component, hearing aid or cochlear implant, or bilateral visual impairment at 18 to 24 months' corrected age. RESULTS:Of 2108 neonates who were eligible, 1545 were in the early-caffeine group and 563 were in the late-caffeine group. Rates of bronchopulmonary dysplasia, patent ductus arteriosus, and severe neurologic injury were lower in the early-caffeine group than in the late-caffeine group. Significant neurodevelopmental impairment (adjusted odds ratio 0.68 [95% confidence interval 0.50-0.94]) and odds of Bayley Scales of Infant and Toddler Development, Third Edition cognitive scores of <85 (adjusted odds ratio 0.67 [95% confidence interval 0.47-0.95]) were lower in the early-caffeine group than in the late-caffeine group. Propensity score-based matched-pair analyses revealed lower odds of cerebral palsy and hearing impairment only. CONCLUSIONS:Early caffeine therapy is associated with better neurodevelopmental outcomes compared with late caffeine therapy in preterm infants born at <29 weeks' gestation.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Lodha A,Entz R,Synnes A,Creighton D,Yusuf K,Lapointe A,Yang J,Shah PS,investigators of the Canadian Neonatal Network (CNN) and the Canadian Neonatal Follow-up Network (CNFUN).doi
10.1542/peds.2018-1348subject
Has Abstractpub_date
2019-01-01 00:00:00issue
1eissn
0031-4005issn
1098-4275pii
peds.2018-1348journal_volume
143pub_type
杂志文章,多中心研究相关文献
PEDIATRICS文献大全abstract:BACKGROUND:Orphan drug development is crucial for children, who are disproportionately affected by rare diseases. Data are lacking on the number, nature, and benefit of recently approved pediatric orphan indications. METHODS:We classified the 402 orphan indications the US Food and Drug Administration approved between ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-3128
更新日期:2020-04-01 00:00:00
abstract::Sophisticated modern methods of fetal monitoring during labor have improved the prognosis for high-risk infants, but the possible adverse side effects have not yet been fully documented. One infant with osteomyelitis and one with streptococcal sepsis are reported. In the future, greater attention should be paid to suc...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1975-02-01 00:00:00
abstract::The potential clinical value of quantitative blood cultures determined by a commercially available lysis-direct plating method was studied in 50 children with either Haemophilus influenzae or Streptococcus pneumoniae bacteremia. The magnitude of bacteremia correlated with the severity of the infection; patients with g...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract::In 1984, an outbreak of gastroenteritis occurred at a school with 1,860 students in Brooklyn, NY. In a single-stage cluster sample of 375 students, 129 (34%) had illnesses that met our case definition of vomiting or diarrhea. The mean incubation period was 26 hours, and the mean illness duration was 24 hours. All case...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:Observational study of 543 infants who weighed <1850 g, published in 1988 reported seriously impaired motor and cognitive development at 18 months in those with recurrent, asymptomatic hypoglycemia (plasma glucose level ≤2.5 mmol/L on ≥3 days). No study has yet replicated this observation. AIM:To quantify d...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-0776
更新日期:2012-12-01 00:00:00
abstract::Milk volume, day of initiation of pumping, duration and frequency of milk expression, and length of night rest interval were evaluated for the first month postpartum in 32 healthy, nonsmoking women (ages 20 to 38 years) who delivered at 28 to 30 weeks' gestation. Early milk volumes were related negatively to the delay...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Approximately half of women with intellectual and developmental disabilities (IDDs) lose custody of their children at some point in their child's development, but their rates of and risk factors for newborn discharge to child protective services from the birth hospitalization are relatively unknown. METHODS...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-1416
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Digital technologies offer new platforms for health promotion and disease management. Few studies have evaluated the use of digital technology among families receiving care in an urban pediatric primary care setting. METHODS:A self-administered survey was given to a convenience sample of caregivers bringing ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0594
更新日期:2013-07-01 00:00:00
abstract::Injury is the third leading cause of death in the United States and the leading cause for children, adolescents, and young adults. Injury results from multiple factors and so may its prevention. The first and simplest approach toward preventing injuries has been to innovatively and aggressively apply a traditional pub...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1992-11-01 00:00:00
abstract::A relationship between sudden infant death syndrome and the use of phenothiazine-containing medications is suspected. In order to investigate the influence of phenothiazines upon cardiorespiratory and sleep characteristics, four normal infants (mean age 15.8 weeks) had polygraphic recordings made for one night. The re...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract:OBJECTIVE:We have used the combination of midazolam, a short-acting benzodiazepine, and ketamine, a "dissociative anesthetic," to provide conscious sedation for invasive or lengthy procedures. METHODS:A total of 350 procedures (74 lumbar punctures, 97 bone marrow aspirations or biopsies, 84 radiotherapy sessions, and ...
journal_title:Pediatrics
pub_type: 临床试验,评论,杂志文章
doi:10.1542/peds.99.3.427
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:Previous studies have shown that selected strains of Lactobacillus have the capacity to antagonize rotavirus-induced diarrhea. However, only a few reports have documented their efficacy against nonrotavirus diarrhea. This study involved an experimental investigation and a clinical trial of the antisecretory a...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2006-2930
更新日期:2007-10-01 00:00:00
abstract::Staphylococcus aureus is a common cause of community and health care-associated bacteremia, with authors of recent studies estimating the incidence of S aureus bacteremia (SAB) in high-income countries between 8 and 26 per 100 000 children per year. Despite this, <300 children worldwide have ever been randomly assigne...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-0134
更新日期:2020-09-01 00:00:00
abstract:INTRODUCTION:Renovascular disease accounts for the vast majority of cases of infantile hypertension with complications resulting from umbilical arterial catheterization predominating in the neonatal period and fibrodysplastic lesions of the renal artery predominating outside the neonatal period. We report a previously ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.5.e66
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To determine whether physicians can estimate accurately the age of an accidental bruise on direct physical examination. METHODS:Children who presented to the emergency department of a children's hospital with accidental bruises of known age and origin had demographic data and information about their injury r...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.4.804
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:We asked whether neonatal jaundice associated with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency commences either in utero or in the immediate postnatal period and whether this perinatal bilirubinemia is the precursor of the subsequent neonatal jaundice and hyperbilirubinemia. METHODS:Mandatory serum...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.4.956
更新日期:2001-10-01 00:00:00
abstract::Acute profound dystonia developed in three previously well infants who were found to have glutaryl-CoA dehydrogenase deficiency in cultured skin fibroblasts. Two patients had excessive urinary excretion of glutaric acid, but one did not. Neuroradiologic studies performed in all three patients at the onset of their ill...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVE:To determine if race/ethnicity-based differences exist in the management of pediatric abdominal pain in emergency departments (EDs). METHODS:Secondary analysis of data from the 2006-2009 National Hospital Ambulatory Medical Care Survey regarding 2298 visits by patients ≤ 21 years old who presented to EDs wit...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-3127
更新日期:2013-10-01 00:00:00
abstract::The pediatrician plays a key role in the prevention of mother-to-child transmission of HIV-1 infection. For infants born to women with HIV-1 infection identified during pregnancy, the pediatrician ensures that antiretroviral prophylaxis is provided to the infant to decrease the risk of acquiring HIV-1 infection and pr...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2008-3076
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To quantify the effect of antibiotic therapy on the probability of subsequent bacterial meningitis in children with fever without source treated as outpatients. DESIGN:Bayesian meta-analyses. REPORTS INCLUDED: All reports of the organism-specific prevalence of occult bacteremia in children with fever without...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:The clinical diagnosis of sepsis remains difficult, particularly in the young child, and would be improved by a rapid and reliable method for identification of bacteria in blood and other body fluids. Polymerase chain reaction (PCR) amplification of highly conserved DNA sequences found in all bacteria would p...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVES:To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected infants. METHODS:We used growth curve modeling to analyze t...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-1517
更新日期:2017-11-01 00:00:00
abstract::In a test of Feingold's hypothesis that food additives trigger the hyperactive response, 26 hyperactive children were randomly assigned to treatment conditions whereby they were given active or placebo medications in combination with challenge cookies with artificial food colors or control cookies without the additive...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND:Skin tests with soluble beta-lactams can be used to diagnose immediate and delayed hypersensitivity (HS) reactions to beta-lactam antibiotics. Very few studies have been performed with children with suspected beta-lactam allergy. In these studies, immediate HS to beta-lactams was diagnosed by skin tests in 4...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.4.e45
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:2-methylbutyryl-CoA dehydrogenase deficiency, also known as short/branched-chain acyl-CoA dehydrogenase (SBCAD) deficiency, is a recently described autosomal recessive disorder of L-isoleucine metabolism. Only 4 affected individuals in 2 families have been described. One patient developed athetoid cerebral pa...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.112.1.74
更新日期:2003-07-01 00:00:00
abstract::Historically, physicians have received little formal education related to alcohol or other drug abuse and dependence. A survey of all pediatric programs in the United States was conducted to assess the current status of alcohol/drug education in pediatrics. At the medical student and residency training levels, only 44...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVES:Multisystem inflammatory syndrome in children (MIS-C) has spread through the pediatric population during the coronavirus disease 2019 pandemic. Our objective for the study was to report the prevalence of conduction anomalies in MIS-C and identify predictive factors for the conduction abnormalities. METHODS:...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-009738
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:A metabolic profile consistent with impaired cobalamin status is prevalent in breastfed infants. We investigated whether this profile reflects immature organ systems or impaired cobalamin status. METHODS:In a single-center, randomized, placebo-controlled trial, we studied 107 six-week-old infants. The infant...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2007-2716
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:The purposes of this study were to report the neurodevelopmental, neurosensory, and functional outcomes of 1151 extremely low birth weight (401-1000 g) survivors cared for in the 12 participating centers of the National Institute of Child Health and Human Development Neonatal Research Network, and to identif...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.105.6.1216
更新日期:2000-06-01 00:00:00
abstract::The proper ethical conduct of studies to evaluate drugs in children is of paramount importance to all those involved in these types of studies. This report is an updated revision to the previously published guidelines from the American Academy of Pediatrics in 1995. Since the previous publication, there have been grea...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-0082
更新日期:2010-04-01 00:00:00