Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants.

Abstract:

BACKGROUND:Although caffeine use for apnea of prematurity is well studied, the long-term safety and benefit of routine early caffeine administration has not been explored. Our objective was to determine the association between early (within 2 days of birth) versus late caffeine exposure and neurodevelopmental outcomes in preterm infants. METHODS:Infants of <29 weeks' gestation born between April 2009 and September 2011 and admitted to Canadian Neonatal Network units and then assessed at Canadian Neonatal Follow-up Network centers were studied. Neonates who received caffeine were divided into early- (received within 2 days of birth) and late-caffeine (received after 2 days of birth) groups. The primary outcome was significant neurodevelopmental impairment, defined as cerebral palsy, or a Bayley Scales of Infant and Toddler Development, Third Edition composite score of <70 on any component, hearing aid or cochlear implant, or bilateral visual impairment at 18 to 24 months' corrected age. RESULTS:Of 2108 neonates who were eligible, 1545 were in the early-caffeine group and 563 were in the late-caffeine group. Rates of bronchopulmonary dysplasia, patent ductus arteriosus, and severe neurologic injury were lower in the early-caffeine group than in the late-caffeine group. Significant neurodevelopmental impairment (adjusted odds ratio 0.68 [95% confidence interval 0.50-0.94]) and odds of Bayley Scales of Infant and Toddler Development, Third Edition cognitive scores of <85 (adjusted odds ratio 0.67 [95% confidence interval 0.47-0.95]) were lower in the early-caffeine group than in the late-caffeine group. Propensity score-based matched-pair analyses revealed lower odds of cerebral palsy and hearing impairment only. CONCLUSIONS:Early caffeine therapy is associated with better neurodevelopmental outcomes compared with late caffeine therapy in preterm infants born at <29 weeks' gestation.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Lodha A,Entz R,Synnes A,Creighton D,Yusuf K,Lapointe A,Yang J,Shah PS,investigators of the Canadian Neonatal Network (CNN) and the Canadian Neonatal Follow-up Network (CNFUN).

doi

10.1542/peds.2018-1348

subject

Has Abstract

pub_date

2019-01-01 00:00:00

issue

1

eissn

0031-4005

issn

1098-4275

pii

peds.2018-1348

journal_volume

143

pub_type

杂志文章,多中心研究
  • Pediatric Orphan Drug Indications: 2010-2018.

    abstract:BACKGROUND:Orphan drug development is crucial for children, who are disproportionately affected by rare diseases. Data are lacking on the number, nature, and benefit of recently approved pediatric orphan indications. METHODS:We classified the 402 orphan indications the US Food and Drug Administration approved between ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-3128

    authors: Kimmel L,Conti RM,Volerman A,Chua KP

    更新日期:2020-04-01 00:00:00

  • Osteomyelitis and sepsis: severe complications of fetal monitoring.

    abstract::Sophisticated modern methods of fetal monitoring during labor have improved the prognosis for high-risk infants, but the possible adverse side effects have not yet been fully documented. One infant with osteomyelitis and one with streptococcal sepsis are reported. In the future, greater attention should be paid to suc...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Overturf GD,Balfour G

    更新日期:1975-02-01 00:00:00

  • Routine quantitative blood cultures in children with Haemophilus influenzae or Streptococcus pneumoniae bacteremia.

    abstract::The potential clinical value of quantitative blood cultures determined by a commercially available lysis-direct plating method was studied in 50 children with either Haemophilus influenzae or Streptococcus pneumoniae bacteremia. The magnitude of bacteremia correlated with the severity of the infection; patients with g...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bell LM,Alpert G,Campos JM,Plotkin SA

    更新日期:1985-12-01 00:00:00

  • Foodborne Snow Mountain agent gastroenteritis in a school cafeteria.

    abstract::In 1984, an outbreak of gastroenteritis occurred at a school with 1,860 students in Brooklyn, NY. In a single-stage cluster sample of 375 students, 129 (34%) had illnesses that met our case definition of vomiting or diarrhea. The mean incubation period was 26 hours, and the mean illness duration was 24 hours. All case...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Guest C,Spitalny KC,Madore HP,Pray K,Dolin R,Herrmann JE,Blacklow NR

    更新日期:1987-04-01 00:00:00

  • 15-year follow-up of recurrent "hypoglycemia" in preterm infants.

    abstract:BACKGROUND:Observational study of 543 infants who weighed <1850 g, published in 1988 reported seriously impaired motor and cognitive development at 18 months in those with recurrent, asymptomatic hypoglycemia (plasma glucose level ≤2.5 mmol/L on ≥3 days). No study has yet replicated this observation. AIM:To quantify d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0776

    authors: Tin W,Brunskill G,Kelly T,Fritz S

    更新日期:2012-12-01 00:00:00

  • Milk production by mothers of premature infants.

    abstract::Milk volume, day of initiation of pumping, duration and frequency of milk expression, and length of night rest interval were evaluated for the first month postpartum in 32 healthy, nonsmoking women (ages 20 to 38 years) who delivered at 28 to 30 weeks' gestation. Early milk volumes were related negatively to the delay...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hopkinson JM,Schanler RJ,Garza C

    更新日期:1988-06-01 00:00:00

  • Maternal Intellectual or Developmental Disability and Newborn Discharge to Protective Services.

    abstract:BACKGROUND:Approximately half of women with intellectual and developmental disabilities (IDDs) lose custody of their children at some point in their child's development, but their rates of and risk factors for newborn discharge to child protective services from the birth hospitalization are relatively unknown. METHODS...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-1416

    authors: Brown HK,Potvin LA,Lunsky Y,Vigod SN

    更新日期:2018-12-01 00:00:00

  • Access to digital technology among families coming to urban pediatric primary care clinics.

    abstract:OBJECTIVE:Digital technologies offer new platforms for health promotion and disease management. Few studies have evaluated the use of digital technology among families receiving care in an urban pediatric primary care setting. METHODS:A self-administered survey was given to a convenience sample of caregivers bringing ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0594

    authors: Demartini TL,Beck AF,Klein MD,Kahn RS

    更新日期:2013-07-01 00:00:00

  • Health consequences of behaviors: injury as a model.

    abstract::Injury is the third leading cause of death in the United States and the leading cause for children, adolescents, and young adults. Injury results from multiple factors and so may its prevention. The first and simplest approach toward preventing injuries has been to innovatively and aggressively apply a traditional pub...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Irwin CE Jr,Cataldo MF,Matheny AP Jr,Peterson L

    更新日期:1992-11-01 00:00:00

  • Phenothiazine-induced sleep apneas in normal infants.

    abstract::A relationship between sudden infant death syndrome and the use of phenothiazine-containing medications is suspected. In order to investigate the influence of phenothiazines upon cardiorespiratory and sleep characteristics, four normal infants (mean age 15.8 weeks) had polygraphic recordings made for one night. The re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kahn A,Hasaerts D,Blum D

    更新日期:1985-05-01 00:00:00

  • Efficacy and safety of intravenous midazolam and ketamine as sedation for therapeutic and diagnostic procedures in children.

    abstract:OBJECTIVE:We have used the combination of midazolam, a short-acting benzodiazepine, and ketamine, a "dissociative anesthetic," to provide conscious sedation for invasive or lengthy procedures. METHODS:A total of 350 procedures (74 lumbar punctures, 97 bone marrow aspirations or biopsies, 84 radiotherapy sessions, and ...

    journal_title:Pediatrics

    pub_type: 临床试验,评论,杂志文章

    doi:10.1542/peds.99.3.427

    authors: Parker RI,Mahan RA,Giugliano D,Parker MM

    更新日期:1997-03-01 00:00:00

  • An experimental study and a randomized, double-blind, placebo-controlled clinical trial to evaluate the antisecretory activity of Lactobacillus acidophilus strain LB against nonrotavirus diarrhea.

    abstract:OBJECTIVE:Previous studies have shown that selected strains of Lactobacillus have the capacity to antagonize rotavirus-induced diarrhea. However, only a few reports have documented their efficacy against nonrotavirus diarrhea. This study involved an experimental investigation and a clinical trial of the antisecretory a...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2006-2930

    authors: Liévin-Le Moal V,Sarrazin-Davila LE,Servin AL

    更新日期:2007-10-01 00:00:00

  • Clinical Management of Staphylococcus aureus Bacteremia in Neonates, Children, and Adolescents.

    abstract::Staphylococcus aureus is a common cause of community and health care-associated bacteremia, with authors of recent studies estimating the incidence of S aureus bacteremia (SAB) in high-income countries between 8 and 26 per 100 000 children per year. Despite this, <300 children worldwide have ever been randomly assigne...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-0134

    authors: McMullan BJ,Campbell AJ,Blyth CC,McNeil JC,Montgomery CP,Tong SYC,Bowen AC

    更新日期:2020-09-01 00:00:00

  • Solitary renal myofibromatosis: an unusual cause of infantile hypertension.

    abstract:INTRODUCTION:Renovascular disease accounts for the vast majority of cases of infantile hypertension with complications resulting from umbilical arterial catheterization predominating in the neonatal period and fibrodysplastic lesions of the renal artery predominating outside the neonatal period. We report a previously ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.5.e66

    authors: Kasaragod AB,Lucia MS,Lum GM,Caldwell S,Stork L,Stenmark KR

    更新日期:1999-05-01 00:00:00

  • Dating of bruises in children: an assessment of physician accuracy.

    abstract:OBJECTIVE:To determine whether physicians can estimate accurately the age of an accidental bruise on direct physical examination. METHODS:Children who presented to the emergency department of a children's hospital with accidental bruises of known age and origin had demographic data and information about their injury r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.4.804

    authors: Bariciak ED,Plint AC,Gaboury I,Bennett S

    更新日期:2003-10-01 00:00:00

  • Onset of jaundice in glucose-6-phosphate dehydrogenase-deficient neonates.

    abstract:OBJECTIVE:We asked whether neonatal jaundice associated with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency commences either in utero or in the immediate postnatal period and whether this perinatal bilirubinemia is the precursor of the subsequent neonatal jaundice and hyperbilirubinemia. METHODS:Mandatory serum...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.4.956

    authors: Kaplan M,Algur N,Hammerman C

    更新日期:2001-10-01 00:00:00

  • Acute profound dystonia in infants with glutaric acidemia.

    abstract::Acute profound dystonia developed in three previously well infants who were found to have glutaryl-CoA dehydrogenase deficiency in cultured skin fibroblasts. Two patients had excessive urinary excretion of glutaric acid, but one did not. Neuroradiologic studies performed in all three patients at the onset of their ill...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Bergman I,Finegold D,Gartner JC Jr,Zitelli BJ,Claassen D,Scarano J,Roe CR,Stanley C,Goodman SI

    更新日期:1989-02-01 00:00:00

  • Association of race and ethnicity with management of abdominal pain in the emergency department.

    abstract:OBJECTIVE:To determine if race/ethnicity-based differences exist in the management of pediatric abdominal pain in emergency departments (EDs). METHODS:Secondary analysis of data from the 2006-2009 National Hospital Ambulatory Medical Care Survey regarding 2298 visits by patients ≤ 21 years old who presented to EDs wit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3127

    authors: Johnson TJ,Weaver MD,Borrero S,Davis EM,Myaskovsky L,Zuckerbraun NS,Kraemer KL

    更新日期:2013-10-01 00:00:00

  • Evaluation and management of the infant exposed to HIV-1 in the United States.

    abstract::The pediatrician plays a key role in the prevention of mother-to-child transmission of HIV-1 infection. For infants born to women with HIV-1 infection identified during pregnancy, the pediatrician ensures that antiretroviral prophylaxis is provided to the infant to decrease the risk of acquiring HIV-1 infection and pr...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2008-3076

    authors: Havens PL,Mofenson LM,American Academy of Pediatrics Committee on Pediatric AIDS.

    更新日期:2009-01-01 00:00:00

  • Effect of antibiotic therapy and etiologic microorganism on the risk of bacterial meningitis in children with occult bacteremia.

    abstract:OBJECTIVE:To quantify the effect of antibiotic therapy on the probability of subsequent bacterial meningitis in children with fever without source treated as outpatients. DESIGN:Bayesian meta-analyses. REPORTS INCLUDED: All reports of the organism-specific prevalence of occult bacteremia in children with fever without...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:

    authors: Baraff LJ,Oslund S,Prather M

    更新日期:1993-07-01 00:00:00

  • Amplification of bacterial DNA using highly conserved sequences: automated analysis and potential for molecular triage of sepsis.

    abstract:OBJECTIVE:The clinical diagnosis of sepsis remains difficult, particularly in the young child, and would be improved by a rapid and reliable method for identification of bacteria in blood and other body fluids. Polymerase chain reaction (PCR) amplification of highly conserved DNA sequences found in all bacteria would p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: McCabe KM,Khan G,Zhang YH,Mason EO,McCabe ER

    更新日期:1995-02-01 00:00:00

  • Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection.

    abstract:OBJECTIVES:To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected infants. METHODS:We used growth curve modeling to analyze t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-1517

    authors: Lopez AS,Lanzieri TM,Claussen AH,Vinson SS,Turcich MR,Iovino IR,Voigt RG,Caviness AC,Miller JA,Williamson WD,Hales CM,Bialek SR,Demmler-Harrison G,Congenital Cytomegalovirus Longitudinal Study Group.

    更新日期:2017-11-01 00:00:00

  • Relative effects of drugs and diet on hyperactive behaviors: an experimental study.

    abstract::In a test of Feingold's hypothesis that food additives trigger the hyperactive response, 26 hyperactive children were randomly assigned to treatment conditions whereby they were given active or placebo medications in combination with challenge cookies with artificial food colors or control cookies without the additive...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Williams JI,Cram DM,Tausig FT,Webster E

    更新日期:1978-06-01 00:00:00

  • Allergy to beta-lactam antibiotics in children.

    abstract:BACKGROUND:Skin tests with soluble beta-lactams can be used to diagnose immediate and delayed hypersensitivity (HS) reactions to beta-lactam antibiotics. Very few studies have been performed with children with suspected beta-lactam allergy. In these studies, immediate HS to beta-lactams was diagnosed by skin tests in 4...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.104.4.e45

    authors: Ponvert C,Le Clainche L,de Blic J,Le Bourgeois M,Scheinmann P,Paupe J

    更新日期:1999-10-01 00:00:00

  • Prospective diagnosis of 2-methylbutyryl-CoA dehydrogenase deficiency in the Hmong population by newborn screening using tandem mass spectrometry.

    abstract:OBJECTIVE:2-methylbutyryl-CoA dehydrogenase deficiency, also known as short/branched-chain acyl-CoA dehydrogenase (SBCAD) deficiency, is a recently described autosomal recessive disorder of L-isoleucine metabolism. Only 4 affected individuals in 2 families have been described. One patient developed athetoid cerebral pa...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.112.1.74

    authors: Matern D,He M,Berry SA,Rinaldo P,Whitley CB,Madsen PP,van Calcar SC,Lussky RC,Andresen BS,Wolff JA,Vockley J

    更新日期:2003-07-01 00:00:00

  • Substance abuse education in pediatrics.

    abstract::Historically, physicians have received little formal education related to alcohol or other drug abuse and dependence. A survey of all pediatric programs in the United States was conducted to assess the current status of alcohol/drug education in pediatrics. At the medical student and residency training levels, only 44...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Adger H Jr,McDonald EM,DeAngelis C

    更新日期:1990-10-01 00:00:00

  • MIS-C and Cardiac Conduction Abnormalities.

    abstract:OBJECTIVES:Multisystem inflammatory syndrome in children (MIS-C) has spread through the pediatric population during the coronavirus disease 2019 pandemic. Our objective for the study was to report the prevalence of conduction anomalies in MIS-C and identify predictive factors for the conduction abnormalities. METHODS:...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-009738

    authors: Choi NH,Fremed M,Starc T,Weller R,Cheung E,Ferris A,Silver ES,Liberman L

    更新日期:2020-12-01 00:00:00

  • Common metabolic profile in infants indicating impaired cobalamin status responds to cobalamin supplementation.

    abstract:OBJECTIVE:A metabolic profile consistent with impaired cobalamin status is prevalent in breastfed infants. We investigated whether this profile reflects immature organ systems or impaired cobalamin status. METHODS:In a single-center, randomized, placebo-controlled trial, we studied 107 six-week-old infants. The infant...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2007-2716

    authors: Bjørke-Monsen AL,Torsvik I,Saetran H,Markestad T,Ueland PM

    更新日期:2008-07-01 00:00:00

  • Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994.

    abstract:OBJECTIVES:The purposes of this study were to report the neurodevelopmental, neurosensory, and functional outcomes of 1151 extremely low birth weight (401-1000 g) survivors cared for in the 12 participating centers of the National Institute of Child Health and Human Development Neonatal Research Network, and to identif...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.105.6.1216

    authors: Vohr BR,Wright LL,Dusick AM,Mele L,Verter J,Steichen JJ,Simon NP,Wilson DC,Broyles S,Bauer CR,Delaney-Black V,Yolton KA,Fleisher BE,Papile LA,Kaplan MD

    更新日期:2000-06-01 00:00:00

  • Clinical report--guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations.

    abstract::The proper ethical conduct of studies to evaluate drugs in children is of paramount importance to all those involved in these types of studies. This report is an updated revision to the previously published guidelines from the American Academy of Pediatrics in 1995. Since the previous publication, there have been grea...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0082

    authors: Shaddy RE,Denne SC,Committee on Drugs and Committee on Pediatric Research.

    更新日期:2010-04-01 00:00:00