Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant: a randomized clinical trial.

Abstract:

:With a randomized clinical trial, the possibility was assessed that a tracheal instillation of pulmonary surfactant prior to the first breath might prevent the development of some of the signs of neonatal respiratory distress syndrome. Of the 72 infants in the trial, all born at a gestational age of less than 30 weeks, 39 received 3 or 4 mL of surfactant, prepared from the lipids extracted from calf lung lavage. The treatment resulted in a significantly improved gas exchange during the first 72 hours of life. On the average, the arterial/alveolar PO2 ratio was 0.15 higher for the treated infants, and only about half as much extra oxygen had to be supplied. The respiratory support (peak inspiratory pressure X frequency) could be lowered significantly. Pulmonary interstitial emphysema occurred in 13 of the 33 control infants, but in only three of the 39 treated infants. Six of the control infants died in the neonatal period, but only one treated infant died. It is concluded that surfactant supplementation prior to the first breath is feasible and is of value as protection against the respiratory distress syndrome and the negative effects of hypoxia and ventilatory support.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Enhorning G,Shennan A,Possmayer F,Dunn M,Chen CP,Milligan J

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

145-53

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

76

pub_type

临床试验,杂志文章,随机对照试验
  • Onset of jaundice in glucose-6-phosphate dehydrogenase-deficient neonates.

    abstract:OBJECTIVE:We asked whether neonatal jaundice associated with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency commences either in utero or in the immediate postnatal period and whether this perinatal bilirubinemia is the precursor of the subsequent neonatal jaundice and hyperbilirubinemia. METHODS:Mandatory serum...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.4.956

    authors: Kaplan M,Algur N,Hammerman C

    更新日期:2001-10-01 00:00:00

  • Blueprint for Action: Visioning Summit on the Future of the Workforce in Pediatrics.

    abstract::The Federation of Pediatric Organizations engaged members of the pediatric community in an 18-month process to envision the future of the workforce in pediatrics, culminating in a Visioning Summit on the Future of the Workforce in Pediatrics. This article documents the planning process and methods used. Four working g...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-3493

    authors: Sectish TC,Hay WW Jr,Mahan JD,Mendoza FS,Spector ND,Stanton B,Szilagyi PG,Turner TL,Walker LR,Slaw K,members of the Federation of Pediatric Organizations' Visioning Summit Working Groups and Planning Committee.

    更新日期:2015-07-01 00:00:00

  • Pediatric medication safety and the media: what does the public see?

    abstract:BACKGROUND:In the safety community, it is widely thought that a culture of safety is required to achieve high levels of safety. However, the press tends to report accidents, which are negative by their nature. Pediatric cases are often especially tragic. Relatively few data have been available on the role that the medi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2017

    authors: Stebbing C,Kaushal R,Bates DW

    更新日期:2006-06-01 00:00:00

  • Epidemiology of a tuberculosis outbreak in a rural Missouri high school.

    abstract:OBJECTIVES:1) Demonstrate the importance of maintaining a tuberculosis (TB) control program even in low-incidence areas by studying a TB-contact investigation of a highly infectious high school student in rural Missouri, and 2) discuss factors that perpetuated or contained this school-based outbreak. METHODS:A case re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.6.e514

    authors: Phillips L,Carlile J,Smith D

    更新日期:2004-06-01 00:00:00

  • Otitis media-related antibiotic prescribing patterns, outcomes, and expenditures in a pediatric medicaid population.

    abstract:BACKGROUND:Treatment of otitis media is the most frequent reason for administering antibiotics to children in the United States. However, only limited data are available on medical effectiveness of antibiotic prescribing patterns for otitis media and their associated expenditures or the factors that influence antibioti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.100.4.585

    authors: Berman S,Byrns PJ,Bondy J,Smith PJ,Lezotte D

    更新日期:1997-10-01 00:00:00

  • Isolated congenital malabsorption of folic acid in a male infant: insights into treatment and mechanism of defect.

    abstract::An instructive case of isolated congenital folate malabsorption provides insight into the understanding of this rare disease. Folate loading tests with both timed serum and cerebrospinal fluid folate determinations suggest that both of the two mechanisms involved in gastrointestinal folate absorption are defective in ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.104.5.1133

    authors: Malatack JJ,Moran MM,Moughan B

    更新日期:1999-11-01 00:00:00

  • Aspirin and acetaminophen: a comparative view of their antipyretic and analgesic activity.

    abstract::Aspirin and acetaminophen have excellent and essentially similar antipyretic activity. For the child, lowering of temperature will be indicated for excessively high temperature and when there is a history of febrile seizures. Specific clinical contraindications will often dictate the selection of one drug over the oth...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Lovejoy FH Jr

    更新日期:1978-11-01 00:00:00

  • Developmental changes in energy expenditure and physical activity in children: evidence for a decline in physical activity in girls before puberty.

    abstract:OBJECTIVE:To examine individual changes in energy expenditure and physical activity during prepubertal growth in boys and girls. METHODS:Total energy expenditure (TEE), resting energy expenditure, physical activity-related energy expenditure, reported physical activity, and fat and fat-free mass were measured three ti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.5.887

    authors: Goran MI,Gower BA,Nagy TR,Johnson RK

    更新日期:1998-05-01 00:00:00

  • Healthy Steps for Young Children program in pediatric residency training: impact on primary care outcomes.

    abstract:OBJECTIVE:Incorporating Healthy Steps for Young Children into pediatric practice has been shown to have positive effects for children and families. Although this model of care has also been integrated into several pediatric and family medicine training programs, published reports to date have focused only on residents'...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-3090

    authors: Niederman LG,Schwartz A,Connell KJ,Silverman K

    更新日期:2007-09-01 00:00:00

  • Improving Health and Safety at Camp.

    abstract::The American Academy of Pediatrics has created recommendations for health appraisal and preparation of young people before participation in day, resident, or family camps and to guide health and safety practices at camp. These recommendations are intended for parents and families, primary health care providers, and ca...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2019-1355

    authors: Ambrose MJ,Walton EA,COUNCIL ON SCHOOL HEALTH.

    更新日期:2019-07-01 00:00:00

  • Optimal thermal management for low birth weight infants nursed under high-powered radiant warmers.

    abstract::Servocontrol of skin temperature for the critically ill premature neonate nursed on a radiant warmer bed has been assumed to be analogous to skin temperature control for infants nursed in convection-warmed incubators. There are significant differences between these two warming techniques, and no definitive data exist ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Malin SW,Baumgart S

    更新日期:1987-01-01 00:00:00

  • Successful direct extubation of very low birth weight infants from low intermittent mandatory ventilation rate.

    abstract::It is common practice to use endotracheal continuous positive airway pressure for various time periods up to 24 hours before attempting extubation in infants who are mechanically ventilated. A few studies in newborns have indicated that airway resistance is increased through small endotracheal tubes. This increases th...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kim EH,Boutwell WC

    更新日期:1987-09-01 00:00:00

  • Persistent pulmonary hypertension of the newborn treated with magnesium sulfate in premature neonates.

    abstract:OBJECTIVE:To evaluate the clinical effects of magnesium sulfate (MgSO4) in the treatment of persistent pulmonary hypertension of the newborn (PPHN) in premature infants. METHODS:This was a prospective, nonrandomized, clinical study. Seven premature neonates with PPHN were treated with MgSO4 as soon as documentation of...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Wu TJ,Teng RJ,Tsou KI

    更新日期:1995-09-01 00:00:00

  • Life events and childhood morbidity: a prospective study.

    abstract::The relationship between family life events and rates of childhood morbidity was studied prospectively in a birth cohort of New Zealand children during the period from ages 1 to 4 years. Family life events were associated with increased risk of medical consultation and hospital attendance for illness of the lower resp...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Beautrais AL,Fergusson DM,Shannon FT

    更新日期:1982-12-01 00:00:00

  • Media literacy education for elementary school substance use prevention: study of media detective.

    abstract:OBJECTIVES:Media Detective is a 10-lesson elementary school substance use prevention program developed on the basis of the message interpretation processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. The purpose of this stud...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-0068

    authors: Kupersmidt JB,Scull TM,Austin EW

    更新日期:2010-09-01 00:00:00

  • Are we allowed to discontinue medical treatment in this child?

    abstract::One of the most difficult ethical dilemmas in pediatrics today arises when a child has complex chronic conditions that are not curable and cause discomfort with no prospect of any improvement on quality of life. In the context of medical futility, it is harmful to prolong medical treatment. The question is: How can me...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0548

    authors: Leeuwenburgh-Pronk WG,Miller-Smith L,Forman V,Lantos JD,Tibboel D,Buysse C

    更新日期:2015-03-01 00:00:00

  • Ten-year study of pediatric drownings and near-drownings in King County, Washington: lessons in injury prevention.

    abstract::The factors associated with submersion events among less than 20-year-old persons that occurred in King County from 1974 to 1983 were studied to focus prevention efforts. Near-drowning (n = 103) and drowning (n = 96) victims were identified from medical examiners' reports, paramedics' reports, and hospital discharge r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Quan L,Gore EJ,Wentz K,Allen J,Novack AH

    更新日期:1989-06-01 00:00:00

  • Severe methemoglobinemia complicating topical benzocaine use during endoscopy in a toddler: a case report and review of the literature.

    abstract::Severe methemoglobinemia resulting from the use of topical benzocaine has been reported in adults as a rare complication. Here we report a case of severe acquired methemoglobinemia resulting from topical use of benzocaine spray during diagnostic upper gastrointestinal endoscopy in a 3-year-old boy with repeated episod...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2005-1952

    authors: Dahshan A,Donovan GK

    更新日期:2006-04-01 00:00:00

  • Dyssomnias and parasomnias in early childhood.

    abstract:OBJECTIVES:Our aim for this study was to determine the prevalence of dyssomnias and various parasomnias in early childhood and to describe their temporal evolution, gender differences, and correlates. METHODS:This research is part of a longitudinal study of child development. A randomized, 3-level, stratified survey d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-2132

    authors: Petit D,Touchette E,Tremblay RE,Boivin M,Montplaisir J

    更新日期:2007-05-01 00:00:00

  • Evaluation of airway complications in high-risk preterm infants: application of flexible fiberoptic airway endoscopy.

    abstract:OBJECTIVES:We sought to determine factors that would predict the development of subglottic stenosis (SGS) and tracheomalacia (TM) in preterm infants. The utility of a semiquantitative measurement of airway dimensions was assessed in relation to signs of airway complications. We also sought to determine from a high-risk...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Downing GJ,Kilbride HW

    更新日期:1995-04-01 00:00:00

  • Effect of maternal lead burden on infant weight and weight gain at one month of age among breastfed infants.

    abstract:INTRODUCTION:Transfer of lead from bone to the bloodstream increases during lactation. However, the effect of maternal lead burden on growth in breastfed newborns is still unknown. This study examined early postnatal growth in a cohort of healthy breastfed newborns in relation to maternal bone lead burden. METHODS:Lea...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.5.1016

    authors: Sanín LH,González-Cossío T,Romieu I,Peterson KE,Ruíz S,Palazuelos E,Hernández-Avila M,Hu H

    更新日期:2001-05-01 00:00:00

  • Specialized assessments for children in foster care.

    abstract:OBJECTIVE:To investigate the differences in health problems identified and health services received by children newly entering foster care who participated in a comprehensive multidisciplinary program, compared with children newly entering foster care who received customary community-based services. METHODS:Using a 2-...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.1.59

    authors: Horwitz SM,Owens P,Simms MD

    更新日期:2000-07-01 00:00:00

  • Anogenital human papillomavirus in sexually abused and nonabused children: a multicenter study.

    abstract:OBJECTIVES:To characterize the epidemiology of genital human papillomavirus (HPV) infection in children without previous consensual sexual activity, comparing HPV prevalence by certainty of child sexual abuse (CSA). PATIENTS AND METHODS:Patients presenting for evaluation of CSA in 8 sites in Atlanta, Houston, Harrisbu...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2010-2247

    authors: Unger ER,Fajman NN,Maloney EM,Onyekwuluje J,Swan DC,Howard L,Beck-Sague CM,Sawyer MK,Girardet RG,Sautter RL,Hammerschlag MR,Black CM

    更新日期:2011-09-01 00:00:00

  • Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development.

    abstract:OBJECTIVE:To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants. DESIGN:Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Koopman-Esseboom C,Weisglas-Kuperus N,de Ridder MA,Van der Paauw CG,Tuinstra LG,Sauer PJ

    更新日期:1996-05-01 00:00:00

  • Echocardiographic evaluation of asymptomatic parental and sibling cardiovascular anomalies associated with congenital left ventricular outflow tract lesions.

    abstract:OBJECTIVE:Left ventricular outflow tract obstructive (LVOTO) malformations are a leading cause of infant mortality from birth defects. Genetic mechanisms are likely, and there may be a higher rate of asymptomatic LVOTO anomalies in relatives of affected children. This study sought to define the incidence of cardiac ano...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2003-0782-L

    authors: Lewin MB,McBride KL,Pignatelli R,Fernbach S,Combes A,Menesses A,Lam W,Bezold LI,Kaplan N,Towbin JA,Belmont JW

    更新日期:2004-09-01 00:00:00

  • Early language development in children exposed to or infected with human immunodeficiency virus.

    abstract:OBJECTIVES:To compare language development in infants and young children with human immunodeficiency virus (HIV) infection to language development in children who had been exposed to HIV but were uninfected, and (among subjects with HIV infection) to compare language development with cognitive and neurologic status. D...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.102.1.e8

    authors: Coplan J,Contello KA,Cunningham CK,Weiner LB,Dye TD,Roberge L,Wojtowycz MA,Kirkwood K

    更新日期:1998-07-01 00:00:00

  • The effect of a community intervention trial on parental knowledge and awareness of antibiotic resistance and appropriate antibiotic use in children.

    abstract:BACKGROUND:Overuse of antibiotics for children's upper respiratory infections is widespread and contributes to the emergence of antibiotic-resistant bacteria. OBJECTIVE:To assess changes in knowledge and awareness regarding antibiotic resistance and appropriate antibiotic use after community-wide educational intervent...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.1.e6

    authors: Trepka MJ,Belongia EA,Chyou PH,Davis JP,Schwartz B

    更新日期:2001-01-01 00:00:00

  • Developmental care does not alter sleep and development of premature infants.

    abstract:OBJECTIVE:The Neonatal Individualized Developmental Care Program (NIDCAP) for very low birth weight (VLBW) preterm infants has been suggested by Als et al to improve several medical outcome variables such as time on ventilator, time to nipple feed, the duration of hospital stay, better behavioral performance on Assessm...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.100.6.e9

    authors: Ariagno RL,Thoman EB,Boeddiker MA,Kugener B,Constantinou JC,Mirmiran M,Baldwin RB

    更新日期:1997-12-01 00:00:00

  • Autistic and dysphasic children. II: Epilepsy.

    abstract::In a previously described population of 314 autistic and 237 dysphasic nonautistic children, after exclusion of 12 autistic girls with Rett syndrome, 14% (42 of 302) of autistic children and 8% (19 of 237) of dysphasic children had epilepsy (P = .03). The major risk factors for epilepsy were severe mental deficiency a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Tuchman RF,Rapin I,Shinnar S

    更新日期:1991-12-01 00:00:00

  • Nonmedical vaccine exemptions and pertussis in California, 2010.

    abstract:BACKGROUND:In 2010, 9120 cases of pertussis were reported in California, more than any year since 1947. Although this resurgence has been widely attributed to waning immunity of the acellular vaccine, the role of vaccine refusal has not been explored in the published literature. Many factors likely contributed to the o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0878

    authors: Atwell JE,Van Otterloo J,Zipprich J,Winter K,Harriman K,Salmon DA,Halsey NA,Omer SB

    更新日期:2013-10-01 00:00:00