Abstract:
:The Haemophilus influenzae vaccine consisting of purified type b capsular polysaccharide (polyribosylribitol-phosphate [PRP]) was shown in Finland to be protective, with 90% efficacy in children older than 18 to 23 months of age. However, a wide range of estimates of vaccine efficacy has been reported in the United States after its licensure in 1985. These estimates range from -55% to +89%. In addition, the PRP vaccine was not effective in children younger than 18 months of age, in whom 70% to 80% of meningitis cases occur. A further development was the introduction of H influenzae type b polysaccharide-protein conjugate vaccines such as the PRP-D. These conjugate vaccines were found to be more immunogenic than PRP vaccine in children of all ages. Two doses of PRP-D in infants 7 months of age and older induced antibody levels equal to or greater than levels in infants 24 months of age who received the PRP vaccine alone. Recently, Eskola et al reported that repeat vaccinations with PRP-D at 3, 4, 6, and 14 months of age was 83% protective (95% confidence interval, 26% to 96%). Yet PRP-D vaccine elicits only low serum antibody levels in infants younger than 7 months of age. Because of the discrepancy in efficacy results for the PRP vaccine in the United States and Finland and the lack of data about the protective efficacy of PRP-D vaccine in infants in the United States, the PRP-D vaccine is currently recommended only for children 18 months of age or older.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Pediatricsjournal_title
Pediatricsauthors
Yogev R,Arditi M,Chadwick EG,Amer MD,Sroka PAsubject
Has Abstractpub_date
1990-04-01 00:00:00pages
690-3issue
4 Pt 2eissn
0031-4005issn
1098-4275journal_volume
85pub_type
临床试验,杂志文章,随机对照试验相关文献
PEDIATRICS文献大全abstract::: media-1vid110.1542/5799875103001PEDS-VA_2017-3616Video Abstract OBJECTIVES: Noncigarette tobacco products may confer a risk of marijuana use similar to combustible cigarettes. We examined whether adolescent electronic cigarette (e-cigarette), hookah, or combustible cigarette use is associated with initiating and cur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-3616
更新日期:2018-09-01 00:00:00
abstract::Motor vehicle-related trauma is the leading cause of death in children in the United States. All states have pediatric restraint requirements for passenger vehicles to help prevent these deaths and injuries. Only a few states, however, possess safety laws or restrictions for passengers who ride in the back of pickup t...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:The association of dietary fat distribution with markers of subclinical atherosclerosis during early life is unknown. We examined whether success in achieving the main target of an infancy-onset dietary intervention based on the distribution of dietary fat was associated with aortic and carotid intima-media ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2019-2786
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity in early childhood have not been consistently reported. The aim of this study was to determine trends in neurodevelopmental outcomes at 8 year...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-4086
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:With this study we aimed to compare survival rates for children with Down syndrome in 2 time periods, 1 before prenatal screening (1988-1990) and 1 contemporaneous with screening (1998-2000), and to examine the frequency of comorbidities and their influence on survival rates. METHODS:Record-linkage was perf...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-2840
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To improve health outcomes of children, the US Maternal and Child Health Bureau has recommended more effective organization of preventive services within primary care practices and more coordination between practices and community-based agencies. However, applying these recommendations in communities is chall...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:10.1542/peds.108.3.e42
更新日期:2001-09-01 00:00:00
abstract::Achieving the ambitious reduction in global neonatal mortality targeted in the Sustainable Development Goals and Every Newborn Action Plan will require reducing geographic disparities in newborn deaths through targeted implementation of evidence-based practices. Helping Babies Survive, a suite of educational programs ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-016915J
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To assess growth retardation in male adolescent patients who have a diagnosis of anorexia nervosa (AN) and the effect of weight restoration on catch-up growth. METHODS:Medical charts of all male adolescent AN patients (n = 12) who were admitted to the Pediatric Psychosomatic Department at the Sheba Medical C...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.2.270
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVES:To determine whether infants who are fed initially and advanced at 30 mL/kg per day (intervention) take fewer days to get to full feedings than those who are fed initially and advanced at 20 mL/kg per day (control), without increasing their incidence of feeding complications and necrotizing enterocolitis (NE...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.2004-1232
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Pediatric functional abdominal pain disorders are common, costly, and disabling. Clinical anxiety is highly prevalent and is associated with increased pain and functional disability. Thus, a psychological screening process is recommended but is infrequently used in current practice. METHODS:A screening proc...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-2876
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Stroke is often a devastating complication of sickle cell disease (SCD). Most children with SCD-related stroke have stenotic and occlusive disease of cerebral blood vessels due to intimal hyperplasia. This hyperplasia is hypothesized to result from an inflammatory response similar to that in atherosclerosis ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.4.e318
更新日期:2004-04-01 00:00:00
abstract::One controversy regarding childhood sexual abuse is whether the increased rate of reported cases reflects a true increase in prevalence. In this report, data obtained in the 1970s and 1980s were compared with those of the 1940s. Using predetermined criteria for quality of information, commonality of definitions of chi...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1991-07-01 00:00:00
abstract::The epidemiology of Helicobacter pylori infection was studied in 245 healthy children (between 3 and 20 years of age) who presented for day surgery at Arkansas Children's Hospital. H pylori infection was identified serologically using an enzyme-linked immunosorbent assay to detect the presence of IgG against the high ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVE:Osteonecrosis of the hip has been reported in human immunodeficiency virus (HIV)-infected adults; whether this is related to HIV infection or its treatment is unknown. There has been 1 report of osteonecrosis among HIV-infected children. Specifically, avascular necrosis of the hip consistent with Legg-Calvé-P...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.109.5.e74
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To identify adverse behavioral and psychological factors associated with forced sex experiences of adolescent girls compared with their sexually active counterparts. METHOD:An anonymous self-report survey examining an array of psychosocial items, to which 3124 grade 8 and grade 10 female students responded. ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:To determine if the incidence of empyema among children in the United States has changed since the introduction of the pneumococcal conjugate vaccine in 2000. METHODS:We used the nationally representative Kids' Inpatient Database to estimate the annual total number of hospitalizations of children < or = 18 y...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0184
更新日期:2010-01-01 00:00:00
abstract::A patient with homozygous sickle cell anemia is the youngest known to have died from acute splenic sequestration crisis. A cord blood screening program might have prevented this infant's death. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract:OBJECTIVE:Few investigations have assessed the primary care detection of adolescent posttraumatic emotional distress after an injury. We aimed to determine (1) the level of attachment to primary care providers (PCPs) and school providers among this group of high-risk adolescents, (2) the emotional status of this popula...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1042
更新日期:2006-01-01 00:00:00
abstract::A growing body of scientific literature demonstrates that children who grow up with 1 or 2 gay and/or lesbian parents fare as well in emotional, cognitive, social, and sexual functioning as do children whose parents are heterosexual. Children's optimal development seems to be influenced more by the nature of the relat...
journal_title:Pediatrics
pub_type:
doi:10.1542/peds.109.2.341
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:Sleep disorders can cause substantial morbidity but often remain undiagnosed among adults. We identified a series of children with sleep-related symptoms and reviewed medical chart notes for the previous 2 years to determine how often sleep problems had been addressed. DESIGN:Observational. Setting. Two univ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.6.1375
更新日期:2001-06-01 00:00:00
abstract::To test the commonly held premise that prematurity is a risk factor for problems of behavior and social interaction, as well as cognitive and physical development, temperament and behavior of children born preterm and full-term control subjects were compared at five separate time periods from infancy through early sch...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Material hardship has been associated with adverse health care use patterns for children with special health care needs (CSHCN). In this study, we assessed if resilience factors were associated with lower emergency department (ED) visits and unmet health care needs and if they buffered associations between m...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-1975
更新日期:2020-02-01 00:00:00
abstract::We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone. The child responded to narcotic reversal. Pediatric physicians should be aware of this possible complication. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-3243
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:In 2006, routine immunization of US infants against rotavirus was initiated. We assessed national, regional, and local trends in rotavirus testing and detection before and after vaccine introduction. METHODS:We examined data for July 2000 through June 2008 from a national network of approximately 70 US labo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3528
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Polysomnography defines the pathophysiology of obstructive sleep apnea syndrome (OSAS) but does not predict some important comorbidities or their response to adenotonsillectomy. We assessed whether OSAS symptoms, as reflected on the Sleep-Related Breathing Disorders Scale of the Pediatric Slee...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2014-3099
更新日期:2015-03-01 00:00:00
abstract:CONTEXT:Utilization of primary care settings offers a promising approach to enhance parenting practices that are critical for promoting early childhood development. Determining the impact of existing primary care interventions on key parenting behaviors will aid providers and policy makers as they seek strategies to im...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1542/peds.2015-3393
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:In previous studies, the oral calcium loading and deprivation test has been used to distinguish between children with renal (fasting) hypercalciuria (RH) and absorptive hypercalciuria (AH). OBJECTIVE:We evaluated the long-term clinical course of 30 children with idiopathic hypercalciuria and investigated th...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVE:The clinical diagnosis of sepsis remains difficult, particularly in the young child, and would be improved by a rapid and reliable method for identification of bacteria in blood and other body fluids. Polymerase chain reaction (PCR) amplification of highly conserved DNA sequences found in all bacteria would p...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:To compare findings on hard copies of cranial ultrasound (US) and magnetic resonance imaging (MRI) obtained between birth and term in a group of preterm infants. PARTICIPANTS AND METHODS:Infants born at or below a gestational age of 30 weeks who underwent cranial US scan and MRI on the same day were eligible...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.4.719
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:Alaska Native and other circumpolar indigenous populations have historically experienced high infant mortality rates, for unknown reasons. Through routine newborn screening, Alaskan and Canadian indigenous infants have been found to have a high frequency of a single sequence variant (c.1436C→T) in the gene co...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-0687
更新日期:2010-11-01 00:00:00