Haemophilus influenzae type b conjugate vaccine (meningococcal protein conjugate): immunogenicity and safety at various doses.

Abstract:

:The Haemophilus influenzae vaccine consisting of purified type b capsular polysaccharide (polyribosylribitol-phosphate [PRP]) was shown in Finland to be protective, with 90% efficacy in children older than 18 to 23 months of age. However, a wide range of estimates of vaccine efficacy has been reported in the United States after its licensure in 1985. These estimates range from -55% to +89%. In addition, the PRP vaccine was not effective in children younger than 18 months of age, in whom 70% to 80% of meningitis cases occur. A further development was the introduction of H influenzae type b polysaccharide-protein conjugate vaccines such as the PRP-D. These conjugate vaccines were found to be more immunogenic than PRP vaccine in children of all ages. Two doses of PRP-D in infants 7 months of age and older induced antibody levels equal to or greater than levels in infants 24 months of age who received the PRP vaccine alone. Recently, Eskola et al reported that repeat vaccinations with PRP-D at 3, 4, 6, and 14 months of age was 83% protective (95% confidence interval, 26% to 96%). Yet PRP-D vaccine elicits only low serum antibody levels in infants younger than 7 months of age. Because of the discrepancy in efficacy results for the PRP vaccine in the United States and Finland and the lack of data about the protective efficacy of PRP-D vaccine in infants in the United States, the PRP-D vaccine is currently recommended only for children 18 months of age or older.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Pediatrics

journal_title

Pediatrics

authors

Yogev R,Arditi M,Chadwick EG,Amer MD,Sroka PA

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

690-3

issue

4 Pt 2

eissn

0031-4005

issn

1098-4275

journal_volume

85

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::: media-1vid110.1542/5799875103001PEDS-VA_2017-3616Video Abstract OBJECTIVES: Noncigarette tobacco products may confer a risk of marijuana use similar to combustible cigarettes. We examined whether adolescent electronic cigarette (e-cigarette), hookah, or combustible cigarette use is associated with initiating and cur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-3616

    authors: Audrain-McGovern J,Stone MD,Barrington-Trimis J,Unger JB,Leventhal AM

    更新日期:2018-09-01 00:00:00

  • Children riding in the back of pickup trucks: a neglected safety issue.

    abstract::Motor vehicle-related trauma is the leading cause of death in children in the United States. All states have pediatric restraint requirements for passenger vehicles to help prevent these deaths and injuries. Only a few states, however, possess safety laws or restrictions for passengers who ride in the back of pickup t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Woodward GA,Bolte RG

    更新日期:1990-11-01 00:00:00

  • Dietary Fats and Atherosclerosis From Childhood to Adulthood.

    abstract:BACKGROUND:The association of dietary fat distribution with markers of subclinical atherosclerosis during early life is unknown. We examined whether success in achieving the main target of an infancy-onset dietary intervention based on the distribution of dietary fat was associated with aortic and carotid intima-media ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2019-2786

    authors: Laitinen TT,Nuotio J,Rovio SP,Niinikoski H,Juonala M,Magnussen CG,Jokinen E,Lagström H,Jula A,Viikari JSA,Rönnemaa T,Simell O,Raitakari OT,Pahkala K

    更新日期:2020-04-01 00:00:00

  • Changing Neurodevelopment at 8 Years in Children Born Extremely Preterm Since the 1990s.

    abstract:BACKGROUND AND OBJECTIVE:Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity in early childhood have not been consistently reported. The aim of this study was to determine trends in neurodevelopmental outcomes at 8 year...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-4086

    authors: Cheong JLY,Anderson PJ,Burnett AC,Roberts G,Davis N,Hickey L,Carse E,Doyle LW,Victorian Infant Collaborative Study Group.

    更新日期:2017-06-01 00:00:00

  • Has prenatal screening influenced the prevalence of comorbidities associated with Down syndrome and subsequent survival rates?

    abstract:OBJECTIVES:With this study we aimed to compare survival rates for children with Down syndrome in 2 time periods, 1 before prenatal screening (1988-1990) and 1 contemporaneous with screening (1998-2000), and to examine the frequency of comorbidities and their influence on survival rates. METHODS:Record-linkage was perf...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2840

    authors: Halliday J,Collins V,Riley M,Youssef D,Muggli E

    更新日期:2009-01-01 00:00:00

  • From concept to application: the impact of a community-wide intervention to improve the delivery of preventive services to children.

    abstract:OBJECTIVE:To improve health outcomes of children, the US Maternal and Child Health Bureau has recommended more effective organization of preventive services within primary care practices and more coordination between practices and community-based agencies. However, applying these recommendations in communities is chall...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.108.3.e42

    authors: Margolis PA,Stevens R,Bordley WC,Stuart J,Harlan C,Keyes-Elstein L,Wisseh S

    更新日期:2001-09-01 00:00:00

  • Helping Babies Survive Programs as an Impetus for Quality Improvement.

    abstract::Achieving the ambitious reduction in global neonatal mortality targeted in the Sustainable Development Goals and Every Newborn Action Plan will require reducing geographic disparities in newborn deaths through targeted implementation of evidence-based practices. Helping Babies Survive, a suite of educational programs ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-016915J

    authors: Ehret DEY,Patterson JK,Kc A,Worku B,Kamath-Rayne BD,Bose CL

    更新日期:2020-10-01 00:00:00

  • Stunting of growth as a major feature of anorexia nervosa in male adolescents.

    abstract:OBJECTIVE:To assess growth retardation in male adolescent patients who have a diagnosis of anorexia nervosa (AN) and the effect of weight restoration on catch-up growth. METHODS:Medical charts of all male adolescent AN patients (n = 12) who were admitted to the Pediatric Psychosomatic Department at the Sheba Medical C...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.2.270

    authors: Modan-Moses D,Yaroslavsky A,Novikov I,Segev S,Toledano A,Miterany E,Stein D

    更新日期:2003-02-01 00:00:00

  • Randomized, controlled trial of slow versus rapid feeding volume advancement in preterm infants.

    abstract:OBJECTIVES:To determine whether infants who are fed initially and advanced at 30 mL/kg per day (intervention) take fewer days to get to full feedings than those who are fed initially and advanced at 20 mL/kg per day (control), without increasing their incidence of feeding complications and necrotizing enterocolitis (NE...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-1232

    authors: Caple J,Armentrout D,Huseby V,Halbardier B,Garcia J,Sparks JW,Moya FR

    更新日期:2004-12-01 00:00:00

  • Integrating Psychological Screening Into Medical Care for Youth With Abdominal Pain.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2876

    authors: Cunningham NR,Moorman E,Brown CM,Mallon D,Chundi PK,Mara CA,Pentiuk S,Lynch-Jordan AM,Dykes DMH,Elfers J,Farrell MK

    更新日期:2018-08-01 00:00:00

  • Is Chlamydia pneumoniae infection associated with stroke in children with sickle cell disease?

    abstract:BACKGROUND:Stroke is often a devastating complication of sickle cell disease (SCD). Most children with SCD-related stroke have stenotic and occlusive disease of cerebral blood vessels due to intimal hyperplasia. This hyperplasia is hypothesized to result from an inflammatory response similar to that in atherosclerosis ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.4.e318

    authors: Goyal M,Miller ST,Hammerschlag MR,Gelling M,Gaydos CA,Hardick J,Wood BJ,Reznik T,Rao SP

    更新日期:2004-04-01 00:00:00

  • Is childhood sexual abuse really increasing in prevalence? An analysis of the evidence.

    abstract::One controversy regarding childhood sexual abuse is whether the increased rate of reported cases reflects a true increase in prevalence. In this report, data obtained in the 1970s and 1980s were compared with those of the 1940s. Using predetermined criteria for quality of information, commonality of definitions of chi...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Feldman W,Feldman E,Goodman JT,McGrath PJ,Pless RP,Corsini L,Bennett S

    更新日期:1991-07-01 00:00:00

  • Factors influencing the epidemiology of Helicobacter pylori infection in children.

    abstract::The epidemiology of Helicobacter pylori infection was studied in 245 healthy children (between 3 and 20 years of age) who presented for day surgery at Arkansas Children's Hospital. H pylori infection was identified serologically using an enzyme-linked immunosorbent assay to detect the presence of IgG against the high ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fiedorek SC,Malaty HM,Evans DL,Pumphrey CL,Casteel HB,Evans DJ Jr,Graham DY

    更新日期:1991-09-01 00:00:00

  • Osteonecrosis of the hip (Legg-Calvé-Perthes disease) in human immunodeficiency virus-infected children.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.5.e74

    authors: Gaughan DM,Mofenson LM,Hughes MD,Seage GR 3rd,Ciupak GL,Oleske JM,Pediatric AIDS Clinical Trials Group Protocol 219 Team.

    更新日期:2002-05-01 00:00:00

  • Adverse factors associated with forced sex among southern adolescent girls.

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    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Nagy S,DiClemente R,Adcock AG

    更新日期:1995-11-01 00:00:00

  • Empyema hospitalizations increased in US children despite pneumococcal conjugate vaccine.

    abstract:OBJECTIVE:To determine if the incidence of empyema among children in the United States has changed since the introduction of the pneumococcal conjugate vaccine in 2000. METHODS:We used the nationally representative Kids' Inpatient Database to estimate the annual total number of hospitalizations of children < or = 18 y...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0184

    authors: Li ST,Tancredi DJ

    更新日期:2010-01-01 00:00:00

  • Fatal acute splenic sequestration at 4 months of age.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Walterspiel JN,Rutledge JC,Bartlett BL

    更新日期:1984-04-01 00:00:00

  • Primary care utilization and detection of emotional distress after adolescent traumatic injury: identifying an unmet need.

    abstract:OBJECTIVE:Few investigations have assessed the primary care detection of adolescent posttraumatic emotional distress after an injury. We aimed to determine (1) the level of attachment to primary care providers (PCPs) and school providers among this group of high-risk adolescents, (2) the emotional status of this popula...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1042

    authors: Sabin JA,Zatzick DF,Jurkovich G,Rivara FP

    更新日期:2006-01-01 00:00:00

  • Technical report: coparent or second-parent adoption by same-sex parents.

    abstract::A growing body of scientific literature demonstrates that children who grow up with 1 or 2 gay and/or lesbian parents fare as well in emotional, cognitive, social, and sexual functioning as do children whose parents are heterosexual. Children's optimal development seems to be influenced more by the nature of the relat...

    journal_title:Pediatrics

    pub_type:

    doi:10.1542/peds.109.2.341

    authors: Perrin EC,Committee on Psychosocial Aspects of Child and Family Health.

    更新日期:2002-02-01 00:00:00

  • Sleep problems seldom addressed at two general pediatric clinics.

    abstract:OBJECTIVE:Sleep disorders can cause substantial morbidity but often remain undiagnosed among adults. We identified a series of children with sleep-related symptoms and reviewed medical chart notes for the previous 2 years to determine how often sleep problems had been addressed. DESIGN:Observational. Setting. Two univ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.6.1375

    authors: Chervin RD,Archbold KH,Panahi P,Pituch KJ

    更新日期:2001-06-01 00:00:00

  • Temperament and behavior of preterm infants: a six-year follow-up.

    abstract::To test the commonly held premise that prematurity is a risk factor for problems of behavior and social interaction, as well as cognitive and physical development, temperament and behavior of children born preterm and full-term control subjects were compared at five separate time periods from infancy through early sch...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Oberklaid F,Sewell J,Sanson A,Prior M

    更新日期:1991-06-01 00:00:00

  • Relationships Between Material Hardship, Resilience, and Health Care Use.

    abstract:BACKGROUND:Material hardship has been associated with adverse health care use patterns for children with special health care needs (CSHCN). In this study, we assessed if resilience factors were associated with lower emergency department (ED) visits and unmet health care needs and if they buffered associations between m...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-1975

    authors: Fuller AE,Garg A,Brown NM,Tripodis Y,Oyeku SO,Gross RS

    更新日期:2020-02-01 00:00:00

  • Methadone-induced rigid-chest syndrome after substantial overdose.

    abstract::We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone. The child responded to narcotic reversal. Pediatric physicians should be aware of this possible complication. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-3243

    authors: Lynch RE,Hack RA

    更新日期:2010-07-01 00:00:00

  • Decline and change in seasonality of US rotavirus activity after the introduction of rotavirus vaccine.

    abstract:BACKGROUND:In 2006, routine immunization of US infants against rotavirus was initiated. We assessed national, regional, and local trends in rotavirus testing and detection before and after vaccine introduction. METHODS:We examined data for July 2000 through June 2008 from a national network of approximately 70 US labo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3528

    authors: Tate JE,Panozzo CA,Payne DC,Patel MM,Cortese MM,Fowlkes AL,Parashar UD

    更新日期:2009-08-01 00:00:00

  • Utility of symptoms to predict treatment outcomes in obstructive sleep apnea syndrome.

    abstract:BACKGROUND AND OBJECTIVES:Polysomnography defines the pathophysiology of obstructive sleep apnea syndrome (OSAS) but does not predict some important comorbidities or their response to adenotonsillectomy. We assessed whether OSAS symptoms, as reflected on the Sleep-Related Breathing Disorders Scale of the Pediatric Slee...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2014-3099

    authors: Rosen CL,Wang R,Taylor HG,Marcus CL,Katz ES,Paruthi S,Arens R,Muzumdar H,Garetz SL,Mitchell RB,Jones D,Weng J,Ellenberg S,Redline S,Chervin RD

    更新日期:2015-03-01 00:00:00

  • Primary Care-Based Interventions to Promote Positive Parenting Behaviors: A Meta-analysis.

    abstract:CONTEXT:Utilization of primary care settings offers a promising approach to enhance parenting practices that are critical for promoting early childhood development. Determining the impact of existing primary care interventions on key parenting behaviors will aid providers and policy makers as they seek strategies to im...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1542/peds.2015-3393

    authors: Shah R,Kennedy S,Clark MD,Bauer SC,Schwartz A

    更新日期:2016-05-01 00:00:00

  • Renal and absorptive hypercalciuria: a metabolic disturbance with varying and interchanging modes of expression.

    abstract:BACKGROUND:In previous studies, the oral calcium loading and deprivation test has been used to distinguish between children with renal (fasting) hypercalciuria (RH) and absorptive hypercalciuria (AH). OBJECTIVE:We evaluated the long-term clinical course of 30 children with idiopathic hypercalciuria and investigated th...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Aladjem M,Barr J,Lahat E,Bistritzer T

    更新日期:1996-02-01 00:00:00

  • Amplification of bacterial DNA using highly conserved sequences: automated analysis and potential for molecular triage of sepsis.

    abstract:OBJECTIVE:The clinical diagnosis of sepsis remains difficult, particularly in the young child, and would be improved by a rapid and reliable method for identification of bacteria in blood and other body fluids. Polymerase chain reaction (PCR) amplification of highly conserved DNA sequences found in all bacteria would p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: McCabe KM,Khan G,Zhang YH,Mason EO,McCabe ER

    更新日期:1995-02-01 00:00:00

  • Comparison of findings on cranial ultrasound and magnetic resonance imaging in preterm infants.

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    journal_title:Pediatrics

    pub_type: 杂志文章

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    journal_title:Pediatrics

    pub_type: 杂志文章

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    authors: Gessner BD,Gillingham MB,Birch S,Wood T,Koeller DM

    更新日期:2010-11-01 00:00:00