Abstract:
:Congenital fibrosarcoma (CFS) is a rare fibrous tissue malignancy that usually presents in the first few years of life. It is unique among human sarcomas in that it has an excellent prognosis. We describe a temporal clustering of a number of cases of CFS and investigate the possible associated prenatal risk factors. The Pediatric Environmental History, a questionnaire developed in our clinic that is instrumental in determining environmental risk factors for tumor-related disease, was essential in documenting the presence or absence of risk factors considered as human carcinogens. We found a history of exposure to petroleum products in four cases of CFS that occurred at a greater than expected rate in a short time frame-an apparent cancer cluster. We call attention to the possibility that exposure to petroleum products raises the risk of developing CFS. While future studies should focus on systematic investigation of CFS and its underlying mechanisms, this report suggests the need for proactive measures to avoid exposure to solvents and petroleum products during pregnancy.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Ortega-García JA,Soldin OP,López-Hernández FA,Trasande L,Ferrís-Tortajada Jdoi
10.1542/peds.2011-1307subject
Has Abstractpub_date
2012-10-01 00:00:00pages
e1019-25issue
4eissn
0031-4005issn
1098-4275pii
peds.2011-1307journal_volume
130pub_type
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