Congenital fibrosarcoma and history of prenatal exposure to petroleum derivatives.

Abstract:

:Congenital fibrosarcoma (CFS) is a rare fibrous tissue malignancy that usually presents in the first few years of life. It is unique among human sarcomas in that it has an excellent prognosis. We describe a temporal clustering of a number of cases of CFS and investigate the possible associated prenatal risk factors. The Pediatric Environmental History, a questionnaire developed in our clinic that is instrumental in determining environmental risk factors for tumor-related disease, was essential in documenting the presence or absence of risk factors considered as human carcinogens. We found a history of exposure to petroleum products in four cases of CFS that occurred at a greater than expected rate in a short time frame-an apparent cancer cluster. We call attention to the possibility that exposure to petroleum products raises the risk of developing CFS. While future studies should focus on systematic investigation of CFS and its underlying mechanisms, this report suggests the need for proactive measures to avoid exposure to solvents and petroleum products during pregnancy.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Ortega-García JA,Soldin OP,López-Hernández FA,Trasande L,Ferrís-Tortajada J

doi

10.1542/peds.2011-1307

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

e1019-25

issue

4

eissn

0031-4005

issn

1098-4275

pii

peds.2011-1307

journal_volume

130

pub_type

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