Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study.

Abstract:

OBJECTIVE:Allergic rhinitis is common and on the rise. Antihistamines are the mainstay of treatment and are the most commonly prescribed drugs in Singapore. Treatment-related sedation and its effect on cognition are a major concern. First- and second-generation antihistamines show varying degrees of sedation, but to date, objective studies in children are lacking. The objective of this study was to assess the sedating effect of cetirizine (second-generation antihistamine) and chlorpheniramine (first-generation antihistamine) compared with placebo using an objective neurophysiological test. METHODS:This was a prospective, double-blind, placebo-controlled, randomized, single-dose, 3-way crossover study. Twenty-four children aged 7 to 14 years with allergic rhinitis completed the study. All children were randomly allocated to medication sequences and received 3 different drugs on 3 different days, at least 1 week apart. The P300 event-related potential was used as an objective test of sedation. Subjective assessment was by a visual analog scale. RESULTS:Chlorpheniramine and cetirizine increased P300 latency when compared with baseline. No significant increase was obtained with placebo. The significant increase in P300 latency was not accompanied by significant change in subjective somnolence as measured by the visual analog scale. CONCLUSION:We have shown that cetirizine has sedative properties in children. The lack of correlation between P300 latency and the visual analog scale indicates that sedation induced by these drugs may not be subjectively noted.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Ng KH,Chong D,Wong CK,Ong HT,Lee CY,Lee BW,Shek LP

doi

10.1542/peds.113.2.e116

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

e116-21

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

113

pub_type

临床试验,杂志文章,随机对照试验
  • Preoperative Blood Transfusions and Morbidity in Neonates Undergoing Surgery.

    abstract:BACKGROUND:Blood transfusions in the neonatal patient population are common, but there are no established guidelines regarding transfusion thresholds. Little is known about postoperative outcomes in neonates who receive preoperative blood transfusions (PBTs). METHODS:Using the American College of Surgeons National Sur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-3718

    authors: Dukleska K,Vinocur CD,Brenn BR,Lim DJ,Keith SW,Dirnberger DR,Berman L

    更新日期:2020-11-01 00:00:00

  • Parental angst making and revisiting decisions about treatment of attention-deficit/hyperactivity disorder.

    abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurobehavioral conditions of childhood and adolescence. Despite availability of effective treatment options, initiation of treatment is variable and persistence with therapeutic regimens is poor. OBJECTIVE:We sought to better underst...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2569

    authors: Brinkman WB,Sherman SN,Zmitrovich AR,Visscher MO,Crosby LE,Phelan KJ,Donovan EF

    更新日期:2009-08-01 00:00:00

  • Long-term subcutaneous protein C replacement in neonatal severe protein C deficiency.

    abstract::We describe here the case of a boy who presented 2 days after birth with purpura fulminans on his feet and scalp. Laboratory investigations revealed signs of disseminated intravascular coagulation. An underlying coagulation disorder was suspected, and therapy with recombinant tissue plasminogen activator, fresh-frozen...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2009-2913

    authors: de Kort EH,Vrancken SL,van Heijst AF,Binkhorst M,Cuppen MP,Brons PP

    更新日期:2011-05-01 00:00:00

  • Decline and change in seasonality of US rotavirus activity after the introduction of rotavirus vaccine.

    abstract:BACKGROUND:In 2006, routine immunization of US infants against rotavirus was initiated. We assessed national, regional, and local trends in rotavirus testing and detection before and after vaccine introduction. METHODS:We examined data for July 2000 through June 2008 from a national network of approximately 70 US labo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3528

    authors: Tate JE,Panozzo CA,Payne DC,Patel MM,Cortese MM,Fowlkes AL,Parashar UD

    更新日期:2009-08-01 00:00:00

  • Trends in the prevalence of autism on the basis of special education data.

    abstract:OBJECTIVE:The goal was to determine whether the increasing prevalence of autism, on the basis of educational data, in Wisconsin between 2002 and 2008 was uniform in all school districts or was greatest in districts with lower baseline (2002) prevalence. METHODS:Special education counts were obtained for all Wisconsin ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1023

    authors: Maenner MJ,Durkin MS

    更新日期:2010-11-01 00:00:00

  • Neonatal apnea: diagnosis by nurse versus computer.

    abstract::In an effort to characterize significant neonatal apnea and evaluate the nursing diagnosis of apnea, apnea type and frequency were determined in 27 infants by continuous computer recording of heart rate, respiratory impedance, end-tidal CO2, and either or both transcutaneous oxygen and pulse oximetry. Of the 1,266 rec...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Muttitt SC,Finer NN,Tierney AJ,Rossmann J

    更新日期:1988-11-01 00:00:00

  • Growth pattern of breastfed and nonbreastfed infants with atopic dermatitis in the first year of life.

    abstract:OBJECTIVE:The growth of infants with atopic dermatitis (AD) has been poorly investigated based on the early type of feeding. The aim of this study was to assess the growth pattern of AD infants during the first 12 months of life in comparison to healthy infants, according to the early type of feeding (breastfed or nonb...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.5.e73

    authors: Agostoni C,Grandi F,Scaglioni S,Giannì ML,Torcoletti M,Radaelli G,Fiocchi A,Riva E

    更新日期:2000-11-01 00:00:00

  • Mental Health Problems and Risk of Suicidal Ideation and Attempts in Adolescents.

    abstract:BACKGROUND:Obtaining recent estimates of the prevalence of suicide-related outcomes across adolescence and its associated mental health problems (MHPs) is important for clinical practice. We estimated the prevalence of suicide-related outcomes at ages 13, 15, 17, and 20 years (2011-2018) in a contemporary population-ba...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-3823

    authors: Orri M,Scardera S,Perret LC,Bolanis D,Temcheff C,Séguin JR,Boivin M,Turecki G,Tremblay RE,Côté SM,Geoffroy MC

    更新日期:2020-07-01 00:00:00

  • Self-reported quality of life of young children with conditions from early infancy: a systematic review.

    abstract:CONTEXT:There is little consistency in the use of instruments for measuring self-reported quality of life (QoL) in young children. OBJECTIVE:To systematically review studies of self-reported QoL in children aged <12 years with congenital health conditions, and to examine the agreement between self- and proxy-reports. ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-0352

    authors: Jardine J,Glinianaia SV,McConachie H,Embleton ND,Rankin J

    更新日期:2014-10-01 00:00:00

  • Interpreters: telephonic, in-person interpretation and bilingual providers.

    abstract:CONTEXT:Language barriers affect health care interactions. Large, randomized studies of the relative efficacy of interpreter modalities have not been conducted. OBJECTIVE:To compare the efficacy of telephonic and in-person medical interpretation to visits with verified bilingual physicians. METHODS:This was a prospec...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2009-0769

    authors: Crossman KL,Wiener E,Roosevelt G,Bajaj L,Hampers LC

    更新日期:2010-03-01 00:00:00

  • Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography.

    abstract:OBJECTIVE:To define normal and abnormal patterns, test interobserver variability, and the prognostic accuracy of amplitude-integrated electroencephalography (aEEG) soon after the onset of neonatal encephalopathy. METHODS:Consecutive cases of neonatal encephalopathy (n = 56; gestation median, 40; range, 35-42 weeks) an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.6.1263

    authors: al Naqeeb N,Edwards AD,Cowan FM,Azzopardi D

    更新日期:1999-06-01 00:00:00

  • Identification and evaluation of children with autism spectrum disorders.

    abstract::Autism spectrum disorders are not rare; many primary care pediatricians care for several children with autism spectrum disorders. Pediatricians play an important role in early recognition of autism spectrum disorders, because they usually are the first point of contact for parents. Parents are now much more aware of t...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2007-2361

    authors: Johnson CP,Myers SM,American Academy of Pediatrics Council on Children With Disabilities.

    更新日期:2007-11-01 00:00:00

  • Hospitalizations of newborns with folate-sensitive birth defects before and after fortification of foods with folic acid.

    abstract:CONTEXT:The prevalence of neural tube defects is reduced in populations of women who receive folic acid supplementation. Since 1998, grain products in the United States have been fortified with folic acid. Fortification may have additional benefits by reducing the national prevalence of newborn hospitalizations for oth...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2784

    authors: Robbins JM,Tilford JM,Bird TM,Cleves MA,Reading JA,Hobbs CA

    更新日期:2006-09-01 00:00:00

  • Electrocardiograph monitor artifacts in a neonatal intensive care unit.

    abstract::A wide variety of artifacts may be found when monitoring the ECG in a neonatal intensive care unit. Many of the artifacts resemble arrhythmias, and unless they are recognized as artifacts they may lead to serious errors of diagnosis and therapy. Many of the artifacts are caused by patient movement such as seizures, tr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Stanger P,Lister G,Silverman NH,Hoffman JI

    更新日期:1977-11-01 00:00:00

  • Sudden child death and 'healthy' affected family members with medium-chain acyl-coenzyme A dehydrogenase deficiency.

    abstract::A family is described in which the father and three (and probably all four) of his children had a decreased capacity for the oxidation of medium-chain fatty acids. One of the children suddenly died at the age of 16 months following an episode of a rapidly deteriorating Reye syndrome-like illness with hypoketotic hypog...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Duran M,Hofkamp M,Rhead WJ,Saudubray JM,Wadman SK

    更新日期:1986-12-01 00:00:00

  • Incidence of rash after amoxicillin treatment in children with infectious mononucleosis.

    abstract:BACKGROUND:"Ampicillin rash," a phenomenon unique to patients with Epstein-Barr virus acute infectious mononucleosis (AIM) treated with ampicillin, was first reported in the 1960s. The incidence was estimated as being between 80% and 100%, and the figures have not been reviewed since those first accounts. We sought to ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2012-1575

    authors: Chovel-Sella A,Ben Tov A,Lahav E,Mor O,Rudich H,Paret G,Reif S

    更新日期:2013-05-01 00:00:00

  • Maternal cigarette smoking and fetal oxygen transport: a study of P50, 2,3-diphosphoglycerate, total hemoglobin, hematocrit, and type F hemoglobin in fetal blood.

    abstract::The current study was undertaken to determine whether the O2 carrying capacity of newborns born to mothers who smoke can accommodate to carbon monoxide poisoning to compensate for the potential tissue hypoxia induced by CO. From a cohort of 1,222 women and newborn infants the total hemogloblin concentration, hematocri...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bureau MA,Shapcott D,Berthiaume Y,Monette J,Blouin D,Blanchard P,Begin R

    更新日期:1983-07-01 00:00:00

  • Hypocalcemic coma following two pediatric phosphate enemas.

    abstract::Coma, tetany, dehydration, hypotension, tachycardia, and hyperpyrexia developed in a 2 1/2-year-old girl following two hypertonic phosphate pediatric enemas. She had marked hyperphosphatemia, hypocalcemia, hypernatremia, and acidosis. Hypocalcemia due to hyperphosphatemia can explain all of these findings. Calculation...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sotos JF,Cutler EA,Finkel MA,Doody D

    更新日期:1977-09-01 00:00:00

  • Severe renal osteodystrophy without elevated serum immunoreactive parathyroid hormone concentrations in hypomagnesemia due to renal magnesium wasting.

    abstract::An 8 1/2-year-old girl presented with a long history of seizures, growth retardation, muscle weakness, gait disturbance, and hearing loss. Her evaluation revealed chronic moderate renal failure (serum creatinine 2.2 mg/dL), severe hypocalcemia (5 mg/dL), hyperphosphatemia (8.1 mg/dL), hypomagnesemia (1.5 mg/dL), incre...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Zelikovic I,Dabbagh S,Friedman AL,Goelzer ML,Chesney RW

    更新日期:1987-03-01 00:00:00

  • Long-term study of a quadrivalent human papillomavirus vaccine.

    abstract:BACKGROUND:We present a long-term safety, immunogenicity, and effectiveness study of a quadrivalent human papillomavirus (HPV4) vaccine. METHODS:Sexually naive boys and girls aged 9 to 15 years (N = 1781) were assigned (2:1) to receive HPV4 vaccine or saline placebo at day 1 and months 2 and 6. At month 30, the placeb...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2013-4144

    authors: Ferris D,Samakoses R,Block SL,Lazcano-Ponce E,Restrepo JA,Reisinger KS,Mehlsen J,Chatterjee A,Iversen OE,Sings HL,Shou Q,Sausser TA,Saah A

    更新日期:2014-09-01 00:00:00

  • Transmission of hepatitis B virus infection by asymptomatic chronic HBsAg carrier mothers.

    abstract::The courses of 18 children born to 13 chronic hepatitis B surface antigen (HBsAg) carrier mothers were followed prospectively for serological and biochemical evidence of type B hepatitis. Three children developed transient HBsAg positivity accompanied by the appearance of antibody to the hepatitis B core antigen. Two ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Papaevangelou G,Hoofnagle JH

    更新日期:1979-04-01 00:00:00

  • Pediatric tuberculosis: what needs to be done to decrease morbidity and mortality.

    abstract:OBJECTIVE:Tuberculosis (TB) control programs have been less successful among children than among adults in the United States. Between 1992 and 1997, the rate of decline of TB cases among 0- to 14-year-old children was less than the rate of decline among any other age group of US-born persons. Because of the higher prev...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.1.e1

    authors: Heymann SJ,Brewer TF,Wilson ME,Colditz GA,Fineberg HV

    更新日期:2000-07-01 00:00:00

  • Daytime television viewing by hospitalized children.

    abstract::To determine whether hospitalized pediatric patients may be inadvertently exposed to excessive amounts of commercial television, a survey of the quantity and quality of daytime television viewing by patients was conducted at the Winnipeg Children's Centre. Television viewing patterns were recorded for 845 patients, ea...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Guttentag DN,Albritton WL,Kettner RB

    更新日期:1981-11-01 00:00:00

  • Media education.

    abstract::The American Academy of Pediatrics recognizes that exposure to mass media (eg, television, movies, video and computer games, the Internet, music lyrics and videos, newspapers, magazines, books, advertising) presents health risks for children and adolescents but can provide benefits as well. Media education has the pot...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.2010-1636

    authors: Strasburger VC,Council on Communications and Media American Academy of Pediatrics.

    更新日期:2010-11-01 00:00:00

  • Use of complementary and alternative medical therapies among children with special health care needs in southern Arizona.

    abstract:OBJECTIVE:The objective of this study was to assess the frequency and type of complementary and alternative medicine (CAM) therapies used by families of children with special health care needs in southern Arizona, as well as the correlates of their use. METHODS:Families of 376 children who were receiving services in a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.3.584

    authors: Sanders H,Davis MF,Duncan B,Meaney FJ,Haynes J,Barton LL

    更新日期:2003-03-01 00:00:00

  • The respective racial and ethnic diversity of US pediatricians and American children.

    abstract:BACKGROUND:Much effort has been directed toward increasing the training of physicians from underrepresented minority groups, yet few direct comparisons have examined the diversity of the racial/ethnic backgrounds of the physicians relative to the patient populations they serve, either currently or into the future. This...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.1.27

    authors: Stoddard JJ,Back MR,Brotherton SE

    更新日期:2000-01-01 00:00:00

  • Hypoxic arousal responses in infants with bronchopulmonary dysplasia.

    abstract::Infants with bronchopulmonary dysplasia have a high incidence of sudden, unexplained death in the postneonatal period, yet the cause of these deaths is unknown. Frequent episodes of clinically unsuspected arterial oxygen desaturation have recently been described in infants with bronchopulmonary dysplasia. We hypothesi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Garg M,Kurzner SI,Bautista D,Keens TG

    更新日期:1988-07-01 00:00:00

  • Revised guidelines for prevention of early-onset group B streptococcal (GBS) infection. American Academy of Pediatrics Committee on Infectious Diseases and Committee on Fetus and Newborn.

    abstract::In 1992, the Committee on Infectious Diseases and Committee on Fetus and Newborn of the American Academy of Pediatrics provided guidelines for prevention of early-onset group B streptococcal (GBS) disease through intrapartum chemoprophylaxis of selected maternal GBS carriers. The guidelines were based on demonstrated ...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.99.3.489

    authors:

    更新日期:1997-03-01 00:00:00

  • Grand round series: hypoglycemia and unilateral pulmonary edema in a newborn.

    abstract::A case of cardiomegaly with unilateral pulmonary edema is presented. The predisposing etiologies were severe hypoglycemia and a hypertonic glucose infusion into a branch of the left lower lobe pulmonary vein. Resolution resulted following maintenance of adequate glucose levels, vigorous cardiopulmonary support, and re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kerkering KW,Robertson LW,Kodroff MB,Mueller DG,Kirkpatrick BV

    更新日期:1980-02-01 00:00:00

  • Mental health problems and overweight in a nationally representative sample of adolescents: effects of race and ethnicity.

    abstract:OBJECTIVES:In this study we examined the relation between mental health problems and weight in a population-based study of youth aged 12 to 17 years and whether the association between mental health problems and weight is moderated by race and ethnicity. METHODS:We used 2003 National Survey on Children's Health data. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0687

    authors: BeLue R,Francis LA,Colaco B

    更新日期:2009-02-01 00:00:00