Failure of hydrocortisone to affect outcome in dengue shock syndrome.

Abstract:

:Despite the absence of a clear-cut rationale for their use, corticosteroids are widely employed in the treatment of dengue shock syndrome. Previous comparative therapeutic trials have yielded contradictory results. Resolution of this therapeutic controversy has been attempted with a double-blind evaluation of the clinical effect of steroid administration in dengue shock syndrome. Placebo or a single dose of hydrocortisone hemisuccinate, 50 mg/kg of body weight, was administered randomly to 97 physiologically treated patients with dengue shock syndrome. The severity of disease on admission to the hospital and the effectiveness of treatment were quantified by a World Health Organization scoring system. The response to therapy as measured by mortality, duration of shock, and amount of replacement fluids required was virtually identical in 47 children who were and 50 children who were not treated with steroids. The comparison groups were composed of children similar in age, sex, and severity of illness. It is concluded that hydrocortisone is of no value in the treatment of dengue shock syndrome. Reliance should be placed on appropriate supportive and physiologic therapy.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Sumarmo,Talogo W,Asrin A,Isnuhandojo B,Sahudi A

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

45-9

issue

1

eissn

0031-4005

issn

1098-4275

journal_volume

69

pub_type

临床试验,杂志文章,随机对照试验
  • Safety of withdrawing inhaled nitric oxide therapy in persistent pulmonary hypertension of the newborn.

    abstract:OBJECTIVE:Because of case reports describing hypoxemia on withdrawal of inhaled nitric oxide (I-NO), we prospectively examined this safety issue in newborns with persistent pulmonary hypertension who were classified as treatment successes or failures during a course of I-NO therapy. METHODS:Randomized, placebo-control...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.104.2.231

    authors: Davidson D,Barefield ES,Kattwinkel J,Dudell G,Damask M,Straube R,Rhines J,Chang CT

    更新日期:1999-08-01 00:00:00

  • Increased diagnosis of Lemierre syndrome and other Fusobacterium necrophorum infections at a Children's Hospital.

    abstract:OBJECTIVE:To assess the apparent increase in the diagnosis of Lemierre syndrome (LS) and other Fusobacterium necrophorum infections at a large children's hospital. Infections with F necrophorum ranged from peritonsillar abscess to potentially fatal LS. LS is an oropharyngeal infection characterized by septic thrombophl...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.112.5.e380

    authors: Ramirez S,Hild TG,Rudolph CN,Sty JR,Kehl SC,Havens P,Henrickson K,Chusid MJ

    更新日期:2003-11-01 00:00:00

  • Optic neuropathy in children with Lyme disease.

    abstract::Involvement of the optic nerve, either because of inflammation or increased intracranial pressure, is a rare manifestation of Lyme disease. Of the 4 children reported here with optic nerve abnormalities, 2 had decreased vision months after disease onset attributable to optic neuritis, and 1 had headache and diplopia e...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.2.477

    authors: Rothermel H,Hedges TR 3rd,Steere AC

    更新日期:2001-08-01 00:00:00

  • Prolonged QTc interval in association with medium-chain acyl-coenzyme A dehydrogenase deficiency.

    abstract::Medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency is the most common disorder of mitochondrial fatty acid oxidation. We report a term male infant who presented at 3 days of age with hypoglycemia, compensated metabolic acidosis, hypocalcemia, and prolonged QTc interval. Pregnancy was complicated by maternal ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-1105

    authors: Wiles JR,Leslie N,Knilans TK,Akinbi H

    更新日期:2014-06-01 00:00:00

  • Randomized trial of a cellular phone-enhanced home visitation parenting intervention.

    abstract:BACKGROUND AND OBJECTIVES:Although home visiting programs have been documented to improve parenting in high-risk families, their effectiveness is diminished when parents disengage from programs. Cellular phones offer an approach to promoting parent engagement and enhancing parenting outcomes. Our objective was to exami...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2013-1021Q

    authors: Carta JJ,Lefever JB,Bigelow K,Borkowski J,Warren SF

    更新日期:2013-11-01 00:00:00

  • Successive multisite peripheral nerve catheters for treatment of complex regional pain syndrome type I.

    abstract::Complex regional pain syndrome (CRPS) type I is a painful and disabling syndrome that is accompanied by physical changes in the affected extremity. It generally occurs after trauma, manifesting as pain that is out of proportion to the inciting event. Treatment of the disorder is difficult, with many patients being ref...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-3779

    authors: Martin DP,Bhalla T,Rehman S,Tobias JD

    更新日期:2013-01-01 00:00:00

  • Executive functioning of 4 children with hyperphenylalaninemia from childhood to adolescence.

    abstract::Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalanine...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-4200

    authors: Sharman R,Sullivan KA,Jones T,Young RM,McGill J

    更新日期:2015-04-01 00:00:00

  • Low-income parents' views on the redesign of well-child care.

    abstract:OBJECTIVE:To examine the perspectives of low-income parents on redesigning well-child care (WCC) for children aged 0 to 3 years, focusing on possible changes in 3 major domains: providers, locations, and formats. METHODS:Eight focus groups (4 English and 4 Spanish) were conducted with 56 parents of children aged 6 mon...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2608

    authors: Coker TR,Chung PJ,Cowgill BO,Chen L,Rodriguez MA

    更新日期:2009-07-01 00:00:00

  • Helping parents cope with the diagnosis of congenital heart defect: an experimental study.

    abstract::An experimental study was designed to help parents cope with the implications of the diagnosis of congenital heart disease. Intervention strategies involving clarification of medical information, discussion of psychological issues, and a combination of the two, were more effective than no intervention in helping paren...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kupst MJ,Blatterbauer S,Westman J,Schulman JL,Paul MH

    更新日期:1977-02-01 00:00:00

  • Improving Access to Care at Autism Treatment Centers: A System Analysis Approach.

    abstract:OBJECTIVE:The prevalence of autism spectrum disorder is steadily increasing and placing more demands on already overburdened diagnostic and treatment systems. A thoughtful, systematic reorganization of autism service delivery may reduce delays and better meet the growing need. METHODS:Two clinical centers in the Autis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2851M

    authors: Austin J,Manning-Courtney P,Johnson ML,Weber R,Johnson H,Murray D,Ratliff-Schaub K,Tadlock AM,Murray M

    更新日期:2016-02-01 00:00:00

  • Substance abuse education in pediatrics.

    abstract::Historically, physicians have received little formal education related to alcohol or other drug abuse and dependence. A survey of all pediatric programs in the United States was conducted to assess the current status of alcohol/drug education in pediatrics. At the medical student and residency training levels, only 44...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Adger H Jr,McDonald EM,DeAngelis C

    更新日期:1990-10-01 00:00:00

  • Vitamin D status of exclusively breastfed 4-month-old infants supplemented during different seasons.

    abstract:OBJECTIVE:To examine the vitamin D status of 4-month-old exclusively breastfed infants supplemented with 400 IU daily of vitamin D and to determine whether there was any seasonal variation in serum 25-hydroxyvitamin D (25(OH)D) levels of infants. METHODS:In this cross-sectional study, serum calcium, phosphorus, alkali...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0017

    authors: Halicioglu O,Sutcuoglu S,Koc F,Yildiz O,Akman SA,Aksit S

    更新日期:2012-10-01 00:00:00

  • Late-onset neutropenia in very low birth weight infants.

    abstract:BACKGROUND:Neutropenia, defined as absolute neutrophil count (ANC) <1500/mm(3), affects 6% to 58% of premature infants in the first week of life. This early-onset neutropenia in premature infants has previously been correlated with sepsis, maternal hypertension, severe asphyxia, and periventricular hemorrhage. Late-ons...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.4.e55

    authors: Omar SA,Salhadar A,Wooliever DE,Alsgaard PK

    更新日期:2000-10-01 00:00:00

  • Effectiveness of pulse oximetry screening for congenital heart disease in asymptomatic newborns.

    abstract:OBJECTIVE:To determine the sensitivity, specificity, predictive value, and accuracy of a program of pulse oximetry screening of asymptomatic newborns for critical congenital cardiovascular malformation (CCVM). METHODS:Pulse oximetry was performed on asymptomatic newborns in the well-infant nurseries of 2 hospitals. Ca...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.111.3.451

    authors: Koppel RI,Druschel CM,Carter T,Goldberg BE,Mehta PN,Talwar R,Bierman FZ

    更新日期:2003-03-01 00:00:00

  • Fruit Consumption by Youth in the United States.

    abstract:OBJECTIVES:To describe the contribution of whole fruit, including discrete types of fruit, to total fruit consumption and to investigate differences in consumption by sociodemographic characteristics. METHODS:We analyzed data from 3129 youth aged 2 to 19 years from the National Health and Nutrition Examination Survey,...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-1709

    authors: Herrick KA,Rossen LM,Nielsen SJ,Branum AM,Ogden CL

    更新日期:2015-10-01 00:00:00

  • The preparedness of schools to respond to emergencies in children: a national survey of school nurses.

    abstract:OBJECTIVES:Because children spend a significant proportion of their day in school, pediatric emergencies such as the exacerbation of medical conditions, behavioral crises, and accidental/intentional injuries are likely to occur. Recently, both the American Academy of Pediatrics and the American Heart Association have p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1474

    authors: Olympia RP,Wan E,Avner JR

    更新日期:2005-12-01 00:00:00

  • Fruit Juice in Infants, Children, and Adolescents: Current Recommendations.

    abstract::Historically, fruit juice was recommended by pediatricians as a source of vitamin C and as an extra source of water for healthy infants and young children as their diets expanded to include solid foods with higher renal solute load. It was also sometimes recommended for children with constipation. Fruit juice is marke...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.2017-0967

    authors: Heyman MB,Abrams SA,SECTION ON GASTROENTEROLOGY, HEPATOLOGY, AND NUTRITION.,COMMITTEE ON NUTRITION.

    更新日期:2017-06-01 00:00:00

  • Dating violence and associated sexual risk and pregnancy among adolescent girls in the United States.

    abstract:OBJECTIVES:To assess the annual prevalence of physical violence from dating partners among a representative sample of sexually experienced adolescent girls attending US public and private high schools, as well as sexual risk behaviors and pregnancy among this population. DESIGN, SETTING, PARTICIPANTS, AND MEASURES:Fem...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.2.e220

    authors: Silverman JG,Raj A,Clements K

    更新日期:2004-08-01 00:00:00

  • Primary care utilization and detection of emotional distress after adolescent traumatic injury: identifying an unmet need.

    abstract:OBJECTIVE:Few investigations have assessed the primary care detection of adolescent posttraumatic emotional distress after an injury. We aimed to determine (1) the level of attachment to primary care providers (PCPs) and school providers among this group of high-risk adolescents, (2) the emotional status of this popula...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1042

    authors: Sabin JA,Zatzick DF,Jurkovich G,Rivara FP

    更新日期:2006-01-01 00:00:00

  • Improving care through collaboration.

    abstract::The opportunity to improve health care using existing scientific knowledge is immense. Much is known that is not being used in routine care, leading to a large gap between knowledge and practice. Collaborative improvement models bring health care professionals together to focus on this gap and to accelerate the pace o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kilo CM

    更新日期:1999-01-01 00:00:00

  • Observations on a recent increase in plagiocephaly without synostosis.

    abstract:OBJECTIVE:To verify and determine the cause of an increase in the referral of infants with plagiocephaly without synostosis (PWS) to a single tertiary craniofacial center. DESIGN:A chart review was performed for 269 infants with a diagnosis of PWS who presented to a single tertiary craniofacial center between 1979 and...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kane AA,Mitchell LE,Craven KP,Marsh JL

    更新日期:1996-06-01 00:00:00

  • Effect of caffeine on oxygen consumption and metabolic rate in very low birth weight infants with idiopathic apnea.

    abstract:OBJECTIVE:Methylxanthines are among the most commonly prescribed drugs in neonatal intensive care. This study evaluates the effect of caffeine on oxygen consumption and metabolic rate in premature infants with idiopathic apnea. METHODS:Eighteen preterm infants at gestational ages from 28 to 33 weeks and birth weights ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.4.660

    authors: Bauer J,Maier K,Linderkamp O,Hentschel R

    更新日期:2001-04-01 00:00:00

  • Practice of feeding premasticated food to infants: a potential risk factor for HIV transmission.

    abstract:OBJECTIVES:Although some caregivers are known to premasticate food for infants, usually during the weaning period, HIV transmission has not been linked to this practice. We describe 3 cases of HIV transmission in the United States possibly related to this practice. PATIENTS AND METHODS:Three cases of HIV infection wer...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3614

    authors: Gaur AH,Dominguez KL,Kalish ML,Rivera-Hernandez D,Donohoe M,Brooks JT,Mitchell CD

    更新日期:2009-08-01 00:00:00

  • Poliomyelitis prevention: revised recommendations for use of inactivated and live oral poliovirus vaccines. American Academy of Pediatrics Committee on Infectious Diseases.

    abstract::Since 1997 when the American Academy of Pediatrics (AAP) issued revised guidelines for the prevention of poliomyelitis, substantial progress in global eradication of poliomyelitis has occurred and the use of inactivated poliovirus vaccine (IPV) has increased considerably in the United States with a corresponding decre...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.103.1.171

    authors:

    更新日期:1999-01-01 00:00:00

  • Pituitary gland gumma in congenital syphilis after failed maternal treatment: a case report.

    abstract::A preterm, very low birth weight infant was born to a mother with early latent syphilis who was treated 10 days and 3 days before delivery with 2.4 mU of benzathine penicillin. The infant had clinical, laboratory, and radiographic abnormalities consistent with congenital syphilis, ie, a Venereal Disease Research Labor...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.104.1.e4

    authors: Benzick AE,Wirthwein DP,Weinberg A,Wendel GD Jr,Alsaadi R,Leos NK,Zeray F,Sánchez PJ

    更新日期:1999-07-01 00:00:00

  • Statistical uncertainty of mortality rates and rankings for children's hospitals.

    abstract:OBJECTIVES:Hospitals are being required to report publically their adjusted mortality rates, which are then being used to rank hospitals. Our objectives were to assess the statistical reliability of the determination of a hospital's adjusted mortality rate, of comparisons of that rate with the rates of other hospitals,...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3074

    authors: Feudtner C,Berry JG,Parry G,Hain P,Morse RB,Slonim AD,Shah SS,Hall M

    更新日期:2011-10-01 00:00:00

  • Renal transplantation in children ages 1 to 5 years.

    abstract::Renal transplantation was carried out in 21 children ages 1 to 5 years. Eighteen received grafts from a living, related donor (LRD). Four children died, one following rejection, and three because of infection. Five children lost their initial grafts and two have received new transplants. Cumulative patient survival tw...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.458

    authors: Hodson EM,Najarian JS,Kjellstrand CM,Simmons RL,Mauer SM

    更新日期:1978-03-01 00:00:00

  • Catastrophic presentation of infant botulism may obscure or delay diagnosis.

    abstract::Three infants with infant botulism are presented to illustrate how atypical, early, and severe features may obscure or delay diagnosis. Two boys aged 6 weeks and 20 days, respectively, presented with rapid deterioration after brief periods of poor feeding, one with an apparent life-threatening event at home and the ot...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0297

    authors: Mitchell WG,Tseng-Ong L

    更新日期:2005-09-01 00:00:00

  • The prevalence, severity, and distribution of childhood food allergy in the United States.

    abstract:OBJECTIVE:The goal of this study was to better estimate the prevalence and severity of childhood food allergy in the United States. METHODS:A randomized, cross-sectional survey was administered electronically to a representative sample of US households with children from June 2009 to February 2010. Eligible participan...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0204

    authors: Gupta RS,Springston EE,Warrier MR,Smith B,Kumar R,Pongracic J,Holl JL

    更新日期:2011-07-01 00:00:00

  • Exemptions From Mandatory Immunization After Legally Mandated Parental Counseling.

    abstract:BACKGROUND:The success of health care provider counseling-based interventions to address vaccine hesitancy is not clear. In 2011, Washington State implemented Senate Bill 5005 (SB5005), requiring counseling and a signed form from a licensed health care provider to obtain an exemption. Evaluating the impact of a counsel...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2364

    authors: Omer SB,Allen K,Chang DH,Guterman LB,Bednarczyk RA,Jordan A,Buttenheim A,Jones M,Hannan C,deHart MP,Salmon DA

    更新日期:2018-01-01 00:00:00