Abstract:
OBJECTIVES:It has been shown that maternal prenatal exposure to selective serotonin reuptake inhibitors (SSRIs) may be a risk factor for attention-deficit/hyperactivity disorder (ADHD) in offspring. Our goal was to examine whether paternal SSRI use before conception increases the risk of ADHD in offspring. METHODS:On the basis of Danish national registers, we conducted a cohort study of 781 470 singletons born between 1996 and 2008 with follow-up throughout 2013. The children whose fathers used SSRIs during the last 3 months before conception were identified as the exposed. Cox regression was used to estimate the hazard ratio (HR) of ADHD. RESULTS:A total of 7216 children (0.92%) were born to fathers who had used SSRIs during the last 3 months before conception. There were 12 520 children diagnosed with ADHD. Compared with unexposed children, the exposed had a 26% increased risk of ADHD (HR = 1.26, 95% confidence interval [CI]: 1.06-1.51) after adjusting for potential confounders. When extending the exposure window to 1 year before conception, paternal use of SSRIs only during the period of 12 to 3 months before conception was associated with the HR of 1.35 (95% CI: 1.10-1.66), whereas paternal use of SSRIs only during the last 3 months before conception was associated with a similarly increased risk of ADHD (adjusted HR = 1.31, 95% CI: 0.95-1.82). CONCLUSIONS:The mildly increased risk of ADHD in offspring associated with paternal SSRI use before conception could probably be due to the underlying indications related to SSRI use.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Yang F,Liang H,Chen J,Miao M,Yuan W,Nørgaard M,Li Jdoi
10.1542/peds.2017-1081subject
Has Abstractpub_date
2018-01-01 00:00:00issue
1eissn
0031-4005issn
1098-4275pii
peds.2017-1081journal_volume
141pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVES:To assess trends in incidence of Candida spp. central line-associated bloodstream infections (CLABSIs) in US NICUs, 1999-2009. METHODS:Data from NICUs participating in the National Nosocomial Infections Surveillance (1999-2004) and National Healthcare Safety Network (2006-2009) were analyzed. Overall and bi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-3620
更新日期:2012-07-01 00:00:00
abstract::Sixty-two premature infants less than 2,000 gm birth weight received parenteral nutrition (PN) during periods of respiratory distress with feeding intolerance. Intrahepatic cholestasis (direct bilirubin greater than or equal to 1.5 mg/dl) associated with PN developed in 14 or 23% of these infants. The mean time on PN ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Diagnostic imaging is often used in the evaluation of children with possible appendicitis. The utility of imaging may vary according to a patient's age and gender. The objectives of this study were (1) to examine the use of computed tomography (CT) and ultrasound for age and gender subgroups o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-3375
更新日期:2012-05-01 00:00:00
abstract::Idiopathic acute eosinophilic pneumonia is a rare and potentially life-threatening condition that is defined by bilateral pulmonary infiltrates and fever in the presence of pulmonary eosinophilia. It often presents acutely in previously healthy individuals and can be difficult to distinguish from infectious pneumonia....
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-3007
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Neutropenia, defined as absolute neutrophil count (ANC) <1500/mm(3), affects 6% to 58% of premature infants in the first week of life. This early-onset neutropenia in premature infants has previously been correlated with sepsis, maternal hypertension, severe asphyxia, and periventricular hemorrhage. Late-ons...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.4.e55
更新日期:2000-10-01 00:00:00
abstract::Adenovirus infection is common in childhood and is generally associated with self-limited disease. Cidofovir, a viral DNA polymerase inhibitor, is used to treat adenovirus infection in select populations but is not often recommended for immunocompetent patients because of limited antiviral activity and nephrotoxicity....
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2019-1632
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Fetal alcohol spectrum disorders (FASD) comprise the continuum of disabilities associated with prenatal alcohol exposure. Although infancy remains the most effective time for initiation of intervention services, current diagnostic schemes demonstrate the greatest confidence, accuracy, and reli...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-2141
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:Although adverse health outcomes are increased among children with BMI above the 85th (overweight) and 95th (obese) percentiles, previous studies have not clearly defined the BMI percentile at which adverse health outcomes begin to increase. We examined whether the existing BMI percentile cutoffs are optimal ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0179
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To study the association of perinatal human immunodeficiency virus (HIV)-1 transmission with birth outcomes, including birth weight, gestational age, ponderal index, head circumference, and weight/head ratio. METHODS:Data from a prospective cohort study of 627 pregnant women and their infants in Butare, Rwan...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.2.e24
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVES:Respiratory infections (RIs) are an important cause of morbidity and excessive antibiotic prescriptions in children attending day care centers (DCCs). We aimed to assess the effectiveness of an educational and hand hygiene program in DCCs and homes in reducing RI incidence and antibiotic prescriptions in chi...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2018-1245
更新日期:2018-11-01 00:00:00
abstract::During a 3-month period, 1,062 mother-infant pairs were studied for infections following internal fetal monitoring during labor. Six infants (0.56%) developed septic scalp dermatitis at the site of the spiral electrode application. Factors associated with septic scalp dermatitis included the number of vaginal examinat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
abstract:OBJECTIVE:To perform hearing screenings on all newborns before hospital discharge, using auditory brainstem evoked responses with analysis of time, cost, and failure rates to evaluate and determine the screening practicality. METHOD:Over a 3-year period from January 1, 1993 to December 31, 1995, auditory brainstem evo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.99.6.e4
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:Young children are generally considered immunologically naive with respect to influenza exposure opportunities; thus, a 2-dose schedule is recommended when a child is first immunized with conventional influenza vaccine lacking adjuvant. We estimated the effectiveness of a single pediatric dose of AS03-adjuvan...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-3492
更新日期:2011-11-01 00:00:00
abstract::Primary type V hyperlipoproteinemia was identified in two preadolescent children. The propositus (kindred N) was a 10-year-old girl with severely creamy plasma, lipemia retinalis, hypertriglyceridemia (triglyceridelevel, 6,800 mg/100 ml), and ypercholesterolemia (cholesterol level, 490 mg/100 ml). Her parents and an 8...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::In an attempt to determine whether iron-fortified infant formulas produced gastrointestinal symptoms in infants, we fed two similar formulas, one with and one without iron fortification, to a group of 93 term infants upon discharge from the nursery on the third day of life. Infants were fed the formulas for a period o...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1980-08-01 00:00:00
abstract:OBJECTIVE:Published data show that plasma creatinine falls steadily during the first 28 days of life and that creatinine levels in the neonatal period are higher in more premature infants. However, the best reference data commence on day 2 of life. The objective of this study was to document how plasma creatinine chang...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.6.e76
更新日期:1999-12-01 00:00:00
abstract:CONTEXT:Disparities in child health are a major public health concern. However, it is unclear whether these are predominantly the result of low income, race, or other social risk factors that may contribute to their health disadvantage. Although others have examined the effects of the accumulation of risk factors, this...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1647
更新日期:2006-04-01 00:00:00
abstract::Two patients with periobital cellulitis, one of whom also had buccal cellulitis, had violaceous discoloration of the skin. Blood cultures from both patients yielded Streptococcus pneumoniae. Therefore, pneumococci should be considered, in addition to Haemophilus influenzae, as possible causes of cellulitis with violac...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract:OBJECTIVE:Preterm birth is associated with respiratory morbidity later in life, including asthma. Previous studies have mainly focused on asthma in early childhood in children born extremely preterm. In this study, we examined the risk of asthma in a national cohort of schoolchildren grouped according to degree of imma...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-3083
更新日期:2011-06-01 00:00:00
abstract::Erythromelalgia is an extraordinary disease which remains elusive in its pathophysiology and management. Victims suffer intense burning and redness of the hands and feet. In what appears to be the antithesis of Raynaud's disease, the pain is relieved by emersion in cold. A child with erythromelalgia is described whose...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:Health care-associated infections persist as a major problem in most neonatal intensive care units. Hand hygiene has been singled out as the most important measure in preventing hospital-acquired infection. However, hand hygiene compliance among health care workers (HCWs) remains low. The objective of this st...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1107
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:We present a long-term safety, immunogenicity, and effectiveness study of a quadrivalent human papillomavirus (HPV4) vaccine. METHODS:Sexually naive boys and girls aged 9 to 15 years (N = 1781) were assigned (2:1) to receive HPV4 vaccine or saline placebo at day 1 and months 2 and 6. At month 30, the placeb...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2013-4144
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:The goals of this study were to (1) develop an approach to ascertain birth asphyxia deaths by using verbal autopsy data from a community-based setting in Nepal, and (2) explore variations in birth asphyxia mortality fractions by using different birth asphyxia case definitions and hierarchical classifications...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-2644
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:To characterize the composition of the pediatric subspecialty workforce in terms of the distribution of women and international medical graduates (IMGs) across pediatric medical subspecialties and to determine whether the proportions of board-certified pediatric subspecialists who are women or IMGs differ be...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2446
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To examine the frequency with which pediatricians provide care coordination services to children, particularly those with special health care needs, in their practices and the barriers to providing these services. METHODS:An 8-page questionnaire was mailed to 1632 randomly selected US members of the American...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:In the safety community, it is widely thought that a culture of safety is required to achieve high levels of safety. However, the press tends to report accidents, which are negative by their nature. Pediatric cases are often especially tragic. Relatively few data have been available on the role that the medi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2017
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:It has been proposed that infection by group A beta-hemolytic streptococci (GABHS) can trigger acute symptom exacerbations among patients with Tourette's syndrome (TS) or obsessive-compulsive disorder (OCD), via autoimmune mechanisms. OBJECTIVE:To examine the temporal relationship between newly acquired GAB...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.6.e578
更新日期:2004-06-01 00:00:00
abstract:CONTEXT:Utilization of primary care settings offers a promising approach to enhance parenting practices that are critical for promoting early childhood development. Determining the impact of existing primary care interventions on key parenting behaviors will aid providers and policy makers as they seek strategies to im...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1542/peds.2015-3393
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Our objective was to determine whether paternal depressive symptoms were associated with less father involvement among African American fathers not living with their children (ie, nonresident fathers). METHODS:We analyzed survey data for 345 fathers enrolled in a program for nonresident African American fath...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0718
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Cardiac arrest is uncommon among pediatric patients. Prehospital data demonstrate differences in care processes between children and adults receiving cardiopulmonary resuscitation and advanced life support. We sought to evaluate whether children receiving in-hospital cardiopulmonary resuscitation would attain...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0453
更新日期:2006-09-01 00:00:00