Successful Use of Cidofovir in an Immunocompetent Child With Severe Adenoviral Sepsis.

Abstract:

:Adenovirus infection is common in childhood and is generally associated with self-limited disease. Cidofovir, a viral DNA polymerase inhibitor, is used to treat adenovirus infection in select populations but is not often recommended for immunocompetent patients because of limited antiviral activity and nephrotoxicity. Here, we report a case of fulminant adenovirus infection associated with lymphopenia and multiple organ failure requiring extracorporeal membrane oxygenation support in a previously healthy child. After 1 week of supportive therapy, the patient had persistent organ failure and continued to have adenoviremia of >560 000 copies per mL. Weekly doses of cidofovir with concurrent probenecid for renal protection was initiated. Adenovirus blood load declined after the first cidofovir dose, becoming undetectable after 3 doses. The patient was successfully decannulated from extracorporeal membrane oxygenation, extubated, and eventually discharged at his functional baseline without need for ongoing respiratory support. Lymphopenia improved after viremia resolved, and a subsequent immunologic workup revealed no evidence of primary immunodeficiency. The viral isolate was genotyped as adenovirus type 7. This case reveals the successful use of cidofovir for management of severe adenovirus infection in a previously healthy child. To date, there are no universally accepted recommendations for the use of cidofovir in this population. Further study is warranted to determine the potential role of cidofovir in treating severe adenovirus infections in immunocompetent children.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Alcamo AM,Wolf MS,Alessi LJ,Chong HJ,Green M,Williams JV,Simon DW

doi

10.1542/peds.2019-1632

subject

Has Abstract

pub_date

2020-01-01 00:00:00

issue

1

eissn

0031-4005

issn

1098-4275

pii

peds.2019-1632

journal_volume

145

pub_type

杂志文章,评审
  • A note on interdisciplinary research in developmental/behavioral pediatrics/psychology.

    abstract::In sum, we have offered a few observations about the practice of interdisciplinary research. Now, in addition to our rather specific suggestions, we want to add a few general comments about the interactions of professionals who are actually involved in interdisciplinary research. Collaboration between physicians and p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ellison PH,Kopp CB

    更新日期:1985-05-01 00:00:00

  • Milk intolerance in children with persistent sleeplessness: a prospective double-blind crossover evaluation.

    abstract::From July 1986 to July 1988, 146 children less than 5 years of age were referred by their physicians to our university sleep clinic for continual waking and crying during sleep hours. For 85 children (58.2%), the sleeplessness was attributed to inappropriate sleep habits. For 17 children (11.6%), no explanation was fo...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kahn A,Mozin MJ,Rebuffat E,Sottiaux M,Muller MF

    更新日期:1989-10-01 00:00:00

  • Variation in Preoperative Testing and Antireflux Surgery in Infants.

    abstract:BACKGROUND:Despite the availability of objective tests, gastroesophageal reflux disease (GERD) diagnosis and management in infants remains controversial and highly variable. Our purpose was to characterize national variation in diagnostic testing and surgical utilization for infants with GERD. METHODS:Using the Pediat...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0536

    authors: Short HL,Braykov NP,Bost JE,Raval MV

    更新日期:2017-08-01 00:00:00

  • Prevention and management of positional skull deformities in infants. American Academy of Pediatrics Committee on Practice and Ambulatory Medicine, Section on Plastic Surgery and Section on Neurological Surgery.

    abstract::Cranial asymmetry may be present at birth or may develop during the first few months of life. Over the past several years, pediatricians have seen an increase in the number of children with cranial asymmetry, particularly unilateral flattening of the occiput. This increase likely is attributable to parents following t...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.112.1.199

    authors: Persing J,James H,Swanson J,Kattwinkel J,American Academy of Pediatrics Committee on Practice and Ambulatory Medicine, Section on Plastic Surgery and Section on Neurological Surgery.

    更新日期:2003-07-01 00:00:00

  • A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns.

    abstract:OBJECTIVES:Severe neonatal jaundice is a common clinical manifestation of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and the most difficult to manage; kernicterus is not an uncommon outcome. We assessed in healthy, direct Coombs test-negative Greek newborns of >/=38 weeks' gestational age 1) the current burd...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.1.25

    authors: Kappas A,Drummond GS,Valaes T

    更新日期:2001-07-01 00:00:00

  • Outcomes of a universal shared reading intervention by 2 years of age: the Let's Read trial.

    abstract:BACKGROUND:Early shared reading and literacy promotion benefits have stimulated international interest in the development of early-years literacy-promotion programs despite limited evidence of effectiveness at a broader population level. OBJECTIVE:To determine whether a population-based primary care literacy promotion...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2009-3043

    authors: Goldfeld S,Napiza N,Quach J,Reilly S,Ukoumunne OC,Wake M

    更新日期:2011-03-01 00:00:00

  • Expanding the availability of extracorporeal cardiopulmonary resuscitation.

    abstract::A healthy 14-year-old presented to an emergency department in Alaska, complaining of shortness of breath, chest pain, and 72 hours of malaise and headache. On admission, her blood pressure was 80/50 mm Hg, and she had cool extremities. Electrocardiography revealed wide-complex ventricular tachycardia. She underwent sy...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-2371

    authors: McMullan DM

    更新日期:2013-03-01 00:00:00

  • Cognitive Outcomes and Positional Plagiocephaly.

    abstract::: media-1vid110.1542/5972296741001PEDS-VA_2018-2373Video Abstract BACKGROUND: Studies have revealed an association between positional plagiocephaly and/or brachycephaly (PPB) and development, although little is known about long-term outcomes. We examined cognition and academic achievement in children with and without ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-2373

    authors: Collett BR,Wallace ER,Kartin D,Cunningham ML,Speltz ML

    更新日期:2019-02-01 00:00:00

  • Preschool child care participation and obesity at the start of kindergarten.

    abstract:OBJECTIVE:We examined the association between type of child care, participation in different types of child care in the year before kindergarten and the likelihood of obesity at the start of kindergarten. METHODS:Using a nationally representative sample of 15 691 first-time kindergartners from the Early Childhood Long...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2233

    authors: Maher EJ,Li G,Carter L,Johnson DB

    更新日期:2008-08-01 00:00:00

  • Effect of donor-specific transfusions on renal transplantation in children.

    abstract::Most family members who are evaluated as kidney donors for children have high reactivity in a mixed lymphocyte culture test and are thus excluded from donation. Fifty children, most of whom had highly reactive mixed lymphocyte cultures with their donors, were challenged with three blood transfusions from their donors ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Potter D,Garovoy M,Hopper S,Terasaki P,Salvatierra O Jr

    更新日期:1985-09-01 00:00:00

  • Case of congenital short small intestine: survival with use of long-term parenteral feeding.

    abstract::Isolated congenital short small intestine is a rare anomaly. Of six (one male, five females) previously reported cases, four died in infancy from intractable diarrhea. We report the case of 7-year-old boy with this syndrome in whom a 2-year period of parenteral feeding at home allowed normal weight gain, growth, and d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Dorney SF,Byrne WJ,Ament ME

    更新日期:1986-03-01 00:00:00

  • Metabolic abnormalities in the idiopathic Fanconi syndrome: studies of carbohydrate metabolism in two patients.

    abstract::Two patients with idiopathic Fanconi syndrome and glucose intolerance were studied from a metabolic perspective. They had fasting hyperglycemia, massive glucosuria, insulinopenia, ketosis, and elevated serum free fatty acids. There was a markedly blunted insulin secretory response to glucagon, tolbutamide, glucose, an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Chesney RW,Kaplan BS,Teitel D,Colle E,McInnes RR,Goldman H,Scriver CR

    更新日期:1981-01-01 00:00:00

  • Cardiovascular support for low birth weight infants and cerebral hemodynamics: a randomized, blinded, clinical trial.

    abstract:BACKGROUND:Maintaining adequate organ blood flow is the target of vasopressor treatment, but the impact of these measures on cerebral perfusion has not yet been evaluated systematically in a randomized, blinded, clinical trial. OBJECTIVES:To explore the effects on brain hemodynamics of 2 different inotropic agents use...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-1396

    authors: Pellicer A,Valverde E,Elorza MD,Madero R,Gayá F,Quero J,Cabañas F

    更新日期:2005-06-01 00:00:00

  • Newborn Resuscitation Training in Resource-Limited Settings: A Systematic Literature Review.

    abstract:CONTEXT:Birth asphyxia contributes substantially to neonatal mortality in low- and middle-income countries (LMICs). The effects of training birth attendants in neonatal resuscitation (NR) on mortality are limited by falloff of skills and knowledge over time and transference of learned skills into clinical practice. OB...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2015-4490

    authors: Reisman J,Arlington L,Jensen L,Louis H,Suarez-Rebling D,Nelson BD

    更新日期:2016-08-01 00:00:00

  • Acute poststreptococcal glomerulonephritis: a manifestation of immune reconstitution inflammatory syndrome.

    abstract::Immune reconstitution inflammatory syndrome (IRIS) is a well-described complication of initiation of highly active antiretroviral therapy in HIV-infected patients. As the immune system recovers, an inappropriate inflammatory response often occurs that causes significant disease. It is most commonly seen in patients na...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1246

    authors: Martin J,Kaul A,Schacht R

    更新日期:2012-09-01 00:00:00

  • Issues in estimating the prevalence of fetal alcohol syndrome: examination of 2 counties in New York State.

    abstract:OBJECTIVE:Two demographically similar counties included in the New York Fetal Alcohol Syndrome Surveillance Network had very different prevalence rates. This study examined the components of the surveillance in an attempt to discover the reasons for this discrepancy. METHODS:Erie County and Monroe County were the 2 mo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0610

    authors: Druschel CM,Fox DJ

    更新日期:2007-02-01 00:00:00

  • Ethical, legal, and social concerns about expanded newborn screening: fragile X syndrome as a prototype for emerging issues.

    abstract::Technology will make it possible to screen for fragile X syndrome and other conditions that do not meet current guidelines for routine newborn screening. This possibility evokes at least 8 broad ethical, legal, and social concerns: (1) early identification of fragile X syndrome, an "untreatable" condition, could lead ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2007-0820

    authors: Bailey DB Jr,Skinner D,Davis AM,Whitmarsh I,Powell C

    更新日期:2008-03-01 00:00:00

  • 3% Hypertonic Saline Versus Normal Saline in Inpatient Bronchiolitis: A Randomized Controlled Trial.

    abstract:BACKGROUND AND OBJECTIVES:Bronchiolitis, the most common reason for hospitalization in children younger than 1 year in the United States, has no proven therapies effective beyond supportive care. We aimed to investigate the effect of nebulized 3% hypertonic saline (HS) compared with nebulized normal saline (NS) on leng...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2015-1037

    authors: Silver AH,Esteban-Cruciani N,Azzarone G,Douglas LC,Lee DS,Liewehr S,Nazif JM,Agalliu I,Villegas S,Rhim HJ,Rinke ML,O'Connor K

    更新日期:2015-12-01 00:00:00

  • Returning a Genomic Result for an Adult-Onset Condition to the Parents of a Newborn: Insights From the BabySeq Project.

    abstract::The return of information from genomic sequencing in children, especially in early life, brings up complex issues around parental autonomy, the child's future autonomy, the best interest standard, and the best interests of the family. These issues are particularly important in considering the return of genomic results...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-1099H

    authors: Holm IA,McGuire A,Pereira S,Rehm H,Green RC,Beggs AH,BabySeq Project Team.

    更新日期:2019-01-01 00:00:00

  • Carbamate poisoning: the 'other' insecticide.

    abstract::A 16-month-old child who ingested rat poison, according to her parents, was noted to have signs of cholinergic poisoning. In the emergency department, the child was intubated and given atropine via the endotracheal tube until venous access was established. Phytonadione (vitamin K) and pralidoxime (2-PAM) were also adm...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Garber M

    更新日期:1987-05-01 00:00:00

  • Prediction of death for extremely low birth weight neonates.

    abstract:OBJECTIVE:To compare multiple logistic regression and neural network models in predicting death for extremely low birth weight neonates at 5 time points with cumulative data sets, as follows: scenario A, limited prenatal data; scenario B, scenario A plus additional prenatal data; scenario C, scenario B plus data from t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2099

    authors: Ambalavanan N,Carlo WA,Bobashev G,Mathias E,Liu B,Poole K,Fanaroff AA,Stoll BJ,Ehrenkranz R,Wright LL,National Institute of Child Health and Human Development Neonatal Research Network.

    更新日期:2005-12-01 00:00:00

  • American Academy of Pediatrics. The role of the school nurse in providing school health services. Committee on School Health.

    abstract::The school nurse has a crucial role in the provision of school health services. This statement describes the school nurse as a member of the school health services team and its relation to children with special health care needs. Recommendations for the professional preparation and education of school nurses also are ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.5.1231

    authors: Committee on School Health.

    更新日期:2001-11-01 00:00:00

  • Epidemiology of COVID-19 Among Children in China.

    abstract:OBJECTIVE:To identify the epidemiological characteristics and transmission patterns of pediatric patients with the 2019 novel coronavirus disease (COVID-19) in China. METHODS:Nationwide case series of 2135 pediatric patients with COVID-19 reported to the Chinese Center for Disease Control and Prevention from January 1...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-0702

    authors: Dong Y,Mo X,Hu Y,Qi X,Jiang F,Jiang Z,Tong S

    更新日期:2020-06-01 00:00:00

  • Safe transportation of preterm and low birth weight infants at hospital discharge.

    abstract::Safe transportation of preterm and low birth weight infants requires special considerations. Both physiologic immaturity and low birth weight must be taken into account to properly position such infants. This clinical report provides guidelines for pediatricians and other caregivers who counsel parents of preterm and ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0559

    authors: Bull MJ,Engle WA,Committee on Injury, Violence, and Poison Prevention and Committee on Fetus and Newborn.,American Academy of Pediatrics.

    更新日期:2009-05-01 00:00:00

  • Use of complementary and alternative medicine in a general pediatric clinic.

    abstract:BACKGROUND:Use of complementary and alternative medical therapies is common and increasing, particularly for children with chronic disease. OBJECTIVES:The purpose of this work was to describe the use of complementary and alternative medicine by children and to identify factors that may influence the use of complementa...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3105

    authors: Jean D,Cyr C

    更新日期:2007-07-01 00:00:00

  • Mental health problems and overweight in a nationally representative sample of adolescents: effects of race and ethnicity.

    abstract:OBJECTIVES:In this study we examined the relation between mental health problems and weight in a population-based study of youth aged 12 to 17 years and whether the association between mental health problems and weight is moderated by race and ethnicity. METHODS:We used 2003 National Survey on Children's Health data. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0687

    authors: BeLue R,Francis LA,Colaco B

    更新日期:2009-02-01 00:00:00

  • Transition to adulthood: the important role of the pediatrician.

    abstract::This article, written by a parent of 2 youths with special health care needs and a pediatrician, builds on the Medical Home framework to give concrete examples of what physicians and families can and should do to prepare families for transition(s). The article consists of 3 parts. The first part is an introduction giv...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.3.e159

    authors: Olsen DG,Swigonski NL

    更新日期:2004-03-01 00:00:00

  • Are we overprescribing antireflux medications for infants with regurgitation?

    abstract:OBJECTIVE:Our goal was to evaluate the diagnosis and treatment of infants with persistent regurgitation who were referred to a pediatric gastroenterology service. METHODS:The records of 64 infants with persistent regurgitation and without any neurodevelopmental abnormalities, underlying illness, or cigarette smoke exp...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1146

    authors: Khoshoo V,Edell D,Thompson A,Rubin M

    更新日期:2007-11-01 00:00:00

  • Smoking patterns among adolescents with asthma attending upper secondary schools: a community-based study.

    abstract:OBJECTIVE:Smoking among people who have asthma may be a serious health problem. We studied the prevalence of smoking and the relations between smoking and asthma, symptoms, medicine, and gender differences among adolescents with asthma. METHODS:A national cross-sectional study on health and lifestyles was performed in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.5.e562

    authors: Precht DH,Keiding L,Madsen M

    更新日期:2003-05-01 00:00:00

  • Range of neurologic disorders in patients with celiac disease.

    abstract:OBJECTIVE:During the past 2 decades, celiac disease (CD) has been recognized as a multisystem autoimmune disorder. A growing body of distinct neurologic conditions such as cerebellar ataxia, epilepsy, myoclonic ataxia, chronic neuropathies, and dementia have been reported, mainly in middle-aged adults. There still are ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.6.1672

    authors: Zelnik N,Pacht A,Obeid R,Lerner A

    更新日期:2004-06-01 00:00:00