Are we overprescribing antireflux medications for infants with regurgitation?

Abstract:

OBJECTIVE:Our goal was to evaluate the diagnosis and treatment of infants with persistent regurgitation who were referred to a pediatric gastroenterology service. METHODS:The records of 64 infants with persistent regurgitation and without any neurodevelopmental abnormalities, underlying illness, or cigarette smoke exposure were evaluated for diagnostic workup and treatment. Forty-four infants underwent extended esophageal pH monitoring. RESULTS:Only 8 of 44 pH studies showed abnormal acid reflux. Forty-two of these 44 infants were already on antireflux medications. Other etiologies included hypertrophic pyloric stenosis (4) and renal tubular acidosis (1). Discontinuation of medication did not result in worsening of symptoms in most infants with normal pH studies. CONCLUSIONS:The majority of infants who were prescribed antireflux drugs did not meet diagnostic criteria for gastroesophageal reflux disease.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Khoshoo V,Edell D,Thompson A,Rubin M

doi

10.1542/peds.2007-1146

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

946-9

issue

5

eissn

0031-4005

issn

1098-4275

pii

120/5/946

journal_volume

120

pub_type

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