Abstract:
BACKGROUND AND OBJECTIVES:Bronchiolitis, the most common reason for hospitalization in children younger than 1 year in the United States, has no proven therapies effective beyond supportive care. We aimed to investigate the effect of nebulized 3% hypertonic saline (HS) compared with nebulized normal saline (NS) on length of stay (LOS) in infants hospitalized with bronchiolitis. METHODS:We conducted a prospective, randomized, double-blind, controlled trial in an urban tertiary care children's hospital in 227 infants younger than 12 months old admitted with a diagnosis of bronchiolitis (190 completed the study); 113 infants were randomized to HS (93 completed the study), and 114 to NS (97 completed the study). Subjects received 4 mL nebulized 3% HS or 4 mL 0.9% NS every 4 hours from enrollment until hospital discharge. The primary outcome was median LOS. Secondary outcomes were total adverse events, subdivided as clinical worsening and readmissions. RESULTS:Patient characteristics were similar in groups. In intention-to-treat analysis, median LOS (interquartile range) of HS and NS groups was 2.1 (1.2-4.6) vs 2.1 days (1.2-3.8), respectively, P = .73. We confirmed findings with per-protocol analysis, HS and NS groups with 2.0 (1.3-3.3) and 2.0 days (1.2-3.0), respectively, P = .96. Seven-day readmission rate for HS and NS groups were 4.3% and 3.1%, respectively, P = .77. Clinical worsening events were similar between groups (9% vs 8%, P = .97). CONCLUSIONS:Among infants admitted to the hospital with bronchiolitis, treatment with nebulized 3% HS compared with NS had no difference in LOS or 7-day readmission rates.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Silver AH,Esteban-Cruciani N,Azzarone G,Douglas LC,Lee DS,Liewehr S,Nazif JM,Agalliu I,Villegas S,Rhim HJ,Rinke ML,O'Connor Kdoi
10.1542/peds.2015-1037subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1036-43issue
6eissn
0031-4005issn
1098-4275pii
peds.2015-1037journal_volume
136pub_type
杂志文章,随机对照试验相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:Mortality trends across modifiable injury mechanisms may reflect how well effective injury prevention efforts are penetrating high-risk populations. This study examined all-cause, unintentional, and intentional injury-related mortality in children who were aged 0 to 4 years for evidence of and to quantify rac...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-2412
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:The maternal phenylketonuria (PKU) syndrome is caused by high blood phenylalanine (Phe) levels during pregnancy, leading to a host of birth defects, especially microcephaly and congenital heart disease (CHD). For finding whether the maternal PKU syndrome could be prevented, an international collaborative stud...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::The confusing area of cow's milk intolerance is explored in an attempt to define the various mechanisms whereby milk affects gastrointestinal function, resulting in clinical symptoms (diarrhea, vomiting, gastrointestinal bleeding, etc.). The adverse reaction of infants to cow's milk ingestion may relate to lactose int...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::The frequency of otitis media with effusion (serous otitis media, secretory otitis media) detected after conventional antibiotic treatment of acute otitis media is approximately 50%. The relationship between pharmacologic compliance and the frequency of otitis media with effusion was studied. A Micrococcus lutea bioin...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-11-01 00:00:00
abstract:OBJECTIVE:This study evaluates the impact that a Medicaid managed care program had on avoidable hospitalization, a form of health care misuse that we hypothesize can be reduced by improved access to and quality of primary care in the context of a managed care program. Ambulatory care sensitive (ACS) hospitalizations, a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.101.3.e1
更新日期:1998-03-01 00:00:00
abstract:CONTEXT:The usefulness of S100B has been noted as a biomarker in the management of mild traumatic brain injury (mTBI) in adults. However, S100B efficacy as a biomarker in children has previously been relatively unclear. OBJECTIVE:A meta-analysis is conducted to assess the prognostic value of S100B in predicting intrac...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2018-0037
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Children with generalized hypermobility of the joints and musculoskeletal complaints frequently visit pediatric clinics, but many show no currently known collagen or other possibly related diseases. Whether the symptoms are confined to the musculoskeletal system is unknown. We assessed whether such children ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.3.e248
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:Currently, the methods for assessing milk ejection in women include serial sampling of plasma oxytocin and measurement of intraductal pressure, both of which are invasive and may induce stress. We hypothesized that milk ejection would cause an increase in milk-duct diameter that could be observed noninvasivel...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.2.361
更新日期:2004-02-01 00:00:00
abstract::The 863 patients, aged 10 years and younger, treated at the Children's Chest Clinic of Bellevue Hospital during three decades (1953 through 1981) clearly indicated the success of antituberculosis therapy. There were no deaths from tuberculosis. Early treatment is associated with a reduction in the serious forms of dis...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to determine the attitudes of a variety of health care providers toward the recommendations that should be made to parents regarding the resuscitation of infants who are born at the margins of viability. METHODS:A written questionnaire was distributed to the medical and nursi...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2006-0913O
更新日期:2006-11-01 00:00:00
abstract::Immigrant children seeking safe haven in the United States, whether arriving unaccompanied or in family units, face a complicated evaluation and legal process from the point of arrival through permanent resettlement in communities. The conditions in which children are detained and the support services that are availab...
journal_title:Pediatrics
pub_type: 历史文章,杂志文章
doi:10.1542/peds.2017-0483
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Our goal was to evaluate the diagnosis and treatment of infants with persistent regurgitation who were referred to a pediatric gastroenterology service. METHODS:The records of 64 infants with persistent regurgitation and without any neurodevelopmental abnormalities, underlying illness, or cigarette smoke exp...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1146
更新日期:2007-11-01 00:00:00
abstract::Neurologically impaired children have an increased frequency of recurrent pain and irritability that persist in some despite comprehensive evaluation and management of possible pain sources. We hypothesized that visceral hyperalgesia was a source of chronic unexplained irritability and report the outcome of gabapentin...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1609
更新日期:2007-02-01 00:00:00
abstract::To determine whether mothers with complicated pregnancies are at increased risk of postpartum depression and whether their children are at increased risk of being perceived as vulnerable, the investigators conducted an interview survey of mothers of 1095 children aged 4 to 8 in a community-based sample of primary care...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In Rwanda, significant progress has been made in advancing access to antiretroviral therapy (ART) among youth. As availability of ART increases, adherence is critical for preventing poor clinical outcomes and transmission of HIV. The goals of the study are to (1) describe ART adherence and men...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-3235
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:To describe the contribution of whole fruit, including discrete types of fruit, to total fruit consumption and to investigate differences in consumption by sociodemographic characteristics. METHODS:We analyzed data from 3129 youth aged 2 to 19 years from the National Health and Nutrition Examination Survey,...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-1709
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Insulin-like growth factor I (IGF-I) is necessary for normal development of retinal blood vessels in mice and humans. Because retinopathy of prematurity (ROP) is initiated by abnormal postnatal retinal development, we hypothesized that prolonged low IGF-I in premature infants might be a risk factor for ROP. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.5.1016
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:Pediatric obstructive sleep apnea syndrome (OSAS) is associated with neurocognitive and endothelial dysfunction. However, it is unclear whether these 2 frequent morbidities of OSAS in children represent similar or different underlying pathophysiological processes, because they have never been concurrently ass...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-0688
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The false-positive rates of previously reported universal newborn hearing screening (UNHS) programs range between 2.5% and 8%. Critics of UNHS programs have claimed that this rate is too high and might lead to a number of the negative effects produced by false-positive screening tests, namely ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.3.e29
更新日期:2001-03-01 00:00:00
abstract::Primary angiitis of the central nervous system (PACNS) is an idiopathic vasculitis confined to the central nervous system. In children with PACNS, small-vessel (SV) involvement is characterized clinically by progressive neurologic symptoms, multifocal lesions on brain imaging, occasional pseudo-tumor presentation, and...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-2729
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To examine whether parent perceptions about care (barriers, disorder knowledge, treatment willingness) vary among children who drop out of or stay in publicly funded care for attention-deficit/hyperactivity disorder (ADHD) and to explore whether parent perceptions are predictive of staying in care over time. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1427f
更新日期:2013-03-01 00:00:00
abstract::The findings reported in this article are based on a nationwide survey of the attitudes and practices of pediatric surgeons and pediatricians with respect to some of the difficult ethical choices confronting them in medical practice. Four hundred fifty-seven physicians completed a questionnaire in the spring of 1975 i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract:OBJECTIVE:Sleep disorders can cause substantial morbidity but often remain undiagnosed among adults. We identified a series of children with sleep-related symptoms and reviewed medical chart notes for the previous 2 years to determine how often sleep problems had been addressed. DESIGN:Observational. Setting. Two univ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.6.1375
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Children with medical complexity have unique needs when facilitating transitions from hospital to home. Defining readiness for discharge is challenging, and preparation requires coordination of family, education, equipment, and medications. Our multidisciplinary team aimed to increase the perce...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-3832
更新日期:2016-08-01 00:00:00
abstract::Gastrointestinal food allergies are a spectrum of disorders that result from adverse immune responses to dietary antigens. The named disorders include immediate gastrointestinal hypersensitivity (anaphylaxis), oral allergy syndrome, allergic eosinophilic esophagitis, gastritis, and gastroenterocolitis; dietary protein...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To determine the correlation between the detection of human immunodeficiency virus type 1 (HIV-1) in breast milk, the duration of breastfeeding, and vertical transmission of HIV-1 infection in Ugandan women. METHODS:A prospective study of HIV-1 infection in pregnant Ugandan women and their infants has been o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:The Hawaii Child Asthma Research to Elevate Standards (CARES) Program implemented an emergency department (ED)-based education and management program to facilitate National Asthma Education and Prevention Program (NAEPP) guideline understanding among asthmatic children and their families, ED staff, and healt...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2005-2000L
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To characterize the clinical spectrum and epidemiology of invasive Kingella kingae infections in children living in southern Israel. DESIGN:Five-year observational, descriptive study. POPULATION:Children in whom K. kingae was isolated from blood or other normally sterile body fluid. RESULTS:Twenty-five pat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::Today clinical information is used for a multitude of purposes beyond patient care documentation including quality review and improvement processes, allocation of resources, budgetary and long-term planning, productivity measurement, and justification to payers for services provided. Providers in perinatal medicine ar...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Universal screening of sexually active adolescents for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) has been recommended in settings in which prevalence is 2% or greater. Although believed to be above 2%, the prevalence of CT and GC infection in private practice settings has not been clearly est...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.6.e103
更新日期:2001-12-01 00:00:00