Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infections.

Abstract:

BACKGROUND:It has been proposed that infection by group A beta-hemolytic streptococci (GABHS) can trigger acute symptom exacerbations among patients with Tourette's syndrome (TS) or obsessive-compulsive disorder (OCD), via autoimmune mechanisms. OBJECTIVE:To examine the temporal relationship between newly acquired GABHS infections (and other immunologic indices) and acute exacerbations of tics and obsessive-compulsive symptoms. METHODS:Pediatric patients (7-17 years of age) with TS and/or OCD (N = 47) and healthy control subjects (N = 19) were prospectively monitored for newly acquired GABHS infections, nonspecific markers of acute inflammatory responses, and D8/17-reactive cells (a marker of rheumatic fever). Objective monthly ratings of tic and obsessive-compulsive symptom severity were used to determine the timing of symptom exacerbations. RESULTS:The overall rate of acute exacerbations of neuropsychiatric symptoms was 0.56 exacerbations per patient per year. The average rate of new GABHS infections, using a stringent definition, was 0.42 infections per subject per year among patients, compared with 0.28 infections per subject per year for control subjects. The association between symptom exacerbations and new GABHS infections among patients was no greater than that expected on the basis of chance. At baseline, patients demonstrated significantly higher levels of D8/17-reactive cells and neopterin, compared with control subjects, but there was no consistent pattern of change when exacerbation time points were compared with baseline or follow-up time points. CONCLUSIONS:The results suggest no clear relationship between new GABHS infections and symptom exacerbations in an unselected group of patients with TS and/or OCD.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Luo F,Leckman JF,Katsovich L,Findley D,Grantz H,Tucker DM,Lombroso PJ,King RA,Bessen DE

doi

10.1542/peds.113.6.e578

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

e578-85

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

113

pub_type

杂志文章
  • Issues in estimating the prevalence of fetal alcohol syndrome: examination of 2 counties in New York State.

    abstract:OBJECTIVE:Two demographically similar counties included in the New York Fetal Alcohol Syndrome Surveillance Network had very different prevalence rates. This study examined the components of the surveillance in an attempt to discover the reasons for this discrepancy. METHODS:Erie County and Monroe County were the 2 mo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0610

    authors: Druschel CM,Fox DJ

    更新日期:2007-02-01 00:00:00

  • Universal newborn hearing screenings: a three-year experience.

    abstract:OBJECTIVE:To perform hearing screenings on all newborns before hospital discharge, using auditory brainstem evoked responses with analysis of time, cost, and failure rates to evaluate and determine the screening practicality. METHOD:Over a 3-year period from January 1, 1993 to December 31, 1995, auditory brainstem evo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.6.e4

    authors: Barsky-Firkser L,Sun S

    更新日期:1997-06-01 00:00:00

  • Violaceous discoloration in pneumococcal cellulitis.

    abstract::Two patients with periobital cellulitis, one of whom also had buccal cellulitis, had violaceous discoloration of the skin. Blood cultures from both patients yielded Streptococcus pneumoniae. Therefore, pneumococci should be considered, in addition to Haemophilus influenzae, as possible causes of cellulitis with violac...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Thirumoorthi MC,Asmar BI,Dajani AS

    更新日期:1978-10-01 00:00:00

  • The triple risk hypotheses in sudden infant death syndrome.

    abstract::Sudden infant death syndrome (SIDS) victims were regarded as normal as a matter of definition (Beckwith 1970) until 1952 when Kinney and colleagues argued for elimination of the clause, "unexpected by history." They argued that "not all SIDS victims were normal," and referred to their hypothesis that SIDS results from...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.110.5.e64

    authors: Guntheroth WG,Spiers PS

    更新日期:2002-11-01 00:00:00

  • Recommendations for the prevention of Streptococcus pneumoniae infections in infants and children: use of 13-valent pneumococcal conjugate vaccine (PCV13) and pneumococcal polysaccharide vaccine (PPSV23).

    abstract::Routine use of the 7-valent pneumococcal conjugate vaccine (PCV7), available since 2000, has resulted in a dramatic reduction in the incidence of invasive pneumococcal disease (IPD) attributable to serotypes of Streptococcus pneumoniae contained in the vaccine. However, IPD caused by nonvaccine pneumococcal serotypes ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1280

    authors: American Academy of Pediatrics Committee on Infectious Diseases.

    更新日期:2010-07-01 00:00:00

  • Fruit Juice in Infants, Children, and Adolescents: Current Recommendations.

    abstract::Historically, fruit juice was recommended by pediatricians as a source of vitamin C and as an extra source of water for healthy infants and young children as their diets expanded to include solid foods with higher renal solute load. It was also sometimes recommended for children with constipation. Fruit juice is marke...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.2017-0967

    authors: Heyman MB,Abrams SA,SECTION ON GASTROENTEROLOGY, HEPATOLOGY, AND NUTRITION.,COMMITTEE ON NUTRITION.

    更新日期:2017-06-01 00:00:00

  • Pediatrician Perspectives on Feasibility and Acceptability of the MOCA-Peds 2017 Pilot.

    abstract:BACKGROUND AND OBJECTIVES:The American Board of Pediatrics (ABP) certifies that general and subspecialty pediatricians meet standards of excellence established by their peers, immediately after training and over the course of their careers (ie, Maintenance of Certification [MOC]). In 2015-2016, the ABP developed the Ma...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-2303

    authors: Leslie LK,Turner AL,Smith AC,Dounoucos V,Olmsted MG,Althouse L

    更新日期:2019-12-01 00:00:00

  • Long-term follow-up and outcome of phenylketonuria patients on sapropterin: a retrospective study.

    abstract:OBJECTIVE:Sapropterin dihydrochloride, the synthetic form of 6R-tetrahydrobiopterin (BH4), is an approved drug for the treatment of patients with BH4-responsive phenylketonuria (PKU). The purpose of this study was to assess genotypes and data on the long-term effects of BH4/sapropterin on metabolic control and patient-...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2012-3291

    authors: Keil S,Anjema K,van Spronsen FJ,Lambruschini N,Burlina A,Bélanger-Quintana A,Couce ML,Feillet F,Cerone R,Lotz-Havla AS,Muntau AC,Bosch AM,Meli CA,Billette de Villemeur T,Kern I,Riva E,Giovannini M,Damaj L,Leuzzi V,B

    更新日期:2013-06-01 00:00:00

  • Psychopathology in children and adolescents with migraine in clinical studies: a systematic review.

    abstract:BACKGROUND:In past decades, numerous population- and hospital-based studies have revealed a relationship between migraine or headache and psychopathology in children. OBJECTIVE:To describe and assess all clinical studies on the prevalence and manifestations of psychological functioning and psychiatric comorbidity in c...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2009-3293

    authors: Bruijn J,Locher H,Passchier J,Dijkstra N,Arts WF

    更新日期:2010-08-01 00:00:00

  • Effect of duration and frequency of breast-feeding on postpartum amenorrhea.

    abstract::The relationship among duration and frequency of breast-feeding, age, level of education, and parity on postpartum amenorrhea were investigated retrospectively in selected married Nigerian women attending the two local maternity centers in Ile-Ife, Nigeria, between January and May 1980. The mean values for duration an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ojofeitimi EO

    更新日期:1982-02-01 00:00:00

  • A parent questionnaire for developmental screening in infants born late and moderately preterm.

    abstract:BACKGROUND:The Parent Report of Children's Abilities-Revised (PARCA-R) is a questionnaire for assessing cognitive and language development in very preterm infants. Given the increased risk of developmental delay in infants born late and moderately preterm (LMPT; 32-36 weeks), this study aimed to validate this questionn...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0266

    authors: Blaggan S,Guy A,Boyle EM,Spata E,Manktelow BN,Wolke D,Johnson S

    更新日期:2014-07-01 00:00:00

  • Recommendations for Prevention and Control of Influenza in Children, 2015-2016.

    abstract::The purpose of this statement is to update recommendations for routine use of seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. The American Academy of Pediatrics recommends annual seasonal influenza immunization for all people 6 months and older, including...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2015-2920

    authors: Committee on Infectious Diseases, American Academy of Pediatrics.

    更新日期:2015-10-01 00:00:00

  • Predictors of fatality in postdiarrheal hemolytic uremic syndrome.

    abstract:OBJECTIVES:Describe the cause of deaths among patients with postdiarrheal hemolytic uremic syndrome (HUS) and identify predictors of death at the time of hospital admission. METHODS:Case-control study of 17 deaths among patients with HUS identified from the Intermountain HUS Patient Registry (1970-2003) compared again...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0785

    authors: Oakes RS,Siegler RL,McReynolds MA,Pysher T,Pavia AT

    更新日期:2006-05-01 00:00:00

  • Intrahepatic cholestasis associated with parenteral nutrition in premature infants.

    abstract::Sixty-two premature infants less than 2,000 gm birth weight received parenteral nutrition (PN) during periods of respiratory distress with feeding intolerance. Intrahepatic cholestasis (direct bilirubin greater than or equal to 1.5 mg/dl) associated with PN developed in 14 or 23% of these infants. The mean time on PN ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Beale EF,Nelson RM,Bucciarelli RL,Donnelly WH,Eitzman DV

    更新日期:1979-09-01 00:00:00

  • Can home visitation improve the health of women and children at environmental risk?

    abstract::We reviewed randomized trials of prenatal and infancy home-visitation programs for socially disadvantaged women and children. Some home-visitation programs were effective in improving women's health-related behaviors during pregnancy, the birth weight and length of gestation of babies born to smokers and young adolesc...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Olds DL,Kitzman H

    更新日期:1990-07-01 00:00:00

  • Autism Spectrum Disorder in Fragile X Syndrome: Cooccurring Conditions and Current Treatment.

    abstract:BACKGROUND AND OBJECTIVE:Individuals with fragile X syndrome (FXS) are frequently codiagnosed with autism spectrum disorder (ASD). Most of our current knowledge about ASD in FXS comes from family surveys and small studies. The objective of this study was to examine the impact of the ASD diagnosis in a large clinic-base...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2016-1159F

    authors: Kaufmann WE,Kidd SA,Andrews HF,Budimirovic DB,Esler A,Haas-Givler B,Stackhouse T,Riley C,Peacock G,Sherman SL,Brown WT,Berry-Kravis E

    更新日期:2017-06-01 00:00:00

  • Infant-feeding methods and childhood sleep-disordered breathing.

    abstract:OBJECTIVE:Childhood sleep-disordered breathing has an adverse impact on cognitive development, behavior, quality of life, and use of health care resources. Early viral infections and other immune-mediated responses may contribute to development of the chronic inflammation of the upper airway and hypertrophic upper airw...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0722

    authors: Montgomery-Downs HE,Crabtree VM,Sans Capdevila O,Gozal D

    更新日期:2007-11-01 00:00:00

  • Diagnosis and treatment of acute otitis media: an assessment.

    abstract:OBJECTIVE:To assess compliance with the Centers for Disease Control and Prevention (CDC) evidence-based guidelines for the judicious use of antimicrobials in children with acute otitis media (AOM). METHODS:Compliance with CDC's recommended diagnostic criteria and antimicrobial treatments for management of AOM was asse...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.1.143

    authors: Garbutt J,Jeffe DB,Shackelford P

    更新日期:2003-07-01 00:00:00

  • Regular monitoring of bone age is not useful in children treated with growth hormone.

    abstract::Although bone age estimates are traditionally used to monitor children receiving growth hormone therapy, few data support this practice. Bone age determination is fraught with technical difficulties, resulting in high interobserver differences. Longitudinal studies show that an individual's bone age can change erratic...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Wilson DM

    更新日期:1999-10-01 00:00:00

  • Enterovirus 71 infection: report of an outbreak with two cases of paralysis and a review of the literature.

    abstract::Enterovirus 71 (E-71) infection was first reported in 19745 in the United States; subsequent outbreaks were reported in worldwide distribution. In the summer of 1977, we identified 12 patients, mostly children, with E-71 infection. The striking feature of this outbreak is the occurrence of two cases with polio-like pa...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Chonmaitree T,Menegus MA,Schervish-Swierkosz EM,Schwalenstocker E

    更新日期:1981-04-01 00:00:00

  • Role of environmental factors in the timing of puberty.

    abstract::Puberty-timing measures have historically been used as indicators of adequate nutrition and growth. More recently, these measures have been examined in relation to exposure to estrogenic or antiandrogenic agents, as well as other environmental factors. The scientific community has debated whether puberty timing is occ...

    journal_title:Pediatrics

    pub_type: 共识发展会议,杂志文章

    doi:10.1542/peds.2007-1813C

    authors: Euling SY,Selevan SG,Pescovitz OH,Skakkebaek NE

    更新日期:2008-02-01 00:00:00

  • Fatal Haemophilus influenzae endocarditis diagnosed by echocardiography in an infant.

    abstract::A 1-year-old boy was admitted to the hospital with Haemophilus influenzae meningitis. On the second hospital day a heart murmur heard on admission seemed louder. No signs of congestive heart failure were present. An echocardiogram demonstrated a persistent echo-dense mass behind the anterior leaflet of the mitral valv...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Laird WP,Nelson JD,Weinberg AG,Huffines FD

    更新日期:1979-09-01 00:00:00

  • Care coordination services in pediatric practices.

    abstract:OBJECTIVE:To examine the frequency with which pediatricians provide care coordination services to children, particularly those with special health care needs, in their practices and the barriers to providing these services. METHODS:An 8-page questionnaire was mailed to 1632 randomly selected US members of the American...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gupta VB,O'Connor KG,Quezada-Gomez C

    更新日期:2004-05-01 00:00:00

  • Decreasing PICU catheter-associated bloodstream infections: NACHRI's quality transformation efforts.

    abstract:OBJECTIVE:Despite the magnitude of the problem of catheter-associated bloodstream infections (CA-BSIs) in children, relatively little research has been performed to identify effective strategies to reduce these complications. In this study, we aimed to develop and evaluate effective catheter-care practices to reduce pe...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2009-1382

    authors: Miller MR,Griswold M,Harris JM 2nd,Yenokyan G,Huskins WC,Moss M,Rice TB,Ridling D,Campbell D,Margolis P,Muething S,Brilli RJ

    更新日期:2010-02-01 00:00:00

  • Impact of very preterm birth on health care costs at five years of age.

    abstract:OBJECTIVE:We assessed the effects of very preterm birth (gestational age <32 weeks or birth weight <1501 g) and prematurity-related morbidities on health care costs during the fifth year of life. METHODS:The study population consisted of 588 very preterm children and 176 term control subjects born in 2001-2002. Costs ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2882

    authors: Korvenranta E,Lehtonen L,Rautava L,Häkkinen U,Andersson S,Gissler M,Hallman M,Leipälä J,Peltola M,Tammela O,Linna M,PERFECT Preterm Infant Study Group.

    更新日期:2010-05-01 00:00:00

  • Maternal glucocorticoid therapy and reduced risk of bronchopulmonary dysplasia.

    abstract::Because of substantial clinical and laboratory evidence of the efficacy of glucocorticoids in the treatment of acute pulmonary surfactant deficiency in preterm newborns, we explored the hypothesis that maternal antenatal glucocorticoid receipt is followed by reduced risk of bronchopulmonary dysplasia (BPD). A sample o...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Van Marter LJ,Leviton A,Kuban KC,Pagano M,Allred EN

    更新日期:1990-09-01 00:00:00

  • Thrombotic storm in a teenager with previously undiagnosed ulcerative colitis.

    abstract::Venous thrombosis can complicate inflammatory bowel diseases, both in adult and pediatric patients, and a few adult cases of thrombotic storm, ie, thrombosis at multiple sites occurring over a period of a few days to a few weeks, have been described. However, venous thrombosis as the first manifestation of an inflamma...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2365

    authors: Maggi U,Rossi G,Avesani EC,Artoni A,Caprioli F,Napolitano L,Martinelli I

    更新日期:2013-04-01 00:00:00

  • Effect of cow's milk on the gastrointestinal tract: a persistent dilemma for the pediatrician.

    abstract::The confusing area of cow's milk intolerance is explored in an attempt to define the various mechanisms whereby milk affects gastrointestinal function, resulting in clinical symptoms (diarrhea, vomiting, gastrointestinal bleeding, etc.). The adverse reaction of infants to cow's milk ingestion may relate to lactose int...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Eastham EJ,Walker WA

    更新日期:1977-10-01 00:00:00

  • Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation.

    abstract::Phenotypic and biological characterization of rare monogenic disorders represents 1 of the most important avenues toward understanding the mechanisms of human disease. Among patients with SH3 and multiple ankyrin repeat domains 3 (SHANK3) mutations, a subset will manifest neurologic regression, psychosis, and mood dis...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2019-1490

    authors: Bey AL,Gorman MP,Gallentine W,Kohlenberg TM,Frankovich J,Jiang YH,Van Haren K

    更新日期:2020-02-01 00:00:00

  • Summary of workgroup meeting on use of family history information in pediatric primary care and public health.

    abstract::A workgroup meeting on the use of family history information in pediatric primary care and public health sponsored by the National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention was held February 24 to 25, 2006. The workgroup participants met to discuss how to ...

    journal_title:Pediatrics

    pub_type:

    doi:10.1542/peds.2007-1010H

    authors: Green RF

    更新日期:2007-09-01 00:00:00