Abstract:
OBJECTIVE:Cerebrovascular abnormalities are serious but underrecognized complications of neurofibromatosis type 1 (NF1). The aim of this study was to investigate the prevalence, clinical presentation, imaging findings, and prognosis of cerebral arteriopathies in childhood NF1. METHODS:Patients followed at the NF1 clinic at the Hospital for Sick Children, Toronto, Ontario, Canada, between 1990 and 2007 were studied. Patients with confirmed NF1 diagnosis and neuroimaging results were included. All neuroimaging studies were reviewed for the presence of arteriopathy by 2 study pediatric neuroradiologists blinded to clinical information. Clinical records of children with cerebral arteriopathy were reviewed. RESULTS:Among 419 children with confirmed NF1, 266 (63%) received neuroimaging. Among children with neuroimaging results, 17 had cerebral arteriopathy (minimum prevalence rate of 6%). Among the 35 patients who received magnetic resonance angiography (MRA), arteriopathy was more common in patients with NF1 with optic gliomas (11 of 21) compared with those without optic glioma (4 of 14). Forty-seven percent of children developed focal deficits months to years after the diagnosis of the arteriopathy. Follow-up at a mean of 7 years after diagnosis of arteriopathy showed that 35% (6 of 17) had progressive arteriopathy requiring revascularization surgery. Seven patients received aspirin for primary stroke prevention. On retrospective review of imaging studies, a mean delay of 51 months to clinical radiographic reporting of these findings was observed. CONCLUSIONS:The prevalence of cerebral arteriopathy in children with NF1 in this study was at least 6% and was associated with young age and optic glioma. Arteriopathy causes stroke with resultant neurologic deficits. Medical and/or surgical interventions may prevent these complications. Therefore, the addition of vascular imaging (MRA/conventional angiography) to brain imaging studies for early detection of arteriopathy should be considered for children with NF1, particularly young patients with optic glioma.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Rea D,Brandsema JF,Armstrong D,Parkin PC,deVeber G,MacGregor D,Logan WJ,Askalan Rdoi
10.1542/peds.2009-0152subject
Has Abstractpub_date
2009-09-01 00:00:00pages
e476-83issue
3eissn
0031-4005issn
1098-4275pii
peds.2009-0152journal_volume
124pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:The Neonatal Individualized Developmental Care Program (NIDCAP) for very low birth weight (VLBW) preterm infants has been suggested by Als et al to improve several medical outcome variables such as time on ventilator, time to nipple feed, the duration of hospital stay, better behavioral performance on Assessm...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.100.6.e9
更新日期:1997-12-01 00:00:00
abstract::We report on 6 infants who underwent elective surgery and developed postoperative encephalopathy, which had features most consistent with intraoperative cerebral hypoperfusion. All infants were <48 weeks' postmenstrual age and underwent procedures lasting 120 to 185 minutes. Intraoperative records revealed that most o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-0973
更新日期:2014-03-01 00:00:00
abstract::Physicians who prescribe a new drug that has not been approved for a specific indication or a specific age group frequently find themselves in a quandary. Physicians who prescribe "old," time-honored drugs usually do not consult the package insert or search for US Food and Drug Administration (FDA) approval. This stat...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:Although several studies have suggested that early menarche is associated with the development of adult overweight, few have accounted for childhood overweight before menarche. STUDY DESIGN:A 30-year follow-up of the original participants in the Newton Girls Study, a prospective study of development in a coh...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1604
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:To examine whether maternal prenatal lifestyle factors were associated with the risk of hospitalization with infectious disease during early childhood and whether a possible association was modified by fetal growth reduction. METHODS:The study was based on a birth cohort of 10 400 newborns whose mothers att...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.107.2.357
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To assess the frequency of clinician-reported delivery of counseling for avoidance of child environmental tobacco smoke (ETS) exposure and tobacco use at periodic well-child visits and at illness visits for asthma and otitis media (OM). METHODS:Combined data from the National Ambulatory Medical Care Survey a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.2.e162
更新日期:2003-02-01 00:00:00
abstract::Phototherapy is known to increase peripheral blood flow in neonates, but information on the associated cardiovascular effects is not available. Using pulsed Doppler echocardiography we evaluated cardiac output and stroke volume in 12 preterm and 13 term neonates during and after phototherapy. We concomitantly measured...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between local macroeconomic indicators and physical abuse admission rates to pediatric hospitals over time. METHODS:Retrospective study of children admitted to 38 hospitals in the Pediatric Hospital Information System database. Hospital data were linked to unemployment, mortgage d...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-3755
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:Hospitals are being required to report publically their adjusted mortality rates, which are then being used to rank hospitals. Our objectives were to assess the statistical reliability of the determination of a hospital's adjusted mortality rate, of comparisons of that rate with the rates of other hospitals,...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-3074
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To determine whether the risk of unintentional injury requiring emergency department (ED) or inpatient care in children is transiently increased over a 90-day period after injury to a sibling. DESIGN:Retrospective cohort. SETTING:King County, Washington. Participants. A total of 41 242 children 0 to 15 year...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.105.3.562
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:Serum alanine transaminase (ALT) and aspartate transaminase (AST) levels are commonly used as biochemical indicators of hepatocellular injury but can also detect occult muscle disease. High concomitant serum creatine phosphokinase (CPK) levels can point to muscle as the source of high transaminase levels. Nev...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-0929
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:We investigated whether the duration and exclusivity of breastfeeding affects the likelihood of gross and fine motor delay in infants and examined the effect of factors that might explain any observed differences. METHODS:The study sample included all term singleton infants who weighed > 2500 g at birth and ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-3141
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To evaluate a healthy lifestyle intervention to reduce adiposity in children aged 5 to 9 years and assess whether adding parenting skills training would enhance this effect. PARTICIPANTS AND METHODS:We conducted a single-blinded randomized controlled trial of prepubertal moderately obese (International Obesi...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2009-1432
更新日期:2011-02-01 00:00:00
abstract::Thirty-three children with acute rheumatic fever were studied using echocardiography to characterize heart involvement in this disease. Among 26 subjects with a first episode of acute rheumatic fever, 18 had a clinical diagnosis of carditis and six had heart failure. Heart failure usually resulted from valvular incomp...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-05-01 00:00:00
abstract::Indirect and qualitative tests of pancreatic function are commonly used to screen patients with cystic fibrosis for pancreatic insufficiency. In an attempt to develop a more quantitative assessment, we compared the usefulness of measuring serum pancreatic lipase using a newly developed enzyme-linked immunosorbent immu...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
abstract::The assumption that children with phenylketonuria (PKU) develop normally until birth was brought into question by the recent report that PKU children weigh several hundred grams less at birth than their unaffected siblings. We have examined intrafamily differences in birthweight in 40 sibships with at least one affect...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1976-12-01 00:00:00
abstract:OBJECTIVES:We sought to determine factors that would predict the development of subglottic stenosis (SGS) and tracheomalacia (TM) in preterm infants. The utility of a semiquantitative measurement of airway dimensions was assessed in relation to signs of airway complications. We also sought to determine from a high-risk...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:To examine whether parent perceptions about care (barriers, disorder knowledge, treatment willingness) vary among children who drop out of or stay in publicly funded care for attention-deficit/hyperactivity disorder (ADHD) and to explore whether parent perceptions are predictive of staying in care over time. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1427f
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to examine the relationship between duration of poverty and the health of preschool children in the Quebec Longitudinal Study of Child Development birth cohort. METHODS:Data from the Quebec Longitudinal Study of Child Development for 1950 children who were followed annually u...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1750
更新日期:2007-05-01 00:00:00
abstract::Congenital cataracts and other ocular media opacities are a leading cause of preventable childhood blindness. Because of the importance of early recognition and treatment of congenital media opacities in newborn infants, we designed a study to determine the ability of relatively inexperienced examiners to detect such ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::From a health viewpoint, early sexual activity among US adolescents is a potential problem because of the risk of pregnancy and sexually transmitted infections. New evidence points to the media adolescents use frequently (television, music, movies, magazines, and the Internet) as important factors in the initiation of...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2010-1544
更新日期:2010-09-01 00:00:00
abstract::Nonfamilial cardiomyopathies in childhood have been only sporadically ascribed to endocrine disorders. We report on a 4-month-old male infant presenting with Cushing's syndrome associated with excessive body weight (8.9 kg; >97th percentile) and features of virilization (Tanner stage 2 for pubic hair development). Abd...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-2692
更新日期:2013-08-01 00:00:00
abstract::In an effort to determine whether iron deficiency, in the absence of anemia (hemoglobin greater than 11.0 g/dL), might produce alterations in behavioral development, four groups of nonanemic infants, 9 to 12 months of age, with varying degrees of iron deficiency were studied. Infants were classified as iron sufficient...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract:OBJECTIVE:Current American Academy of Pediatrics and United States Public Health Service Immunization Practices Advisory Committee recommendations for hepatitis B immunization in premature infants weighing <2 kg at birth born to hepatitis B surface antigen (HBSAg)-negative mothers are to delay the initiation of vaccina...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.2.e14
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVES:Television viewing and physical inactivity increase the risk of obesity in youth. Thus, identifying new interventions that increase physical activity and reduce television viewing would be helpful in the prevention and treatment of pediatric obesity. This study evaluated the effects of open-loop feedback plu...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2005-3052
更新日期:2006-07-01 00:00:00
abstract::An experimental study was designed to help parents cope with the implications of the diagnosis of congenital heart disease. Intervention strategies involving clarification of medical information, discussion of psychological issues, and a combination of the two, were more effective than no intervention in helping paren...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract:OBJECTIVE:Sensitization to perennial aeroallergens is associated with asthma in industrialized countries with a Western lifestyle. Because silk products are commonly used in Chinese society, we were interested in examining the relation between sensitization to silk and asthma. DESIGN:Cross-sectional study of 871 child...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.5.e80
更新日期:2001-05-01 00:00:00
abstract::We report an atypical case of complete DiGeorge (DG) anomaly that presented initially exclusively as severe combined immunodeficiency (SCID). The child had severe infections at diagnosis, in keeping with the SCID phenotype; however, normal lymphocyte counts and immunoglobulin levels were noted at admission, which dela...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-0371
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To compare perinatal outcomes among the managed care organizations (MCOs) providing care to beneficiaries enrolled in TennCare, Tennessee's capitated Medicaid managed care program. DESIGN:Retrospective cohort analysis. SUBJECTS:Infants born in Tennessee during 1995 to women enrolled in TennCare. PRIMARY OU...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.3.525
更新日期:1999-09-01 00:00:00
abstract::The American Academy of Pediatrics has created recommendations for health appraisal and preparation of young people before participation in day, resident, or family camps and to guide health and safety practices at camp. These recommendations are intended for parents and families, primary health care providers, and ca...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2019-1355
更新日期:2019-07-01 00:00:00