Ten-year follow-up of children born at

Abstract:

BACKGROUND:Thyroid hormones are essential for brain development. We conducted a randomized, controlled trial with thyroxine (T4) supplementation in infants <30 weeks' gestation and with the last neurodevelopmental follow-up moment at the age of 5.5 years. T4 supplementation was associated with improved outcome of infants <28 weeks' gestation and worse outcome of infants of 29 weeks' gestation. We studied gestational age-dependent effects of T4 supplementation at the mean age of 10.5 years in children participating in our randomized, controlled trial. METHODS:Questionnaires regarding school outcome, behavior, quality of life, motor problems, and parental stress were sent to the parents and children and their teachers at the same time point for all surviving children (9-12 years of age). RESULTS:Seventy-two percent of the families responded to our questionnaires. Nonrespondents had more sociodemographic risk factors and worse development until 5.5 years. At the mean age of 10.5 years, T4 supplementation was associated with better school outcome in those who were <27 weeks' gestation and better motor outcome in those who were <28 weeks' gestation, whereas the reverse was true for those who were born at 29 weeks' gestation. No other gestational age-dependent outcomes were found. CONCLUSIONS:Gestation-dependent effects of T4 supplementation remain stable over time. These effects do not prove beneficial effects of T4 in infants <28 weeks but should be the background for a new randomized, controlled trial with thyroid hormone in this age group.

journal_name

Pediatrics

journal_title

Pediatrics

authors

van Wassenaer AG,Westera J,Houtzager BA,Kok JH

doi

10.1542/peds.2005-0876

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

e613-8

issue

5

eissn

0031-4005

issn

1098-4275

pii

peds.2005-0876

journal_volume

116

pub_type

杂志文章,随机对照试验
  • Autistic and dysphasic children. II: Epilepsy.

    abstract::In a previously described population of 314 autistic and 237 dysphasic nonautistic children, after exclusion of 12 autistic girls with Rett syndrome, 14% (42 of 302) of autistic children and 8% (19 of 237) of dysphasic children had epilepsy (P = .03). The major risk factors for epilepsy were severe mental deficiency a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Tuchman RF,Rapin I,Shinnar S

    更新日期:1991-12-01 00:00:00

  • Measles outbreak in a pediatric practice: airborne transmission in an office setting.

    abstract::In February 1981, a measles outbreak occurred in a pediatric practice in DeKalb County, GA. The source case, a 12-year-old boy vaccinated against measles at 11 1/2 months of age, was in the office for one hour on the second day of rash, primarily in a single examining room. On examination, he was noted to be coughing ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bloch AB,Orenstein WA,Ewing WM,Spain WH,Mallison GF,Herrmann KL,Hinman AR

    更新日期:1985-04-01 00:00:00

  • Sexual and Reproductive Health Care Services in the Pediatric Setting.

    abstract::Pediatricians are an important source of health care for adolescents and young adults and can play a significant role in addressing their patients' sexual and reproductive health needs, including preventing unintended pregnancies and sexually transmitted infections (STIs), including HIV, and promoting healthy relation...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2017-2858

    authors: Marcell AV,Burstein GR,COMMITTEE ON ADOLESCENCE.

    更新日期:2017-11-01 00:00:00

  • Sudden child death and 'healthy' affected family members with medium-chain acyl-coenzyme A dehydrogenase deficiency.

    abstract::A family is described in which the father and three (and probably all four) of his children had a decreased capacity for the oxidation of medium-chain fatty acids. One of the children suddenly died at the age of 16 months following an episode of a rapidly deteriorating Reye syndrome-like illness with hypoketotic hypog...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Duran M,Hofkamp M,Rhead WJ,Saudubray JM,Wadman SK

    更新日期:1986-12-01 00:00:00

  • Cross-Cultural Differences in Communication About a Dying Child.

    abstract::There are more migrants, refugees, and immigrants adrift in the world today than at any time in the recent past. Doctors and hospitals must care for people from many different cultures, countries, and religious backgrounds. We sometimes find our own deeply held beliefs and values challenged. In this "Ethics Rounds," w...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0690

    authors: Cochran D,Saleem S,Khowaja-Punjwani S,Lantos JD

    更新日期:2017-11-01 00:00:00

  • Economic evaluation of the routine childhood immunization program in the United States, 2009.

    abstract:OBJECTIVES:To evaluate the economic impact of the 2009 routine US childhood immunization schedule, including diphtheria and tetanus toxoids and acellular pertussis, Haemophilus influenzae type b conjugate, inactivated poliovirus, measles/mumps/rubella, hepatitis B, varicella, 7-valent pneumococcal conjugate, hepatitis ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0698

    authors: Zhou F,Shefer A,Wenger J,Messonnier M,Wang LY,Lopez A,Moore M,Murphy TV,Cortese M,Rodewald L

    更新日期:2014-04-01 00:00:00

  • Early administration of intratracheal surfactant (calfactant) after hydrocarbon aspiration.

    abstract::Hydrocarbon ingestions account for a substantial number of accidental poisonings; when aspirated, it can lead to severe pneumonitis. Treatment for severe pneumonitis is generally supportive, and outcomes are frequently poor. We report here the case of a 19-month-old girl who was treated successfully with early adminis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3229

    authors: Mastropietro CW,Valentine K

    更新日期:2011-06-01 00:00:00

  • Epidemiologic features of the presentation of critical congenital heart disease: implications for screening.

    abstract:OBJECTIVE:Critical congenital heart disease has been proposed as a target of newborn screening. This study aimed to define the incidence and timing of significant physiologic compromise attributable to critical congenital heart disease as well as the distribution of vulnerable lesions. These descriptive parameters must...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0421

    authors: Schultz AH,Localio AR,Clark BJ,Ravishankar C,Videon N,Kimmel SE

    更新日期:2008-04-01 00:00:00

  • Should fewer premature infants be screened for retinopathy of prematurity in the managed care era?

    abstract:OBJECTIVE:To determine appropriate upper limits for gestational age and birth weight when screening infants for retinopathy of prematurity (ROP). DESIGN:Retrospective survey. SETTING:Tertiary neonatal intensive care nursery. PATIENTS:Seven hundred seven infants born July 1, 1990 to June 30, 1996 and screened for ROP...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.1.31

    authors: Wright K,Anderson ME,Walker E,Lorch V

    更新日期:1998-07-01 00:00:00

  • Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development.

    abstract:OBJECTIVE:To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants. DESIGN:Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Koopman-Esseboom C,Weisglas-Kuperus N,de Ridder MA,Van der Paauw CG,Tuinstra LG,Sauer PJ

    更新日期:1996-05-01 00:00:00

  • Distinguishing sepsis from blood culture contamination in young infants with blood cultures growing coagulase-negative staphylococci.

    abstract::In the ideal situation, the evaluation for sepsis in the young infant should include collection of multiple blood cultures before the institution of antibiotics. Unfortunately, in some infants, it may not be possible to obtain more than a single blood culture at the time of initial evaluation. If this single culture u...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: St Geme JW 3rd,Bell LM,Baumgart S,D'Angio CT,Harris MC

    更新日期:1990-08-01 00:00:00

  • Selective screening device for the early detection of normal or delayed cognitive development in infants at risk for later mental retardation.

    abstract::The present study tested the predictive validity at 3 years of age of a screening device for the early identification of later cognitive delay. The screening device, administered between 3 and 7 months of age, is based on the infant's differential fixation "to novel" over previously shown pictures. The sample was comp...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fagan JF 3rd,Singer LT,Montie JE,Shepherd PA

    更新日期:1986-12-01 00:00:00

  • Recognition of a Kawasaki disease shock syndrome.

    abstract:OBJECTIVE:We sought to define the characteristics that distinguish Kawasaki disease shock syndrome from hemodynamically normal Kawasaki disease. METHODS:We collected data prospectively for all patients with Kawasaki disease who were treated at a single institution during a 4-year period. We defined Kawasaki disease sh...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-1871

    authors: Kanegaye JT,Wilder MS,Molkara D,Frazer JR,Pancheri J,Tremoulet AH,Watson VE,Best BM,Burns JC

    更新日期:2009-05-01 00:00:00

  • Proteolysis associated with insulin resistance in cystic fibrosis.

    abstract:OBJECTIVE:We hypothesized that patients with cystic fibrosis (CF) have higher rates of protein breakdown than normal volunteers and that the infusion of insulin would result in less suppression of proteolysis. Methods. Using [1-C]leucine and a three-step hyperinsulinemic euglycemic clamp, we measured rates of leucine a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.3.433

    authors: Hardin DS,LeBlanc A,Lukenbaugh S,Para L,Seilheimer DK

    更新日期:1998-03-01 00:00:00

  • Intima-media thickness and flow-mediated dilatation in the Helsinki study of very low birth weight adults.

    abstract:BACKGROUND:Adults born at a very low birth weight (VLBW) (< 1500 g), compared with those born at term, bear risk factors for cardiovascular disease, including higher blood pressure and insulin resistance. OBJECTIVE:We studied, in young adults born at a VLBW, early signs of an accelerated atherosclerotic process and th...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2010-2199

    authors: Hovi P,Turanlahti M,Strang-Karlsson S,Wehkalampi K,Järvenpää AL,Eriksson JG,Kajantie E,Andersson S

    更新日期:2011-02-01 00:00:00

  • Neural tube defects: knowledge and preconceptional prevention practices in minority young women.

    abstract:OBJECTIVE:To assess 1) knowledge of neural tube defect (NTD) prevention by folic acid, 2) frequency of intake of multivitamins and folate- and folic acid-fortified food, and 3) factors associated with knowledge and prevention practices among sexually active minority adolescent and young adult women. METHODS:Young mino...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.3.536

    authors: Chacko MR,Anding R,Kozinetz CA,Grover JL,Smith PB

    更新日期:2003-09-01 00:00:00

  • Clostridium difficile in normal infants and sudden infant death syndrome: an association with infant formula feeding.

    abstract::Large numbers Clostridium difficile were found in the stools of two victims of sudden infant death syndrome (SIDS). This prompted a study of normal infants in the SIDS age group. Thirty-two infants were studied, using two selective culture techniques and two assays for bacterial products. Thirteen of the normal infant...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Cooperstock MS,Steffen E,Yolken R,Onderdonk A

    更新日期:1982-07-01 00:00:00

  • Preimmunization anti-pneumococcal antibody levels are protective in a majority of patients with cystic fibrosis.

    abstract:OBJECTIVE:Although invasive pneumococcal disease is infrequent in cystic fibrosis (CF), it is recommended that all patients with CF receive pneumococcal immunization. As part of a comprehensive program to immunize our clinic population, we obtained preimmunization anti-pneumococcal antibody levels. We hypothesized that...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.4.e62

    authors: Lahiri T,Waltz DA

    更新日期:2001-10-01 00:00:00

  • A perimortem protocol for suspected genetic disease.

    abstract::A considerable portion of pediatric deaths represent disease with risk of recurrence in subsequent family members. Procedures to obtain samples of body fluids and tissues suitable for diagnosis of mendelian and chromosomal disorders are described. These procedures, the "perimortem protocol," are used in studying child...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kronick JB,Scriver CR,Goodyer PR,Kaplan PB

    更新日期:1983-06-01 00:00:00

  • Utility of symptoms to predict treatment outcomes in obstructive sleep apnea syndrome.

    abstract:BACKGROUND AND OBJECTIVES:Polysomnography defines the pathophysiology of obstructive sleep apnea syndrome (OSAS) but does not predict some important comorbidities or their response to adenotonsillectomy. We assessed whether OSAS symptoms, as reflected on the Sleep-Related Breathing Disorders Scale of the Pediatric Slee...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2014-3099

    authors: Rosen CL,Wang R,Taylor HG,Marcus CL,Katz ES,Paruthi S,Arens R,Muzumdar H,Garetz SL,Mitchell RB,Jones D,Weng J,Ellenberg S,Redline S,Chervin RD

    更新日期:2015-03-01 00:00:00

  • Effect of exchange transfusion on bilirubin binding.

    abstract::The bilirubin titration point--the lowest bilirubin concentration at which loosely bound bilirubin could be demonstrated by Sephadex gel filtration--was determined in samples collected before, during, and on completion of 17 exchange transfusions as well as in the discarded and donor blood. The bilirubin titration poi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Valaes T,Hyte M

    更新日期:1977-06-01 00:00:00

  • Adolescents' beliefs about the risks involved in smoking "light" cigarettes.

    abstract:BACKGROUND:Light cigarettes have been marketed by the tobacco industry as being a healthier smoking choice, a safe alternative to cessation, and a first step toward quitting smoking altogether. Research, however, has failed to show a reduction in smoking-related health risks, an increase in rates of smoking cessation, ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-0893

    authors: Kropp RY,Halpern-Felsher BL

    更新日期:2004-10-01 00:00:00

  • Financial burden of raising CSHCN: association with state policy choices.

    abstract:OBJECTIVE:We examined the association between state Medicaid and State Children's Health Insurance Program (SCHIP) income eligibility and the financial burden reported by low-income families raising children with special health care needs (CSHCN). SAMPLE AND METHODS:Data on low-income CSHCN and their families were fro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-1255P

    authors: Parish SL,Shattuck PT,Rose RA

    更新日期:2009-12-01 00:00:00

  • Diagnosis, Epidemiology, and Management of Hypertension in Children.

    abstract::National guidelines for the diagnosis and management of hypertension in children have been available for nearly 40 years. Unfortunately, knowledge and recognition of the problem by clinicians remain poor. Prevalence estimates are highly variable because of differing standards, populations, and blood pressure (BP) meas...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2015-3616

    authors: Rao G

    更新日期:2016-08-01 00:00:00

  • Health information technology and the medical home.

    abstract::The American Academy of Pediatrics (AAP) supports development and universal implementation of a comprehensive electronic infrastructure to support pediatric information functions of the medical home. These functions include (1) timely and continuous management and tracking of health data and services over a patient's ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2011-0454

    authors: Council on Clinical Information Technology.

    更新日期:2011-05-01 00:00:00

  • Educational principles of community-based education.

    abstract::Much of medical education remains teacher centered, as exemplified by the continued emphasis on lectures. Increasingly, however, the importance of the learner is being recognized and acknowledged in medical school curricula. The distinction between teaching and learning is also an issue for graduate medical education;...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Roberts KB

    更新日期:1996-12-01 00:00:00

  • Recognizing and treating toilet-seat contact dermatitis in children.

    abstract::Toilet-seat contact dermatitis is a common condition around the world and is reemerging in the United States. It can be easily recognized and treated. However, few practitioners consider this diagnosis, which results in a delay in treatment and often exacerbation of the skin eruption. In the past, exposure to wooden t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2430

    authors: Litvinov IV,Sugathan P,Cohen BA

    更新日期:2010-02-01 00:00:00

  • Prediction of digoxin treatment failure in infants with supraventricular tachycardia: role of transesophageal pacing.

    abstract::Transesophageal atrial pacing was used to initiate and terminate tachycardia in 24 infants (seven female and 17 male, aged 1 to 34 days) with ECG documentation of supraventricular tachycardia. Six infants received no chronic treatment, and chronic oral digoxin prophylaxis was administered to 18 infants in an effort to...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Benson DW Jr,Dunnigan A,Benditt DG,Thompson TR,Narayan A,Boros S

    更新日期:1985-02-01 00:00:00

  • Delivery Room Management of Meconium-Stained Newborns and Respiratory Support.

    abstract::: media-1vid110.1542/5839992674001PEDS-VA_2018-1485Video Abstract BACKGROUND AND OBJECTIVES: Recently, the Neonatal Resuscitation Program (NRP) recommended against routine endotracheal suctioning of meconium-stained nonvigorous newborns but suggested resuscitation with positive pressure ventilation. Our purpose is to ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-1485

    authors: Chiruvolu A,Miklis KK,Chen E,Petrey B,Desai S

    更新日期:2018-12-01 00:00:00

  • Age Legislation and Off-Road Vehicle Injuries in Children.

    abstract:BACKGROUND AND OBJECTIVES:In 2010, the Massachusetts Legislature passed a comprehensive law that restricted off-road vehicle (ORV) use by children <14 years old and regulated ORV use by children up to the age of 18 years. We aimed to examine the impact of the 2010 Massachusetts law on the rates of ORV-related injuries....

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-1164

    authors: Flaherty MR,Raybould T,Kelleher CM,Seethala R,Lee J,Kaafarani HMA,Masiakos PT

    更新日期:2017-10-01 00:00:00