Adverse effects in children after unintentional buprenorphine exposure.

Abstract:

:Buprenorphine in sublingual formulation was recently introduced to the American market for treatment of opioid dependence. We report a series of 5 toddlers with respiratory and mental-status depression after unintentional buprenorphine exposure. Despite buprenorphine's partial agonist activity and ceiling effect on respiratory depression, all children required hospital admission and either opioid-antagonist therapy or mechanical ventilation. Results of routine urine toxicology screening for opioids were negative in all cases. Confirmatory testing was sent for 1 child and returned with a positive result. The increasing use of buprenorphine as a home-based therapy for opioid addiction in the United States raises public health concerns for the pediatric population.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Geib AJ,Babu K,Ewald MB,Boyer EW

doi

10.1542/peds.2006-0948

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

1746-51

issue

4

eissn

0031-4005

issn

1098-4275

pii

118/4/1746

journal_volume

118

pub_type

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