Abstract:
:Buprenorphine in sublingual formulation was recently introduced to the American market for treatment of opioid dependence. We report a series of 5 toddlers with respiratory and mental-status depression after unintentional buprenorphine exposure. Despite buprenorphine's partial agonist activity and ceiling effect on respiratory depression, all children required hospital admission and either opioid-antagonist therapy or mechanical ventilation. Results of routine urine toxicology screening for opioids were negative in all cases. Confirmatory testing was sent for 1 child and returned with a positive result. The increasing use of buprenorphine as a home-based therapy for opioid addiction in the United States raises public health concerns for the pediatric population.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Geib AJ,Babu K,Ewald MB,Boyer EWdoi
10.1542/peds.2006-0948subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1746-51issue
4eissn
0031-4005issn
1098-4275pii
118/4/1746journal_volume
118pub_type
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