Neurobehavioral Outcomes 11 Years After Neonatal Caffeine Therapy for Apnea of Prematurity.

Abstract:

BACKGROUND AND OBJECTIVES:Caffeine is effective in the treatment of apnea of prematurity. Although caffeine therapy has a benefit on gross motor skills in school-aged children, effects on neurobehavioral outcomes are not fully understood. We aimed to investigate effects of neonatal caffeine therapy in very low birth weight (500-1250 g) infants on neurobehavioral outcomes in 11-year-old participants of the Caffeine for Apnea of Prematurity trial. METHODS:Thirteen academic hospitals in Canada, Australia, Great Britain, and Sweden participated in this part of the 11-year follow-up of the double-blind, randomized, placebo-controlled trial. Measures of general intelligence, attention, executive function, visuomotor integration and perception, and behavior were obtained in up to 870 children. The effects of caffeine therapy were assessed by using regression models. RESULTS:Neurobehavioral outcomes were generally similar for both the caffeine and placebo group. The caffeine group performed better than the placebo group in fine motor coordination (mean difference [MD] = 2.9; 95% confidence interval [CI]: 0.7 to 5.1; P = .01), visuomotor integration (MD = 1.8; 95% CI: 0.0 to 3.7; P < .05), visual perception (MD = 2.0; 95% CI: 0.3 to 3.8; P = .02), and visuospatial organization (MD = 1.2; 95% CI: 0.4 to 2.0; P = .003). CONCLUSIONS:Neonatal caffeine therapy for apnea of prematurity improved visuomotor, visuoperceptual, and visuospatial abilities at age 11 years. General intelligence, attention, and behavior were not adversely affected by caffeine, which highlights the long-term safety of caffeine therapy for apnea of prematurity in very low birth weight neonates.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Mürner-Lavanchy IM,Doyle LW,Schmidt B,Roberts RS,Asztalos EV,Costantini L,Davis PG,Dewey D,D'Ilario J,Grunau RE,Moddemann D,Nelson H,Ohlsson A,Solimano A,Tin W,Anderson PJ,Caffeine for Apnea of Prematurity (CAP) Trial Gro

doi

10.1542/peds.2017-4047

subject

Has Abstract

pub_date

2018-05-01 00:00:00

issue

5

eissn

0031-4005

issn

1098-4275

pii

peds.2017-4047

journal_volume

141

pub_type

杂志文章,随机对照试验
  • Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia.

    abstract:BACKGROUND AND OBJECTIVES:β blockers are widely used in the treatment of hypertensive disorders during pregnancy. These medications cross the placenta and may cause physiologic changes in neonates exposed in utero. We sought to define the risks of neonatal hypoglycemia and bradycardia associated with maternal exposure ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-0731

    authors: Bateman BT,Patorno E,Desai RJ,Seely EW,Mogun H,Maeda A,Fischer MA,Hernandez-Diaz S,Huybrechts KF

    更新日期:2016-09-01 00:00:00

  • Evidence for an association between infant mortality and a carnitine palmitoyltransferase 1A genetic variant.

    abstract:OBJECTIVE:Alaska Native and other circumpolar indigenous populations have historically experienced high infant mortality rates, for unknown reasons. Through routine newborn screening, Alaskan and Canadian indigenous infants have been found to have a high frequency of a single sequence variant (c.1436C→T) in the gene co...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0687

    authors: Gessner BD,Gillingham MB,Birch S,Wood T,Koeller DM

    更新日期:2010-11-01 00:00:00

  • Cobalamin C defect presenting with isolated pulmonary hypertension.

    abstract::Cobalamin C (cblC) defect is the most common inborn error of vitamin B12 metabolism. Clinical features vary as does the severity of the disease. In most cases, the clinical symptoms of cblC defect tend to appear during infancy or early childhood as a multisystem disease with severe neurologic, ocular, hematologic, ren...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1945

    authors: Iodice FG,Di Chiara L,Boenzi S,Aiello C,Monti L,Cogo P,Dionisi-Vici C

    更新日期:2013-07-01 00:00:00

  • Tachypnea of infancy as the first sign of Sanfilippo syndrome.

    abstract::This report describes the first known case of Mucopolysaccharidosis type IIIA presenting with respiratory symptoms and characteristic lung pathology. This case highlights under-recognized areas of systemic involvement and earlier modes of presentation in lysosomal storage disorders as well as the importance of investi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-2765

    authors: Chiang J,Raiman J,Cutz E,Solomon M,Dell S

    更新日期:2014-09-01 00:00:00

  • Effects of nephrotic syndrome on the family: a controlled study.

    abstract::The hypothesis that the parents and siblings of children with nephrotic syndrome are more likely to develop psychosocial problems than those of healthy children was tested. Seventy-nine siblings from 36 such families were compared with 79 healthy children from closely matched families using interviews, parent rating s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Vance JC,Fazan LE,Satterwhite B,Pless IB

    更新日期:1980-05-01 00:00:00

  • Advanced Ultrasound Techniques for Pediatric Imaging.

    abstract::Ultrasound has become a useful tool in the workup of pediatric patients because of the highly convenient, cost-effective, and safe nature of the examination. With rapid advancements in anatomic and functional ultrasound techniques over the recent years, the diagnostic and interventional utility of ultrasound has risen...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2018-2609

    authors: Hwang M,Piskunowicz M,Darge K

    更新日期:2019-03-01 00:00:00

  • Relative effects of drugs and diet on hyperactive behaviors: an experimental study.

    abstract::In a test of Feingold's hypothesis that food additives trigger the hyperactive response, 26 hyperactive children were randomly assigned to treatment conditions whereby they were given active or placebo medications in combination with challenge cookies with artificial food colors or control cookies without the additive...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Williams JI,Cram DM,Tausig FT,Webster E

    更新日期:1978-06-01 00:00:00

  • Validation of the Rapid Estimate for Adolescent Literacy in Medicine Short Form (REALM-TeenS).

    abstract:BACKGROUND:This study was designed to develop and validate a brief adolescent health literacy assessment tool (Rapid Estimate of Adolescent Literacy in Medicine Short Form [REALM-TeenS]). METHODS:We combined datasets from 2 existing research studies that used the REALM-Teen (n = 665) and conducted an item response the...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-3286

    authors: Manganello JA,Colvin KF,Chisolm DJ,Arnold C,Hancock J,Davis T

    更新日期:2017-05-01 00:00:00

  • Back to sleep: can we influence child care providers?

    abstract:OBJECTIVE:Despite the fact that 20% of sudden infant death syndrome (SIDS) deaths occur in child care settings, many child care providers continue to be unaware of the association of SIDS and infant sleep position and/or are misinformed as to the risks and benefits of the various sleep positions. The objective of this ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.4.878

    authors: Moon RY,Oden RP

    更新日期:2003-10-01 00:00:00

  • Returning a Genomic Result for an Adult-Onset Condition to the Parents of a Newborn: Insights From the BabySeq Project.

    abstract::The return of information from genomic sequencing in children, especially in early life, brings up complex issues around parental autonomy, the child's future autonomy, the best interest standard, and the best interests of the family. These issues are particularly important in considering the return of genomic results...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-1099H

    authors: Holm IA,McGuire A,Pereira S,Rehm H,Green RC,Beggs AH,BabySeq Project Team.

    更新日期:2019-01-01 00:00:00

  • Fatal Haemophilus influenzae endocarditis diagnosed by echocardiography in an infant.

    abstract::A 1-year-old boy was admitted to the hospital with Haemophilus influenzae meningitis. On the second hospital day a heart murmur heard on admission seemed louder. No signs of congestive heart failure were present. An echocardiogram demonstrated a persistent echo-dense mass behind the anterior leaflet of the mitral valv...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Laird WP,Nelson JD,Weinberg AG,Huffines FD

    更新日期:1979-09-01 00:00:00

  • Neurodevelopmental Outcomes in Infants With Birth Weight ≤500 g at 3 Years of Age.

    abstract:OBJECTIVES:To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS:Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study populat...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-4286

    authors: Inoue H,Ochiai M,Sakai Y,Yasuoka K,Tanaka K,Ichiyama M,Kurata H,Fujiyoshi J,Matsushita Y,Honjo S,Nonaka K,Taguchi T,Kato K,Ohga S,Neonatal Research Network of Japan.

    更新日期:2018-12-01 00:00:00

  • Age, academic performance, and stimulant prescribing for ADHD: a nationwide cohort study.

    abstract:BACKGROUND:We evaluated whether younger age in class is associated with poorer academic performance and an increased risk of being prescribed stimulants for attention-deficit/hyperactivity disorder (ADHD). METHODS:This was a nationwide population-based cohort study, linking data from national registries of prescribed ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0689

    authors: Zoëga H,Valdimarsdóttir UA,Hernández-Díaz S

    更新日期:2012-12-01 00:00:00

  • Service Use Classes Among School-aged Children From the Autism Treatment Network Registry.

    abstract:BACKGROUND AND OBJECTIVES:Use of specific services may help to optimize health for children with autism spectrum disorder (ASD); however, little is known about their service use patterns. We aimed to (1) define service use groups and (2) determine associations of sociodemographic, developmental, behavioral, and health ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2019-1895Q

    authors: Lindly OJ,Chan J,Levy SE,Parker RA,Kuhlthau KA

    更新日期:2020-04-01 00:00:00

  • Do questions about lead exposure predict elevated lead levels?

    abstract:OBJECTIVE:To assess the usefulness of the lead poisoning questionnaire developed by the Centers for Disease Control and Prevention as a screening tool for elevated lead levels. METHODS:This descriptive study used a five-question questionnaire at our hospital-based general pediatric clinic and in two local private prac...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Tejeda DM,Wyatt DD,Rostek BR,Solomon WB

    更新日期:1994-02-01 00:00:00

  • Enterobacter aerogenes primary bacteremia in pediatric patients.

    abstract::Enterobacter aerogenes bacteremia associated with the infusion of contaminated admixed intravenous (IV) fluid occurred in seven patients in a pediatric hospital over a five-day period. Clinical illness was characterized by spiking fever in all patients. The temporal clustering of cases allowed for rapid recognition of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Edwards KE,Allen JR,Miller MJ,Yogev R,Hoffman PC,Klotz R,Marubio S,Burkholder E,Williams T,Davis AT

    更新日期:1978-09-01 00:00:00

  • Corneal abrasions in young infants.

    abstract:OBJECTIVES:We sought to determine the prevalence of corneal abrasions and possible associations with fingernail length, demographic information, sleeping, and crying among young infants. METHODS:Parents of 1- to 12-week-old infants without symptoms who were presenting for well-child visits completed a brief questionna...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2023

    authors: Shope TR,Rieg TS,Kathiria NN

    更新日期:2010-03-01 00:00:00

  • Variability in Very Preterm Stillbirth and In-Hospital Mortality Across Europe.

    abstract:BACKGROUND AND OBJECTIVE:Stillbirth and in-hospital mortality rates associated with very preterm births (VPT) vary widely across Europe. International comparisons are complicated by a lack of standardized data collection and differences in definitions, registration, and reporting. This study aims to determine what prop...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-1990

    authors: Draper ES,Manktelow BN,Cuttini M,Maier RF,Fenton AC,Van Reempts P,Bonamy AK,Mazela J,Bᴓrch K,Koopman-Esseboom C,Varendi H,Barros H,Zeitlin JJ,EPICE Cohort.

    更新日期:2017-04-01 00:00:00

  • United States vaccine research: a delicate fabric of public and private collaboration. National Vaccine Advisory Committee.

    abstract::In the last 20 years, two thirds of all new vaccines provided worldwide have been produced by a US network of independent industrial, governmental, and academic partners engaged in vaccine research and development. Vaccines are complex products and the science of vaccinology is difficult. To achieve the full promise o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.100.6.1015

    authors:

    更新日期:1997-12-01 00:00:00

  • Immunoglobulin subclass antibodies to varicella-zoster virus.

    abstract::Commercially available mouse monoclonal antibodies to human IgG subclass (IgG1 to IgG4) were applied to an enzyme-linked immunosorbent assay to measure IgG subclass-specific antibodies to varicella-zoster virus in children naturally infected with varicella-zoster virus and in varicella vaccine recipients. In children ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Asano Y,Hiroishi Y,Itakura N,Hirose S,Kajita Y,Nagai T,Yazaki T,Takahashi M

    更新日期:1987-12-01 00:00:00

  • Osteomyelitis and sepsis: severe complications of fetal monitoring.

    abstract::Sophisticated modern methods of fetal monitoring during labor have improved the prognosis for high-risk infants, but the possible adverse side effects have not yet been fully documented. One infant with osteomyelitis and one with streptococcal sepsis are reported. In the future, greater attention should be paid to suc...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Overturf GD,Balfour G

    更新日期:1975-02-01 00:00:00

  • Economic evaluation of the US Environmental Protection Agency's SunWise program: sun protection education for young children.

    abstract:OBJECTIVE:The SunWise School Program is a school-based sun safety education program that was developed by the US Environmental Protection Agency and aims to teach children how to protect themselves from overexposure to the sun. The objectives of this study were to assess the health benefits of the SunWise School Progra...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1400

    authors: Kyle JW,Hammitt JK,Lim HW,Geller AC,Hall-Jordan LH,Maibach EW,De Fabo EC,Wagner MC

    更新日期:2008-05-01 00:00:00

  • Revised guidelines for prevention of early-onset group B streptococcal (GBS) infection. American Academy of Pediatrics Committee on Infectious Diseases and Committee on Fetus and Newborn.

    abstract::In 1992, the Committee on Infectious Diseases and Committee on Fetus and Newborn of the American Academy of Pediatrics provided guidelines for prevention of early-onset group B streptococcal (GBS) disease through intrapartum chemoprophylaxis of selected maternal GBS carriers. The guidelines were based on demonstrated ...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.99.3.489

    authors:

    更新日期:1997-03-01 00:00:00

  • Health care transition: destinations unknown.

    abstract::The movement of young adults with special health care needs from pediatric-oriented care to adult-oriented care has been a growing concern in the health care literature over the past 20 years. This article reviews the development and evaluation of health care transition policy over that period of time. These health ca...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Reiss J,Gibson R

    更新日期:2002-12-01 00:00:00

  • Changes in children's physical activity over 12 months: longitudinal results from the SPEEDY study.

    abstract:OBJECTIVE:We measured physical activity changes among 10-year-old British children over 12 months and assessed biological and demographic determinants. METHODS:Physical activity was measured with accelerometers (counts per minute) over ≥3 days at baseline and 1 year later in a prospective study of 844 children (41.6% ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0048

    authors: Corder K,van Sluijs EM,Ekelund U,Jones AP,Griffin SJ

    更新日期:2010-10-01 00:00:00

  • Elimination of Perinatal Hepatitis B: Providing the First Vaccine Dose Within 24 Hours of Birth.

    abstract::After the introduction of the hepatitis B vaccine in the United States in 1982, a greater than 90% reduction in new infections was achieved. However, approximately 1000 new cases of perinatal hepatitis B infection are still identified annually in the United States. Prevention of perinatal hepatitis B relies on the pro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-1870

    authors: COMMITTEE ON INFECTIOUS DISEASES.,COMMITTEE ON FETUS AND NEWBORN.

    更新日期:2017-09-01 00:00:00

  • Vesicoureteral reflux in the primate. IV. Infection as cause of prolonged high-grade reflux.

    abstract::High-grade reflux commonly lasts longer than moderate reflux, which disappears with maturation of the ureterovesical junction. It is known that ureteral function is affected by urinary tract infection from studies in experimental animals, as well as through clinical findings in patients with upper tract infection. Whe...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Roberts JA,Kaack MB,Morvant AB

    更新日期:1988-07-01 00:00:00

  • Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections.

    abstract:OBJECTIVES:To determine the association between parenteral antibiotic duration and outcomes in infants ≤60 days old with bacteremic urinary tract infection (UTI). METHODS:This multicenter retrospective cohort study included infants ≤60 days old who had concomitant growth of a pathogen in blood and urine cultures at 11...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-3844

    authors: Desai S,Aronson PL,Shabanova V,Neuman MI,Balamuth F,Pruitt CM,DePorre AG,Nigrovic LE,Rooholamini SN,Wang ME,Marble RD,Williams DJ,Sartori L,Leazer RC,Mitchell C,Shah SS,FEBRILE YOUNG INFANT RESEARCH COLLABORATIVE.

    更新日期:2019-09-01 00:00:00

  • Sleepwalking and sleep terrors in prepubertal children: what triggers them?

    abstract:OBJECTIVES:To evaluate the clinical presentation and polysomnography of prepubertal children with repetitive sleep terrors and sleepwalking, to compare them with a control group, and to evaluate the treatment of associated sleep disorders. METHODS:Patients with complaint of sleep terrors with or without sleepwalking w...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.1.e17

    authors: Guilleminault C,Palombini L,Pelayo R,Chervin RD

    更新日期:2003-01-01 00:00:00

  • Reducing distress in mothers of children with autism and other disabilities: a randomized trial.

    abstract:BACKGROUND:Compared with other parents, mothers of children with autism spectrum disorder or other neurodevelopmental disabilities experience more stress, illness, and psychiatric problems. Although the cumulative stress and disease burden of these mothers is exceptionally high, and associated with poorer outcomes in c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-3164

    authors: Dykens EM,Fisher MH,Taylor JL,Lambert W,Miodrag N

    更新日期:2014-08-01 00:00:00