Abstract:
:Neonates born to mothers with Graves' disease are at risk for significant morbidity and mortality and need to be appropriately identified and managed. Because no consensus guidelines regarding the treatment of these newborns exist, we sought to generate a literature-based management algorithm. The suggestions include the following: (1) Base initial risk assessment on maternal thyroid stimulating hormone (TSH) receptor antibodies. If levels are negative, no specific neonatal follow-up is necessary; if unavailable or positive, regard the newborn as "at risk" for the development of hyperthyroidism. (2) Determine levels of TSH-receptor antibodies in cord blood, or as soon as possible thereafter, so that newborns with negative antibodies can be discharged from follow-up. (3) Measurement of cord TSH and fT4 levels is not indicated. (4) Perform fT4 and TSH levels at day 3 to 5 of life, repeat at day 10 to 14 of life and follow clinically until 2 to 3 months of life. (5) Use the same testing schedule in neonates born to mothers with treated or untreated Graves' disease. (6) When warranted, use methimazole (MMI) as the treatment of choice; β-blockers can be added for sympathetic hyperactivity. In refractory cases, potassium iodide may be used in conjunction with MMI. The need for treatment of asymptomatic infants with biochemical hyperthyroidism is uncertain. (7) Assess the MMI-treated newborn on a weekly basis until stable, then every 1 to 2 weeks, with a decrease of MMI (and other medications) as tolerated. MMI treatment duration is most commonly 1 to 2 months. (8) Be cognizant that central or primary hypothyroidism can occur in these newborns.
journal_name
Pediatricsjournal_title
Pediatricsauthors
van der Kaay DC,Wasserman JD,Palmert MRdoi
10.1542/peds.2015-1878subject
Has Abstractpub_date
2016-04-01 00:00:00issue
4eissn
0031-4005issn
1098-4275pii
peds.2015-1878journal_volume
137pub_type
杂志文章,评审相关文献
PEDIATRICS文献大全abstract::We present a 6-week-old male infant with persistent hyperbilirubinemia, hypertriglyceridemia, elevated creatine kinase levels, and transaminitis since the second week of life. When he developed hyperkalemia, clinical suspicion was raised for adrenal insufficiency despite hemodynamic stability. A full endocrine workup ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-1479
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:Connatal pneumonia caused by group B streptococcal (GBS) infection may be associated with surfactant dysfunction. We investigated the effects of surfactant treatment in term and preterm neonates with GBS infection and respiratory failure, in comparison with corresponding data from a control population of noni...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1542/peds.106.5.957
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:Dental caries is a common, chronic disease of childhood. The impact of contemporary changes in beverage patterns, specifically decreased milk intakes and increased 100% juice and soda pop intakes, on dental caries in young children is unknown. We describe associations among caries experience and intakes of da...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.3.e184
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To determine whether making a low-fat entree available as one of two choices in an elementary school lunch program would reduce the fat content of meals selected by children. DESIGN:In this before-after trial, students had a daily choice between two entrees, one of which was sometimes low-fat. For 93% of sch...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:This population-based study investigated the psychological problems associated with daytime wetting in children. METHODS:A sample of 8213 children (age range: 7 years 6 months to 9 years 3 months) who were enrolled in the population-based Avon Longitudinal Study of Parents and Children participated in this s...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0894
更新日期:2006-11-01 00:00:00
abstract::It is common practice to use endotracheal continuous positive airway pressure for various time periods up to 24 hours before attempting extubation in infants who are mechanically ventilated. A few studies in newborns have indicated that airway resistance is increased through small endotracheal tubes. This increases th...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:Two demographically similar counties included in the New York Fetal Alcohol Syndrome Surveillance Network had very different prevalence rates. This study examined the components of the surveillance in an attempt to discover the reasons for this discrepancy. METHODS:Erie County and Monroe County were the 2 mo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0610
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:Studies of US adolescents have linked exposure to movie smoking with smoking behavior. It is unclear whether European adolescents are also responsive to movie tobacco imagery. METHODS:A longitudinal study was conducted to assess exposure to movie smoking in 2711 German never-smokers (aged 10 to 16 years). Mo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1201
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:In the US, a higher incidence of sudden infant death syndrome (SIDS) and a slower decline in the incidence of SIDS has been found among blacks when compared with white infants. The continued racial disparity in SIDS is thought to be attributable to lack of compliance with SIDS risk reduction recommendations....
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.111.4.e347
更新日期:2003-04-01 00:00:00
abstract::The relationships between selected child health outcomes and programmatic interventions using home visitors are analyzed. The following features of seven programs are systematically reported: program characteristics; description of the home visitors; program objectives, sample size, and research design; outcome measur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:The 9-valent human papillomavirus vaccine (9vHPV) was approved for females and males aged 9 to 26 years in 2014. We analyzed postlicensure surveillance reports to the Vaccine Adverse Event Reporting System (VAERS). METHODS:We searched VAERS data for US reports of adverse events (AEs) after 9vHPV from Decemb...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-1791
更新日期:2019-12-01 00:00:00
abstract::Cobalamin C (cblC) defect is the most common inborn error of vitamin B12 metabolism. Clinical features vary as does the severity of the disease. In most cases, the clinical symptoms of cblC defect tend to appear during infancy or early childhood as a multisystem disease with severe neurologic, ocular, hematologic, ren...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1945
更新日期:2013-07-01 00:00:00
abstract::Fatal lead encephalopathy has disappeared and blood lead concentrations have decreased in US children, but approximately 25% still live in housing with deteriorated lead-based paint and are at risk of lead exposure with resulting cognitive impairment and other sequelae. Evidence continues to accrue that commonly encou...
journal_title:Pediatrics
pub_type: 指南,杂志文章,实务指引
doi:10.1542/peds.2005-1947
更新日期:2005-10-01 00:00:00
abstract::A child with a poorly differentiated lymphoma developed varicella while being treated with maintenance chemotherapeutic agents. He received a transfusion of nonirradiated leukocytes from 1 unit of whole blood donated by a healthy volunteer who had recently recovered from varicella. The clinical course of varicella was...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract:OBJECTIVE:We evaluated the influence of outdoor air pollution on infant death in the South Coast Air Basin of California, an area characterized by some of the worst air quality in the United States. METHODS:Linking birth and death certificates for infants who died between 1989 and 2000, we identified all infant deaths...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0027
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:For preventing nosocomial influenza infections and to facilitate prompt antiviral therapy, an accessible, rapid diagnostic method for influenzavirus is needed. We evaluated the performance of a lateral-flow immunoassay (QuickVue Influenza Test) completed at the bedside of hospitalized children during the infl...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.110.1.83
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:Health care-associated infections persist as a major problem in most neonatal intensive care units. Hand hygiene has been singled out as the most important measure in preventing hospital-acquired infection. However, hand hygiene compliance among health care workers (HCWs) remains low. The objective of this st...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1107
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVES:To compare the detection of facial attributes by computer-based facial recognition software of 2-D images against standard, manual examination in fetal alcohol spectrum disorders (FASD). METHODS:Participants were gathered from the Fetal Alcohol Syndrome Epidemiology Research database. Standard frontal and o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-2028
更新日期:2017-12-01 00:00:00
abstract::Infants born to women who are asymptomatic hepatitis B surface antigen (HBsAg) carriers frequently acquire hepatitis B virus infection in infancy. The spectrum of disease in such affected infants includes mild transient acute hepatitis B, chronic active hepatitis with or without cirrhosis, chronic persistent hepatitis...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract::Recent improvement in child mortality has taken place in all regions of the world. In developing countries, major remaining causes are neonatal problems, diarrheal diseases, vaccine-preventable diseases, and respiratory diseases. Foreign aid has come in many forms, among them individual persons, nongovernmental organi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.3.646
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVES:Adolescents often display heterogenous trajectories of alcohol use. Initiation and escalation of drinking may be important predictors of later harms, including alcohol use disorder (AUD). Previous conceptualizations of these trajectories lacked adjustment for known confounders of adolescent drinking, which w...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-0440
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review of rigorously evaluated treatments for infant colic. METHODS:Online bibliographic databases were searched for the term "colic" in articles classified as clinical trials or randomized controlled trials and conducted in infants. Reference lists from review articles, meta-analyses...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Immunization rates have improved in the United States, but are still far from the national 90% goal for the year 2000. There is scant evidence about the effectiveness and costs of automated telephone messages to improve immunization rates among privately insured children. OBJECTIVE:To evaluate the effective...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.101.4.e3
更新日期:1998-04-01 00:00:00
abstract::This article reviews current evidence for autism spectrum disorder (ASD) interventions for children aged <3 years, based on peer-reviewed articles published up to December 2013. Several groups have adapted treatments initially designed for older, preschool-aged children with ASD, integrating best practice in behaviora...
journal_title:Pediatrics
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1542/peds.2014-3667E
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although home visiting programs have been documented to improve parenting in high-risk families, their effectiveness is diminished when parents disengage from programs. Cellular phones offer an approach to promoting parent engagement and enhancing parenting outcomes. Our objective was to exami...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2013-1021Q
更新日期:2013-11-01 00:00:00
abstract::Severity-of-illness scales have proven valuable in assessing clinical outcomes and resource consumption in adult and pediatric intensive care, but they have been less extensively developed for neonatal care. The National Therapeutic Intervention Scoring System (NTISS) was created by modifying the Therapeutic Intervent...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::Achieving the ambitious reduction in global neonatal mortality targeted in the Sustainable Development Goals and Every Newborn Action Plan will require reducing geographic disparities in newborn deaths through targeted implementation of evidence-based practices. Helping Babies Survive, a suite of educational programs ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-016915J
更新日期:2020-10-01 00:00:00
abstract:CONTEXT:The prevalence of neural tube defects is reduced in populations of women who receive folic acid supplementation. Since 1998, grain products in the United States have been fortified with folic acid. Fortification may have additional benefits by reducing the national prevalence of newborn hospitalizations for oth...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2784
更新日期:2006-09-01 00:00:00
abstract::Progress in therapy has made survival into adulthood a reality for most children, adolescents, and young adults diagnosed with cancer today. Notably, this growing population remains vulnerable to a variety of long-term therapy-related sequelae. Systematic ongoing follow-up of these patients, therefore, is important fo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3688
更新日期:2009-03-01 00:00:00
abstract::Developmental dysplasia of the hip (DDH) encompasses a wide spectrum of clinical severity, from mild developmental abnormalities to frank dislocation. Clinical hip instability occurs in 1% to 2% of full-term infants, and up to 15% have hip instability or hip immaturity detectable by imaging studies. Hip dysplasia is t...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-3107
更新日期:2016-12-01 00:00:00