Abstract:
:A child with a poorly differentiated lymphoma developed varicella while being treated with maintenance chemotherapeutic agents. He received a transfusion of nonirradiated leukocytes from 1 unit of whole blood donated by a healthy volunteer who had recently recovered from varicella. The clinical course of varicella was aborted, but a classic graft-versus-host reaction developed and ultimately proved fatal. The host may have presented a large population of antigen-bearing cells to an infusion of presensitized immunocompetent donor cells, leading to an overwhelming aggressor lymphocyte reaction. We speculate that a modified approach using irradiated donor cells could be of benefit in the treatment of varicella infections in the immunosuppressed host.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Betzhold J,Hong Rsubject
Has Abstractpub_date
1978-07-01 00:00:00pages
63-6issue
1eissn
0031-4005issn
1098-4275journal_volume
62pub_type
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