Fatal graft-versus-host disease after a small leukocyte transfusion in a patient with lymphoma and varicella.

Abstract:

:A child with a poorly differentiated lymphoma developed varicella while being treated with maintenance chemotherapeutic agents. He received a transfusion of nonirradiated leukocytes from 1 unit of whole blood donated by a healthy volunteer who had recently recovered from varicella. The clinical course of varicella was aborted, but a classic graft-versus-host reaction developed and ultimately proved fatal. The host may have presented a large population of antigen-bearing cells to an infusion of presensitized immunocompetent donor cells, leading to an overwhelming aggressor lymphocyte reaction. We speculate that a modified approach using irradiated donor cells could be of benefit in the treatment of varicella infections in the immunosuppressed host.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Betzhold J,Hong R

subject

Has Abstract

pub_date

1978-07-01 00:00:00

pages

63-6

issue

1

eissn

0031-4005

issn

1098-4275

journal_volume

62

pub_type

杂志文章
  • Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure?

    abstract:OBJECTIVE:The goal was to estimate the level of delivered continuous positive airway pressure by measuring oral cavity pressure with the mouth closed in infants of various weights and ages treated with heated, humidified high-flow nasal cannula at flow rates of 1-5 L/minute. We hypothesized that clinically relevant lev...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0957

    authors: Kubicka ZJ,Limauro J,Darnall RA

    更新日期:2008-01-01 00:00:00

  • Routine quantitative blood cultures in children with Haemophilus influenzae or Streptococcus pneumoniae bacteremia.

    abstract::The potential clinical value of quantitative blood cultures determined by a commercially available lysis-direct plating method was studied in 50 children with either Haemophilus influenzae or Streptococcus pneumoniae bacteremia. The magnitude of bacteremia correlated with the severity of the infection; patients with g...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bell LM,Alpert G,Campos JM,Plotkin SA

    更新日期:1985-12-01 00:00:00

  • Sleep deprivation for pediatric sedated procedures: not worth the effort.

    abstract:OBJECTIVE:Sleep deprivation is commonly used to enhance the effectiveness of pediatric sedation and to decrease sedation failures. We reviewed our sedation database to evaluate the efficacy of sleep deprivation. METHODS:The entire pediatric sedation unit database (n = 5640) was reviewed retrospectively. Patients witho...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.5.1204

    authors: Shields CH,Johnson S,Knoll J,Chess C,Goldberg D,Creamer K

    更新日期:2004-05-01 00:00:00

  • Prescribing assistive-technology systems: focus on children with impaired communication.

    abstract::This clinical report defines common terms of use and provides information on current practice, research, and limitations of assistive technology that can be used in systems for communication. The assessment process to determine the best devices for use with a particular child (ie, the best fit of a device) is also rev...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2008-0695

    authors: Desch LW,Gaebler-Spira D,Council on Children With Disabilities.

    更新日期:2008-06-01 00:00:00

  • Philosophic objection to vaccination as a risk for tetanus among children younger than 15 years.

    abstract:OBJECTIVES:Although safe and effective vaccines are available to protect against tetanus in the United States and vaccination rates are high, cases of tetanus among children continue to occur. The objectives of this article are to describe reported cases of tetanus in children in the United States and to identify the r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.1.e2

    authors: Fair E,Murphy TV,Golaz A,Wharton M

    更新日期:2002-01-01 00:00:00

  • Perinatal Risk Factors for Feeding and Eating Disorders in Children Aged 0 to 3 Years.

    abstract:OBJECTIVE:To describe the incidence, age at diagnosis, and associations between perinatal risk factors of feeding and eating disorders (FED) diagnosed at hospital in children aged 0 to 3 years. METHODS:A nationwide cohort of 901 227 children was followed until 48 months of age in the national registers from 1997 to 20...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2575

    authors: Hvelplund C,Hansen BM,Koch SV,Andersson M,Skovgaard AM

    更新日期:2016-02-01 00:00:00

  • INSIGHT Responsive Parenting Intervention and Infant Sleep.

    abstract:OBJECTIVES:Inadequate sleep during infancy is associated with adverse outcomes for infants and families. We sought to improve sleep behaviors and duration through a responsive parenting (RP) intervention designed for obesity prevention. METHODS:The Intervention Nurses Start Infants Growing on Healthy Trajectories (INS...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2016-0762

    authors: Paul IM,Savage JS,Anzman-Frasca S,Marini ME,Mindell JA,Birch LL

    更新日期:2016-07-01 00:00:00

  • Treatment of plastic bronchitis in a Fontan patient with tissue plasminogen activator: a case report and review of the literature.

    abstract::Plastic bronchitis is a condition in which large, bronchial casts with rubber-like consistency develop in the tracheobronchial tree and cause airway obstruction. We describe a 4-year-old girl who had Fontan physiology and who developed plastic bronchitis and report for the first time the use of aerosolized tissue plas...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.109.4.e67

    authors: Costello JM,Steinhorn D,McColley S,Gerber ME,Kumar SP

    更新日期:2002-04-01 00:00:00

  • Elevated lead levels in children with nonorganic failure to thrive.

    abstract::Every child with failure to thrive has at least one organic medical disease: malnutrition. It is well documented that lead and other heavy metals are absorbed more readily in the presence of both malnutrition and iron deficiency anemia. Malnutrition and lead exposure tend to be found in the same population groups. Fur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bithoney WG

    更新日期:1986-11-01 00:00:00

  • Predictability of esophageal injury from signs and symptoms: a study of caustic ingestion in 378 children.

    abstract::The accuracy of signs and symptoms as predictors of the presence and severity of esophageal injury was evaluated in 378 children admitted to three pediatric hospitals between 1970 and 1980. The signs and symptoms analyzed included nausea, vomiting, dysphagia, refusal to drink, abdominal pain, increased salivation, oro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gaudreault P,Parent M,McGuigan MA,Chicoine L,Lovejoy FH Jr

    更新日期:1983-05-01 00:00:00

  • Relative impact of influenza and respiratory syncytial virus in young children.

    abstract:OBJECTIVE:We measured the relative impact of influenza and respiratory syncytial virus (RSV) infections in young children in terms of emergency department (ED) visits, clinical care requirements, and overall resource use. METHODS:Patients who were aged

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3074

    authors: Bourgeois FT,Valim C,McAdam AJ,Mandl KD

    更新日期:2009-12-01 00:00:00

  • The increasing number of children using psychiatric services: analysis of a cumulative psychiatric case register.

    abstract::Psychosocial problems of children have received increasing attention in the pediatric literature, but it remains unclear to what extent psychiatric services are available and used for the treatment of these problems. This paper examines the utilization of psychiatric services by children over an 18-year period in Monr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Roghmann KJ,Babigian HM,Goldberg ID,Zastowny TR

    更新日期:1982-11-01 00:00:00

  • The Cockayne syndrome: an evaluation of hypertension and studies of renal pathology.

    abstract::Three children with renal disease, hypertension, and the Cockayne syndrome were evaluated. All patients had severe hypertension; peripheral vein renin was elevated in two patients. Renal biopsy specimens from two patients were studied by light microscopy, electron microscopy, and immunofluoresence. Immunohistologic st...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Higginbottom MC,Griswold WR,Jones KL,Vasquez MD,Mendoza SA,Wilson CB

    更新日期:1979-12-01 00:00:00

  • Effect of age and sedative agent on the accuracy of bispectral index in detecting depth of sedation in children.

    abstract:OBJECTIVE:This study evaluated age- and sedative agent-related differences in bispectral index across observed sedation levels in a large sample of children < 18 years of age. PATIENTS AND METHODS:With institutional review board approval and waiver of consent, data from 4 independently conducted studies were combined ...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2006-2577

    authors: Malviya S,Voepel-Lewis T,Tait AR,Watcha MF,Sadhasivam S,Friesen RH

    更新日期:2007-09-01 00:00:00

  • Temporomandibular joint dysfunction with facial pain in children.

    abstract::Temporomandibular joint dysfunction with myofascial pain, a well-known clinical disorder in adults, is reported in children. In a series of 400 patients, 40 children less than 16 years of age were seen. Of these pediatric patients, 35% had a reactive depression as primary psychopathology. The multifactorial nature of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Belfer ML,Kaban LB

    更新日期:1982-05-01 00:00:00

  • Use of complementary and alternative medical therapies among children with special health care needs in southern Arizona.

    abstract:OBJECTIVE:The objective of this study was to assess the frequency and type of complementary and alternative medicine (CAM) therapies used by families of children with special health care needs in southern Arizona, as well as the correlates of their use. METHODS:Families of 376 children who were receiving services in a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.3.584

    authors: Sanders H,Davis MF,Duncan B,Meaney FJ,Haynes J,Barton LL

    更新日期:2003-03-01 00:00:00

  • Developmental Outcomes of Preterm Infants With Neonatal Hypoglycemia.

    abstract:BACKGROUND AND OBJECTIVES:Neonatal hypoglycemia has been associated with abnormalities on brain imaging and a spectrum of developmental delays, although historical and recent studies show conflicting results. We compared the cognitive, academic, and behavioral outcomes of preterm infants with neonatal hypoglycemia with...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2016-1424

    authors: Goode RH,Rettiganti M,Li J,Lyle RE,Whiteside-Mansell L,Barrett KW,Casey PH

    更新日期:2016-12-01 00:00:00

  • Global Health: Preparation for Working in Resource-Limited Settings.

    abstract::Trainees and clinicians from high-income countries are increasingly engaging in global health (GH) efforts, particularly in resource-limited settings. Concomitantly, there is a growing demand for these individuals to be better prepared for the common challenges and controversies inherent in GH work. This is a state-of...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-3783

    authors: St Clair NE,Pitt MB,Bakeera-Kitaka S,McCall N,Lukolyo H,Arnold LD,Audcent T,Batra M,Chan K,Jacquet GA,Schutze GE,Butteris S,Global Health Task Force of the American Board of Pediatrics.

    更新日期:2017-11-01 00:00:00

  • Comprehensive evaluation of the child with intellectual disability or global developmental delays.

    abstract::Global developmental delay and intellectual disability are relatively common pediatric conditions. This report describes the recommended clinical genetics diagnostic approach. The report is based on a review of published reports, most consisting of medium to large case series of diagnostic tests used, and the proporti...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-1839

    authors: Moeschler JB,Shevell M,Committee on Genetics.

    更新日期:2014-09-01 00:00:00

  • Candidate genes and cerebral palsy: a population-based study.

    abstract:OBJECTIVE:The objective of this study was to examine whether selected genetic polymorphisms in the infant are associated with later-diagnosed cerebral palsy. METHODS:A population-based case-control study was conducted of 28 single-nucleotide polymorphisms measured in newborn screening blood spots. A total of 413 child...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-3758

    authors: Gibson CS,Maclennan AH,Dekker GA,Goldwater PN,Sullivan TR,Munroe DJ,Tsang S,Stewart C,Nelson KB

    更新日期:2008-11-01 00:00:00

  • Exploring emergency contraception knowledge, prescription practices, and barriers to prescription for adolescents in the emergency department.

    abstract:OBJECTIVE:The objective of this study was to assess the proportion of emergency medicine physicians who had prescribed emergency contraception pills to adolescents, to identify potential barriers to emergency contraception pill prescription for adolescents, and to assess physician knowledge of emergency contraception p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0193

    authors: Goyal M,Zhao H,Mollen C

    更新日期:2009-03-01 00:00:00

  • Defining asthma in the preschool-aged child.

    abstract::A physician faces many challenges in making a definitive diagnosis of asthma in young children. Although there are clinical and historical features consistent with asthma, identical features are present in many other diseases. Furthermore, there is no specific test for asthma. Other diseases must always be ruled out b...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Strunk RC

    更新日期:2002-02-01 00:00:00

  • Community physician's role in case management of children with chronic illnesses.

    abstract::There is general agreement that case management should be provided to children with chronic illnesses, yet it is not clear who should provide this service. A survey of physicians and parents of children with chronic illnesses was conducted to evaluate the practice and views of pediatricians and compare their assessmen...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Liptak GS,Revell GM

    更新日期:1989-09-01 00:00:00

  • Wide variation in reference values for aluminum levels in children.

    abstract:BACKGROUND:Some parents are requesting aluminum testing in their children with developmental issues. Although aluminum can be measured in plasma, serum, or urine, there is scant scientific information about normal ranges. We sought to determine the basis for laboratory reference ranges and whether these ranges are appl...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3481

    authors: Zeager M,Woolf AD,Goldman RH

    更新日期:2012-01-01 00:00:00

  • Adverse effects in children after unintentional buprenorphine exposure.

    abstract::Buprenorphine in sublingual formulation was recently introduced to the American market for treatment of opioid dependence. We report a series of 5 toddlers with respiratory and mental-status depression after unintentional buprenorphine exposure. Despite buprenorphine's partial agonist activity and ceiling effect on re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0948

    authors: Geib AJ,Babu K,Ewald MB,Boyer EW

    更新日期:2006-10-01 00:00:00

  • Beliefs about the health effects of "thirdhand" smoke and home smoking bans.

    abstract:OBJECTIVE:There is no safe level of exposure to tobacco smoke. Thirdhand smoke is residual tobacco smoke contamination that remains after the cigarette is extinguished. Children are uniquely susceptible to thirdhand smoke exposure. The objective of this study was to assess health beliefs of adults regarding thirdhand s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2184

    authors: Winickoff JP,Friebely J,Tanski SE,Sherrod C,Matt GE,Hovell MF,McMillen RC

    更新日期:2009-01-01 00:00:00

  • Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys.

    abstract:OBJECTIVE:Exercise can enhance growth and development in children, but recent investigations have revealed an intriguing paradox. Namely, the early (4-5 weeks) response to training programs in children lead to a catabolic, growth hormone (GH)-resistant state rather than the expected anabolic activation of the GH-->insu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.4.681

    authors: Nemet D,Oh Y,Kim HS,Hill M,Cooper DM

    更新日期:2002-10-01 00:00:00

  • Medicaid Managed Care Structures and Care Coordination.

    abstract:BACKGROUND:Child enrollment in Medicaid managed care (MMC) has expanded dramatically, primarily through state mandates. Care coordination is a key metric in MMC evaluation because it drives much of the proposed cost savings and may be associated with improved health outcomes and utilization. We evaluated the relationsh...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-3820

    authors: Gilchrist-Scott DH,Feinstein JA,Agrawal R

    更新日期:2017-09-01 00:00:00

  • Lamotrigine adjunctive therapy among children and adolescents with primary generalized tonic-clonic seizures.

    abstract:CONTEXT AND OBJECTIVE:Primary generalized tonic-clonic seizures are relatively more common among children than among adults. Primary generalized tonic-clonic seizures are associated with increased risk of injury and death. Therefore, effective control of primary generalized tonic-clonic seizures is necessary to reduce ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2006-0148

    authors: Trevathan E,Kerls SP,Hammer AE,Vuong A,Messenheimer JA

    更新日期:2006-08-01 00:00:00

  • Prone and supine positioning effects on energy expenditure and behavior of low birth weight neonates.

    abstract::The effect of body position (supine v prone) on energy expenditure and behavior of 42 healthy low birth weight (920 to 1,760 g) infants was evaluated in 66 studies. Each infant was randomly assigned to the supine or prone position for the first three-hour epoch; the position was reversed for the second three-hour epoc...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Masterson J,Zucker C,Schulze K

    更新日期:1987-11-01 00:00:00