Abstract：
:We have developed two methods for determining serum concentrations of felbamate, a new anticonvulsant drug. The first method is based on protein precipitation with acetonitrile, followed by HPLC. The between-run CV for this method is 5.7% (mean 55 mg/L), and the linearity extends from 5 to 175 mg/L. Results by this method compared well with those by an HPLC method based on chloroform extraction (r = 0.98, n = 21). In the second method, based on micellar electrokinetic capillary chromatography, the drug is measured by capillary electrophoresis with direct injection of serum. This method can be completed in 5 min compared with 12 min for the HPLC method, and there is no need for sample extraction. The between-run CV is 5.2% (mean 58 mg/L) and the linearity range is 5-160 mg/L. Results of this direct method correlated well (r = 0.98, n = 37) with those by the HPLC assay. The mean trough serum concentration of felbamate in 123 patients taking this drug was 44.9 mg/L (range 12-129 mg/L).
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Shihabi ZK,Oles KSsubject
Has Abstractpub_date
1994-10-01 00:00:00pages
1904-8issue
10eissn
0009-9147issn
1530-8561journal_volume
40pub_type
杂志文章abstract：:This paper reviews our ability to predict survival and neurodevelopmental outcome in the newborn period. Traditionally, prognosis is based on individual risk factors or disease states. The laboratory plays an important role in diagnosing some of these. For example, prenatal and newborn screening are important in the d...
journal_title：Clinical chemistry
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更新日期：1997-01-01 00:00:00
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journal_title：Clinical chemistry
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更新日期：1988-12-01 00:00:00
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更新日期：1986-07-01 00:00:00
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1976-11-01 00:00:00
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doi：
更新日期：1997-11-01 00:00:00
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doi：10.1373/clinchem.2013.214213
更新日期：2014-05-01 00:00:00
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doi：
更新日期：1990-02-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1997-01-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1991-04-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1988-09-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1990-12-01 00:00:00
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doi：
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doi：
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更新日期：1996-08-01 00:00:00
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更新日期：2002-01-01 00:00:00
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doi：
更新日期：1993-06-01 00:00:00
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doi：
更新日期：1988-05-01 00:00:00
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更新日期：1994-06-01 00:00:00
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更新日期：1998-06-01 00:00:00
