Lipoprotein lipids in women with androgen excess: independent associations with increased insulin and androgen.

Abstract:

:Concentrations of triglycerides are increased and concentrations of high-density lipoprotein (HDL) cholesterol are low in women with hyperandrogenism. These alterations could be related to excessive androgen or estrogen, to hyperinsulinism, or to a combination of these abnormalities. We examined their independent influences on lipids in 21 women with hyperandrogenism, subgrouped according to apparent source of androgen excess. Results for lipid, androgen, and insulin did not differ among subgroups, so these data were pooled. Free plus albumin-bound testosterone (uT) was correlated with triglycerides (r = 0.69, P less than 0.01) and HDL cholesterol (r = -0.56, P less than 0.01). Both triglycerides (r = 0.66, P less than 0.01) and HDL cholesterol (r = -0.48, P less than 0.05) were also correlated with insulin measured during fasting. Partial correlation revealed that, after adjusting for insulin, lipids were associated with uT. This suggests that androgen excess is independently related to lipid excess. Insulin also was correlated with lipids when adjusted for uT. Free plus albumin-bound estradiol was not associated with any of the lipids. We conclude that altered lipids in women with hyperandrogenism result from the independent effects of androgen and insulin.

journal_name

Clin Chem

journal_title

Clinical chemistry

authors

Wild RA,Applebaum-Bowden D,Demers LM,Bartholomew M,Landis JR,Hazzard WR,Santen RJ

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

283-9

issue

2

eissn

0009-9147

issn

1530-8561

journal_volume

36

pub_type

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