Abstract：
BACKGROUND:An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population. PATIENTS AND METHODS:The study involved 95 Middle European pediatric hospitals. We collected blood samples from, and clinical information about, 285 previously healthy children with meningococcal infection. We used a newly developed multiplexed mutagenic separated PCR assay to analyze 6 polymorphisms within the IL1 cluster: IL1A (-889)C/T, IL1A (+4845)G/T, IL1B (-511)C/T, IL1B (-31)C/T, IL1B (+3954), and IL1RA (+2018)C/T. We studied the same polymorphisms in a comparison group of 481 healthy newborns. RESULTS:Genotype frequencies between patients and the comparison group differed significantly only for the IL1RA (+2018)C/T variant: The CC genotype was more frequent in patients (11%) than in healthy controls (5%; P = 0.008). In the patient group, the C allele was significantly more prevalent (67%) in nonsurvivors than in survivors (42%; P = 0.02). CONCLUSION:The IL1RA (+2018)C/T polymorphism is associated with the risk of meningococcal disease and with its outcome.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Endler G,Marculescu R,Starkl P,Binder A,Geishofer G,Müller M,Zöhrer B,Resch B,Zenz W,Mannhalter C,Central European Meningococcal Genetic Study Group.doi
10.1373/clinchem.2005.058537subject
Has Abstractpub_date
2006-03-01 00:00:00pages
511-4issue
3eissn
0009-9147issn
1530-8561pii
52/3/511journal_volume
52pub_type
杂志文章,多中心研究abstract：:We developed a simple method for the analysis of bismuth (Bi) in biological tissue, using wet digestion for sample pretreatment. Bi was determined by electrothermal atomic absorption spectrometry with platinum as a matrix modifier to decrease the volatility of Bi. The furnace program included a gas stop for sensitivit...
journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1985-12-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1983-12-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1983-02-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：10.1093/clinchem/hvaa187
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1981-04-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1990-02-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1992-06-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：2000-08-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1983-08-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章,随机对照试验
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更新日期：2014-10-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：1994-02-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 临床试验,杂志文章
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
pub_type： 杂志文章,评审
doi：
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1980-10-01 00:00:00
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journal_title：Clinical chemistry
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doi：
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