Classic congenital adrenal hyperplasia and puberty.

abstract：BACKGROUND:A substantial proportion of all pheochromocytomas is currently detected during the evaluation of an adrenal incidentaloma. Recently, it has been suggested that biochemical testing to rule out pheochromocytoma is unnecessary in case of an adrenal incidentaloma with an unenhanced attenuation value ≤10 Hounsfie...

journal_title：European journal of endocrinology

authors： Buitenwerf E,Korteweg T,Visser A,Haag CMSC,Feelders RA,Timmers HJLM,Canu L,Haak HR,Bisschop PHLT,Eekhoff EMW,Corssmit EPM,Krak NC,Rasenberg E,van den Bergh J,Stoker J,Greuter MJW,Dullaart RPF,Links TP,Kerstens MN

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To investigate the association between plasma vitamin D (VD) levels and histological liver damage in children with nonalcoholic fatty liver disease (NAFLD). SUBJECTS AND METHODS:In this cross-sectional study, carried out in a tertiary care center for obesity, 73 consecutive overweight and obese children with...

journal_title：European journal of endocrinology

authors： Nobili V,Giorgio V,Liccardo D,Bedogni G,Morino G,Alisi A,Cianfarani S

更新日期：2014-03-08 00:00:00

abstract：OBJECTIVE:KLF7 encodes Krüppel-like factor (KLF) 7, a member of the KLF family of transcription factors, initially shown to play important roles in cellular development and differentiation, and reported to be specifically involved in adipogenesis. Several single nucleotide polymorphisms (SNPs) have been identified in K...

journal_title：European journal of endocrinology

authors： Zobel DP,Andreasen CH,Burgdorf KS,Andersson EA,Sandbaek A,Lauritzen T,Borch-Johnsen K,Jørgensen T,Maeda S,Nakamura Y,Eiberg H,Pedersen O,Hansen T

更新日期：2009-04-01 00:00:00

abstract：:Hypothyroidism is associated with increased morbidity from cardiovascular disease, and an increase in serum osteoprotegerin (OPG) has recently been reported to be associated with the severity of coronary heart disease and cardiovascular mortality. The present study was designed to examine whether hypothyroidism causes...

journal_title：European journal of endocrinology

authors： Nagasaki T,Inaba M,Jono S,Hiura Y,Tahara H,Shirakawa K,Onoda N,Ishikawa T,Ishimura E,Nishizawa Y

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Hyperthyroidism in rats produces organ hypertrophy and increases in circulating IGF-I and IGF-binding protein (IGFBP)-3. Chronic treatment with thyroxine (T(4)) during pregnancy advances parturition, blocks lactation and changes several hormone receptors in mammary gland and liver. Since IGFs are implicated i...

journal_title：European journal of endocrinology

authors： Rosato R,Lindenbergh-Kortleve D,Neck Jv,Drop S,Jahn G

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To study whether serum parathyroid hormone (PTH) and serum calcium are associated with body mass index (BMI), and their predicting role in obesity. DESIGN:Population based, cross-sectional study. METHODS:In 2001 a population-based health survey was held in Tromsø, North Norway. Questionnaires on medical his...

journal_title：European journal of endocrinology

authors： Kamycheva E,Sundsfjord J,Jorde R

更新日期：2004-08-01 00:00:00

abstract：:To know the role of sex hormone-binding globulin (SHBG) in the intracellular steroidal actions in human ovarian cancers, the expression of SHBG mRNA as a substitute for intracellular SHBG expression was investigated in normal ovarian tissues and ovarian tumors. In the present study, we used competitive reverse transcr...

journal_title：European journal of endocrinology

authors： Misao R,Nakanishi Y,Fujimoto J,Hori M,Ichigo S,Tamaya T

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses ...

journal_title：European journal of endocrinology

authors： Eng PH,Cardona GR,Previti MC,Chin WW,Braverman LE

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To assess whether TCF7L2 single nucleotide polymorphisms rs7903146 C/T and rs11196236 C/T are associated with polycystic ovary syndrome (PCOS) in South Brazilian women. DESIGN:Cross-sectional study. METHODS:Two hundred PCOS patients and 102 non-hirsute, ovulatory controls were genotyped by real-time PCR. Ha...

journal_title：European journal of endocrinology

authors： Ramos RB,Wiltgen D,Spritzer PM

更新日期：2013-10-01 00:00:00

abstract：:Several lines of evidence suggest that tumor necrosis factor-alpha (TNFalpha) may contribute to the pathogenesis of autoimmune thyroid disease. It is not known, however, whether increased thyroidal TNFalpha levels are associated with changes in thyroid function. The purpose of the present study was to utilize in situ ...

journal_title：European journal of endocrinology

authors： Mori K,Mori M,Stone S,Braverman LE,DeVito WJ

更新日期：1998-11-01 00:00:00

abstract：:Pyridostigmine (PST), a cholinesterase inhibitor, induces a clear growth hormone (GH) release in man by suppression of hypothalamic somatostatin (SRIH). Somatostatin suppresses thyrotrophin (TSH) release in rats and men. Earlier studies showed that the thryotrophin-releasing hormone (TRH)-induced TSH response was not ...

journal_title：European journal of endocrinology

authors： Yang I,Woo J,Kim S,Kim J,Kim Y,Choi Y

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:To examine local actions of nitric oxide (NO) on the neural mechanisms controlling the release of vasopressin (AVP) and the cardiovascular system in the anteroventral third ventricular region (AV3V), a pivotal area for autonomic functions, and to pursue the problem of whether it may have any role in the AVP a...

journal_title：European journal of endocrinology

authors： Yamaguchi K,Watanabe K,Yamaya K

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:To examine the genes for AMP-activated protein kinase (AMPK) subunits alpha2 (PRKAA2) and gamma3 (PRKAG3) as candidates for polycystic ovary syndrome (PCOS) and its component traits. DESIGN AND METHODS:A total of 287 white PCOS women were recruited from the reproductive endocrinology clinic at the University...

journal_title：European journal of endocrinology

authors： Sproul K,Jones MR,Azziz R,Goodarzi MO

更新日期：2009-09-01 00:00:00

abstract：:All children and adolescents with Graves' disease in the county of Uppsala (catchment area population 250,000) treated between 1970 and 1994 were evaluated in a retrospective study. The material comprised 31 patients with a mean age of 11 years (range 4-16), 29 (94%) of whom were girls, and four (13%) of the patients ...

journal_title：European journal of endocrinology

authors： Rudberg C,Johansson H,Akerström G,Tuvemo T,Karlsson FA

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVES:Gel filtration chromatography (GFC), the gold standard for macroprolactinaemia (MPRL) diagnosis, is a slow, costly and labour-intensive method. To limit the number of GFC required, we evaluated two screening tests for MPRL: prolactin (PRL) recovery after polyethylene glycol (PEG) precipitation and PRL concen...

journal_title：European journal of endocrinology

authors： Parlant-Pinet L,Harthé C,Roucher F,Morel Y,Borson-Chazot F,Raverot G,Raverot V

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Evidence of the association between vitamin D and cardiovascular risk factors in the young is limited. We therefore assessed the relationships between circulating 25-hydroxyvitamin D(3) (25(OH)D(3)) and metabolic syndrome (MetS), its components, and early atherosclerotic changes in 452 (304 overweight/obese ...

journal_title：European journal of endocrinology

authors： Pacifico L,Anania C,Osborn JF,Ferraro F,Bonci E,Olivero E,Chiesa C

更新日期：2011-10-01 00:00:00

abstract：:The objective was to compare the changes in prostaglandin synthesis and metabolism occurring within the fetal membranes that are associated with the onset of parturition and to study the effect of steroid hormones on prostaglandin metabolism. A tissue explant study was made of discs of amnion and chorion obtained from...

journal_title：European journal of endocrinology

authors： Brennand JE,Leask R,Kelly RW,Greer IA,Calder AA

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS:We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits...

journal_title：European journal of endocrinology

authors： Wickman S,Saukkonen T,Dunkel L

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Gastric carcinoid tumours type 1 (GCA1) originate from hyperplastic enterochromaffin-like (ECL) cells secondary to hypergastrinaemia. Treatment with somatostatin analogues (SSA) might impede ECL-cell hyperplasia by suppressing gastrin secretion and/or by a direct anti-proliferative effect on ECL cells. We co...

journal_title：European journal of endocrinology

authors： Grozinsky-Glasberg S,Kaltsas G,Gur C,Gal E,Thomas D,Fichman S,Alexandraki K,Barak D,Glaser B,Shimon I,Gross DJ

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Transient neonatal hyperthyrotropinemia (TNH) is defined as a neonatal abnormality of thyroid function, which reverts to normal at re-examination after 2 weeks of life. The thyroid function of these infants has not been sufficiently studied in terms of the risk of developing persistent hyperthyrotropinemia (P...

journal_title：European journal of endocrinology

authors： Cuestas E,Gaido MI,Capra RH

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:A sex difference in fetal and neonatal pituitary-gonadal function has been well documented. The aim of the following study was to determine sex differences and patterns of basal LH/FSH in the neonatal period. DESIGN:Peripheral venous blood was obtained from 164 healthy full term newborns (91 males, 73 female...

journal_title：European journal of endocrinology

authors： Schmidt H,Schwarz HP

更新日期：2000-08-01 00:00:00

abstract：AIM:It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship betw...

journal_title：European journal of endocrinology

authors： Guo X,Zhang S,Zhang Q,Liu L,Wu H,Du H,Shi H,Wang C,Xia Y,Liu X,Li C,Sun S,Wang X,Zhou M,Huang G,Jia Q,Zhao H,Song K,Niu K

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:In type I diabetes mellitus, early markers of beta cell damage are needed in order to detect the infraclinical development of the disease. The reg protein may be a good candidate, as the reg gene has been proposed to play a role in the pancreatic beta cell destruction/regeneration process during diabetogenesi...

journal_title：European journal of endocrinology

authors： Christofilis MA,Carrere J,Atlan-Gepner C,Zevaco-Mattei C,Thivolet C,Baeza N,Figarella C,Vialettes B

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:In the absence of widely available measures of determining free and/or bioavailable testosterone (BioT) physicians may use formulae such as the free androgen index (FAI) to estimate free testosterone. We compared the efficacy of calculated markers of androgen status in predicting serum BioT and hypogonadism. ...

journal_title：European journal of endocrinology

authors： Morris PD,Malkin CJ,Channer KS,Jones TH

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:We studied the intervention of nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) in mediating responses to acetylcholine in thyroid arteries from euthyroid and methimazole-treated (MT) patients. DESIGN AND METHODS:Branches of the superior thyroid artery were obtained from ...

journal_title：European journal of endocrinology

authors： Ortega J,Vila JM,Mauricio MD,Segarra G,Medina P,Martínez-León JB,Lluch S

更新日期：2005-04-01 00:00:00

abstract：CONTEXT:A wide range (15-56%) of prevalences of anterior pituitary insufficiency are reported in patients after traumatic brain injury (TBI). However, different study populations, study designs, and diagnostic procedures were used. No data are available on emergency-department-based cohorts of TBI patients. OBJECTIVE:...

journal_title：European journal of endocrinology

authors： van der Eerden AW,Twickler MT,Sweep FC,Beems T,Hendricks HT,Hermus AR,Vos PE

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To determine if human growth hormone (hGH) replacement therapy alters pharmacokinetics of hydrocortisone (CS) substitution in hypopituitary adults. DESIGN:To this aim, we analysed serum and salivary CS profiles 270 min after oral CS administration at baseline and 6 and 12 months after initiation of hGH repla...

journal_title：European journal of endocrinology

authors： Tschöp M,Lahner H,Feldmeier H,Grasberger H,Morrison KM,Janssen OE,Attanasio AF,Strasburger CJ

更新日期：2000-12-01 00:00:00

abstract：:The recent onslaught of mass spectrometry (MS) to measurements of steroid hormones, including demands that they should be the only acceptable method, has confused clinicians and scientists who have relied for more than 40 years on a variety of immunoassay (IA) methods in steroid hormone measurements. There is little d...

journal_title：European journal of endocrinology

authors： Taylor AE,Keevil B,Huhtaniemi IT

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The human androgen receptor (AR) gene contains two polymorphisms of CAG and GGN repeats respectively. The GGN repeat function is still largely unknown and to date there are no in vivo data on this segment with respect to the general population. METHODS:We investigated the impact of CAG and GGN repeats on ma...

journal_title：European journal of endocrinology

authors： Lundin KB,Giwercman YL,Rylander L,Hagmar L,Giwercman A

更新日期：2006-08-01 00:00:00

abstract：:Bone loss due to menopause, natural or artificial, has been attributed solely to low estrogen. However, in a woman's life, the most precipitous bone loss begins 2 years prior to the last menstrual period, during which time estrogen levels are unperturbed whereas FSH is elevated. Our cell-based and mouse genetic studie...

journal_title：European journal of endocrinology

authors： Iqbal J,Sun L,Zaidi M

更新日期：2010-07-01 00:00:00