Antagonists of bacitracin.

Abstract:

:Three groups of substances were identified which inhibit the bactericidal activity of bacitracin. Beside two divalent metals, Mg2+ and Ca2+, and a metabolite with chelating properties, citrate, the most pronounced effect was observed with pyrophosphate. Metals probably prevent access of bacitracin to the lipid carrier whereas metabolites with chelating properties deprive the bacitracin of a metal ion needed for its binding to the lipid carrier. Pyrophosphate, effective as an antagonist at very low concentrations, may intercept the binding of bacitracin to the pyrophosphate part of the target molecule.

journal_name

Lett Appl Microbiol

authors

Podlesek Z,Comino A

doi

10.1111/j.1472-765x.1994.tb00916.x

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

102-4

issue

2

eissn

0266-8254

issn

1472-765X

journal_volume

19

pub_type

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