Flurbiprofen, a unique non-steroidal anti-inflammatory drug with antimicrobial activity against Trichophyton, Microsporum and Epidermophyton species.

Abstract:

AIMS:The objective of this study was to determine the antifungal activity of flurbiprofen against dermatophytes like Trichophyton, Microsporum and Epidermophyton species. METHODS AND RESULTS:Susceptibility tests were performed against dermatophytes like Trichophyton, Microsporum and Epidermophyton species by the microbroth dilution method. Among the dermatophytes tested, Trichophyton, Microsporum and Epidermophyton species are remarkably susceptible to this compound (MIC(50): 8-16 microg ml(-1)). A yeast pathogen, Candida albicans, and a bacterium, Staphylococcus aureus, are also susceptible to flurbiprofen. CONCLUSIONS:Flurbiprofen is a non-steroidal anti-inflammatory compound with strong antifungal activity, which is not found in two well known and medically used antifungal organic acids like benzoic and salicylic acids. SIGNIFICANCE AND IMPACT OF THE STUDY:The present action of flurbiprofen on microbes indicates its future prospects as an antimicrobial agent against dermatophytes and yeast pathogens. However, in view of the anti-inflammatory property of flurbiprofen, its antifungal action may provide an additional advantage for use as a skin ointment.

journal_name

Lett Appl Microbiol

authors

Chowdhury B,Adak M,Bose SK

doi

10.1046/j.1472-765x.2003.01370.x

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

158-61

issue

2

eissn

0266-8254

issn

1472-765X

pii

1370

journal_volume

37

pub_type

杂志文章
  • A simple artificial urine for the growth of urinary pathogens.

    abstract::A simple artificial urine medium (AUM) has been developed which provides conditions similar to that found in human urine. AUM solidified with agar enabled the recovery of a wide range of urease-positive and -negative urinary pathogens. Liquid AUM supported growth at concentrations of up to 10(8) cfu ml-1, as found in ...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1472-765x.1997.00378.x

    authors: Brooks T,Keevil CW

    更新日期:1997-03-01 00:00:00

  • Glucose metabolism and internal pH of Lactococcus lactis subsp. lactis cells utilizing NMR spectroscopy.

    abstract::The metabolism of glucose was studied in Lactococcus lactis subsp. CNRZ 125 by 13C NMR. The initial rate of glucose utilization was higher for exponential phase cells than for stationary phase cells [150 vs 85 nmol g (dry wt)-1 s -1]. 31P NMR was used to determine changes in glycolytic phosphorylated intermediates (fr...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765x.1995.tb00994.x

    authors: Foucaud C,Herve M,Neumann JM,Hemme D

    更新日期:1995-07-01 00:00:00

  • Rapid and sensitive detection of Vibrio cholerae by loop-mediated isothermal amplification targeted to the gene of outer membrane protein ompW.

    abstract:AIMS:The present study was aimed to develop a loop-mediated isothermal amplification (LAMP) assay for rapid and specific detection of Vibrio cholerae. METHODS AND RESULTS:A set of five designed primers that recognized specifically the V. cholerae ompW gene was used. The optimized time and temperature conditions for th...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2009.02749.x

    authors: Srisuk C,Chaivisuthangkura P,Rukpratanporn S,Longyant S,Sridulyakul P,Sithigorngul P

    更新日期:2010-01-01 00:00:00

  • A heat inducible tyrosinase with distinct properties from Bacillus thuringiensis.

    abstract:AIMS:The objective of this work was to purify the tyrosinase from Bacillusthuringiensis subsp. kurstaki (Bt) (CCTCC AB 90010) and study its enzymatic properties. METHODS AND RESULTS:A 'one-step' purification method was used in this work, which was an easy, high-yield purification method. Tyrosinase activity of this pu...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2004.01599.x

    authors: Liu N,Zhang T,Wang YJ,Huang YP,Ou JH,Shen P

    更新日期:2004-01-01 00:00:00

  • Evaluation of the use of the bioMerieux Rapid ID32 A for the identification of Clostridium botulinum.

    abstract::The neurotoxins produced by Clostridium botulinum are amongst the most potent known to man. Toxin production is detected by a mouse bioassay, which requires several days for a result and is not acceptable for routine use unless there is a high level of suspicion. The Rapid ID32 A kit produced by bioMerieux gives an id...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1472-765x.1998.00283.x

    authors: Brett MM

    更新日期:1998-01-01 00:00:00

  • Antimicrobial efficacy of cryotreatment against Enterococcus faecalis in root canals.

    abstract::The purpose of this investigation was to evaluate intracanal bacterial reduction by cryotreatment using a dental instrument equipped with a duct and connected to a cryogenic fluid source. A total of 86 roots were infected with Enterococcus faecalis and incubated. After incubation, the contaminated roots were divided i...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/lam.12017

    authors: Mandras N,Allizond V,Bianco A,Banche G,Roana J,Piazza L,Viale P,Cuffini AM

    更新日期:2013-02-01 00:00:00

  • A rapid method to screen degradation ability in chlorophenoxyalkanoic acid herbicide-degrading bacteria.

    abstract:AIMS:An agar medium containing a range of related chlorophenoxyalkanoic acid herbicides, 2,4-dichlorophenoxyacetic acid (2,4-D), 2-methyl-4-chlorophenoxyacetic acid (MCPA), racemic mecoprop, (R)-mecoprop and racemic 2,4-DP (2-(2,4-dichlorophenoxy) propionic acid) was developed to assess the catabolic activity of a rang...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1472-765x.2001.00900.x

    authors: Smejkal CW,Vallaeys T,Burton SK,Lappin-Scott HM

    更新日期:2001-04-01 00:00:00

  • Hydroxyaldimines as potent in vitro anticryptococcal agents.

    abstract:UNLABELLED:Cryptococcosis, a fungal infection that affects both immunocompromised and immunocompetent individuals, contributes to increasing indices of mortality and morbidity. The development of resistance by Cryptococcus spp., the limited number of commercial antifungal drugs and the various side effects of these dru...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/lam.12086

    authors: Magalhães TF,da Silva CM,de Fátima Â,da Silva DL,Modolo LV,Martins CV,Alves RB,Ruiz AL,Longato GB,de Carvalho JE,de Resende-Stoianoff MA

    更新日期:2013-08-01 00:00:00

  • Comparison of the adherence of three Lactobacillus strains to Caco-2 and Int-407 human intestinal cell lines.

    abstract::Adhesion of three Lactobacillus strains onto human epithelial intestinal Caco-2 and Int-407 cell lines was compared. More adhesion occurred onto Int-407. The trypsin and sodium periodate pretreatment of bacteria revealed different mechanisms of adhesion depending on the Caco-2 and Int-407, involving carbohydrates and ...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765x.1996.tb01198.x

    authors: Sarem F,Sarem-Damerdji LO,Nicolas JP

    更新日期:1996-06-01 00:00:00

  • Occurrence of Pseudomonas aeruginosa in waters: implications for patients with cystic fibrosis (CF).

    abstract::Chronic Pseudomonas aeruginosa infection is associated with increased morbidity and mortality in patients with cystic fibrosis (CF). Current understanding of risk factors for acquisition is limited and so the aim of this study was to examine a large sample of environmental waters from diverse sources. Environmental wa...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/lam.12876

    authors: Caskey S,Stirling J,Moore JE,Rendall JC

    更新日期:2018-06-01 00:00:00

  • A rapid sample preparation method for PCR detection of food pathogens based on buoyant density centrifugation.

    abstract::The use of buoyant density centrifugation (BDC) to prepare samples for PCR analysis of food pathogens is described. Blue cheese and milk homogenates were inoculated with Shigella flexneri and layered on top of Percoll media. After BDC, the food homogenates remained in the upper part of the centrifuge tube, separated f...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1472-765x.1997.00069.x

    authors: Lindqvist R,Norling B,Lambertz ST

    更新日期:1997-04-01 00:00:00

  • The incidence and PCR detection of Campylobacter upsaliensis in dogs and cats.

    abstract::A study was made of the incidence of Campylobacter upsaliensis among dogs and cats suffering from acute or chronic diarrhoea; 225 dogs and cats were examined and 51 strains were identified, 16 (7%) of which were Camp. upsaliensis. When rectal swabs were taken from a control group of 126 dogs and cats without clinical ...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2672.2000.00799.x

    authors: Steinhauserova I,Fojtikova K,Klimes J

    更新日期:2000-09-01 00:00:00

  • Plasmid profile typing provides a method for the differentiation of strains of Salmonella enteritidis phage type 4 isolated in Turkey.

    abstract::Five phage types have been identified in 38 strains of Salmonella enteritidis isolated in Turkey in the 20-month period June 1992-January 1994. Strains belonging to phage type 4 predominated. Within phage type 4, plasmid profile typing has proved a useful method of strain discrimination and has confirmed the identity ...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765x.1994.tb00960.x

    authors: Erdem B,Threlfall EJ,Schofield SL,Ward LR,Rowe B

    更新日期:1994-10-01 00:00:00

  • Comparison of bacteriostatic and bactericidal activity of 13 essential oils against strains with varying sensitivity to antibiotics.

    abstract:AIMS:To compare the bacteriostatic and bactericidal activity of 13 chemotyped essential oils (EO) on 65 bacteria with varying sensitivity to antibiotics. METHODS AND RESULTS:Fifty-five bacterial strains were tested with two methods used for evaluation of antimicrobial activity (CLSI recommendations): the agar dilution...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2008.02406.x

    authors: Mayaud L,Carricajo A,Zhiri A,Aubert G

    更新日期:2008-09-01 00:00:00

  • Studies of the release of small molecules during pressure germination of spores of Bacillus subtilis.

    abstract:AIMS:To measure rates of release of small molecules during pressure germination of Bacillus subtilis spores, and the role of SpoVA proteins in dipicolinic acid (DPA) release. METHODS AND RESULTS:Rates of DPA release during B. subtilis spore germination with pressures of 150 or 500 megaPascals were much higher in spore...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2007.02204.x

    authors: Vepachedu VR,Hirneisen K,Hoover DG,Setlow P

    更新日期:2007-09-01 00:00:00

  • Re-interpretation of the logistic equation for batch microbial growth in relation to Monod kinetics.

    abstract:AIMS:To determine the underlying substrate utilization mechanism in the logistic equation for batch microbial growth by revealing the relationship between the logistic and Monod kinetics. Also, to determine the logistic rate constant in terms of Monod kinetic constants. METHODS AND RESULTS:The logistic equation used t...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2008.02537.x

    authors: Kargi F

    更新日期:2009-04-01 00:00:00

  • Pseudomonas syringae pv. japonica (Mukoo 1955) Dye et al. 1980 is a junior synonym of Ps. syringae pv. syringae van Hall 1902.

    abstract::An investigation of the biochemical, nutritional and pathogenic reactions of strains of Pseudomonas syringae pv. japonica and Ps. syringae pv. syringae showed them to be indistinguishable. Pseudomonas syringae pv. japonica is a junior synonym of Ps. syringae pv. syringae. ...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.1992.tb00744.x

    authors: Young JM

    更新日期:1992-10-01 00:00:00

  • Atypical mycobacterial infection in patients with cystic fibrosis: update on clinical microbiology methods.

    abstract::While patients with cystic fibrosis (CF) have had dramatic improvement in their survival rates, this has been accompanied by the emergence of more virulent pathogens such as Pseudomonas aeruginosa and Burkholderia cepacia complex organisms. In addition, there has been emergence of organisms of increasing clinical sign...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2007.02130.x

    authors: Jordan PW,Stanley T,Donnelly FM,Elborn JS,McClurg RB,Millar BC,Goldsmith CE,Moore JE

    更新日期:2007-05-01 00:00:00

  • Damage of staphylococcal cytoplasmic membrane by Quercus infectoria G. Olivier and its components.

    abstract:AIMS:In traditional Thai medicine, nutgall of Quercus infectoria G. Olivier is well-documented as an effective agent for wound and skin infections. The present study was aimed to establish modes of action of the ethanol extract of the plant as well as its main constituents to induce anti-methicillin-resistant Staphyloc...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2011.03041.x

    authors: Chusri S,Voravuthikunchai SP

    更新日期:2011-06-01 00:00:00

  • Electronic paramagnetic resonance investigation of the activity of Origanum vulgare L. essential oil on the Listeria monocytogenes membrane.

    abstract:AIMS:To evaluate the effect of oregano essential oil on Listeria monocytogenes cytoplasmic membrane. METHODS AND RESULTS:Nitroxide free-radical Electron Paramagnetic Resonance was applied on L. monocytogenes after 30 min exposure to oregano essential oil concentrations ranging from 0 to 1.25%. The impact of essential ...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2010.02877.x

    authors: Serio A,Chiarini M,Tettamanti E,Paparella A

    更新日期:2010-08-01 00:00:00

  • Genetic diversity of gamma-hexachlorocyclohexane-degrading sphingomonads isolated from a single experimental field.

    abstract:AIMS:To isolate gamma-hexachlorocyclohexane (gamma-HCH)-degrading bacteria from a single field and to examine their genetic diversity. METHODS AND RESULTS:Gamma-HCH-degrading bacteria were screened from a long-term experimental field in which gamma-HCH has been continuously applied to, and a gamma-HCH-degrading sphing...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2009.02691.x

    authors: Yamamoto S,Otsuka S,Murakami Y,Nishiyama M,Senoo K

    更新日期:2009-10-01 00:00:00

  • Extracellular protectants produced by Clostridium perfringens cells at elevated temperatures.

    abstract:AIM:The mechanisms of adaptation of Clostridium perfringens to high temperatures are not well understood. In this work, the involvement of extracellular compounds in protection to heat was determined. METHODS AND RESULTS:Cells were grown in fluid thioglycollate medium or chicken broth. When mid-log phase was reached, ...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2008.02504.x

    authors: Heredia N,Ybarra P,Hernández C,García S

    更新日期:2009-01-01 00:00:00

  • Detection and discrimination of four Aspergillus section Nigri species by PCR.

    abstract::Species of Aspergillus section Nigri are not easily distinguished by traditional morphological techniques, and typically are identified by DNA sequencing methods. We developed four PCR primers to distinguish between Aspergillus niger, Aspergillus welwitschiae, Aspergillus carbonarius and Aspergillus tubingensis, based...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/lam.12358

    authors: Palumbo JD,O'Keeffe TL

    更新日期:2015-02-01 00:00:00

  • X-ray microanalysis of chlorhexidine-treated cells of Saccharomyces cerevisiae.

    abstract::The use of energy dispersive analysis of X-rays (EDAX) to identify and quantify the presence of chlorhexidine diacetate (CHA) within Saccharomyces cerevisiae cells was examined. Chlorine was used as the elemental marker tag. Saccharomyces cerevisiae cells exposed to 1000 micrograms ml-1 CHA took up increasing amounts ...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765x.1995.tb01319.x

    authors: Hiom SJ,Hann AC,Furr JR,Russell AD

    更新日期:1995-06-01 00:00:00

  • Characterization of amino acid transport in the dairy strain Leuconostoc mesenteroides subsp. mesenteroides CNRZ 1273.

    abstract:AIMS:To identify and characterize amino acid transport in Leuconostoc mesenteroides. METHODS AND RESULTS:The transport of labelled amino acids was measured in whole cells of Leuc. mesenteroides CNRZ 1273. Systems were operative under physiological conditions of growth, energy dependent and differed from peptide transp...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1472-765x.2002.01191.x

    authors: Gendrot F,Foucaud-Scheunemann C,Ferchichi M,Hemme D

    更新日期:2002-01-01 00:00:00

  • Specific molecular detection of Carnobacterium piscicola SF668 in cold smoked salmon.

    abstract:AIMS:To establish a rapid and reliable multiplex PCR (mPCR)-based method allowing specific identification of Carnobacterium piscicola SF668 during storage of cold smoked salmon (CSS). METHODS AND RESULTS:CSS was inoculated with C. piscicola SF668 and stored at 4 degrees C. Samples were withdrawn at regular time interv...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2005.01696.x

    authors: Pellé E,Dousset X,Prévost H,Drider D

    更新日期:2005-01-01 00:00:00

  • Efficacy of biocides on laboratory-generated Legionella biofilms.

    abstract::Results of biocide efficacy testing on laboratory-generated microbial biofilms containing Legionella bozemanii is presented. These show that chlorine is effective at recommended concentrations in cooling towers; at least 48 h contact between free chlorine and the biofilm is necessary. Of five commercial biocides teste...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765x.1993.tb00384.x

    authors: Green PN

    更新日期:1993-10-01 00:00:00

  • Development of an enzyme-linked immunosorbent assay for Bartonella henselae infection detection.

    abstract:UNLABELLED:Several serological diagnostics rely on enzyme-linked immunosorbent assay (ELISA) to detect bacterial infections. However, for some pathogens, including Bartonella henselae, diagnosis still depends on manually intensive, time-consuming assays including micro-immunofluorescence, Western blotting or indirect i...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/lam.12286

    authors: Ferrara F,Di Niro R,D'Angelo S,Busetti M,Marzari R,Not T,Sblattero D

    更新日期:2014-09-01 00:00:00

  • Kinetics and effects of trace elements and electron complexes on 2-keto-4-methylthiobutyric acid-dependent biosynthesis of ethylene in soil.

    abstract:AIMS:2-Keto-4-methylthiobutyric acid (KMBA) is an established intermediate in microbial biosynthesis of ethylene from methionine. This study demonstrates the kinetics and effects of trace elements and electron complexes on substrate (KMBA)-derived C2H4 biosynthesis in soil. METHODS AND RESULTS:We have previously repor...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1472-765X.2004.01590.x

    authors: Arshad M,Nazli ZH,Khalid A,Zahir ZA

    更新日期:2004-01-01 00:00:00

  • Improved antimicrobial activity of nisin-incorporated polymer films by formulation change and addition of food grade chelator.

    abstract:AIMS:The following polymers were developed: polyethylene (PE), a PE and polyethylene oxide (70% PE and 30% PEO; PE + PEO) blend, PE and nisin (PE + nisin), PE, nisin, and EDTA (PE + nisin + EDTA), and PE + PEO with nisin (PE + PEO + nisin). METHODS AND RESULTS:Of the polymers tested, PE and PE + PEO did not exhibit an...

    journal_title:Letters in applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1472-765x.2001.01005.x

    authors: Cutter CN,Willett JL,Siragusa GR

    更新日期:2001-10-01 00:00:00