Abstract:
:Simian foamy virus (SFV) infection and the subsequent immune response are not well characterized. Blood plasma, saliva, and urine were obtained from four humans and nine chimpanzees persistently infected with chimpanzee-type SFV for an unknown length of time. SFV-specific immunoglobulin G (IgG) antibodies, but not IgA antibodies, against the Gag and Bet proteins were detected, by Western blotting, in all sample types from infected humans and chimpanzees. Overall, chimpanzee samples had higher anti-SFV IgG titers than humans. These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response.
journal_name
J Viroljournal_title
Journal of virologyauthors
Cummins JE Jr,Boneva RS,Switzer WM,Christensen LL,Sandstrom P,Heneine W,Chapman LE,Dezzutti CSdoi
10.1128/JVI.79.20.13186-13189.2005subject
Has Abstractpub_date
2005-10-01 00:00:00pages
13186-9issue
20eissn
0022-538Xissn
1098-5514pii
79/20/13186journal_volume
79pub_type
杂志文章abstract::Domains required late in the virus budding process (L domains) have been identified in the Gag proteins of a number of retroviruses. Here we show that the human T-cell leukemia virus type 1 candidate L domain motif PPPY is indeed required for virus production. Strikingly, however, mutation of this motif arrested virus...
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doi:10.1128/JVI.68.10.6523-6534.1994
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journal_title:Journal of virology
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doi:10.1128/JVI.69.9.5912-5916.1995
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.10.5114-5122.1990
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