Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu.

abstract：:DDB2, a gene mutated in XPE patients, is involved in global genomic repair especially the repair of cyclobutane pyrimidine dimers (CPDs), and is regulated by p53 in human cells. We show that DDB2 is expressed in mouse tissues and demonstrate, using primary mouse epithelial cells, that mouse DDB2 is regulated by E2F tr...

journal_title：Oncogene

authors： Prost S,Lu P,Caldwell H,Harrison D

更新日期：2007-05-24 00:00:00

abstract：:Tumor suppressor p53 forms a homo-tetramer through its COOH-terminal oligomerization domain and acts as a sequence-specific transcription factor. We have analysed the interrelation among the transcriptional activities, the structure and the cancer-related mutations in the oligomerization domain by using a comprehensiv...

journal_title：Oncogene

authors： Kawaguchi T,Kato S,Otsuka K,Watanabe G,Kumabe T,Tominaga T,Yoshimoto T,Ishioka C

更新日期：2005-10-20 00:00:00

abstract：:Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial for both normal cell migration and Src kinase-mediated metastasis of cancer cells. However, althoug...

journal_title：Oncogene

authors： Arpaia E,Blaser H,Quintela-Fandino M,Duncan G,Leong HS,Ablack A,Nambiar SC,Lind EF,Silvester J,Fleming CK,Rufini A,Tusche MW,Brüstle A,Ohashi PS,Lewis JD,Mak TW

更新日期：2012-02-16 00:00:00

abstract：:Expression of oncogenic H-Ras in 23A2 myoblasts (A2:H-Ras cells) is sufficient to induce both a transformed phenotype and a differentiation-defective phenotype. Because oncogenic Ras is known to induce the secretion of several different growth factors involved in maintaining the transformed phenotype of both fibroblas...

journal_title：Oncogene

authors： Weyman CM,Wolfman A

更新日期：1997-11-20 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with proper treatment. Antiangiogenic therapy is the most effective medical treatment for metastatic ccRCC. Thus, exploration of novel approaches t...

journal_title：Oncogene

authors： Li YL,Wu LW,Zeng LH,Zhang ZY,Wang W,Zhang C,Lin NM

更新日期：2020-09-01 00:00:00

abstract：:Head and neck squamous carcinomas (HNSCC) present as dense epithelioid three-dimensional (3D) tumor nests that can mediate signals via the human epidermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growth. We examined the role of the tumor microenvironment on ErbB recepto...

journal_title：Oncogene

authors： Humtsoe JO,Pham E,Louie RJ,Chan DA,Kramer RH

更新日期：2016-03-24 00:00:00

abstract：:We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...

journal_title：Oncogene

authors： Kuga H,Morisaki T,Nakamura K,Onishi H,Noshiro H,Uchiyama A,Tanaka M,Katano M

更新日期：2003-10-30 00:00:00

abstract：:Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial-mesenchymal transition (EMT) with cells exhibiting enhanced migration and invasion potential in vit...

journal_title：Oncogene

authors： Gu G,Tian L,Herzog SK,Rechoum Y,Gelsomino L,Gao M,Du L,Kim JA,Dustin D,Lo HC,Beyer AR,Edwards DG,Gonzalez T,Tsimelzon A,Huang HJ,Fernandez NM,Grimm SL,Hilsenbeck SG,Liu D,Xu J,Alaniz A,Li S,Mills GB,Janku F

更新日期：2020-12-15 00:00:00

abstract：:Targeting altered cancer cell metabolism with the glycolysis inhibitor, 2-deoxyglucose (2DG), is a viable therapeutic strategy, but the effects of 2DG on lymphoma cells and the mechanism of action are unknown. Five T-cell lymphoma lines and two B-cell lymphoma lines were shown to be highly sensitive to 2DG. Examinatio...

journal_title：Oncogene

authors： Zagorodna O,Martin SM,Rutkowski DT,Kuwana T,Spitz DR,Knudson CM

更新日期：2012-05-31 00:00:00

abstract：:Hexokinase-II (HK2) is a key enzyme involved in glycolysis, which is required for breast cancer progression. However, the underlying post-translational mechanisms of HK2 activity are poorly understood. Here, we showed that Proviral Insertion in Murine Lymphomas 2 (PIM2) directly bound to HK2 and phosphorylated HK2 on ...

journal_title：Oncogene

authors： Yang T,Ren C,Qiao P,Han X,Wang L,Lv S,Sun Y,Liu Z,Du Y,Yu Z

更新日期：2018-11-01 00:00:00

abstract：:We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. We observed that expression of trkB.T1 leads to a striking change in cell morphology characterized by outgrowth of filopodia and processes. A similar morphological response...

journal_title：Oncogene

authors： Haapasalo A,Saarelainen T,Moshnyakov M,Arumäe U,Kiema TR,Saarma M,Wong G,Castrén E

更新日期：1999-02-11 00:00:00

abstract：:We have examined the presence of p16MTS1/CDK4I gene deletions, mutations and methylation status, and 9p21-23 deletions in a series of 46 squamous cell carcinomas of the larynx and paired normal mucosa previously characterized for cyclin D1 gene amplification and overexpression. pRb expression was also examined by immu...

journal_title：Oncogene

authors： Jares P,Fernández PL,Nadal A,Cazorla M,Hernández L,Pinyol M,Hernández S,Traserra J,Cardesa A,Campo E

更新日期：1997-09-18 00:00:00

abstract：:TSG101 has been identified as a candidate tumor suppressor gene and abnormal transcripts have been identified in a substantial fraction of breast cancers. To determine whether TSG101 expression is commonly altered in other tumors, a series of 15 primary and metastatic prostate cancers were analysed by reverse transcri...

journal_title：Oncogene

authors： Sun Z,Pan J,Bubley G,Balk SP

更新日期：1997-12-18 00:00:00

abstract：:Treatment with retinoic acid (RA) is effective to restore radioactive iodine uptake in metastases of a small fraction of thyroid cancer patients. In order to find predictive markers of response, we took advantage of two thyroid cancer cell lines, FTC133 and FTC238, with low RA-receptor (RAR)beta expression but differi...

journal_title：Oncogene

authors： Cras A,Darsin-Bettinger D,Balitrand N,Cassinat B,Soulié A,Toubert ME,Delva L,Chomienne C

更新日期：2007-06-07 00:00:00

abstract：:Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Ju...

journal_title：Oncogene

authors： Venugopal R,Jaiswal AK

更新日期：1998-12-17 00:00:00

abstract：:Transcription factors of the Maf proto-oncogene family have been shown to participate in the regulation of several differentiation specific genes. We previously reported that a member(s) of this family is involved in the regulation of the neuroretina specific gene, QR1, through a promoter region, designated the A box,...

journal_title：Oncogene

authors： Benkhelifa S,Provot S,Lecoq O,Pouponnot C,Calothy G,Felder-Schmittbuhl MP

更新日期：1998-07-16 00:00:00

abstract：:Heat shock protein (Hsp)90 regulates many key pathways in oncogenesis, including Akt and mammalian target of rapamycin (mTOR). The strengths of disruption of Hsp90 in cancer therapy include their versatility in inhibiting a wide range of oncogenic pathways. The present study demonstrated that synuclein γ (SNCG) protec...

journal_title：Oncogene

authors： Liang W,Miao S,Zhang B,He S,Shou C,Manivel P,Krishna R,Chen Y,Shi YE

更新日期：2015-04-30 00:00:00

abstract：:Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-independent activation. We have previously demonstrated that pulmonary surfactant protein D (SP-D, SFTPD) suppre...

journal_title：Oncogene

authors： Umeda Y,Hasegawa Y,Otsuka M,Ariki S,Takamiya R,Saito A,Uehara Y,Saijo H,Kuronuma K,Chiba H,Ohnishi H,Sakuma Y,Takahashi H,Kuroki Y,Takahashi M

更新日期：2017-11-16 00:00:00

abstract：:Chromosome end-to-end associations seen at metaphase involve telomeres and are commonly observed in cells derived from individuals with ataxia telangiectasia and most types of human tumors. The associations may arise because of short telomeres and/or alterations of chromatin structure. There is a growing consensus tha...

journal_title：Oncogene

authors： Pandita TK,Hall EJ,Hei TK,Piatyszek MA,Wright WE,Piao CQ,Pandita RK,Willey JC,Geard CR,Kastan MB,Shay JW

更新日期：1996-10-03 00:00:00

abstract：:Like other types of pre-malignant lesions and carcinoma, angiogenesis is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular endothelial cell growth factor (VEGF) is known to be one of the most important inducers of angiogenesis and is upregulated in carcinoma of ...

journal_title：Oncogene

authors： López-Ocejo O,Viloria-Petit A,Bequet-Romero M,Mukhopadhyay D,Rak J,Kerbel RS

更新日期：2000-09-21 00:00:00

abstract：:The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) is an important component of the cell cycle and inactivation of the gene has been found in a variety of human cancers. In order to investigate the role of p16 gene in the tumorigenesis of hepatocellular carcinoma (HCC), 48 cases of HCC were analysed for p16 alterations...

journal_title：Oncogene

authors： Liew CT,Li HM,Lo KW,Leow CK,Chan JY,Hin LY,Lau WY,Lai PB,Lim BK,Huang J,Leung WT,Wu S,Lee JC

更新日期：1999-01-21 00:00:00

abstract：:Mammalian Stanniocalcin-1 (STC1) is a glycoprotein that has been implicated in various biological processes including angiogenesis. Aberrant STC1 expression has been reported in breast, ovarian and prostate cancers, but the significance of this is not well understood. Here, we report that oxidative stress caused a 40-...

journal_title：Oncogene

authors： Nguyen A,Chang AC,Reddel RR

更新日期：2009-05-07 00:00:00

abstract：:The fibroblast growth factor-binding protein (FGF-BP) modulates FGF activity through binding and release from the extracellular matrix. Consequently, the expression of FGF-BP in certain tumor types is a rate-limiting regulator of FGF-mediated angiogenesis. FGF-BP is upregulated in squamous cell carcinoma by treatment ...

journal_title：Oncogene

authors： Harris VK,Kagan BL,Ray R,Coticchia CM,Liaudet-Coopman ED,Wellstein A,Tate Riegel A

更新日期：2001-03-29 00:00:00

abstract：:The most frequent genetic alterations described in neuroblastoma (NB) are amplification of MYCN oncogene and deletion of chromosome 1p, although somatic deletions have been demonstrated at other chromosomal intervals. Since loss of heterozygosity (LOH) at distal 4p has been observed in about 20-29% of neuroblastomas, ...

journal_title：Oncogene

authors： Perri P,Longo L,Cusano R,McConville CM,Rees SA,Devoto M,Conte M,Ferrara GB,Seri M,Romeo G,Tonini GP

更新日期：2002-11-28 00:00:00

abstract：:Identification and characterization of genes expressed in normal cells and decreased in their malignant counterparts is an important method for detecting candidate tumor suppressors. Using differential display of mRNAs from nontumorigenic infinite life span human fibroblast cell strain MSU-1.1 and an isogenic fibrosar...

journal_title：Oncogene

authors： Qing J,Wei D,Maher VM,McCormick JJ

更新日期：1999-01-14 00:00:00

abstract：:Activation of the mitogen-activated protein kinase (MAPK) cascade is a well documented mechanism for the G-protein-coupled receptors. Here, we have analysed the requirements for ERKs and p38 MAPK activation by thrombin in Jurkat T cells. We show that thrombin-mediated ERKs activation requires both PTK and PKC activiti...

journal_title：Oncogene

authors： Maulon L,Mari B,Bertolotto C,Ricci JE,Luciano F,Belhacene N,Deckert M,Baier G,Auberger P

更新日期：2001-04-12 00:00:00

abstract：:Proliferating cells need to produce a large amount of energy and, at the same time, need to maintain a constant supply of biosynthetic precursors of macromolecules that are used as building blocks for generating new cells. Indeed, many cancer cells undergo a switch from mitochondrial to glycolytic metabolism and displ...

journal_title：Oncogene

authors： Deblois G,St-Pierre J,Giguère V

更新日期：2013-07-25 00:00:00

abstract：:Cancer-Associated Fibroblasts (CAFs) are the most prominent stromal cell type in breast tumors. CAFs promote tumor growth and metastasis by multiple mechanisms, including by mediating tumor-promoting inflammation. Immune modulation in the tumor microenvironment plays a central role in determining disease outcome. Howe...

journal_title：Oncogene

authors： Cohen N,Shani O,Raz Y,Sharon Y,Hoffman D,Abramovitz L,Erez N

更新日期：2017-08-01 00:00:00

abstract：:Recently, the MLL gene at 11q23 was found to be involved in a subset of leukemias with an 11q23 abnormality. In the present study, we isolated chimeric cDNAs between the MLL and a gene designated MLLT3 at 9p22 from a cDNA library of an IMS-M1 cell line with a t(9;11)(p22;q23) translocation, a representative karyotypic...

journal_title：Oncogene

authors： Iida S,Seto M,Yamamoto K,Komatsu H,Tojo A,Asano S,Kamada N,Ariyoshi Y,Takahashi T,Ueda R

更新日期：1993-11-01 00:00:00

abstract：:We have used two different, but complementary assays to characterize functions of SV40 T antigen that are necessary for its ability to immortalize rat embryo fibroblasts. In accordance with previous work, we found that several functions were required. These include activities that map to the p53 binding domain and the...

journal_title：Oncogene

authors： Powell AJ,Darmon AJ,Gonos ES,Lam EW,Peden KW,Jat PS

更新日期：1999-12-02 00:00:00