Abstract:
:Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Jun, Jun-B and Jun-D) proteins to upregulate ARE-mediated expression and coordinated induction of detoxifying enzymes in response to antioxidants and xenobiotics. Nrf-Jun association/heterodimerization and binding to the ARE required unknown cytosolic factor(s). Nrf2 containing one mutated leucine in its leucine zipper region was more efficient in upregulation of ARE-mediated gene expression, as compared to Nrf1 with two mutated leucines.
journal_name
Oncogenejournal_title
Oncogeneauthors
Venugopal R,Jaiswal AKdoi
10.1038/sj.onc.1202237subject
Has Abstractpub_date
1998-12-17 00:00:00pages
3145-56issue
24eissn
0950-9232issn
1476-5594journal_volume
17pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.534
更新日期:2013-10-17 00:00:00
abstract::As part of a cloning strategy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with similar sequences to the Drosophila melanogaster gene goliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fat body, and the heart. Praja1 is a 2...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201405
更新日期:1997-11-06 00:00:00
abstract::Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine wheth...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200203
更新日期:1998-04-30 00:00:00
abstract::The present study was designed to elucidate the relationship between p53 and ceramide, both of which are involved in apoptotic signaling. Treatment of human glioma cells with etoposide caused apoptosis only in cells expressing functional p53. p53 activation was followed by the formation of reactive oxygen species (ROS...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204207
更新日期:2001-03-15 00:00:00
abstract::The progression and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene. The underlying cause of this dysregulation, however, remains a subject of discussion, as the majority of cancer patients do not present with activating mutations in c-Met recept...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.586
更新日期:2011-04-28 00:00:00
abstract::The p53 tumor suppressor protein activates transcription and induces cell death. A close homologue of p53, termed p73, is expressed in transactivating (TA) forms that induce growth arrest and apoptosis much like p53. However, the p73 gene contains a second promoter, giving rise to the expression of p73 Delta N, a spec...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205584
更新日期:2002-07-18 00:00:00
abstract::The sirtuins (SIRT 1-7) comprise a family of NAD⁺-dependent protein-modifying enzymes with activities in lysine deacetylation, adenosinediphospho(ADP)-ribosylation, and/or deacylation. These enzymes are involved in the cell's stress response systems and in regulating gene expression, DNA damage repair, metabolism and ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.120
更新日期:2014-03-27 00:00:00
abstract::O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown that in a subset of tumors, MGMT expression is inversely linked to hypermethylation of the CpG island in the promoter r...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207183
更新日期:2003-12-04 00:00:00
abstract::Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotype changes related to malignant progression including increased motility and invasion. Concurrent with these phenotypic effects are changes in the expression of multiple gene targets. We previously demonstrated that e...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205857
更新日期:2002-10-10 00:00:00
abstract::Cyclooxygenase (COX)-2 is upregulated in hepatocellular carcinoma (HCC). However, the direct causative effect of COX-2 in spontaneous HCC formation remains unknown. We thus investigate the role and molecular pathogenesis of COX-2 in HCC by using liver-specific COX-2 transgenic (TG) mice. We found spontaneous HCC forma...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.73
更新日期:2017-08-01 00:00:00
abstract::Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however,...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0624-2
更新日期:2019-04-01 00:00:00
abstract::Ectopic expression of the intracellular domain of NOTCH-4/INT-3 leads to tumorigenesis in the mouse mammary gland. This results from a gain-of-function mutation. To evaluate gain-of-function NOTCH-4/INT-3 activity in human cancers we have surveyed human breast, lung, and colon carcinoma tissue culture cell lines for e...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203295
更新日期:2000-01-13 00:00:00
abstract::Two hepatocarcinoma cell lines, the Hepa-1 wild-type (c1c7) and the beta-subunit mutated (c4) lacking hypoxia-inducible factor-1 (HIF-1) activity, were differentially susceptible to apoptosis by hepatocyte growth factor (HGF). The c4 cells were 40% apoptotic 48 h after HGF treatment. On the contrary, the wild-type c1c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206519
更新日期:2003-06-26 00:00:00
abstract::The transformation suppressor gene, programmed cell death gene 4 (Pdcd4), inhibits tumor-promoter-mediated transformation of mouse keratinocytes and has been implicated as a tumor suppressor gene in the development of human cancer. The Pdcd4 protein interacts with translation initiation factors eIF4A and eIF4G and bin...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.115
更新日期:2008-08-14 00:00:00
abstract::Heat shock protein 70 (HSP70) can inhibit apoptosis by neutralizing and interacting with apoptosis-inducing factor (AIF), a mitochondrial flavoprotein that translocates upon apoptosis induction to the nucleus, via the cytosol. Here, we show that only members of the HSP70 family interact with AIF. Systematic deletion m...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206794
更新日期:2003-10-02 00:00:00
abstract::SMARCB1 (Snf5/Ini1/Baf47) is a potent tumor suppressor, the loss of which serves as the diagnostic feature in malignant rhabdoid tumors (MRT) and atypical teratoid/rhabdoid tumors (AT/RT), two highly aggressive forms of pediatric neoplasms. SMARCB1 is a core subunit of Swi/Snf chromatin remodeling complexes, and loss ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.261
更新日期:2014-06-05 00:00:00
abstract::In an effort to understand the mechanisms governing the regulation of the mouse Ron receptor gene, a mouse genomic library was screened and overlapping clones coding for the Ron gene and flanking DNA were identified. Continuous DNA sequence was obtained for approximately 16.4 kilobases. The gene, from the initiator me...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201508
更新日期:1998-01-08 00:00:00
abstract::FUS (also called TLS), EWSR1 and TAF15 (also called TAF2N) are related genes involved in tumor type-specific fusion oncogenes in human malignancies. The FUS-DDIT3 fusion oncogene results from a t(12;16)(q13;p11) chromosome translocation and has a causative role in the initiation of myxoid/round cell liposarcomas (MLS/...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.378
更新日期:2009-01-15 00:00:00
abstract::We have determined the genomic structure of the mouse fra-1 gene, which consists of four exons and three introns at positions also found in the other members of the fos gene family. Fra-1 is expressed rather highly in the brain and testes of adult mice, and at low levels in most other tissues. Absence of c-Fos leads t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201460
更新日期:1997-09-04 00:00:00
abstract::Hedgehog (Hh) is an oncogenic signaling pathway that regulates the activity of Gli transcription factors. Canonical Hh is a Smoothened- (Smo-) driven process that alters the post-translational processing of Gli2/Gli3 proteins. Though evidence supports a role for Gli action in prostate cancer (PCa) cell growth and prog...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0098-7
更新日期:2018-04-01 00:00:00
abstract::The transcription factor Ets-1 regulates the expression of several angiogenic and extracellular matrix remodeling factors, and might be implicated in disease progression of breast cancer. In the present study, the prognostic value of Ets-1 expression was assessed by quantitative real-time fluorescence RT-PCR in 123 sp...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206040
更新日期:2002-12-05 00:00:00
abstract::The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype wi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01431-8
更新日期:2020-10-01 00:00:00
abstract::Hox genes encode DNA-binding proteins that are deployed in overlapping domains along various body axes during embryonic development. This sequential activation of Hox genes in temporal and spatial mode, the Hox code, is critical for the proper positioning of segmented structures along those axes, which include the ver...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2010.484
更新日期:2011-01-27 00:00:00
abstract::Targeted therapeutics are potential therapeutic agents because of their selectivity and efficacy against tumors resistant to conventional therapy. The goal of this study was to determine the comparative activity of monovalent, engineered anti-Her2/neu immunotoxins fused to recombinant gelonin (rGel) to the activity of...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.612
更新日期:2014-01-23 00:00:00
abstract::Hepatitis B virus (HBV) infection is a major risk factor worldwide for the development of hepatocellular carcinoma (HCC). Integrated HBV DNA fragments, often highly rearranged, are frequently detected in HCC. In woodchuck, the viral enhancer plays a central role in hepatocarcinogenesis, but in humans the mechanism of ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204879
更新日期:2001-10-18 00:00:00
abstract::Recently the rat and mouse Growth Factor Independence (Gfi-1) genes have been cloned (Gilks et al., 1993; Zoring et al; 1996). This gene allows cells in culture to overcome the depletion of growth factors in the culture medium and maintain their proliferative potential. As part of a cloning strategy to isolated genes ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200910
更新日期:1997-02-27 00:00:00
abstract::The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in response to nerve growth factor (NGF). To assess the importance of adaptor proteins and Ras in NGF control of phosphoinositide 3-OH kinase (PI 3-kinase), specific receptor mutations in Trk ha...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201980
更新日期:1998-08-13 00:00:00
abstract::Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is activated by trypsin-like proteinases. PAR2 is detected in breast tumor specimens; however, it is not clear how PAR2 level in breast cancer cell/tissues compares with normal cell/tissues. Here, we show the elevation of PAR2 protein level in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.163
更新日期:2009-08-27 00:00:00
abstract::Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.298
更新日期:2010-01-07 00:00:00
abstract::Cyr61 is a secreted, cysteine-rich, heparin-binding protein that mediates diverse functions including extracellular matrix formation, differentiation, cell proliferation, adhesion, migration, survival, as well as angiogenesis and tumorigenesis. In this study, we found that Cyr61 gene expression is significantly downre...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208550
更新日期:2005-06-02 00:00:00