Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients.

abstract：:Mutations in the transmembrane receptor patched1 (ptc1) are responsible for the majority of basal cell carcinoma (BCC) cases. Many of these mutations, including ptc1-Q688X, result in premature truncation of the ptc1 protein. ptc1-Q688X has been identified in patients with both BCC and nevoid basal cell carcinoma syndr...

journal_title：Oncogene

authors： Barnes EA,Heidtman KJ,Donoghue DJ

更新日期：2005-01-27 00:00:00

abstract：:Growing evidence demonstrates that hepatitis B virus (HBV) integration and resulting insertional mutagenesis play an important role in cell growth or maintenance in hepatocellular carcinomas (HCCs). To determine if HBV integration occurs and affects cellular genes at such a stage of infection, we analysed viral-host j...

journal_title：Oncogene

authors： Minami M,Daimon Y,Mori K,Takashima H,Nakajima T,Itoh Y,Okanoue T

更新日期：2005-06-23 00:00:00

abstract：:Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. Although PPARβ/δ in fibroblasts was shown to modulate oxidative stress in the wound microenvironment, there has been no evidence of a similar e...

journal_title：Oncogene

authors： Tan EHP,Sng MK,How ISB,Chan JSK,Chen J,Tan CK,Wahli W,Tan NS

更新日期：2018-04-01 00:00:00

abstract：:NIH sponsored a meeting of medical and veterinary pathologists with mammary gland expertise in Annapolis in March 1999. Rapid development of mouse mammary models has accentuated the need for definitions of the mammary lesions in genetically engineered mice (GEM) and to assess their usefulness as models of human breast...

journal_title：Oncogene

authors： Cardiff RD,Anver MR,Gusterson BA,Hennighausen L,Jensen RA,Merino MJ,Rehm S,Russo J,Tavassoli FA,Wakefield LM,Ward JM,Green JE

更新日期：2000-02-21 00:00:00

abstract：:The rel oncogene from the avian reticuloendotheliosis virus strain T is a 59 kd phosphoprotein localized primarily to the cytoplasm of transformed cells. Recently, the v-rel protein was shown to associate with several cellular proteins with molecular weights of 124 kd, 115 kd, and 36 kd. We have analysed the subcellul...

journal_title：Oncogene

authors： Morrison LE,Kabrun N,Mudri S,Hayman MJ,Enrietto PJ

更新日期：1989-06-01 00:00:00

abstract：:The E6 proteins of specific cancer-associated human papillomaviruses (HPVs) complex with and mediate degradation of the cellular anti-oncogene p53 in vitro. A critical property of p53 is its ability to stimulate transcription from promoters containing its recognition sequence. HPV E6, mutant p53 proteins, and several ...

journal_title：Oncogene

authors： Mansur CP,Marcus B,Dalal S,Androphy EJ

更新日期：1995-02-02 00:00:00

abstract：:The clonality of lymphomas that originate in myc/pim-1 bitransgenic mice due to synergistic action of both oncogenes indicates the requirement of additional events for progression to full malignancy. To isolate genes that cooperate with both myc and pim-1, we have used provirus tagging with E mu L-myc/pim-1 double tra...

journal_title：Oncogene

authors： Zörnig M,Schmidt T,Karsunky H,Grzeschiczek A,Möröy T

更新日期：1996-04-18 00:00:00

abstract：:Identification and characterization of genes expressed in normal cells and decreased in their malignant counterparts is an important method for detecting candidate tumor suppressors. Using differential display of mRNAs from nontumorigenic infinite life span human fibroblast cell strain MSU-1.1 and an isogenic fibrosar...

journal_title：Oncogene

authors： Qing J,Wei D,Maher VM,McCormick JJ

更新日期：1999-01-14 00:00:00

abstract：:The progression and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene. The underlying cause of this dysregulation, however, remains a subject of discussion, as the majority of cancer patients do not present with activating mutations in c-Met recept...

journal_title：Oncogene

authors： Szabo R,Rasmussen AL,Moyer AB,Kosa P,Schafer JM,Molinolo AA,Gutkind JS,Bugge TH

更新日期：2011-04-28 00:00:00

abstract：:Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...

journal_title：Oncogene

authors： Lee Y,Kim SJ,Park HD,Park EH,Huang SM,Jeon SB,Kim JM,Lim DS,Koh SS

更新日期：2010-01-07 00:00:00

abstract：:The expression of normal and mutant ras genes in human acute leukemias was assessed by the direct analysis of p21ras polypeptides, using immunoprecipitation with monoclonal antibodies. High-resolution two-dimensional gel electrophoresis permits the identification of a wide array of activated ras alleles encoding prote...

journal_title：Oncogene

authors： Shen WP,Aldrich TH,Venta-Perez G,Franza BR Jr,Furth ME

更新日期：1987-05-01 00:00:00

abstract：:The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the four zinc-fingers and...

journal_title：Oncogene

authors： Menke AL,Riteco N,van Ham RC,de Bruyne C,Rauscher FJ 3rd,van der Eb AJ,Jochemsen AG

更新日期：1996-02-01 00:00:00

abstract：:Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members rem...

journal_title：Oncogene

authors： Longworth MS,Laimins LA

更新日期：2006-07-27 00:00:00

abstract：:The mouse mammary epithelial cell hierarchy contains both multipotent stem cell as well as lineage-limited duct and lobular progenitor cell functions. The latter-also termed parity-identified mammary epithelial cells (PI-MECs)-are marked by beta-galactosidase (β Gal) expression following pregnancy and involution in wh...

journal_title：Oncogene

authors： Bruno RD,Boulanger CA,Smith GH

更新日期：2012-01-05 00:00:00

abstract：:The nucleolus is one of the functional nuclear compartments in which the ribosome biogenesis takes place. Proteomic analysis revealed a large number of nucleolar proteins that are involved in diverse cellular processes, including biogenesis of ribonucleoprotein particles, stress responses, cell proliferation and cell ...

journal_title：Oncogene

authors： Yao Z,Duan S,Hou D,Wang W,Wang G,Liu Y,Wen L,Wu M

更新日期：2010-03-25 00:00:00

abstract：:Lung cancer is the most widely diagnosed malignancy in the world. Understanding early-stage disease will give insight into its pathogenesis. Despite the fact that pre-invasive lesions are challenging to isolate, and often yield insufficient DNA for the analysis of multiple loci, genomic profiling of such lesions will ...

journal_title：Oncogene

authors： Garnis C,Davies JJ,Buys TP,Tsao MS,MacAulay C,Lam S,Lam WL

更新日期：2005-07-14 00:00:00

abstract：:In the present study, we have analysed the effects of transforming growth factor-beta (TGF-beta) signaling on the growth behavior of pancreatic carcinoma cells in vitro and on their tumorigenicity in vivo. Ectopic expression of dominant-negative mutants of the TGF-beta type II receptor or type I receptor/activin recep...

journal_title：Oncogene

authors： Schniewind B,Groth S,Sebens Müerköster S,Sipos B,Schäfer H,Kalthoff H,Fändrich F,Ungefroren H

更新日期：2007-07-19 00:00:00

abstract：:To explore the mechanism of estrogen-induced growth of normal endometrium, the transactivation system of the cyclin D1 gene was analysed using cultured normal endometrial glandular cells. Estradiol (E2) treatment of cultured normal endometrial glandular cells induced upregulation of c-Jun, and then cyclin D1 proteins,...

journal_title：Oncogene

authors： Shiozawa T,Miyamoto T,Kashima H,Nakayama K,Nikaido T,Konishi I

更新日期：2004-11-11 00:00:00

abstract：:There is currently a great interest in delayed chromosomal and other damaging effects of low-dose exposure to a variety of pollutants which appear collectively to act through induction of stress-response pathways related to oxidative stress and ageing. These have been studied mostly in the radiation field but evidence...

journal_title：Oncogene

authors： Glaviano A,Nayak V,Cabuy E,Baird DM,Yin Z,Newson R,Ladon D,Rubio MA,Slijepcevic P,Lyng F,Mothersill C,Case CP

更新日期：2006-06-08 00:00:00

abstract：:O-linked glycans of secreted and membrane-bound proteins have an important role in the pathogenesis of pancreatic cancer by modulating immune responses, inflammation and tumorigenesis. A critical aspect of O-glycosylation, the position at which proteins are glycosylated with N-acetyl-galactosamine on serine and threon...

journal_title：Oncogene

authors： Taniuchi K,Cerny RL,Tanouchi A,Kohno K,Kotani N,Honke K,Saibara T,Hollingsworth MA

更新日期：2011-12-08 00:00:00

abstract：:An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechanisms are poorly known. In this study, we report that in colon cancer patients, higher proteasome activity was d...

journal_title：Oncogene

authors： Arlt A,Bauer I,Schafmayer C,Tepel J,Müerköster SS,Brosch M,Röder C,Kalthoff H,Hampe J,Moyer MP,Fölsch UR,Schäfer H

更新日期：2009-11-12 00:00:00

abstract：:The recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) in the scatter factor family, which includes the c-Met receptor. RON exhibits increased expression in a significant number of human breast cancer tissues as well as in many established breast cancer cell lines. Recent studies have indicated that...

journal_title：Oncogene

authors： Feres KJ,Ischenko I,Hayman MJ

更新日期：2009-01-15 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation (PARylation). However, it remains largely unclear how PARP1 activity is regulated. Interestingly, the data obtained through this study revealed that PARP1 was co-immunoprecipitate...

journal_title：Oncogene

authors： Hsu PC,Gopinath RK,Hsueh YA,Shieh SY

更新日期：2019-02-01 00:00:00

abstract：:c-myc is a proto-oncogene essential for cell growth. When activated, its expression can lead to uncontrolled cell proliferation, transformation and tumorigenesis. The cell line tEMmyc4 is a murine myelomonocytic cell line that was established following transformation by v-myc. It has a high level of v-myc expression a...

journal_title：Oncogene

authors： Dolnikov A,Ward RL,Hawkins NJ,Symonds G

更新日期：1996-03-21 00:00:00

abstract：:Post-irradiation complications including thrombus formation result from increased procoagulant activity of vascular endothelial cells and elevated levels of von Willebrand factor (VWF) contribute to this process. We have previously demonstrated that irradiation induction of the VWF is mediated through interaction of N...

journal_title：Oncogene

authors： Peng Y,Stewart D,Li W,Hawkins M,Kulak S,Ballermann B,Jahroudi N

更新日期：2007-11-29 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that tran...

journal_title：Oncogene

authors： Matsuoka M,Jeang KT

更新日期：2011-03-24 00:00:00

abstract：:Cells in culture become competent to replicate in the absence of growth factor after progressing beyond the late G1 restriction point, suggesting that a set of genes expressed during G1 phase is sufficient to trigger completion of the cell cycle. However, this has not been demonstrated in an in vivo system. In this st...

journal_title：Oncogene

authors： Nelsen CJ,Hansen LK,Rickheim DG,Chen C,Stanley MW,Krek W,Albrecht JH

更新日期：2001-04-05 00:00:00

abstract：:Expression of oncogenic H-Ras in 23A2 myoblasts (A2:H-Ras cells) is sufficient to induce both a transformed phenotype and a differentiation-defective phenotype. Because oncogenic Ras is known to induce the secretion of several different growth factors involved in maintaining the transformed phenotype of both fibroblas...

journal_title：Oncogene

authors： Weyman CM,Wolfman A

更新日期：1997-11-20 00:00:00

abstract：:Obesity is a highly prevalent and modifiable breast cancer risk factor. While the role of obesity in fueling breast cancer progression is well established, the mechanisms linking obesity to breast cancer initiation are poorly understood. A hallmark of breast cancer initiation is the disruption of apical polarity in ma...

journal_title：Oncogene

authors： Tenvooren I,Jenks MZ,Rashid H,Cook KL,Muhlemann JK,Sistrunk C,Holmes J,Wang K,Bonin K,Hodges K,Lo HW,Shaikh A,Camarillo IG,Lelièvre SA,Seewaldt V,Vidi PA

更新日期：2019-05-01 00:00:00

abstract：:Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by eliminating Chk1-mediated checkpoint responses. Using mouse models, we...

journal_title：Oncogene

authors： Origanti S,Cai SR,Munir AZ,White LS,Piwnica-Worms H

更新日期：2013-01-31 00:00:00