PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression.

abstract：:In the presence of ERbeta, trans-hydroxytamoxifen (TOT) protects cells against 17beta-estradiol (E(2))-induced oxidative DNA damage (ODD) and this correlates with increased expression of the antioxidative enzyme quinone reductase (QR). Here, we investigate the molecular mechanism responsible for ERbeta-mediated protec...

journal_title：Oncogene

authors： Sripathy SP,Chaplin LJ,Gaikwad NW,Rogan EG,Montano MM

更新日期：2008-10-23 00:00:00

abstract：:Multiple endocrine neoplasia type 2 (MEN 2) is an inherited cancer syndrome that includes pheochromocytoma. Germline mutations in RET are responsible for MEN 2 but the precise pathogenetic mechanisms of tumorigenesis are unknown. We have recently identified possible mechanisms of tumor formation in patients with MEN 2...

journal_title：Oncogene

authors： Koch CA,Huang SC,Zhuang Z,Stolle C,Azumi N,Chrousos GP,Vortmeyer AO,Pacak K

更新日期：2002-01-17 00:00:00

abstract：:Recognition and elimination of malignant cells by cytotoxic T lymphocytes depends on antigenic peptides generated by proteasomes. It has been established that impairment of the immunoproteasome subunits, that is, PSMB8, PSMB9 and PSMB10 (PSMBs), is critical for malignant cells to escape immune recognition. We report h...

journal_title：Oncogene

authors： Yang XW,Wang P,Liu JQ,Zhang H,Xi WD,Jia XH,Wang KK

更新日期：2014-05-22 00:00:00

abstract：:Transcriptomic screens in breast cancer cell lines have identified a protein named anterior gradient-2 (AGR2) as a potentially novel oncogene overexpressed in estrogen receptor (ER) positive tumours. As targeting the ER is responsible for major improvements in cure rates and prevention of breast cancers, we have evalu...

journal_title：Oncogene

authors： Hrstka R,Nenutil R,Fourtouna A,Maslon MM,Naughton C,Langdon S,Murray E,Larionov A,Petrakova K,Muller P,Dixon MJ,Hupp TR,Vojtesek B

更新日期：2010-08-26 00:00:00

abstract：:NF-kappaB is known to exert a cytoprotective action against TNF-alpha-induced apoptosis. To study the role of NF-kappaB in various TNF-alpha-treated epithelial cell lines, we generated stable transfectants overexpressing a mutated unresponsive form of the IkappaBalpha inhibitor (MT cells). As NF-kappaB prevented TNF-a...

journal_title：Oncogene

authors： Delhalle S,Deregowski V,Benoit V,Merville MP,Bours V

更新日期：2002-05-30 00:00:00

abstract：:The C-terminal src kinase (Csk) is responsible for the phosphorylation of the carboxy-terminal tyrosine of several tyrosine kinases of the Src family. This phosphorylation site has a negative regulatory function. Csk is unique among the members of the protein tyrosine kinase family because it lacks the conserved tyros...

journal_title：Oncogene

authors： Bougeret C,Rothhut B,Jullien P,Fischer S,Benarous R

更新日期：1993-05-01 00:00:00

abstract：:Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-independent activation. We have previously demonstrated that pulmonary surfactant protein D (SP-D, SFTPD) suppre...

journal_title：Oncogene

authors： Umeda Y,Hasegawa Y,Otsuka M,Ariki S,Takamiya R,Saito A,Uehara Y,Saijo H,Kuronuma K,Chiba H,Ohnishi H,Sakuma Y,Takahashi H,Kuroki Y,Takahashi M

更新日期：2017-11-16 00:00:00

abstract：:Inhibition of apoptosis or abnormal cell survival can result in tumorigenesis by facilitating the insurgence of various mutations. Immediate-early response gene X-1 (IEX-1), protects T cells from apoptosis induced by the ligation of Fas or the T-cell receptor (TCR)/CD3 complex in Emu-IEX-1 mice that direct the gene ex...

journal_title：Oncogene

authors： Zhang Y,Finegold MJ,Porteu F,Kanteti P,Wu MX

更新日期：2003-10-09 00:00:00

abstract：:We have developed a new yeast-based assay for the detection of PTEN nonsense mutation, and applied it to a total of 42 astrocytic tumors. The assay utilizes homologous recombination of PCR-amplified PTEN cDNA samples to a yeast vector which expresses an in-frame PTEN::ADE2 chimera protein. An allele of nonsense mutati...

journal_title：Oncogene

authors： Zhang CL,Tada M,Kobayashi H,Nozaki M,Moriuchi T,Abe H

更新日期：2000-09-07 00:00:00

abstract：:The autosomal dominantly inherited disease tuberous sclerosis (TSC) affects approximately 1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. TSC1, encoding hamartin, and TSC2, encoding tuberin are tumor suppressor genes responsible for TSC. Hamartin and tube...

journal_title：Oncogene

authors： Rosner M,Freilinger A,Hengstschläger M

更新日期：2007-01-25 00:00:00

abstract：:We have previously reported that there is a high incidence of microsatellite instability (MSI) and germline mismatch repair gene mutation in colorectal cancer arising from young Hong Kong Chinese. Most of the germline mutations involve hMSH2, which is different from the mutation spectrum in the Western population. It ...

journal_title：Oncogene

authors： Chan TL,Yuen ST,Ho JW,Chan AS,Kwan K,Chung LP,Lam PW,Tse CW,Leung SY

更新日期：2001-05-24 00:00:00

abstract：:The hyperactivated Wnt/β-catenin signaling acts as a switch to induce epithelial to mesenchymal transition and promote colorectal cancer. However, due to its essential role in gut homeostasis, therapeutic targeting of this pathway has proven challenging. Additionally, IL-6/Stat-3 signaling, activated by microbial tran...

journal_title：Oncogene

authors： Ahmad R,Kumar B,Chen Z,Chen X,Müller D,Lele SM,Washington MK,Batra SK,Dhawan P,Singh AB

更新日期：2017-11-23 00:00:00

abstract：:The c-Jun NH2-terminal kinase (JNK) pathway represents one subgroup of MAP kinases that are activated primarily by cytokines and exposure to environmental stress. Autophagy is a protein-degradation system characterized by the formation of double-membrane vacuoles termed autophagosomes. Autophagy-related gene beclin 1 ...

journal_title：Oncogene

authors： Li DD,Wang LL,Deng R,Tang J,Shen Y,Guo JF,Wang Y,Xia LP,Feng GK,Liu QQ,Huang WL,Zeng YX,Zhu XF

更新日期：2009-02-12 00:00:00

abstract：:Experimental studies performed prior to 1990 led to the widely held belief that matrix metalloproteinases (MMPs) produced by cancer cells are of critical importance in tumor invasion and metastasis. Based on this evidence, the pharmaceutical industry produced several well tolerated, orally active MMP inhibitors (MMPIs...

journal_title：Oncogene

authors： Zucker S,Cao J,Chen WT

更新日期：2000-12-27 00:00:00

abstract：:The osteogenic transcription factor, Runx2, is abnormally expressed in prostate cancer (PCa) and associated with metastatic disease. During bone development, Runx2 is activated by signals known to be hyperactive in PCa including the RAS/MAP kinase pathway, which phosphorylates Runx2 on multiple serine residues includi...

journal_title：Oncogene

authors： Ge C,Zhao G,Li Y,Li H,Zhao X,Pannone G,Bufo P,Santoro A,Sanguedolce F,Tortorella S,Mattoni M,Papagerakis S,Keller ET,Franceschi RT

更新日期：2016-01-21 00:00:00

abstract：:Triple negative breast cancer (TNBC) refers to tumors that do not express clinically significant levels of estrogen and progesterone receptors, and lack membrane overexpression or gene amplification of ErbB-2/HER2, a receptor tyrosine kinase. Transcriptome and proteome heterogeneity of TNBC poses a major challenge to ...

journal_title：Oncogene

authors： Chervo MF,Cordo Russo RI,Petrillo E,Izzo F,De Martino M,Bellora N,Cenciarini ME,Chiauzzi VA,Santa María de la Parra L,Pereyra MG,Güttlein LN,Podhajcer OL,Daniotti JL,Dupont A,Barchuk S,Figurelli S,Lopez Della Vecchia D,

更新日期：2020-09-01 00:00:00

abstract：:Prostate cancer is the most common malignancy of elderly men in the United States. Since there is no curative treatment for advanced prostate cancer, exploration of novel modalities of treatment is essential. Telomerase, a ribonucleoprotein, is detected in the vast majority of prostate cancer, but not in normal or ben...

journal_title：Oncogene

authors： Kondo Y,Koga S,Komata T,Kondo S

更新日期：2000-04-27 00:00:00

abstract：:Lung cancer is one of the major causes of cancer death and clarification of its molecular pathology is highly prioritized. The physiological importance of mRNA degradation through the CCR4-NOT deadenylase has recently been highlighted. For example, mutation in CNOT3, a gene coding for CNOT3 subunit of the CCR4-NOT com...

journal_title：Oncogene

authors： Shirai YT,Mizutani A,Nishijima S,Horie M,Kikuguchi C,Elisseeva O,Yamamoto T

更新日期：2019-04-01 00:00:00

abstract：:Homeodomain interacting protein kinase-2 (HIPK2) is a member of the HIPK family of stress-responsive kinases that modulates cell growth, apoptosis, proliferation and development. HIPK2 has several well-characterised tumour suppressor roles, but recent studies suggest it can also contribute to tumour progression, altho...

journal_title：Oncogene

authors： Torrente L,Sanchez C,Moreno R,Chowdhry S,Cabello P,Isono K,Koseki H,Honda T,Hayes JD,Dinkova-Kostova AT,de la Vega L

更新日期：2017-11-02 00:00:00

abstract：:Although Kruppel-like factor 5 (KLF5) is a transcription factor that has been implicated in pathways critical to carcinogenesis, controversy persists as to whether it functions as a tumor suppressor or as an oncogene. Here, we describe a novel role for KLF5 in a p53-independent apoptotic pathway. Using RNA-interferenc...

journal_title：Oncogene

authors： Zhao Y,Hamza MS,Leong HS,Lim CB,Pan YF,Cheung E,Soo KC,Iyer NG

更新日期：2008-01-03 00:00:00

abstract：:The c-myc oncogene is the most extensively studied member of the myc gene family which now consists of three characterized members, namely the c-myc, N-myc and L-myc genes. These genes are often found amplified in cell lines from small cell carcinomas of the lung (SCLC). In this study the L-myc gene was examined in a ...

journal_title：Oncogene

authors： Saksela K

更新日期：1987-01-01 00:00:00

abstract：:The retinoblastoma suppressor gene product Rb has been assigned a critical role in cell cycle regulation, the induction of differentiation, and inhibition of oncogenic transformation. Inheritance of a mutant RB allele in humans is responsible for bilateral retinoblastoma, a malignant tumor of the retina. Trilateral re...

journal_title：Oncogene

authors： Vooijs M,te Riele H,van der Valk M,Berns A

更新日期：2002-07-11 00:00:00

abstract：:We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog (hTERT), and the presence of reverse transcriptase and telomerase specific motifs. Furthermore, we show functional interchangeability with hTERT in in vitro telomeras...

journal_title：Oncogene

authors： Greenberg RA,Allsopp RC,Chin L,Morin GB,DePinho RA

更新日期：1998-04-02 00:00:00

abstract：:RET/PTC1 is a chimeric oncogene created by the fusion of the tyrosine kinase domain of RET to the 5'-terminal region of another gene named H4. So far, this oncogene has been found activated only in human papillary thyroid carcinomas. In order to investigate its transforming properties in vivo, we have produced transge...

journal_title：Oncogene

authors： Portella G,Salvatore D,Botti G,Cerrato A,Zhang L,Mineo A,Chiappetta G,Santelli G,Pozzi L,Vecchio G,Fusco A,Santoro M

更新日期：1996-11-07 00:00:00

abstract：:Glioblastoma (GBM) is a highly malignant glioma, which has the propensity to infiltrate throughout the brain in contrast to pilocytic astrocytoma (PA) of the posterior fossa, which does not spread and can be cured by surgery. We have used Suppression Subtractive Hybridization to define markers that better delineate th...

journal_title：Oncogene

authors： Colin C,Baeza N,Bartoli C,Fina F,Eudes N,Nanni I,Martin PM,Ouafik L,Figarella-Branger D

更新日期：2006-05-04 00:00:00

abstract：:Overexpression of hepatocyte growth factor (HGF), also called scatter factor (SF), and its receptor c-Met are associated with poor prognosis for cancer patients. In particular, breast cancer cells can produce HGF that acts in a paracrine as well as in an autocrine manner. Therefore, HGF and c-Met are putative targets ...

journal_title：Oncogene

authors： Gallego MI,Bierie B,Hennighausen L

更新日期：2003-11-20 00:00:00

abstract：:Upstream stimulating factor (USF2) is a basic helix-loop-helix leucine zipper transcription factor, which is found in most tissues. A critical role for USF2 in cellular proliferation has been proposed based on its importance in the regulation of various cyclins and P53 and its capability to antagonize c-myc. In this p...

journal_title：Oncogene

authors： Zhang ZC,Nechushtan H,Jacob-Hirsch J,Avni D,Meyuhas O,Razin E

更新日期：1998-02-12 00:00:00

abstract：:In an effort to understand the mechanisms governing the regulation of the mouse Ron receptor gene, a mouse genomic library was screened and overlapping clones coding for the Ron gene and flanking DNA were identified. Continuous DNA sequence was obtained for approximately 16.4 kilobases. The gene, from the initiator me...

journal_title：Oncogene

authors： Waltz SE,Toms CL,McDowell SA,Clay LA,Muraoka RS,Air EL,Sun WY,Thomas MB,Degen SJ

更新日期：1998-01-08 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells, overactivation of mTOR has been reported. In addition, mTOR inhibitors, such as rapamycin and its derivatives, are being evaluated ...

journal_title：Oncogene

authors： Sato T,Nakashima A,Guo L,Coffman K,Tamanoi F

更新日期：2010-05-06 00:00:00

abstract：:The oncogene, v-rel is a member of the rel/NF-kappaB family of transcription factors. It causes a rapidly fatal lymphoma in young chicks and is capable of transforming both fibroblasts and primitive hematopoietic cells in culture. To understand the role of v-rel in transformation we constructed an inducible form of v-...

journal_title：Oncogene

authors： Walker AK,Enrietto PJ

更新日期：1996-06-20 00:00:00