Abstract：
:RET/PTC1 is a chimeric oncogene created by the fusion of the tyrosine kinase domain of RET to the 5'-terminal region of another gene named H4. So far, this oncogene has been found activated only in human papillary thyroid carcinomas. In order to investigate its transforming properties in vivo, we have produced transgenic mice carrying RET/PTC1 under the control of the H4 promoter. The transgene was expressed in several tissues, consistently with the ubiquitous expression of the wild type H4 gene. Mammary adenocarcinomas and, less frequently, hyperplasia of sebaceous glands and rare benign skin tumors, named pilomatrixomas, developed in these mice. The tumors were shown to express the transgene both at the RNA and protein level. These results demonstrate that the transforming ability of the RET/PTC1 oncogene is not restricted to the thyroid epithelium in vivo. Despite its ubiquitous expression, however, RET/PTC1 was able to induce only a limited number of tumor types; specifically mammary epithelium was affected by transgene expression, thus suggesting that RET/PTC1 is able to couple with transforming pathways specific for these glandular cells.
journal_name
Oncogenejournal_title
Oncogeneauthors
Portella G,Salvatore D,Botti G,Cerrato A,Zhang L,Mineo A,Chiappetta G,Santelli G,Pozzi L,Vecchio G,Fusco A,Santoro Msubject
Has Abstractpub_date
1996-11-07 00:00:00pages
2021-6issue
9eissn
0950-9232issn
1476-5594journal_volume
13pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:Fas-associated death domain (FADD) is an adaptor protein recruiting complexes of caspase 8 to death ligand receptors to induce extrinsic apoptotic cell death in response to a TNF superfamily member. Although, formation of the complex of FADD and caspase 8 upon death stimuli has been studied in detail, posttranslationa...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0323-z
更新日期：2018-09-01 00:00:00
abstract：:The p53/p21Cip1/Waf1-dependent checkpoint control of G1/S and G2/M phases of the cell cycle in response to DNA damage is an important mechanism of genome stability maintenance in normal cells. In many tumor cells, due to frequent point mutations and deletions of p53, the stringent control of the cell cycle and apoptos...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202945
更新日期：1999-10-07 00:00:00
abstract：:Myc family proteins play an important role in cellular processes such as proliferation, differentiation, apoptosis and transformation. A number of interaction partners of Myc have been identified, such as Max, p107, TBP, YY1, Miz-1, AP-2 and Nmi. Both Max and Nmi also bind to MycN. In contrast to the well defined bind...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203090
更新日期：1999-11-18 00:00:00
abstract：:Provirus modifications which can occur in tumors may lead to tumor antigenic variants. To investigate this possibility we compared the restriction fragment length patterns of mouse mammary tumor virus (MMTV), murine leukemia virus and xenotropic and mink cell-focus inducing (MCF)-related sequences, using Southern blot...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：:The naked mole rat (nmr) is cancer resistant due to the abundant production of extremely high-molecular-weight hyaluronan (EHMW-HA). However, whether EHMW-HA has similar anti-cancer effects in mice and humans remains to be determined. The present study used breast cancer cells to clarify the effect of EHMW-HA on breas...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-019-0719-4
更新日期：2019-05-01 00:00:00
abstract：:The role of thromboxane A(2) (TxA(2)) in smoking-associated lung cancer is poorly understood. This study was conducted to study the role of TxA(2) in smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-promoted cell survival and growth in human lung cancer cells. We found that NNK increased TxA(2) ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.390
更新日期：2011-01-06 00:00:00
abstract：:Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We previously showed that β1 integrins are activated in metastatic prostate cancer (PCa) cells, increasing PCa metastasis to lymph n...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2014.116
更新日期：2015-04-02 00:00:00
abstract：:B-Myb, a highly conserved member of the Myb oncoprotein family, is a 110 kDa sequence-specific DNA binding protein expressed in virtually all proliferating cells. B-myb expression reaches its maximum at the G1/S phase boundary and during the S phase of the cell cycle. We have previously shown that B-Myb activity is ce...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203618
更新日期：2000-06-15 00:00:00
abstract：:TSC1 and TSC2 are responsible for the tumor suppressor gene syndrome tuberous sclerosis (TSC). Mammalian TSC genes have been shown to be involved in cell cycle regulation. Recently, in Drosophila, these data have been confirmed and TSC genes have further been demonstrated to affect cell size control. Here we provide s...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206776
更新日期：2003-07-31 00:00:00
abstract：:The chicken c-ets-1 locus encodes two transcription factors, p54c-ets-1 and p68c-ets-1 that differ in their N-termini, encoded respectively by the I54 and alpha beta exons. p68c-ets-1 equivalents are only found in birds and reptiles while p54c-ets-1 is widely conserved in vertebrates, from amphibians to mammals. Thus,...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has been implicated in MPNST formation, but its precise role and relevant signaling pathways remain unknown. We found that EGFR overexpression pro...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.579
更新日期：2014-01-09 00:00:00
abstract：:Hexokinase-II (HK2) is a key enzyme involved in glycolysis, which is required for breast cancer progression. However, the underlying post-translational mechanisms of HK2 activity are poorly understood. Here, we showed that Proviral Insertion in Murine Lymphomas 2 (PIM2) directly bound to HK2 and phosphorylated HK2 on ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0386-x
更新日期：2018-11-01 00:00:00
abstract：:This study addresses the question of whether loss of p16INK4 expression contributes to the immortalization of human cells. In vitro immortalization usually proceeds through two phases. In the first phase (lifespan extension), cells continue proliferating and their telomeres continue shortening beyond the point at whic...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-09-19 00:00:00
abstract：:Cyclooxygenase (COX)-2 is upregulated in hepatocellular carcinoma (HCC). However, the direct causative effect of COX-2 in spontaneous HCC formation remains unknown. We thus investigate the role and molecular pathogenesis of COX-2 in HCC by using liver-specific COX-2 transgenic (TG) mice. We found spontaneous HCC forma...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2017.73
更新日期：2017-08-01 00:00:00
abstract：:The mechanism by which Bcl-2 inhibits apoptosis is unknown. The Bcl-2 protein is localized to intracellular membranes, including the endoplasmic reticulum (ER). The ER is the major intracellular reservoir of Ca2+ in non-muscle cells, sequestering Ca2+ for use in intracellular signaling, and is a prime target of oxidat...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-05-16 00:00:00
abstract：:The p53 and MDM2 genes are part of a physiological pathway frequently impaired in human cancer. With the exception of tumours occasionally associated with hereditary predisposition, childhood malignancies have not been studied in detail yet. This is the first report on the analysis of p53 and MDM2 in a group of non-he...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Max is a small helix-loop-helix protein which forms heterodimers with members of the Myc protein family. Myc/Max heterodimers exhibit sequence-specific DNA binding with much greater affinity than Myc homodimers. The Xenopus laevis homologue of Max, XMax, is shorter than the equivalent mammalian protein. This differenc...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:A large body of physiological evidence shows that either upregulation or downregulation of intracellular c-Myc activity has profound consequences on cell cycle progression. Recent work suggests that c-Myc may stimulate the activity of cyclin E/cyclin-dependent kinase 2 (Cdk2) complexes and antagonize the action of the...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1202749
更新日期：1999-05-13 00:00:00
abstract：:We have previously reported on the identification of a cDNA (placenta growth factor, PlGF) coding for a novel angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). Biochemical and functional characterization of PlGF derived from t...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. It has recently been implicated in granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and erythropoietin signal transduction. To better understand the role played by FES i...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-03-16 00:00:00
abstract：:Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation during extravasation remain unclear. Using intravital imaging and loss of function experiments, we determined invadopodia contain receptors involved in chemota...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0667-4
更新日期：2019-05-01 00:00:00
abstract：:Inter-alpha-trypsin inhibitors (ITIs) are protease inhibitors stabilizing the extracellular matrix. ITIs consist of one light (bikunin) and two heavy chains (ITIHs). We have recently characterized ITIH5, a novel member of the ITIH gene family, and showed that its messenger RNA is lost in a high proportion of breast tu...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210669
更新日期：2008-01-31 00:00:00
abstract：:We identified IFIX as a new member of the hematopoietic interferon (IFN)-inducible nuclear protein with the 200-amino-acid repeat (HIN-200) family. Six different alternatively spliced forms of mRNA are transcribed from the IFIX gene, which are predicted to encode six different isoforms of IFIX proteins (IFIXalpha1, al...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207592
更新日期：2004-06-03 00:00:00
abstract：:DNA methylation alterations are now widely recognized as a contributing factor in human tumorigenesis. A significant number of tumor suppressor genes are transcriptionally silenced by promoter hypermethylation, and recent research implicates alterations in chromatin structure as the mechanistic basis for this repressi...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1205602
更新日期：2002-08-12 00:00:00
abstract：:The Ets family of transcription factors is one of a growing number of master regulators of development. This family was originally defined by the presence of a conserved DNA binding domain, the Ets domain. To date, nearly 30 members of this family have been identified and implicated in a wide range of physiological an...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1204038
更新日期：2000-12-18 00:00:00
abstract：:The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210454
更新日期：2007-09-20 00:00:00
abstract：:Ubiquitin-conjugation targets numerous cellular regulators for proteasome-mediated degradation. Thus, the identification of ubiquitin ligases and their physiological substrates is crucially important, especially for those cases in which aberrant levels of regulatory proteins (e.g., beta-catenin, p27) result from a der...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202653
更新日期：1999-01-28 00:00:00
abstract：:In the presence of ERbeta, trans-hydroxytamoxifen (TOT) protects cells against 17beta-estradiol (E(2))-induced oxidative DNA damage (ODD) and this correlates with increased expression of the antioxidative enzyme quinone reductase (QR). Here, we investigate the molecular mechanism responsible for ERbeta-mediated protec...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2008.235
更新日期：2008-10-23 00:00:00
abstract：:Despite the fact that objective response rates to 5-FU are as low as 20%, 5-FU remains the most commonly used drug for the treatment of colorectal cancer. The lack of understanding of resistance to 5-FU, therefore, remains a significant impediment in maximizing its efficacy. We used intestinal epithelial cells with an...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208552
更新日期：2005-06-02 00:00:00
abstract：:Normal function of the p53 gene is integral to the cellular response to genotoxic stress. One prediction arising from this is that p53 deficiency results in an increased mutation frequency. However, limited evidence has been produced in support of this idea. In order to further investigate the in vivo role of p53 in s...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201040
更新日期：1997-05-01 00:00:00
