Analysis of the role of v-rel in transcriptional regulation of high mobility group 14.

abstract：:In the presence of ERbeta, trans-hydroxytamoxifen (TOT) protects cells against 17beta-estradiol (E(2))-induced oxidative DNA damage (ODD) and this correlates with increased expression of the antioxidative enzyme quinone reductase (QR). Here, we investigate the molecular mechanism responsible for ERbeta-mediated protec...

journal_title：Oncogene

authors： Sripathy SP,Chaplin LJ,Gaikwad NW,Rogan EG,Montano MM

更新日期：2008-10-23 00:00:00

abstract：:Clinical and epidemiological data support a role for human papilloma virus (HPV) type 16 in the pathogenesis of cervical carcinoma. The W12 cell line contains HPV16 sequences, predominantly as a high copy number episome, and is immortalised in vitro, but non-tumourigenic. A morphologically distinct sub-line of the par...

journal_title：Oncogene

authors： Crook T,Greenfield I,Howard J,Stanley M

更新日期：1990-04-01 00:00:00

abstract：:The phosphatidylinositol 3'-kinase (PI3K) pathway is dysregulated in multiple myeloma (MM); we therefore tested a highly selective class I PI3K inhibitor, GDC-0941, for anti-myeloma activity. Functional and mechanistic studies were first performed in MM cell lines, then extended to primary MM patient samples cultured ...

journal_title：Oncogene

authors： Munugalavadla V,Mariathasan S,Slaga D,Du C,Berry L,Del Rosario G,Yan Y,Boe M,Sun L,Friedman LS,Chesi M,Leif Bergsagel P,Ebens A

更新日期：2014-01-16 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is thought to have a pivotal role in the transformation of thymocytes and is as...

journal_title：Oncogene

authors： Fleskens V,Mokry M,van der Leun AM,Huppelschoten S,Pals CE,Peeters J,Coenen S,Cardoso BA,Barata JT,van Loosdregt J,Coffer PJ

更新日期：2016-08-04 00:00:00

abstract：:Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...

journal_title：Oncogene

authors： Liu SK,Berry DM,McGlade CJ

更新日期：2001-10-01 00:00:00

abstract：:Non small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the United States and worldwide. Unfortunately, standard therapies remain inadequate. An increased understanding of the molecular biology of lung cancer biology is required to develop more effective new therapies. In this report, we show that ...

journal_title：Oncogene

authors： Uematsu K,He B,You L,Xu Z,McCormick F,Jablons DM

更新日期：2003-10-16 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) causes fibrosis, cancer progression and metastasis. Integrin-linked kinase (ILK) is a focal adhesion adaptor and a serine/threonine protein kinase that regulates cell proliferation, survival and EMT. Elucidating the molecular mechanisms necessary for development and progressi...

journal_title：Oncogene

authors： Serrano I,McDonald PC,Lock FE,Dedhar S

更新日期：2013-01-03 00:00:00

abstract：:Recent evidence suggests that squamous cell carcinoma of the vulva may have more than one etiology, with only some tumors associated with human papillomavirus (HPV). Cells infected with HPV produce a viral protein (E6) which binds to and causes rapid degradation of p53, possibly contributing to cellular transformation...

journal_title：Oncogene

authors： Lee YY,Wilczynski SP,Chumakov A,Chih D,Koeffler HP

更新日期：1994-06-01 00:00:00

abstract：:The hepatitis B virus (HBV) X protein (pX) stimulates transcription regulated by cis-acting elements that control many viral and cellular genes, including the c-myc and the c-fos proto-oncogenes. Using several c-fos promoter deletion mutants, we found the serum-responsive element (SRE) located at -315, the modified TP...

journal_title：Oncogene

authors： Avantaggiati ML,Natoli G,Balsano C,Chirillo P,Artini M,De Marzio E,Collepardo D,Levrero M

更新日期：1993-06-01 00:00:00

abstract：:A two-stage (initiation and promotion) model of chemical transformation of mouse embryonic fibroblasts was used to elucidate the molecular mechanisms of tumor promotion in vitro. C3H10T1/2 cells which had been initiated with a subcarcinogenic dose (0.5 micrograms ml-1) of benzo[a]pyrene (B[a]P) were isolated after 12-...

journal_title：Oncogene

authors： Wu WS,Lin JK,Wu FY

更新日期：1992-11-01 00:00:00

abstract：:The Src family kinases c-Src, and its downstream effectors, the Rho family of small GTPases RhoA and Jun N-terminal kinase (JNK) have a significant role in tumorigenesis. In this report, using the Drosophila wing disc epithelium as a model system, we demonstrate that the actin-Capping Protein (CP) αβ heterodimer, whic...

journal_title：Oncogene

authors： Fernández BG,Jezowska B,Janody F

更新日期：2014-04-17 00:00:00

abstract：:The trans-activator protein, tax, from the human T leukemia virus type 1 (HTLV-1) trans-activates both viral and cellular genes. It has previously been shown that granulocyte macrophage-colony stimulating factor (GM-CSF) is constitutively expressed in HTLV-1 infected cells and in cells artificially expressing tax. We ...

journal_title：Oncogene

authors： Himes SR,Coles LS,Katsikeros R,Lang RK,Shannon MF

更新日期：1993-12-01 00:00:00

abstract：:Bcl-2 and Bcl-XL serve as critical inhibitors of apoptosis triggered by a broad range of stimuli, mainly acting on the mitochondria. We identified two members of the reticulon (RTN) family as Bcl-XL binding proteins, i.e., NSP-C (RTN1-C) and a new family member, RTN-XS, both of which did not belong to the Bcl-2 family...

journal_title：Oncogene

authors： Tagami S,Eguchi Y,Kinoshita M,Takeda M,Tsujimoto Y

更新日期：2000-11-23 00:00:00

abstract：:Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle, especially during mitosis. Antimitotic drugs trigger mitotic checkpoint activation, mitotic arrest and eventually cell death. However, mitotic slippage represents a major mechanism of resistance to these treatments. I...

journal_title：Oncogene

authors： Sánchez-Pérez T,Medema RH,López-Rivas A

更新日期：2015-01-29 00:00:00

abstract：:The management of pain and morbidity due to the spreading and growth of cancer within bone remains to be a paramount problem in clinical care. Cancer cells actively transform bone, however, the molecular requirements and mechanisms of this process remain unclear. This study shows that functional modulation of the alph...

journal_title：Oncogene

authors： McCabe NP,De S,Vasanji A,Brainard J,Byzova TV

更新日期：2007-09-13 00:00:00

abstract：:Earlier we showed that RACK1 regulates growth of human colon cells by suppressing Src activity at G(1) and mitotic checkpoints. Here, we show that RACK1 also induces apoptosis of the cells, partly by inhibiting Src. In the intrinsic pathway, RACK1 inhibits expression of anti-apoptotic Bcl-2 and Bcl-X(L), induces expre...

journal_title：Oncogene

authors： Mamidipudi V,Cartwright CA

更新日期：2009-12-17 00:00:00

abstract：:Accumulating evidences have shown the association between aberrantly expressed microRNAs (miRs) and cancer, where these small regulatory RNAs appear to dictate the cell fate by regulating all the main biological processes. We demonstrated the responsibility of the circuitry connecting the oncomiR-221&222 with the tumo...

journal_title：Oncogene

authors： Felli N,Errico MC,Pedini F,Petrini M,Puglisi R,Bellenghi M,Boe A,Felicetti F,Mattia G,De Feo A,Bottero L,Tripodo C,Carè A

更新日期：2016-06-09 00:00:00

abstract：:Early studies demonstrated that male melanoma patients have worse survival than female patients, yet the detailed mechanisms for this gender difference remain unclear. We analyzed around 100 cases of human melanoma and found that androgen receptor (AR) positive melanoma patients have worse survival outcomes compared w...

journal_title：Oncogene

authors： Wang Y,Ou Z,Sun Y,Yeh S,Wang X,Long J,Chang C

更新日期：2017-03-23 00:00:00

abstract：:There is increasing evidence that mast cells (MCs) and their mediators are involved in the remodeling of the tumor microenvironment and promote tumor growth, angiogenesis and metastasis. We have found that an increased density of MCs in thyroid cancer (TC) correlates with enhanced invasiveness. However, the MC-derived...

journal_title：Oncogene

authors： Visciano C,Liotti F,Prevete N,Cali' G,Franco R,Collina F,de Paulis A,Marone G,Santoro M,Melillo RM

更新日期：2015-10-01 00:00:00

abstract：:Cell lines derived from cervical neoplasias, as well as cells from normal cervix and neonatal foreskin were examined in an in vitro culture system (raft system) that allows for stratification and differentiation of epithelial cells at an air-liquid interface. Epithelial cells from human foreskin and ectocervix were ob...

journal_title：Oncogene

authors： Rader JS,Golub TR,Hudson JB,Patel D,Bedell MA,Laimins LA

更新日期：1990-04-01 00:00:00

abstract：:pp60c-src, a cellular tyrosine kinase homologous to the retroviral v-src oncogene, becomes transiently activated during mitosis. Activation is accompanied by phosphorylation of three sites in the amino-terminal regulatory domain of the protein, threonine 34, threonine 46 and serine 72. These sites can be phosphorylate...

journal_title：Oncogene

authors： Kaech S,Schnierle B,Wyss A,Ballmer-Hofer K

更新日期：1993-03-01 00:00:00

abstract：:ErbB4, a member of the epidermal growth factor receptor family, plays a role in normal breast and breast cancer development by regulating mammary epithelial cell proliferation, survival and differentiation. In this study, we show that WWP1, a C2-WW-HECT type E3 ubiquitin ligase, binds, ubiquitinates and destructs ErbB...

journal_title：Oncogene

authors： Li Y,Zhou Z,Alimandi M,Chen C

更新日期：2009-08-20 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes. HIF-1 is composed of an HIF-1alpha subunit and an HIF-1beta subunit. HIF-1alpha is degraded following enzyme-dependent hydroxylation of prolines of HIF-1al...

journal_title：Oncogene

authors： Wang M,Kirk JS,Venkataraman S,Domann FE,Zhang HJ,Schafer FQ,Flanagan SW,Weydert CJ,Spitz DR,Buettner GR,Oberley LW

更新日期：2005-12-08 00:00:00

abstract：:Axl is a receptor that induces proliferation, migration and invasion in cancer. In this study, we show that specific microRNAs (miRNAs) target the 3'-UTR of Axl. Luciferase-reporter assays with wild-type and deleted miR-34 and miR-199a/b seed sequences of Axl 3'-UTR confirmed the specificity of targeting. An inverse c...

journal_title：Oncogene

authors： Mudduluru G,Ceppi P,Kumarswamy R,Scagliotti GV,Papotti M,Allgayer H

更新日期：2011-06-23 00:00:00

abstract：:P53 wild-type and p53-null or mutant cells undergo a G(2)-phase cell-cycle arrest in response to ionizing radiation (IR). In this study we examined the effect of heat-shock protein 90 (HSP90) inhibitor, geldanamycin (GA), on IR-induced G(2) arrest in human colon adenocarcinoma cells with different p53 status. We show ...

journal_title：Oncogene

authors： Moran DM,Gawlak G,Jayaprakash MS,Mayar S,Maki CG

更新日期：2008-09-18 00:00:00

abstract：:During the evolution into castration or therapy resistance, prostate cancer cells reprogram the androgen responses to cope with the diminishing level of androgens, and undergo metabolic adaption to the nutritionally deprived and hypoxia conditions. AR (androgen receptor) and PKM2 (pyruvate kinase M2) have key roles in...

journal_title：Oncogene

authors： Wang HJ,Pochampalli M,Wang LY,Zou JX,Li PS,Hsu SC,Wang BJ,Huang SH,Yang P,Yang JC,Chu CY,Hsieh CL,Sung SY,Li CF,Tepper CG,Ann DK,Gao AC,Evans CP,Izumiya Y,Chuu CP,Wang WC,Chen HW,Kung HJ

更新日期：2019-01-01 00:00:00

abstract：:Loss of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal cell carcinoma. Modulation of the proteostasis of VHL, especially missense point-mutated VHL, is a promising approach to augmenting VHL levels and function. VHL proteostasis is regulated ...

journal_title：Oncogene

authors： German P,Bai S,Liu XD,Sun M,Zhou L,Kalra S,Zhang X,Minelli R,Scott KL,Mills GB,Jonasch E,Ding Z

更新日期：2016-09-22 00:00:00

abstract：:Cancer cells can use a variety of metabolic substrates to fulfill the bioenergetic and biosynthetic needs of their oncogenic program. Besides bioenergetics, cancer cell metabolism also directly influences genetic, epigenetic and signaling events associated with tumor progression. Many cancer cells are addicted to glut...

journal_title：Oncogene

authors： Cacace A,Sboarina M,Vazeille T,Sonveaux P

更新日期：2017-04-01 00:00:00

abstract：:A protein of 300 kDa (p300) associates with the adenovirus E1A proteins and has been implicated in the control of cell cycle progression. In mammalian cells, p300 is actively phosphorylated in both quiescent and proliferating cells and its level of phosphorylation increases as it travels from late G1 into M phase. E1A...

journal_title：Oncogene

authors： Banerjee AC,Recupero AJ,Mal A,Piotrkowski AM,Wang DM,Harter ML

更新日期：1994-06-01 00:00:00

abstract：:Estrogen receptor-alpha (ERalpha) and its ligand estradiol (E2) has critical roles in breast cancer growth and are key therapeutic targets. In this study, we report a novel dual role of the adenosine A1 receptor (Adora1) as an E2/ERalpha target and a regulator of ERalpha transcriptional activity. In ERalpha-positive b...

journal_title：Oncogene

authors： Lin Z,Yin P,Reierstad S,O'Halloran M,Coon VJ,Pearson EK,Mutlu GM,Bulun SE

更新日期：2010-02-25 00:00:00