Myristylation and amino-terminal phosphorylation are required for activation of pp60c-src during mitosis.

abstract：:Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not. Serine, glutamic acid, and prolin...

journal_title：Oncogene

authors： Roussel MF,Downing JR,Sherr CJ

更新日期：1990-01-01 00:00:00

abstract：:A single heat shock factor (HSF), mediating the heat shock response, exists from yeast to Drosophila, whereas several related HSFs have been found in mammals. This raises the question of the specific or redundant functions of the different members of the HSF family and in particular of HSF1 and HSF2, which are both ub...

journal_title：Oncogene

authors： Lecomte S,Desmots F,Le Masson F,Le Goff P,Michel D,Christians ES,Le Dréan Y

更新日期：2010-07-22 00:00:00

abstract：:The p53 tumor suppressor protein and the Akt/PKB kinase play important roles in the transduction of pro-apoptotic and anti-apoptotic signals, respectively. We provide evidence that conflicting signals transduced by Akt and p53 are integrated via negative feedback between the two pathways. On the one hand, the combinat...

journal_title：Oncogene

authors： Gottlieb TM,Leal JF,Seger R,Taya Y,Oren M

更新日期：2002-02-14 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and remains incurable with conventional chemotherapy treatment approaches. CLL as a disease entity is defined by a relatively parsimonious set of diagnostic criteria and therefore likely constitutes an umbrella term for multiple relate...

journal_title：Oncogene

authors： Malek SN

更新日期：2013-06-06 00:00:00

abstract：:It is now well established that the immune system can control neoplastic development and growth in a process termed immunosurveillance. A link between host immunosurveillance and neoplastic progression is revealed in cases where the immune response becomes compromised due to genetic or other pathological conditions, r...

journal_title：Oncogene

authors： Stewart TJ,Abrams SI

更新日期：2008-10-06 00:00:00

abstract：:The oncogene EWS-FLI1 encodes a chimeric transcription factor expressed in Ewing's sarcoma family tumors (ESFTs). EWS-FLI1 target gene expression is thought to drive ESFT pathogenesis and, therefore, inhibition of EWS-FLI1 activity holds high therapeutic promise. As the activity of many transcription factors is regula...

journal_title：Oncogene

authors： Bachmaier R,Aryee DN,Jug G,Kauer M,Kreppel M,Lee KA,Kovar H

更新日期：2009-03-05 00:00:00

abstract：:The epidermal growth factor (EGF)/EGF-receptor (ErbB1-4) family is involved in the biology of multiple myeloma (MM). In particular, ErbB-specific inhibitors induce strong apoptosis of myeloma cells (MMC) in vitro. To delineate the contribution of the 10 EGF-family ligands to the pathogenesis of MM, we have assessed th...

journal_title：Oncogene

authors： Mahtouk K,Cremer FW,Rème T,Jourdan M,Baudard M,Moreaux J,Requirand G,Fiol G,De Vos J,Moos M,Quittet P,Goldschmidt H,Rossi JF,Hose D,Klein B

更新日期：2006-11-16 00:00:00

abstract：:ErbB2 amplification and overexpression in breast cancer correlates with aggressive disease and poor prognosis. To find novel ErbB2-interacting proteins, we used stable isotope labeling of amino acids in cell culture followed by peptide affinity pull-downs and identified specific binders using relative quantification b...

journal_title：Oncogene

authors： Heinrich C,Keller C,Boulay A,Vecchi M,Bianchi M,Sack R,Lienhard S,Duss S,Hofsteenge J,Hynes NE

更新日期：2010-03-18 00:00:00

abstract：:Glioblastoma multifome is the most common and most aggressive primary brain tumor with no current curative therapy. We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed. ATF5 is not detectably expressed by mature brain neurons and as...

journal_title：Oncogene

authors： Angelastro JM,Canoll PD,Kuo J,Weicker M,Costa A,Bruce JN,Greene LA

更新日期：2006-02-09 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine with important roles in regulating inflammatory responses as well as cell cycle proliferation and apoptosis. Although TNFalpha stimulates apoptosis, it also activates the transcription factor NF-kappa B, and studies have shown that inhibition of NF-...

journal_title：Oncogene

authors： Zhou A,Scoggin S,Gaynor RB,Williams NS

更新日期：2003-04-03 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...

journal_title：Oncogene

authors： Joseph J,Radulovich N,Wang T,Raghavan V,Zhu CQ,Tsao MS

更新日期：2020-01-01 00:00:00

abstract：:To evaluate the role of the NF-kappaB signaling pathway in oncogenic transformation, we expressed IkappaBbeta, a specific inhibitor of NF-kappaB, in two human lung adenocarcinoma cell lines, A549 and H441. Expression of IkappaBbeta significantly reduced NF-kappaB activation induced by cotransfection with p65/RelA or T...

journal_title：Oncogene

authors： Jiang Y,Cui L,Yie TA,Rom WN,Cheng H,Tchou-Wong KM

更新日期：2001-04-26 00:00:00

abstract：:The NF2 gene product, merlin/schwannomin, is a cytoskeleton organizer with unique growth-inhibiting activity in specific cell types. A narrow spectrum of tumors is associated with NF2 deficiency, mainly schwannomas and meningiomas, suggesting cell-specific mechanisms of growth control. We have investigated merlin func...

journal_title：Oncogene

authors： Lallemand D,Manent J,Couvelard A,Watilliaux A,Siena M,Chareyre F,Lampin A,Niwa-Kawakita M,Kalamarides M,Giovannini M

更新日期：2009-02-12 00:00:00

abstract：:Murine radiation-induced acute myeloid leukaemia (AML) is characterized by loss of one copy of chromosome 2. Previously, we positioned the critical haematopoietic-specific transcription factor PU.1 within a minimally deleted region. We now report a high frequency (>65%) of missense mutation at codon 235 in the DNA-bin...

journal_title：Oncogene

authors： Suraweera N,Meijne E,Moody J,Carvajal-Carmona LG,Yoshida K,Pollard P,Fitzgibbon J,Riches A,van Laar T,Huiskamp R,Rowan A,Tomlinson IP,Silver A

更新日期：2005-05-19 00:00:00

abstract：:A previous report demonstrated that AP-2alpha favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2alpha in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2alpha in SKOV3 human ovarian cancer cells, which originally possess...

journal_title：Oncogene

authors： Sumigama S,Ito T,Kajiyama H,Shibata K,Tamakoshi K,Kikkawa F,Williams T,Tainsky MA,Nomura S,Mizutani S

更新日期：2004-07-15 00:00:00

abstract：:Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transg...

journal_title：Oncogene

authors： Sansom OJ,Griffiths DF,Reed KR,Winton DJ,Clarke AR

更新日期：2005-12-08 00:00:00

abstract：:Inherited mutations in the BRCA1 gene confer increased susceptibility to breast and ovarian cancer. Its role in sporadic carcinogenesis is not well defined. Somatic mutations in breast cancers have not been reported and to date there are only three reports of somatic mutations in sporadic ovarian cancers. To investiga...

journal_title：Oncogene

authors： Khoo US,Ozcelik H,Cheung AN,Chow LW,Ngan HY,Done SJ,Liang AC,Chan VW,Au GK,Ng WF,Poon CS,Leung YF,Loong F,Ip P,Chan GS,Andrulis IL,Lu J,Ho FC

更新日期：1999-08-12 00:00:00

abstract：:Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the BCL-2 dependency of luminal tumor cells is nevertheless mitigated by breast cancer-associated fibroblasts (bCAFs) in a manner that defines MCL-1 as another critical...

journal_title：Oncogene

authors： Louault K,Bonneaud TL,Séveno C,Gomez-Bougie P,Nguyen F,Gautier F,Bourgeois N,Loussouarn D,Kerdraon O,Barillé-Nion S,Jézéquel P,Campone M,Amiot M,Juin PP,Souazé F

更新日期：2019-04-01 00:00:00

abstract：:Mouse embryonic stem (ES) cells are known to express D-type cyclins at very low levels and these levels increase dramatically during in vitro and in vivo differentiation. Here, we investigate some of the signalling pathways regulating expression of cyclin D1 and progression to S phase, the Ras/Extracellular signal-reg...

journal_title：Oncogene

authors： Jirmanova L,Afanassieff M,Gobert-Gosse S,Markossian S,Savatier P

更新日期：2002-08-15 00:00:00

abstract：:The tumor suppressor gene Pdcd4 (programmed cell death gene 4) has drawn considerable attention because its downregulation is involved in the development of several types of cancer. Because Pdcd4 interacts with the translation initiation factor eIF4A and inhibits its helicase activity, Pdcd4 has been implicated in the...

journal_title：Oncogene

authors： Biyanee A,Ohnheiser J,Singh P,Klempnauer KH

更新日期：2015-03-12 00:00:00

abstract：:Cyclooxygenase (COX)-2 is upregulated in hepatocellular carcinoma (HCC). However, the direct causative effect of COX-2 in spontaneous HCC formation remains unknown. We thus investigate the role and molecular pathogenesis of COX-2 in HCC by using liver-specific COX-2 transgenic (TG) mice. We found spontaneous HCC forma...

journal_title：Oncogene

authors： Chen H,Cai W,Chu ESH,Tang J,Wong CC,Wong SH,Sun W,Liang Q,Fang J,Sun Z,Yu J

更新日期：2017-08-01 00:00:00

abstract：:Inflammation can act as a crucial mediator of epithelial-to-mesenchymal transition (EMT). In this study, we show that oncostatin M (OSM) is expressed in an autocrine/paracrine fashion in invasive breast carcinoma. OSM stimulation promotes spontaneous lung metastasis of MCF-7 xenografts in nude mice. A conspicuous epig...

journal_title：Oncogene

authors： Guo L,Chen C,Shi M,Wang F,Chen X,Diao D,Hu M,Yu M,Qian L,Guo N

更新日期：2013-11-07 00:00:00

abstract：:A better understanding of the link between cellular metabolism and tumorigenesis is needed. Here, we report characterization of a novel protein named coiled-coil helix tumor and metabolism 1 (CHTM1). We have found that CHTM1 is associated with cancer and cellular metabolism. CHTM1 localizes to mitochondria and cytosol...

journal_title：Oncogene

authors： Babbar M,Huang Y,An J,Landas SK,Sheikh MS

更新日期：2018-04-01 00:00:00

abstract：:Bloom's syndrome (BS) arises through mutations in both copies of the BLM gene that encodes a RecQ 3'-5' DNA helicase. BS patients are predisposed to developing all the cancers that affect the general population, and BS cells exhibit marked genetic instability. We showed recently that BLM protein contributes to the cel...

journal_title：Oncogene

authors： Ababou M,Dumaire V,Lécluse Y,Amor-Guéret M

更新日期：2002-03-27 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western countries and is currently incurable due, in part, to difficulty in eliminating the leukemia cells protected by stromal microenvironment. Based on previous observations that CLL cells exhibit mitochondrial dysfunction and altered lipid...

journal_title：Oncogene

authors： Liu PP,Liu J,Jiang WQ,Carew JS,Ogasawara MA,Pelicano H,Croce CM,Estrov Z,Xu RH,Keating MJ,Huang P

更新日期：2016-10-27 00:00:00

abstract：:Thymidine kinase (TK) is a nucleotide salvage pathway enzyme whose activity is highly dependent on the growth state and cell cycle phase of a cell. Cells in the resting or quiescent (G0) phase express very low levels of TK mRNA and protein. When quiescent cells are stimulated to enter the cell cycle by the addition of...

journal_title：Oncogene

authors： Kauffman MG,Rose PA,Kelly TJ

更新日期：1991-08-01 00:00:00

abstract：:Heregulins are a group of growth factors that play diverse and critical roles in the signaling network of the human epidermal growth factor receptor (HER or EGFR) superfamily. Our earlier studies have shown that recombinant heregulinbeta1 (HRG) induces apoptosis in SKBr3 breast cancer cells that overexpress HER2. Here...

journal_title：Oncogene

authors： Le XF,Marcelli M,McWatters A,Nan B,Mills GB,O'Brian CA,Bast RC Jr

更新日期：2001-12-13 00:00:00

abstract：:Shb is a recently described Src homology 2 (SH2) domain-containing adaptor protein. Here we show that Shb is expressed in lymphoid tissues, and is recruited into signaling complexes upon activation of Jurkat T cells. Grb2 binds proline-rich motifs in Shb via its SH3 domains. As a result, a number of proteins detected ...

journal_title：Oncogene

authors： Welsh M,Songyang Z,Frantz JD,Trüb T,Reedquist KA,Karlsson T,Miyazaki M,Cantley LC,Band H,Shoelson SE

更新日期：1998-02-19 00:00:00

abstract：:The cell polarity regulator, human Scribble (hScrib), is a potential tumour suppressor whose loss is a frequent event in late-stage cancer development. Little is yet known about the mode of action of hScrib, although recent reports suggest its role in the regulation of cell signalling. In this study we show that hScri...

journal_title：Oncogene

authors： Nagasaka K,Pim D,Massimi P,Thomas M,Tomaić V,Subbaiah VK,Kranjec C,Nakagawa S,Yano T,Taketani Y,Myers M,Banks L

更新日期：2010-09-23 00:00:00

abstract：:Histone acetyltransferases (HATs) have a central role in the modification of chromatin as well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first identified transcription-related HAT that has been implicated in the regulation of diverse cellular functions. However, how Gcn5 proteins...

journal_title：Oncogene

authors： Li Y,Jaramillo-Lambert AN,Yang Y,Williams R,Lee NH,Zhu W

更新日期：2012-02-02 00:00:00