Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline.

abstract：:Checkpoint protein Chk1 has been identified as an Hsp90 client. Treatment with 100 nM geldanamycin (GM) for 24 h markedly reduced the Chk1 amount in Jurkat and ML-1 leukemia cell lines. Because Chk1 plays a central role in G2 checkpoint, we added GM to G2-arrested Jurkat and HL-60 cells pretreated with 50 nM doxorubic...

journal_title：Oncogene

authors： Sugimoto K,Sasaki M,Isobe Y,Tsutsui M,Suto H,Ando J,Tamayose K,Ando M,Oshimi K

更新日期：2008-05-15 00:00:00

abstract：:Here we report that ALDH1L1 (FDH, a folate enzyme with tumor suppressor-like properties) inhibits cell motility. The underlying mechanism involves F-actin stabilization, re-distribution of cytoplasmic actin toward strong preponderance of filamentous actin and formation of actin stress fibers. A549 cells expressing FDH...

journal_title：Oncogene

authors： Oleinik NV,Krupenko NI,Krupenko SA

更新日期：2010-11-25 00:00:00

abstract：:The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and Max proteins have been shown to possess sequence-specific DNA-binding act...

journal_title：Oncogene

authors： Gilladoga AD,Edelhoff S,Blackwood EM,Eisenman RN,Disteche CM

更新日期：1992-06-01 00:00:00

abstract：:Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribution of the Na+,HCO3--cotransporter NBCn1 (Slc4a7) to intracellular a...

journal_title：Oncogene

authors： Lee S,Axelsen TV,Jessen N,Pedersen SF,Vahl P,Boedtkjer E

更新日期：2018-10-01 00:00:00

abstract：:We examined the biological role of p12(CDK2-AP1) in cisplatin-mediated responses by using murine ES p12(CDK2-AP1) knockout clones generated by a targeted disruption of murine p12(CDK2-AP1). Homozygous knockout clones showed an increased cellular proliferation along with an increase in S and a decrease in G2/M phase po...

journal_title：Oncogene

authors： Kim Y,McBride J,Zhang R,Zhou X,Wong DT

更新日期：2005-01-13 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation...

journal_title：Oncogene

authors： Altieri DC

更新日期：2003-11-24 00:00:00

abstract：:Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by ...

journal_title：Oncogene

authors： Gupta A,Jha S,Engel DA,Ornelles DA,Dutta A

更新日期：2013-10-17 00:00:00

abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

journal_title：Oncogene

authors： Sachsenmaier C,Sadowski HB,Cooper JA

更新日期：1999-06-17 00:00:00

abstract：:Blockade of the mitogen-activated protein (MAP) kinase pathway suppresses growth of colon cancer in vivo. Here we demonstrate a direct link between the extracellular signal-regulated kinase ERK2 and the growth-promoting cell adhesion molecule, integrin alphavbeta6, in colon cancer cells. Down-regulation of beta6 integ...

journal_title：Oncogene

authors： Ahmed N,Niu J,Dorahy DJ,Gu X,Andrews S,Meldrum CJ,Scott RJ,Baker MS,Macreadie IG,Agrez MV

更新日期：2002-02-21 00:00:00

abstract：:Chromosome 1p36.23 is frequently deleted in glioblastoma multiforme (GBM). miR-34a localizes in this region. Our experiments found that miR-34a was often deleted and epidermal growth factor receptor (EGFR) was frequently amplified in genomic DNA of 55 GBMs using single-nucleotide polymorphism DNA microarray. Notably, ...

journal_title：Oncogene

authors： Yin D,Ogawa S,Kawamata N,Leiter A,Ham M,Li D,Doan NB,Said JW,Black KL,Phillip Koeffler H

更新日期：2013-02-28 00:00:00

abstract：:Stat3 (signal transducer and activator of transcription-3) activity is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic transformation. Although in most instances Stat3 is growth-promoting, the impact of cell density on Stat3 act...

journal_title：Oncogene

authors： Vultur A,Cao J,Arulanandam R,Turkson J,Jove R,Greer P,Craig A,Elliott B,Raptis L

更新日期：2004-04-08 00:00:00

abstract：:Tumor suppressor Pdcd4 has recently been shown to inhibit invasion by activating activator protein-1 (AP-1); however, little is known of the functionally significant Pdcd4-target genes. The urokinase receptor (u-PAR) promotes invasion/metastasis, and is associated with poor cancer-patient survival. The present study w...

journal_title：Oncogene

authors： Leupold JH,Yang HS,Colburn NH,Asangani I,Post S,Allgayer H

更新日期：2007-07-05 00:00:00

abstract：:The steady-state levels of p53 mRNA were dramatically lower in immortal chicken embryo fibroblast (CEF) cell lines compared to primary CEF cells. In the presence of cycloheximide (CHX), the steady-state levels of p53 mRNA markedly increased in immortal CEF cell lines, similar to levels found in primary cells. The de n...

journal_title：Oncogene

authors： Kim H,You S,Foster LK,Farris J,Foster DN

更新日期：2001-08-23 00:00:00

abstract：:For many years the precise genetic etiology of the majority of Wilms' tumors has remained unexplained. Recently, the WTX gene, mapped to chromosome Xq11.1, has been reported to be lost or mutated in approximately one-third of Wilms' tumors. Moreover, in female cases, the somatically inactivated alleles were found to i...

journal_title：Oncogene

authors： Perotti D,Gamba B,Sardella M,Spreafico F,Terenziani M,Collini P,Pession A,Nantron M,Fossati-Bellani F,Radice P

更新日期：2008-07-31 00:00:00

abstract：:Activation of the Met tyrosine kinase growth factor receptor by its ligand HGF/SF has been shown to increase in vitro invasiveness in epithelial cell lines. To study the effect of Met-HGF/SF signaling in breast cancer cells, we transfected met, hgf/sf and dominant negative (DN) forms of met into the poorly differentia...

journal_title：Oncogene

authors： Firon M,Shaharabany M,Altstock RT,Horev J,Abramovici A,Resau JH,Vande Woude GF,Tsarfaty I

更新日期：2000-05-11 00:00:00

abstract：:BCL11 genes play crucial roles in lymphopoiesis and have been associated with hematopoietic malignancies. Specifically, disruption of the BCL11B (B-cell chronic lymphocytic leukemia/lymphoma 11B) locus is linked to T-cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T-cell lymphoma. ...

journal_title：Oncogene

authors： Cismasiu VB,Adamo K,Gecewicz J,Duque J,Lin Q,Avram D

更新日期：2005-10-13 00:00:00

abstract：:The c-fos proto-oncogene is found to be overexpressed at least 30-fold in SMS-SB, a pre-B leukemic cell line compared to other cell types. No gross alteration of the c-fos gene structure in SMS-SB cells can be detected by karyotypic or Southern analyses. C-fos in SMS-SB cells can still be induced by serum, TPA and the...

journal_title：Oncogene

authors： Tsai LH,Nanu L,Smith RG,Ozanne B

更新日期：1991-01-01 00:00:00

abstract：:Although the prognosis of advanced extramammary Paget's disease (EMPD) is poor, there have been no preclinical research models for the development of novel therapeutics. This study aims to establish a preclinical research model for EMPD. We transplanted EMPD tissue into immunodeficient NOD/Scid mice. Histopathological...

journal_title：Oncogene

authors： Maeda T,Kitamura S,Nishihara H,Yanagi T

更新日期：2020-09-01 00:00:00

abstract：:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Harkin DP

更新日期：2006-09-25 00:00:00

abstract：:Although it has been demonstrated that transformed progenitor cell population can contribute to tumor initiation, factors contributing to this malignant transformation are poorly known. Using in vitro and xenograft-based models, previous studies demonstrated that miR-489 acts as a tumor suppressor miRNA by targeting v...

journal_title：Oncogene

authors： Patel Y,Soni M,Awgulewitsch A,Kern MJ,Liu S,Shah N,Singh UP,Chen H

更新日期：2019-01-01 00:00:00

abstract：:RRR-alpha-tocopheryl succinate (alpha-vitamin E succinate, VES), one of the vitamin E derivatives, can effectively inhibit the proliferation of human prostate cancer cells. However, little is known about its effect on prostate cancer cell invasive ability. Tumor metastasis is a complex process and the extracellular ma...

journal_title：Oncogene

authors： Zhang M,Altuwaijri S,Yeh S

更新日期：2004-04-15 00:00:00

abstract：:Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however,...

journal_title：Oncogene

authors： Lan Q,Peyvandi S,Duffey N,Huang YT,Barras D,Held W,Richard F,Delorenzi M,Sotiriou C,Desmedt C,Lorusso G,Rüegg C

更新日期：2019-04-01 00:00:00

abstract：:The v-Myb oncogene causes monoblastic leukemia and transforms only myelomonocytic cells in culture. The v-Myb protein is nuclear and binds to specific DNA sequences. To identify genes regulated by v-Myb, we utilized primary cells transformed by a retrovirus encoding a v-Myb-estrogen receptor (ER) fusion protein. The E...

journal_title：Oncogene

authors： Wang DM,Sevcikova S,Wen H,Roberts S,Lipsick JS

更新日期：2007-02-22 00:00:00

abstract：:Artemis is a multifunctional phospho-protein with roles in V(D)J recombination, repair of double-strand breaks by nonhomologous end-joining and regulation of cell-cycle checkpoints after DNA damage. Here, we describe a new function of Artemis as a negative regulator of p53 in response to oxidative stress in both prima...

journal_title：Oncogene

authors： Zhang X,Zhu Y,Geng L,Wang H,Legerski RJ

更新日期：2009-06-04 00:00:00

abstract：:Myogenic transcription is repressed in myoblasts by serum-activated cyclin-dependent kinases, such as cdk2 and cdk4. Serum withdrawal promotes muscle-specific gene expression at least in part by down-regulating the activity of these cdks. Unlike the other cdks, cdk9 is not serum- or cell cycle-regulated and is instead...

journal_title：Oncogene

authors： Simone C,Stiegler P,Bagella L,Pucci B,Bellan C,De Falco G,De Luca A,Guanti G,Puri PL,Giordano A

更新日期：2002-06-13 00:00:00

abstract：:The gfi-1 gene encodes a zinc finger containing protein that is specifically expressed in T-lymphocytes and is a frequent target of proviral insertion in T-cell lymphoma provoked by infection with MoMuLV--a non acute transforming retrovirus. Expression of a gfi-1 transgene targeted to T-cells by the lck proximal promo...

journal_title：Oncogene

authors： Schmidt T,Karsunky H,Gau E,Zevnik B,Elsässer HP,Möröy T

更新日期：1998-11-19 00:00:00

abstract：:Several lines of evidence suggest that gastrin and the CCK-2 receptor (CCK2R) could contribute to pancreatic carcinogenesis by modulating processes such as proliferation, cell adhesion or migration. In the current study, we used a 'cancer gene array' and identified beta1-integrin subunit as a new gastrin-regulated gen...

journal_title：Oncogene

authors： Cayrol C,Clerc P,Bertrand C,Gigoux V,Portolan G,Fourmy D,Dufresne M,Seva C

更新日期：2006-07-27 00:00:00

abstract：:After publication of this Article, the Authors noticed errors in some of the Figures. In Figures 2e, 2f-g, 4a, 4j, 5a and 6b, unmatched β-actin was inadvertently used as loading control for the immunoblots. These have been corrected using repeat data from a similar set of samples and the revised Figures containing mat...

journal_title：Oncogene

authors： Vantaku V,Putluri V,Bader DA,Maity S,Ma J,Arnold JM,Rajapakshe K,Donepudi SR,von Rundstedt FC,Devarakonda V,Dubrulle J,Karanam B,McGuire SE,Stossi F,Jain AK,Coarfa C,Cao Q,Sikora AG,Villanueva H,Kavuri SM,Lotan Y

更新日期：2020-10-01 00:00:00

abstract：:Leukemogenesis requires two classes of mutations, one that promotes proliferation and one that blocks differentiation. The erythroleukemia induced by Friend virus is a multistage disease characterized by an early proliferative stage driven by the interaction of the viral glycoprotein, gp55, with Sf-Stk and the EpoR, a...

journal_title：Oncogene

authors： Hegde S,Ni S,He S,Yoon D,Feng GS,Watowich SS,Paulson RF,Hankey PA

更新日期：2009-09-24 00:00:00

abstract：:Cancer cells show deviant behavior that induces apoptotic signaling. To survive, cancer cells typically acquire changes enabling evasion of death signals. One way they do this is by increasing the expression of anti-apoptotic BCL-2 proteins. Anti-apoptotic BCL-2 family proteins antagonize death signaling by forming he...

journal_title：Oncogene

authors： Ni Chonghaile T,Letai A

更新日期：2008-12-01 00:00:00