Abstract:
:The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and Max proteins have been shown to possess sequence-specific DNA-binding activity. Here we report the mapping of the MAX gene to a single region on human chromosome 14 (bands q22-q24) and to mouse chromosome 12 (region D). Chromosome abnormalities linked to several neoplasms have been previously associated with this region on human chromosome 14. The mapping results also confirm a region of homology between human chromosome 14q22-24 and mouse chromosome 12 region D.
journal_name
Oncogenejournal_title
Oncogeneauthors
Gilladoga AD,Edelhoff S,Blackwood EM,Eisenman RN,Disteche CMsubject
Has Abstractpub_date
1992-06-01 00:00:00pages
1249-51issue
6eissn
0950-9232issn
1476-5594journal_volume
7pub_type
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