Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.

abstract：:Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...

journal_title：Oncogene

authors： Liu SK,Berry DM,McGlade CJ

更新日期：2001-10-01 00:00:00

abstract：:Oncogenic forms of the c-myb protein (Myb) often exhibit amino-terminal and/or carboxyl-terminal truncations. When the transcriptional activity of these proteins was examined it was found that carboxyl-truncated Myb is more effective as a transcriptional activator than full-length or amino-truncated Myb. In order to d...

journal_title：Oncogene

authors： Ramsay RG,Ishii S,Gonda TJ

更新日期：1991-10-01 00:00:00

abstract：:Topoisomerase IIalpha (topoIIalpha) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry because of insuffici...

journal_title：Oncogene

authors： Bower JJ,Karaca GF,Zhou Y,Simpson DA,Cordeiro-Stone M,Kaufmann WK

更新日期：2010-08-26 00:00:00

abstract：:The transcriptional activity of the androgen receptor (AR) is regulated by both ligand binding and post-translational modifications, including acetylation and small ubiquitin-like modifier (SUMO)ylation. Histone deacetylases (HDACs) are known to catalyze the removal of acetyl groups from both histones and non-histone ...

journal_title：Oncogene

authors： Yang Y,Tse AK,Li P,Ma Q,Xiang S,Nicosia SV,Seto E,Zhang X,Bai W

更新日期：2011-05-12 00:00:00

abstract：:The expression of normal and mutant ras genes in human acute leukemias was assessed by the direct analysis of p21ras polypeptides, using immunoprecipitation with monoclonal antibodies. High-resolution two-dimensional gel electrophoresis permits the identification of a wide array of activated ras alleles encoding prote...

journal_title：Oncogene

authors： Shen WP,Aldrich TH,Venta-Perez G,Franza BR Jr,Furth ME

更新日期：1987-05-01 00:00:00

abstract：:Abundant data support a key role for the transcription factor nuclear factor-kappaB (NF-kappaB) signaling pathway in controlling the initiation and progression of human cancer. NF-kappaB and associated regulatory proteins such as IkappaB kinase (IKK) are activated downstream of many oncoproteins and there is much evid...

journal_title：Oncogene

authors： Bassères DS,Baldwin AS

更新日期：2006-10-30 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of critical cell processes such as apoptosis, cell proliferation and differentiation. A small set of miRNAs is differentially expressed in hematopoietic cells and seemingly has an important role in granulopoiesis and lineage differentiation. In th...

journal_title：Oncogene

authors： Careccia S,Mainardi S,Pelosi A,Gurtner A,Diverio D,Riccioni R,Testa U,Pelosi E,Piaggio G,Sacchi A,Lavorgna S,Lo-Coco F,Blandino G,Levrero M,Rizzo MG

更新日期：2009-11-12 00:00:00

abstract：:Loss of PTEN tumor suppressor enhances metastatic risk in breast cancer, although the underlying mechanisms are poorly defined. We report that homozygous deletion of PTEN in mammary epithelial cells induces tubulin-based microtentacles (McTNs) that facilitate cell reattachment and homotypic aggregation. Treatment with...

journal_title：Oncogene

authors： Vitolo MI,Boggs AE,Whipple RA,Yoon JR,Thompson K,Matrone MA,Cho EH,Balzer EM,Martin SS

更新日期：2013-04-25 00:00:00

abstract：:Constitutive NF-kappaB activity varies widely among cancer cell lines. In this report, we studied the expression and the role of different I kappaB inhibitors in adenocarcinoma cell lines. High constitutive NF-kappaB activity and low I kappaB-alpha expression was found in a number of these cell lines. Moreover, some o...

journal_title：Oncogene

authors： Dejardin E,Deregowski V,Chapelier M,Jacobs N,Gielen J,Merville MP,Bours V

更新日期：1999-04-22 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Oncogene

authors： Wang K,Ji W,Yu Y,Li Z,Niu X,Xia W,Lu S

更新日期：2020-10-01 00:00:00

abstract：:Basic helix-loop-helix (bHLH) transcription factors play a pivotal role in the regulation of tumorigenesis, and also in a wide range of other developmental processes in diverse species from yeast to humans. Here we demonstrate for the first time that Ret finger protein (RFP), a member of the TRIM family of proteins in...

journal_title：Oncogene

authors： Bloor AJ,Kotsopoulou E,Hayward P,Champion BR,Green AR

更新日期：2005-10-13 00:00:00

abstract：:The integrin linked kinase (ILK) is a cytoplasmic effector of integrin receptors, involved in the regulation of integrin binding properties as well as the activation of cell survival and proliferative pathways, including those involving MAP kinase, PKB/Akt and GSK-3beta. Overexpression of ILK in cultured intestinal an...

journal_title：Oncogene

authors： White DE,Cardiff RD,Dedhar S,Muller WJ

更新日期：2001-10-25 00:00:00

abstract：:Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin rec...

journal_title：Oncogene

authors： Langlais P,Dong LQ,Hu D,Liu F

更新日期：2000-06-08 00:00:00

abstract：:Loss of the tumor suppressive effect of transforming growth factor-beta (TGF-beta) has been commonly found at later stages in carcinogenic progression. Although the genes encoding TGF-beta receptors and Smads have been found genetically altered in certain human cancers, no mutation in Smad3 has been observed. Therefor...

journal_title：Oncogene

authors： Han SU,Kim HT,Seong DH,Kim YS,Park YS,Bang YJ,Yang HK,Kim SJ

更新日期：2004-02-19 00:00:00

abstract：:Tumor-derived DNA from a non-Hodgkin's (T cell) lymphoma patient, assayed by NIH3T3 transfection followed by inoculation of cells into nude mice, was found to contain an activated N-ras proto-oncogene. The mode of activation was determined by hybridization with N-ras-specific oligonucleotide probes detecting mutations...

journal_title：Oncogene

authors： Wodnar-Filipowicz A,Senn HP,Jiricny J,Signer E,Moroni C

更新日期：1987-01-01 00:00:00

abstract：:A key hallmark of many cancers, particularly the most aggressive, is the capacity to metabolize glucose at an elevated rate, a phenotype detected clinically using positron emission tomography (PET). This phenotype provides cancer cells, including those that participate in metastasis, a distinct competitive edge over n...

journal_title：Oncogene

authors： Mathupala SP,Ko YH,Pedersen PL

更新日期：2006-08-07 00:00:00

abstract：:We previously reported the presence of mitotic check-point impairment in about 40% of lung cancer cell lines. To gain an insight into the molecular basis of this impairment, we examined 49 lung cancer specimens for alterations in the hMAD1 mitotic checkpoint gene and identified a somatic, non-conservative missense mut...

journal_title：Oncogene

authors： Nomoto S,Haruki N,Takahashi T,Masuda A,Koshikawa T,Takahashi T,Fujii Y,Osada H,Takahashi T

更新日期：1999-11-25 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non-PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that ...

journal_title：Oncogene

authors： Totani H,Shinjo K,Suzuki M,Katsushima K,Mase S,Masaki A,Ito A,Ri M,Kusumoto S,Komatsu H,Ishida T,Inagaki H,Iida S,Kondo Y

更新日期：2020-08-01 00:00:00

abstract：:While advances in laboratory automation has dramatically increased throughout of compound screening efforts, development of robust cell-based assays in relevant disease models remain resource-intensive and time-consuming, presenting a bottleneck to drug discovery campaigns. To address this issue, we present a modified...

journal_title：Oncogene

authors： Morris SM,Mhyre AJ,Carmack SS,Myers CH,Burns C,Ye W,Ferrer M,Olson JM,Klinghoffer RA

更新日期：2018-08-01 00:00:00

abstract：:We have recently described the N-terminal RAS association domain family of genes, RASSF7-10. Previously, we cloned the N-terminal RASSF10 gene and demonstrated frequent methylation of the associated 5'-CpG island in acute lymphoblastic leukemia. To characterize RASSF10 gene expression, we demonstrate that in developin...

journal_title：Oncogene

authors： Hill VK,Underhill-Day N,Krex D,Robel K,Sangan CB,Summersgill HR,Morris M,Gentle D,Chalmers AD,Maher ER,Latif F

更新日期：2011-02-24 00:00:00

abstract：:To understand the mechanism of interferon (IFN)-mediated suppression of cell cycle progression, we have earlier shown that IFN-alpha enhances the expression of underphosphorylated retinoblastoma protein by inhibiting the cyclin-dependent kinase-2 (CDK-2) activity (Kumar and Atlas, Proc. Natl. Acad. Sci. 89, 6599-6603,...

journal_title：Oncogene

authors： Mandal M,Bandyopadhyay D,Goepfert TM,Kumar R

更新日期：1998-01-15 00:00:00

abstract：:Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell a...

journal_title：Oncogene

authors： Godin-Heymann N,Brabetz S,Murillo MM,Saponaro M,Santos CR,Lobley A,East P,Chakravarty P,Matthews N,Kelly G,Jordan S,Castellano E,Downward J

更新日期：2016-06-23 00:00:00

abstract：:Protein kinase C (PKC)ɛ, a member of the novel PKC family, has key roles in mitogenesis and survival in normal and cancer cells. PKCɛ is frequently overexpressed in epithelial cancers, particularly in lung cancer. Using a short-hairpin RNA approach, here we established that PKCɛ is required for non-small cell lung car...

journal_title：Oncogene

authors： Caino MC,Lopez-Haber C,Kim J,Mochly-Rosen D,Kazanietz MG

更新日期：2012-05-17 00:00:00

abstract：:Keratinocyte growth factor is a potent and specific mitogen for different types of epithelial cells, including keratinocytes of the skin. Furthermore, it has been implicated in morphogenetic processes of several organs. To further define the mechanisms of KGF action in the skin, we attempted to identify genes which ar...

journal_title：Oncogene

authors： Frank S,Munz B,Werner S

更新日期：1997-02-27 00:00:00

abstract：:The trans-activator protein, tax, from the human T leukemia virus type 1 (HTLV-1) trans-activates both viral and cellular genes. It has previously been shown that granulocyte macrophage-colony stimulating factor (GM-CSF) is constitutively expressed in HTLV-1 infected cells and in cells artificially expressing tax. We ...

journal_title：Oncogene

authors： Himes SR,Coles LS,Katsikeros R,Lang RK,Shannon MF

更新日期：1993-12-01 00:00:00

abstract：:Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the critical type-I PKA ...

journal_title：Oncogene

authors： Beristain AG,Molyneux SD,Joshi PA,Pomroy NC,Di Grappa MA,Chang MC,Kirschner LS,Privé GG,Pujana MA,Khokha R

更新日期：2015-02-26 00:00:00

abstract：:From the sequences of Rel/NF-kappa B and I kappa B proteins, we constructed an alignment of their Rel Homology Domain (RHD) and ankyrin repeat domain. Using this alignment, we performed tree reconstruction with both distance matrix and parsimony analysis and estimated the branching robustness using bootstrap resamplin...

journal_title：Oncogene

authors： Huguet C,Crepieux P,Laudet V

更新日期：1997-12-11 00:00:00

abstract：:ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have described iASPP, a ...

journal_title：Oncogene

authors： Slee EA,Gillotin S,Bergamaschi D,Royer C,Llanos S,Ali S,Jin B,Trigiante G,Lu X

更新日期：2004-12-02 00:00:00

abstract：:Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic. These e...

journal_title：Oncogene

authors： Krokan HE,Drabløs F,Slupphaug G

更新日期：2002-12-16 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel isoform abundantly expressed in colon carcinoma cell li...

journal_title：Oncogene

authors： Grassilli E,Pisano F,Cialdella A,Bonomo S,Missaglia C,Cerrito MG,Masiero L,Ianzano L,Giordano F,Cicirelli V,Narloch R,D'Amato F,Noli B,Ferri GL,Leone BE,Stanta G,Bonin S,Helin K,Giovannoni R,Lavitrano M

更新日期：2016-08-18 00:00:00