Abstract:
:Following discovery of c-Cbl, a cellular form of the transforming retroviral protein v-Cbl, multiple Cbl-related proteins have been identified in vertebrate and invertebrate organisms. c-Cbl and its homologues are capable of interacting with numerous proteins involved in cell signaling, including various molecular adapters and protein tyrosine kinases. It appears that Cbl proteins play several functional roles, acting both as multivalent adapters and inhibitors of various protein tyrosine kinases. The latter function is linked, to a substantial extent, to the E3 ubiquitin-ligase activity of Cbl proteins. Experimental evidence for these functions, interrelations between them, and their biological significance are addressed in this review, with the main accent placed on the adapter functions of Cbl proteins.
journal_name
Oncogenejournal_title
Oncogeneauthors
Tsygankov AY,Teckchandani AM,Feshchenko EA,Swaminathan Gdoi
10.1038/sj.onc.1204781subject
Has Abstractpub_date
2001-10-01 00:00:00pages
6382-402issue
44eissn
0950-9232issn
1476-5594journal_volume
20pub_type
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