当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway.

Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway.

Abstract：

:Upregulation and activation of epidermal growth factor receptor and/or urokinase-type plasminogen activator receptor in a variety of cancers have been shown to be associated with poor prognosis. High-molecular-weight kininogen can be hydrolysed by plasma kallikrein to bradykinin and cleaved high-molecular-weight kininogen (HKa). HKa and its domain 5 (D5) both have been shown to have potent anti-angiogenic activity. We now show that HKa blocks human prostate cancer cell (DU145) migration by 76.0+/-2.4% at 300 nM and invasion by 78.0+/-12.9% at 11.1 nM. D5 inhibits tumor migration and invasion in a concentration-dependent manner. Stimulation by basic fibroblast growth factor (bFGF) or vascular endothelial growth factor results in clustering of urokinase-type plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) on the surface of DU145 cells. The co-localization of uPAR and EGFR is prevented by HKa. Immunoprecipitation suggests that uPAR, EGFR and alpha5beta1 integrin formed a ternary complex. Immunoblotting shows that HKa significantly decreases the bFGF-transactivated phosphorylation of EGFR at Tyr 1173 between 30 min and 4 h. The phosphorylation of extracellular signal-regulated kinase (ERK) and AKT, which are downstream effectors of EGFR, is also inhibited by HKa. These novel data indicate that HKa and D5 inhibit migration and invasion of human prostate cancer cells through an EGFR/uPAR pathway, suggesting the therapeutic potential of HKa and D5 to decrease metastasis of human prostate cancer.

journal_name

Oncogene

journal_title

Oncogene

authors

Liu Y,Pixley R,Fusaro M,Godoy G,Kim E,Bromberg ME,Colman RW

doi

10.1038/onc.2009.132

subject

Has Abstract

pub_date

2009-07-30 00:00:00

pages

2756-65

issue

30

eissn

0950-9232

issn

1476-5594

pii

onc2009132

journal_volume

28

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Cell-cycle progression is not essential for c-Myc to block differentiation.

    abstract：:The c-myc proto-oncogene has been shown to cause blockages to differentiation in many cell lineages. Although the mechanism by which c-Myc affects this process remains unknown, it is considered that it might result indirectly as an outcome of the continued cell-cycle progression invoked by c-Myc in cells which must gr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201124

    authors： Ryan KM,Birnie GD

    更新日期：1997-06-12 00:00:00

  • Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth.

    abstract：:AP-1 transcription factors play a critical role in signal transduction pathways in many cells. We have investigated the role of AP-1 in controlling proliferative signals in breast cells, and have previously shown that AP-1 complexes are activated by peptide and steroid growth factors in both normal and malignant breas...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205883

    authors： Liu Y,Ludes-Meyers J,Zhang Y,Munoz-Medellin D,Kim HT,Lu C,Ge G,Schiff R,Hilsenbeck SG,Osborne CK,Brown PH

    更新日期：2002-10-31 00:00:00

  • KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC.

    abstract：:During the evolution into castration or therapy resistance, prostate cancer cells reprogram the androgen responses to cope with the diminishing level of androgens, and undergo metabolic adaption to the nutritionally deprived and hypoxia conditions. AR (androgen receptor) and PKM2 (pyruvate kinase M2) have key roles in...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0414-x

    authors： Wang HJ,Pochampalli M,Wang LY,Zou JX,Li PS,Hsu SC,Wang BJ,Huang SH,Yang P,Yang JC,Chu CY,Hsieh CL,Sung SY,Li CF,Tepper CG,Ann DK,Gao AC,Evans CP,Izumiya Y,Chuu CP,Wang WC,Chen HW,Kung HJ

    更新日期：2019-01-01 00:00:00

  • Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.

    abstract：:The NAD-dependent deacetylase sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, plays a pivotal role in deacetylating histone and nonhistone proteins. Recently, it has been reported that SIRT1 is upregulated in various kinds of tumors and is associated with cell growth and metastasis. However, the factors a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-1298-0

    authors： Yu L,Dong L,Li H,Liu Z,Luo Z,Duan G,Dai X,Lin Z

    更新日期：2020-05-01 00:00:00

  • Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma.

    abstract：:The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma. In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Clark J,Benjamin H,Gill S,Sidhar S,Goodwin G,Crew J,Gusterson BA,Shipley J,Cooper CS

    更新日期：1996-01-18 00:00:00

  • Stimulation of the mitogen-activated protein kinase pathway antagonizes TRAIL-induced apoptosis downstream of BID cleavage in human breast cancer MCF-7 cells.

    abstract：:We studied the role of the mitogen-activated protein kinase (MAPK) pathway in the regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in breast tumor MCF-7 cells. We found that addition of a protein kinase C (PKC) activator to MCF-7 cultures prevented TRAIL-induced apoptosi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205523

    authors： Sarker M,Ruiz-Ruiz C,Robledo G,López-Rivas A

    更新日期：2002-06-20 00:00:00

  • Regulation of autophagy by ATF4 in response to severe hypoxia.

    abstract：:Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we have used small inter...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.191

    authors： Rzymski T,Milani M,Pike L,Buffa F,Mellor HR,Winchester L,Pires I,Hammond E,Ragoussis I,Harris AL

    更新日期：2010-08-05 00:00:00

  • The Phox2B homeobox gene is mutated in sporadic neuroblastomas.

    abstract：:Neuroblastomas are embryonal tumours of the sympatho-adrenal lineage with a clinical course ranging from spontaneous regression to fatal progression. The Phox2B homeobox transcription factor functions in the differentiation of the sympatho-adrenal lineage. Targets of Phox2B are, for example, genes of the (nor)adrenali...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208157

    authors： van Limpt V,Schramm A,van Lakeman A,Sluis P,Chan A,van Noesel M,Baas F,Caron H,Eggert A,Versteeg R

    更新日期：2004-12-09 00:00:00

  • Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death.

    abstract：:We have analysed the importance of proper substrate methylation by S-adenosylmethionine-dependent methyltransferases for cell survival and cell cycle progression. We show that treatment of cells with the methyltransferase inhibitor adenosine dialdehyde (AdOx) causes cell cycle arrest and death in different cell types....

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208855

    authors： Schwerk C,Schulze-Osthoff K

    更新日期：2005-10-27 00:00:00

  • Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.

    abstract：:The BNLF-1 protein is the only non-nuclear Epstein-Barr virus (EBV) encoded protein that has been detected in B-lymphocytes immortalized by EBV. We demonstrate that the BNLF-1 gene induces anchorage-independent growth and tumorigenic transformation of the murine cell-line, Balb/3T3. This demonstration extends the earl...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Baichwal VR,Sugden B

    更新日期：1988-05-01 00:00:00

  • CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis.

    abstract：:Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed t...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209183

    authors： Howlin J,McBryan J,Napoletano S,Lambe T,McArdle E,Shioda T,Martin F

    更新日期：2006-03-09 00:00:00

  • Tamoxifen induces p21WAF1 and p27KIP1 expression in estrogen receptor-negative lung cancer cells.

    abstract：:Tamoxifen (Tam), besides its action as an anti-estrogen, also inhibits cell proliferation of estrogen receptor (ER)-negative cancer cells by an unknown mechanism. In this study, we used ER-negative lung cancer cells to clarify such ER-independent inhibitory effect of Tam. We found that Tam induced G1 growth arrest in ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202755

    authors： Lee TH,Chuang LY,Hung WC

    更新日期：1999-07-22 00:00:00

  • Correction: ASPM promotes prostate cancer stemness and progression by augmenting Wnt-Dvl-3-β-catenin signaling.

    abstract：:In the published version of this paper the author Shu-Pin Huang's surname was incorrectly given as Hwang instead of Huang. This has now been corrected in the HTML and PDF versions of the paper. ...

    journal_title：Oncogene

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41388-018-0561-0

    authors： Pai VC,Hsu CC,Chan TS,Liao WY,Chuu CP,Chen WY,Li CR,Lin CY,Huang SP,Chen LT,Tsai KK

    更新日期：2019-02-01 00:00:00

  • Differential induction of c-fos and c-jun proto-oncogenes and AP-1 activity by tumor promoter 12-O-tetradecanoyl phorbol 13-acetate in cells at different stages of tumor promotion in vitro.

    abstract：:A two-stage (initiation and promotion) model of chemical transformation of mouse embryonic fibroblasts was used to elucidate the molecular mechanisms of tumor promotion in vitro. C3H10T1/2 cells which had been initiated with a subcarcinogenic dose (0.5 micrograms ml-1) of benzo[a]pyrene (B[a]P) were isolated after 12-...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Wu WS,Lin JK,Wu FY

    更新日期：1992-11-01 00:00:00

  • Isolation of chromosome-specific DNA sequences from an Alu polymerase chain reaction library to define the breakpoint in a patient with a constitutional translocation t(1;13) (q22;q12) and ganglioneuroblastoma.

    abstract：:We describe the cytogenetic and molecular characterization of a t(1;13)(q22;q12) constitutional rearrangement occurring in a patient with a relatively benign form of neuroblastoma, called ganglioneuroblastoma. Somatic cell hybrids were generated between mouse 3T3 cells and a lymphoblastoid cell line from this patient,...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Michalski AJ,Cotter FE,Cowell JK

    更新日期：1992-08-01 00:00:00

  • Apc deficiency predisposes to renal carcinoma in the mouse.

    abstract：:Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transg...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208956

    authors： Sansom OJ,Griffiths DF,Reed KR,Winton DJ,Clarke AR

    更新日期：2005-12-08 00:00:00

  • The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells.

    abstract：:The cytoplasmic tyrosine kinase Src has been implicated in signal transduction induced by growth factors and integrins. Src also shows oncogenic activity when deregulated. Accumulating evidence indicates that the tyrosine kinase Abl is an important substrate for Src signalling in normal cells. Here we show that Abl is...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210543

    authors： Sirvent A,Boureux A,Simon V,Leroy C,Roche S

    更新日期：2007-11-15 00:00:00

  • Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways.

    abstract：:IL-4 and IL-13 are related cytokines which induce both pro- and anti-inflammatory effects depending on the cell type they act upon and the nature of the receptors expressed. The type I receptor complex is composed of the IL-4Ralpha and gammac and only binds IL-4, whereas, in the type II receptor, IL-4Ralpha dimerizes ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204629

    authors： David M,Ford D,Bertoglio J,Maizel AL,Pierre J

    更新日期：2001-10-11 00:00:00

  • Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells.

    abstract：:As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiat...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.74

    authors： Kim KW,Moretti L,Mitchell LR,Jung DK,Lu B

    更新日期：2010-06-03 00:00:00

  • Serum induction of the fibroblast growth factor-binding protein (FGF-BP) is mediated through ERK and p38 MAP kinase activation and C/EBP-regulated transcription.

    abstract：:The fibroblast growth factor-binding protein (FGF-BP) modulates FGF activity through binding and release from the extracellular matrix. Consequently, the expression of FGF-BP in certain tumor types is a rate-limiting regulator of FGF-mediated angiogenesis. FGF-BP is upregulated in squamous cell carcinoma by treatment ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204249

    authors： Harris VK,Kagan BL,Ray R,Coticchia CM,Liaudet-Coopman ED,Wellstein A,Tate Riegel A

    更新日期：2001-03-29 00:00:00

  • Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cells.

    abstract：:Constitutive NF-kappaB activity varies widely among cancer cell lines. In this report, we studied the expression and the role of different I kappaB inhibitors in adenocarcinoma cell lines. High constitutive NF-kappaB activity and low I kappaB-alpha expression was found in a number of these cell lines. Moreover, some o...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202599

    authors： Dejardin E,Deregowski V,Chapelier M,Jacobs N,Gielen J,Merville MP,Bours V

    更新日期：1999-04-22 00:00:00

  • Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein-protein interactions.

    abstract：:LASP-1 is a multidomain protein predominantly localized at focal contacts, where it regulates cytoskeleton dynamics and cell migration. However, in different tumor entities, a nuclear LASP-1 accumulation is observed, thought to have an important role in cancer progression. Until now, the molecular mechanisms that cont...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2012.216

    authors： Mihlan S,Reiß C,Thalheimer P,Herterich S,Gaetzner S,Kremerskothen J,Pavenstädt HJ,Lewandrowski U,Sickmann A,Butt E

    更新日期：2013-04-18 00:00:00

  • Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype.

    abstract：:Bloom syndrome and ataxia-telangiectasia are autosomal recessive human disorders characterized by immunodeficiency, genome instability and predisposition to develop cancer. Recent data reveal that the products of these two genes, BLM and ATM, interact and function together in recognizing abnormal DNA structures. To in...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207276

    authors： Fukao T,Chen P,Ren J,Kaneko H,Zhang GX,Kondo M,Yamamoto K,Furuichi Y,Takeda S,Kondo N,Lavin MF

    更新日期：2004-02-26 00:00:00

  • Identification of two translational products for c-myb.

    abstract：:The c-myb gene is the normal cellular homolog of v-myb, the oncogenic component of Avian Myeloblastosis Virus (AMV). The c-myb gene has previously been shown to code for a single protein species of about 75 kd. However, accumulating evidence indicates that this gene could code for multiple mRNAs as a result of differe...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Dudek H,Reddy EP

    更新日期：1989-09-01 00:00:00

  • β2-AR signaling controls trastuzumab resistance-dependent pathway.

    abstract：:Currently, trastuzumab resistance is a major clinical problem in the treatment of Her2-overexpressing breast cancer. The underlying molecular mechanisms are not fully understood. Our previous study demonstrates that β2-adrenergic receptor (β2-AR) and Her2 comprise a positive feedback loop in human breast cancer cells ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2015.58

    authors： Liu D,Yang Z,Wang T,Yang Z,Chen H,Hu Y,Hu C,Guo L,Deng Q,Liu Y,Yu M,Shi M,Du N,Guo N

    更新日期：2016-01-07 00:00:00

  • Transactivation of host and viral genes by the adenovirus E1B 19K tumor antigen.

    abstract：:Adenovirus contains two nuclear oncogenes, the EIA and EIB genes, which cooperatively can transform cells through mechanisms that are not understood. The transcriptional activities of the E1A gene (transactivation and repression) are well studied. Using transient expression assays, we show here that the 19,000-Da E1B ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Herrmann CH,Dery CV,Mathews MB

    更新日期：1987-01-01 00:00:00

  • Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutics-induced apoptosis of human cervical carcinoma cells.

    abstract：:The role of cyclooxygenase-2 (COX-2) in cancer remains controversial. Using cervical carcinoma cells (HeLa), the present study investigates the involvement of COX-2 in apoptosis elicited by the chemotherapeutics paclitaxel, cisplatin and 5-fluorouracil. Each compound led to a profound induction of COX-2 expression and...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210962

    authors： Eichele K,Ramer R,Hinz B

    更新日期：2008-05-08 00:00:00

  • A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma.

    abstract：:Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, ne...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204723

    authors： Tanaka S,Sugimachi K,Saeki H,Kinoshita J,Ohga T,Shimada M,Maehara Y,Sugimachi K

    更新日期：2001-09-06 00:00:00

  • Structure-function analysis of the interaction between Bax and the cytomegalovirus-encoded protein vMIA.

    abstract：:The viral mitochondrial inhibitor of apoptosis (vMIA) encoded by the human cytomegalovirus exerts cytopathic effects and neutralizes the proapoptotic endogenous Bcl-2 family member Bax by recruiting it to mitochondria, inducing its oligomerization and membrane insertion. Using a combination of computational modeling a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210511

    authors： Pauleau AL,Larochette N,Giordanetto F,Scholz SR,Poncet D,Zamzami N,Goldmacher VS,Kroemer G

    更新日期：2007-11-01 00:00:00

  • Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein.

    abstract：:The PLZF gene was identified first by its fusion with the retinoic acid receptor alpha gene in the t(11;17) translocation associated with a retinoic acid resistant form of acute promyelocytic leukemia (APL). It encodes a krüppel-like zinc finger protein with a POZ domain shared with a subset of regulatory proteins inc...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202043

    authors： David G,Alland L,Hong SH,Wong CW,DePinho RA,Dejean A

    更新日期：1998-05-14 00:00:00