Tamoxifen induces p21WAF1 and p27KIP1 expression in estrogen receptor-negative lung cancer cells.

abstract：:Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the BCL-2 dependency of luminal tumor cells is nevertheless mitigated by breast cancer-associated fibroblasts (bCAFs) in a manner that defines MCL-1 as another critical...

journal_title：Oncogene

authors： Louault K,Bonneaud TL,Séveno C,Gomez-Bougie P,Nguyen F,Gautier F,Bourgeois N,Loussouarn D,Kerdraon O,Barillé-Nion S,Jézéquel P,Campone M,Amiot M,Juin PP,Souazé F

更新日期：2019-04-01 00:00:00

abstract：:The microtubule-targeting antineoplastic agent, paclitaxel, is highly efficacious against a wide spectrum of human cancers. However, dose-limiting toxicity and development of drug resistance limit its clinical application. Development of novel strategies that overcome chemoresistance and sensitize cancer cells to pacl...

journal_title：Oncogene

authors： Sreekanth CN,Bava SV,Sreekumar E,Anto RJ

更新日期：2011-07-14 00:00:00

abstract：:An essential mode of acquired resistance to radiotherapy (RT) appears to be promotion of tumor cell motility and invasiveness in various cancer types, including glioblastoma, a process resembling 'evasive resistance'. Hence, a logical advancement of RT would be to identify suitable complementary treatment strategies, ...

journal_title：Oncogene

authors： Weiler M,Pfenning PN,Thiepold AL,Blaes J,Jestaedt L,Gronych J,Dittmann LM,Berger B,Jugold M,Kosch M,Combs SE,von Deimling A,Weller M,Bendszus M,Platten M,Wick W

更新日期：2013-02-28 00:00:00

abstract：:Amplified segments of the long arm of chromosome 12 are frequently observed in human sarcomas. In most cases there are separate amplified regions around the MDM2 and CDK4 genes. Here we show recurrent amplification of a third region encompassing HMGIC, a human architectural transcription factor gene. Reduced amplifica...

journal_title：Oncogene

authors： Berner JM,Meza-Zepeda LA,Kools PF,Forus A,Schoenmakers EF,Van de Ven WJ,Fodstad O,Myklebost O

更新日期：1997-06-19 00:00:00

abstract：:We have identified a novel mechanism of cross-talk between cell signaling and metabolic pathways, whereby the signaling kinase p21-activated kinase 1 (Pak1) binds to, phosphorylates and enhances the enzymatic activity of phosphoglucomutase 1 (PGM), an important regulatory enzyme in cellular glucose utilization and ene...

journal_title：Oncogene

authors： Gururaj A,Barnes CJ,Vadlamudi RK,Kumar R

更新日期：2004-10-21 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine with important roles in regulating inflammatory responses as well as cell cycle proliferation and apoptosis. Although TNFalpha stimulates apoptosis, it also activates the transcription factor NF-kappa B, and studies have shown that inhibition of NF-...

journal_title：Oncogene

authors： Zhou A,Scoggin S,Gaynor RB,Williams NS

更新日期：2003-04-03 00:00:00

abstract：:LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR). Ectopic expression of IRS-1 in LNCaP cells increases cell adhesion a...

journal_title：Oncogene

authors： Reiss K,Wang JY,Romano G,Tu X,Peruzzi F,Baserga R

更新日期：2001-01-25 00:00:00

abstract：:Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis. Previously we reported that FLT3 with ITD (FLT3/ITD) formed a homodimer and was autophosphorylated on tyrosin...

journal_title：Oncogene

authors： Kiyoi H,Ohno R,Ueda R,Saito H,Naoe T

更新日期：2002-04-11 00:00:00

abstract：:Genetic and biochemical evidence suggest that conserved region 3 (CR3) of the adenovirus Ela polypeptide can provide two distinct and separable functions: an N-terminal transcriptional activation region and a C-terminal promoter targeting region. It is thought that the promoter targeting region of Ela CR3 interacts wi...

journal_title：Oncogene

authors： Agoff SN,Wu B

更新日期：1994-12-01 00:00:00

abstract：:The steady-state levels of p53 mRNA and protein were barely detectable by Northern and Western blot analysis in spontaneously immortalized (10)3 and (10)7 murine embryo fibroblast (MEF) cells. But when cells were treated with cycloheximide (CHX) or emetine, expression levels were restored to those observed in primary ...

journal_title：Oncogene

authors： Kim H,You S,Farris J,Foster LK,Foster DN

更新日期：2001-05-31 00:00:00

abstract：:The Src family kinases c-Src, and its downstream effectors, the Rho family of small GTPases RhoA and Jun N-terminal kinase (JNK) have a significant role in tumorigenesis. In this report, using the Drosophila wing disc epithelium as a model system, we demonstrate that the actin-Capping Protein (CP) αβ heterodimer, whic...

journal_title：Oncogene

authors： Fernández BG,Jezowska B,Janody F

更新日期：2014-04-17 00:00:00

abstract：:Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younger people. Compared with most other skin cancers, a feature of melanoma is its high metastatic capacity, although the mechanisms that confer this are not well understood. The Hippo pathway i...

journal_title：Oncogene

authors： Zhang X,Yang L,Szeto P,Abali GK,Zhang Y,Kulkarni A,Amarasinghe K,Li J,Vergara IA,Molania R,Papenfuss AT,McLean C,Shackleton M,Harvey KF

更新日期：2020-07-01 00:00:00

abstract：:We have characterized a chromosomal translocation in a cell line (SU-DUL5) established from a patient with lymphoblastic lymphoma in which the c-myc gene on chromosome 8 was juxtaposed to a t(14;18). Cytogenetic analysis of this cell line showed 14q+, 18q-, and 8p+q+ marker chromosomes in the absence of t(14;18). Geno...

journal_title：Oncogene

authors： Kiem HP,Nourse J,Saltman DL,Blume KG,Cleary ML

更新日期：1990-12-01 00:00:00

abstract：:Genomic imprinting at 11p15 is suggested to play a role in certain pediatric tumors such as Wilms' tumor, based on the findings of selective maternal loss of this chromosomal region. Although the allele loss at 11p15 is also frequent in a number of cancers of adults including lung, breast, and bladder cancers, possibl...

journal_title：Oncogene

authors： Kondo M,Matsuoka S,Uchida K,Osada H,Nagatake M,Takagi K,Harper JW,Takahashi T,Elledge SJ,Takahashi T

更新日期：1996-03-21 00:00:00

abstract：:We have analysed the importance of proper substrate methylation by S-adenosylmethionine-dependent methyltransferases for cell survival and cell cycle progression. We show that treatment of cells with the methyltransferase inhibitor adenosine dialdehyde (AdOx) causes cell cycle arrest and death in different cell types....

journal_title：Oncogene

authors： Schwerk C,Schulze-Osthoff K

更新日期：2005-10-27 00:00:00

abstract：:Alterations in expression of c-myb can have profound effects on the growth and differentiation of hematopoietic cells. Thus, it is important to understand the mechanisms by which c-myb is regulated during hematopoietic cell differentiation. Previous studies pertaining to the regulation of c-myb have been carried out w...

journal_title：Oncogene

authors： Boise LH,Gorse KM,Westin EH

更新日期：1992-09-01 00:00:00

abstract：:The MT-2 cell-line, which had been established through in vitro cell to cell transmission of human T-cell leukemia virus type I (HTLV-I) among human primary lymphocytes, was shown to possess multiple copies of integrated proviruses, including defective proviral genomes. By analysing a genomic clone, we identified the ...

journal_title：Oncogene

authors： Kubota S,Siomi H,Hatanaka M,Pomerantz RJ

更新日期：1996-04-04 00:00:00

abstract：:The BCL6 gene, mapped at the chromosomal band 3q27, encodes a POZ/Zinc finger transcription repressor protein. It is frequently activated in Non-Hodgkin's lymphomas (NHL) by translocations with breakpoints clustering in the 5' major breakpoint region (MBR) as well as by mutations in the same region. The translocations...

journal_title：Oncogene

authors： Chen W,Butler M,Rao PH,Chaganti SR,Louie DC,Dalla-Favera R,Chaganti RS

更新日期：1998-10-01 00:00:00

abstract：:The understanding of the organisation of cell cycle events is of utmost importance to devise effective therapeutic strategies for cancer. In this article we gather evidences from the literature in support of a system model of the cell cycle, in which a growth-sensitive threshold controls entry into S phase and the seq...

journal_title：Oncogene

authors： Alberghina L,Porro D,Cazzador L

更新日期：2001-03-01 00:00:00

abstract：:Two hepatocarcinoma cell lines, the Hepa-1 wild-type (c1c7) and the beta-subunit mutated (c4) lacking hypoxia-inducible factor-1 (HIF-1) activity, were differentially susceptible to apoptosis by hepatocyte growth factor (HGF). The c4 cells were 40% apoptotic 48 h after HGF treatment. On the contrary, the wild-type c1c...

journal_title：Oncogene

authors： Matteucci E,Modora S,Simone M,Desiderio MA

更新日期：2003-06-26 00:00:00

abstract：:SEMA3B, a member of class 3 semaphorins, is a tumor suppressor. Competition with vascular endothelial growth factor (VEGF)165 explains a portion of the activity, whereas the VEGF-independent mechanism was not elucidated. We employed a microarray and screened for the genes whose expression was increased by SEMA3B in NC...

journal_title：Oncogene

authors： Koyama N,Zhang J,Huqun,Miyazawa H,Tanaka T,Su X,Hagiwara K

更新日期：2008-11-20 00:00:00

abstract：:Over 70% of human breast cancers are estrogen receptor-positive (ER+), most of which express MYB. In these and other cell types, the MYB transcription factor regulates the expression of many genes involved in cell proliferation, differentiation, tumorigenesis, and apoptosis. So far, no clear link has been established ...

journal_title：Oncogene

authors： Yang RM,Nanayakkara D,Kalimutho M,Mitra P,Khanna KK,Dray E,Gonda TJ

更新日期：2019-06-01 00:00:00

abstract：:Apoptosis is essential for normal development and maintenance of homeostasis, and disruption of apoptotic pathways is associated with multiple disease states, including cancer. Although initially identified as central regulators of apoptosis at the level of mitochondria, an important role for BCL-2 proteins at the end...

journal_title：Oncogene

authors： Heath-Engel HM,Chang NC,Shore GC

更新日期：2008-10-27 00:00:00

abstract：:Leukemogenesis requires two classes of mutations, one that promotes proliferation and one that blocks differentiation. The erythroleukemia induced by Friend virus is a multistage disease characterized by an early proliferative stage driven by the interaction of the viral glycoprotein, gp55, with Sf-Stk and the EpoR, a...

journal_title：Oncogene

authors： Hegde S,Ni S,He S,Yoon D,Feng GS,Watowich SS,Paulson RF,Hankey PA

更新日期：2009-09-24 00:00:00

abstract：:Interleukin-8 (IL-8), a chemokine implicated in the metastasis and angiogenesis of a variety of cancers, has been reported to be overexpressed in prostate cancer. In this study, we ascribe a new role for IL-8 in prostate cancer progression using LNCaP cells. We demonstrate that IL-8 activates the androgen receptor and...

journal_title：Oncogene

authors： Lee LF,Louie MC,Desai SJ,Yang J,Chen HW,Evans CP,Kung HJ

更新日期：2004-03-18 00:00:00

abstract：:Molecular, functional, and clinical analyses strongly suggest that chromosome segment 11p15.5 contains a gene involved in lung cancer pathogenesis. The critical region of allele loss is 310 kb in size. We used our contig of P1-phage artificial chromosome (PAC) clones together with newly identified bacterial artificial...

journal_title：Oncogene

authors： Zhao B,Bepler G

更新日期：2001-12-06 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are strongly immunosuppressive via producing nitric oxide (NO) and known to migrate into tumor sites to promote tumor growth, but the underlying mechanisms remain largely elusive. Here, we found that interferon alpha (IFNα)-secreting MSCs showed more dramatic inhibition effect on tumor...

journal_title：Oncogene

authors： Shou P,Chen Q,Jiang J,Xu C,Zhang J,Zheng C,Jiang M,Velletri T,Cao W,Huang Y,Yang Q,Han X,Zhang L,Wei L,Rabson AB,Chin YE,Wang Y,Shi Y

更新日期：2016-11-17 00:00:00

abstract：:Synemin (SYNM) is a type IV intermediate filament that has recently been shown to interact with the LIM domain protein zyxin, thereby possibly modulating cell adhesion and cell motility. Owing to this multiplicity of potential functions relevant to cancer development, we initiated a study to decipher SYNM expression a...

journal_title：Oncogene

authors： Noetzel E,Rose M,Sevinc E,Hilgers RD,Hartmann A,Naami A,Knüchel R,Dahl E

更新日期：2010-08-26 00:00:00

abstract：:The aspartic protease cathepsin D (cath-D) is a key mediator of induced-apoptosis and its proteolytic activity has been generally involved in this event. During apoptosis, cath-D is translocated to the cytosol. Because cath-D is one of the lysosomal enzymes that requires a more acidic pH to be proteolytically active r...

journal_title：Oncogene

authors： Beaujouin M,Baghdiguian S,Glondu-Lassis M,Berchem G,Liaudet-Coopman E

更新日期：2006-03-23 00:00:00

abstract：:We have evaluated the transcriptional activation of a human p21 promoter reporter construct by transfection of BRCA1 expression constructs into tumorigenic and nontumorigenic human breast cell lines. Two cell lines with wildtype p53 (MCF-7 and MCF10A) demonstrated transcriptional activation of the p21 promoter by full...

journal_title：Oncogene

authors： Lu M,Arrick BA

更新日期：2000-12-14 00:00:00