Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.

abstract：:Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase which belongs to the insulin receptor superfamily and is mainly expressed in pre-B lymphocytes and neuronal tissues. Recently, we demonstrated that LTK utilizes Shc and IRS-1 as two major substrates and while both equally activate the Ras pathway, only IRS-...

journal_title：Oncogene

authors： Ueno H,Honda H,Nakamoto T,Yamagata T,Sasaki K,Miyagawa K,Mitani K,Yazaki Y,Hirai H

更新日期：1997-06-26 00:00:00

abstract：:Several lines of evidence suggest that gastrin and the CCK-2 receptor (CCK2R) could contribute to pancreatic carcinogenesis by modulating processes such as proliferation, cell adhesion or migration. In the current study, we used a 'cancer gene array' and identified beta1-integrin subunit as a new gastrin-regulated gen...

journal_title：Oncogene

authors： Cayrol C,Clerc P,Bertrand C,Gigoux V,Portolan G,Fourmy D,Dufresne M,Seva C

更新日期：2006-07-27 00:00:00

abstract：:The mouse mammary epithelial cell hierarchy contains both multipotent stem cell as well as lineage-limited duct and lobular progenitor cell functions. The latter-also termed parity-identified mammary epithelial cells (PI-MECs)-are marked by beta-galactosidase (β Gal) expression following pregnancy and involution in wh...

journal_title：Oncogene

authors： Bruno RD,Boulanger CA,Smith GH

更新日期：2012-01-05 00:00:00

abstract：:Elucidating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation (IR) treatments while minimizing injury to surrounding normal tissue is an important clinical goal. Due to their sequence-derived specificity and properties as gene regulators in IR-affected pathways, microRNAs (miRNAs) coul...

journal_title：Oncogene

authors： Metheetrairut C,Adams BD,Nallur S,Weidhaas JB,Slack FJ

更新日期：2017-01-26 00:00:00

abstract：:Somatic mutations of FLT3 involving internal tandem duplication (ITD) of the juxtamembrane domain or point mutations in the tyrosine kinase domain (TKD) appear to activate FLT3 in a FLT3 ligand (FL)-independent manner. To determine whether or not FLT3 mutants respond to FL for their activation, a FL-deficient (FL(-/-)...

journal_title：Oncogene

authors： Zheng R,Bailey E,Nguyen B,Yang X,Piloto O,Levis M,Small D

更新日期：2011-09-22 00:00:00

abstract：:Although the prognosis of advanced extramammary Paget's disease (EMPD) is poor, there have been no preclinical research models for the development of novel therapeutics. This study aims to establish a preclinical research model for EMPD. We transplanted EMPD tissue into immunodeficient NOD/Scid mice. Histopathological...

journal_title：Oncogene

authors： Maeda T,Kitamura S,Nishihara H,Yanagi T

更新日期：2020-09-01 00:00:00

abstract：:Abundant levels of the hyperactive low molecular weight (LMW) forms of cyclin E contribute to deregulation of Cdk2 in breast tumors, but the mechanism through which they arise is not fully understood. Here, we explored the hypothesis that post-translational processing by a protease generates the LMW forms of cyclin E ...

journal_title：Oncogene

authors： Wang XD,Rosales JL,Magliocco A,Gnanakumar R,Lee KY

更新日期：2003-02-06 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation (PARylation). However, it remains largely unclear how PARP1 activity is regulated. Interestingly, the data obtained through this study revealed that PARP1 was co-immunoprecipitate...

journal_title：Oncogene

authors： Hsu PC,Gopinath RK,Hsueh YA,Shieh SY

更新日期：2019-02-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are the standard endocrine therapy for postmenopausal breast cancer; however, currently used biomarkers, such as, estrogen receptor-alpha/progesterone receptor (ERα/PR), predict only slightly more than half of the potential responders to AI treatment. To identify novel markers of AI responsi...

journal_title：Oncogene

authors： Moy I,Todorović V,Dubash AD,Coon JS,Parker JB,Buranapramest M,Huang CC,Zhao H,Green KJ,Bulun SE

更新日期：2015-01-15 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF-A) is highly subjected to alternative pre-mRNA splicing that generates several splice variants. The VEGFxxx and VEGFxxxb families encode splice variants of VEGF-A that differ only at the level of six amino acids in their C-terminal part. The expression level of VEGFxxx splice...

journal_title：Oncogene

authors： Boudria A,Abou Faycal C,Jia T,Gout S,Keramidas M,Didier C,Lemaître N,Manet S,Coll JL,Toffart AC,Moro-Sibilot D,Albiges-Rizo C,Josserand V,Faurobert E,Brambilla C,Brambilla E,Gazzeri S,Eymin B

更新日期：2019-02-01 00:00:00

abstract：:I briefly review the discovery and characterization of the first human retrovirus, human T-cell leukemia virus type 1, focusing on contributions from Japanese researchers. The unique regulatory mechanisms for the viral regulation with Tax and Rex, etiology of ATL and possible leukemogenic mechanism with Tax are also d...

journal_title：Oncogene

authors： Yoshida M

更新日期：2005-09-05 00:00:00

abstract：:The p53 family of proteins play instrumental roles in mediating the cellular response to stress. The p53-related gene product, p73, occurs as two distinct protein isoforms, referred to as alpha and beta, which differ in the length of the C-terminal region and arise through alternative splicing of the p73 RNA. Here, we...

journal_title：Oncogene

authors： Lee CW,La Thangue NB

更新日期：1999-07-22 00:00:00

abstract：:Stimulation of resting W53 cells (lymphoid murine cells expressing prolactin (PRL) receptor) by PRL induced expression of growth-related immediate-early genes (IEG), and proliferation through activation of the Src kinases. Since IEG are essential for cell cycle progression, we have studied how PRL controls expression ...

journal_title：Oncogene

authors： Domínguez-Cáceres MA,García-Martínez JM,Calcabrini A,González L,Porque PG,León J,Martín-Pérez J

更新日期：2004-09-23 00:00:00

abstract：:Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancreas. We showed that the ...

journal_title：Oncogene

authors： Xu X,Ehdaie B,Ohara N,Yoshino T,Deng CX

更新日期：2010-02-04 00:00:00

abstract：:We identified the chromosome 11q23 region as containing a putative tumour suppressor gene(s) frequently deleted in nonfamilial breast and other cancers. To define this region(s) further, we performed a systematic genetic analysis at chromosome 11q14-qterm in sporadic breast and colorectal cancer. Tumour and constituti...

journal_title：Oncogene

authors： Koreth J,Bakkenist CJ,McGee JO

更新日期：1997-01-30 00:00:00

abstract：:The high incidence of loss of chromosome 10 alleles in glioblastoma multiforme suggests the presence on this chromosome of a tumor suppressor gene that is important in glioma tumorigenesis and progression. Our initial deletion mapping studies using restriction fragment length polymorphism markers indicated a common de...

journal_title：Oncogene

authors： Rasheed BK,McLendon RE,Friedman HS,Friedman AH,Fuchs HE,Bigner DD,Bigner SH

更新日期：1995-06-01 00:00:00

abstract：:Metastasis is the process through which the primary cancer cells spread beyond the primary tumor and disseminate to other organs. Most cancer patients die of metastatic disease. EMT is proposed to be the initial event associated with cancer metastasis and how it occurred is still a mystery. CtBP is known as a co-repre...

journal_title：Oncogene

authors： Zhao Z,Hao D,Wang L,Li J,Meng Y,Li P,Wang Y,Zhang C,Zhou H,Gardner K,Di LJ

更新日期：2019-03-01 00:00:00

abstract：:Pdcd4 is a novel transformation suppressor that is highly expressed in promotion-resistant (P-) mouse epidermal JB6 cells but not in susceptible (P+) cells. Overexpression of pdcd4 cDNA in stably transfected P+ cells rendered cells resistant to tumor promoter-induced transformation, indicating that elevated expression...

journal_title：Oncogene

authors： Yang HS,Jansen AP,Nair R,Shibahara K,Verma AK,Cmarik JL,Colburn NH

更新日期：2001-02-08 00:00:00

abstract：:MEK kinases (MEKKs) are serine-threonine kinases that regulate sequential protein phosphorylation pathways involving mitogen-activated protein kinases (MAPKs), including members of the Jun kinase (JNK) family. MEKK1 is a 196 kDa protein that when cleaved by caspase-3-like proteases generates an active COOH-terminal ki...

journal_title：Oncogene

authors： Widmann C,Johnson NL,Gardner AM,Smith RJ,Johnson GL

更新日期：1997-11-13 00:00:00

abstract：:The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype wi...

journal_title：Oncogene

authors： Ren S,Gaykalova DA,Guo T,Favorov AV,Fertig EJ,Tamayo P,Callejas-Valera JL,Allevato M,Gilardi M,Santos J,Fukusumi T,Sakai A,Ando M,Sadat S,Liu C,Xu G,Fisch KM,Wang Z,Molinolo AA,Gutkind JS,Ideker T,Koch WM,Cali

更新日期：2020-10-01 00:00:00

abstract：:The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified Parkin, the gene involved in the pathogenesis of many cases of juvenile, early-onset and, rarely, late-onset Parkinson's disease, as the third large gene to be localized within a large CFS. Initial analyses of Parkin indicated th...

journal_title：Oncogene

authors： Denison SR,Wang F,Becker NA,Schüle B,Kock N,Phillips LA,Klein C,Smith DI

更新日期：2003-11-13 00:00:00

abstract：:Dysregulation of cellular signaling pathways can lead to colon cancer. However, research on the key signaling effectors or regulators in colon carcinogenesis is limited. Casein kinase-2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is crucial during adult bone formation and is a promising drug target for osteo...

journal_title：Oncogene

authors： Nie J,Liu L,Xing G,Zhang M,Wei R,Guo M,Li X,Xie P,Li L,He F,Han W,Zhang L

更新日期：2014-07-10 00:00:00

abstract：:We have characterized a chromosomal translocation in a cell line (SU-DUL5) established from a patient with lymphoblastic lymphoma in which the c-myc gene on chromosome 8 was juxtaposed to a t(14;18). Cytogenetic analysis of this cell line showed 14q+, 18q-, and 8p+q+ marker chromosomes in the absence of t(14;18). Geno...

journal_title：Oncogene

authors： Kiem HP,Nourse J,Saltman DL,Blume KG,Cleary ML

更新日期：1990-12-01 00:00:00

abstract：:One of the key events in tumor initiation in mouse skin is mutational activation of the H-ras gene. Papillomas induced by the most carcinogenic environmental polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DB[a,l]P), in SENCAR mouse skin contain a specific H-ras codon 61 (CAA-->CTA) mutation. We describe he...

journal_title：Oncogene

authors： Chakravarti D,Mailander P,Franzen J,Higginbotham S,Cavalieri EL,Rogan EG

更新日期：1998-06-18 00:00:00

abstract：:This report describes a new polymorphism, in intron 3 of the p53 gene, which consists of a single repeat of 16 nucleotides, absent in the published wild-type p53 gene sequence. In the Caucasian population tested (n = 82), 28% of individuals were heterozygotes for this polymorphism. Using PCR-based analysis, we were ab...

journal_title：Oncogene

authors： Lazar V,Hazard F,Bertin F,Janin N,Bellet D,Bressac B

更新日期：1993-06-01 00:00:00

abstract：:Human papillomaviruses (HPVs) are involved in the pathogenesis of cancer of the cervix (CaCx). MicroRNA (miRNA) expression analysis using Ambion (Austin, TX, USA) arrays showed that three miRNAs were overexpressed and 24 underexpressed in cervical cell lines containing integrated HPV-16 DNA compared to the normal cerv...

journal_title：Oncogene

authors： Martinez I,Gardiner AS,Board KF,Monzon FA,Edwards RP,Khan SA

更新日期：2008-04-17 00:00:00

abstract：:The proto-oncogene BMI1 and its product, Bmi1, is overexpressed in various types of tumors, particularly in aggressive tumors and tumors resistant to conventional chemotherapy. BMI1/Bmi1 is also crucially involved in cancer-initiating cell maintenance, and is recurrently upregulated in mantle cell lymphoma (MCL), espe...

journal_title：Oncogene

authors： Teshima K,Nara M,Watanabe A,Ito M,Ikeda S,Hatano Y,Oshima K,Seto M,Sawada K,Tagawa H

更新日期：2014-04-24 00:00:00

abstract：:The Cbl family proteins Cbl, Cbl-b, and Cbl-c/Cbl-3 are thought to regulate signaling through protein-tyrosine kinases, positively as scaffold proteins and negatively as ubiquitin ligases. However, the precise signaling pathways and target proteins for each Cbl family member are not well understood. Here we show that ...

journal_title：Oncogene

authors： Kim M,Tezuka T,Tanaka K,Yamamoto T

更新日期：2004-03-04 00:00:00

abstract：:Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 catalyzes arginine methylation on histones and other proteins. PRMT5-MEP50 activity is elevated in cancer cells and its expression is highly correlated with poor prognosis in many human tumors. We demonstrate that PRMT5-MEP50 is essential for tran...

journal_title：Oncogene

authors： Chen H,Lorton B,Gupta V,Shechter D

更新日期：2017-01-19 00:00:00

abstract：:The c-Myb transcriptional regulator is crucial to the development and functioning of haemopoietic cells, so much so that mouse embryos homozygous for an inactivated c-myb allele die from anaemia at about day 15 of gestation. By analysing c-myb(-/-) chimaeras we show that no mature cells of any lymphoid or myeloid line...

journal_title：Oncogene

authors： Sumner R,Crawford A,Mucenski M,Frampton J

更新日期：2000-07-13 00:00:00