Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.

abstract：:In Xiphophorus the causative, primary cellular oncogene for melanoma formation has been assigned by classical genetics to a sex-chromosomal locus, designated Tu. Activation of Tu was proposed to be the result of the elimination of Tu-specific regulatory genes which normally suppress the transforming function in the no...

journal_title：Oncogene

authors： Mäueler W,Raulf F,Schartl M

更新日期：1988-05-01 00:00:00

abstract：:Triple-negative breast cancers (TNBCs) are characterized by a poor prognosis and lack of targeted treatments, and thus, new therapeutic strategies are urgently needed. Inhibitors against programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have shown significant efficacy in various solid cancers, but their activity against T...

journal_title：Oncogene

authors： Castagnoli L,Cancila V,Cordoba-Romero SL,Faraci S,Talarico G,Belmonte B,Iorio MV,Milani M,Volpari T,Chiodoni C,Hidalgo-Miranda A,Tagliabue E,Tripodo C,Sangaletti S,Di Nicola M,Pupa SM

更新日期：2019-05-01 00:00:00

abstract：:Intraductal papillary mucinous neoplasm (IPMN), the most common pancreatic cystic neoplasm, is known to progress to invasive ductal adenocarcinoma. IPMNs commonly harbor activating somatic mutations in GNAS and KRAS, primarily GNAS(R201H) and KRAS(G12D). GNAS encodes the stimulatory G-protein α subunit (Gsα) that medi...

journal_title：Oncogene

authors： Taki K,Ohmuraya M,Tanji E,Komatsu H,Hashimoto D,Semba K,Araki K,Kawaguchi Y,Baba H,Furukawa T

更新日期：2016-05-05 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a critical regulator of prostate cancer (PC) progression. Here, we report that PAK4 activation promotes PC progression through the EMT regulator Slug. We find tha...

journal_title：Oncogene

authors： Park JJ,Park MH,Oh EH,Soung NK,Lee SJ,Jung JK,Lee OJ,Yun SJ,Kim WJ,Shin EY,Kim EG

更新日期：2018-09-01 00:00:00

abstract：:Density-enhanced protein-tyrosine phosphatase-1 (DEP-1 also CD148) is a transmembrane molecule with a single intracellular PTP domain. It has recently been proposed to function as a tumor suppressor. We have previously shown that DEP-1 dephosphorylates the activated platelet-derived growth factor (PDGF) beta-receptor ...

journal_title：Oncogene

authors： Jandt E,Denner K,Kovalenko M,Ostman A,Böhmer FD

更新日期：2003-07-03 00:00:00

abstract：:The long-term cellular response to DNA damage is controlled by the tumor suppressor p53. It results in cell-cycle arrest followed by DNA repair and, depending on the degree of damage inflicted, premature senescence or apoptotic cell death. Here we show that in normal diploid fibroblasts the ubiquitin ligase anaphase-p...

journal_title：Oncogene

authors： Wiebusch L,Hagemeier C

更新日期：2010-06-17 00:00:00

abstract：:Using a temperature-sensitive mutant of the p210 BCR-ABL gene, transfected into a growth factor-dependent cell line (BaF3), we show that transient BCR-ABL kinase expression increases single cell and clonogenic resistance to apoptosis arising from genotoxic damage induced by ionizing radiation and VP-16/etoposide. This...

journal_title：Oncogene

authors： Nishii K,Kabarowski JH,Gibbons DL,Griffiths SD,Titley I,Wiedemann LM,Greaves MF

更新日期：1996-11-21 00:00:00

abstract：:Within the superfamily of ras-related GTP-binding proteins, only ras itself has been shown to act as an oncogene. Seven other proteins, however, have greater than 50% amino acid identity to ras and one of them, rap1A, has been shown to interact with the ras GTPase activating protein, ras-GAP, and to inhibit ras functi...

journal_title：Oncogene

authors： Rey I,Taylor-Harris P,van Erp H,Hall A

更新日期：1994-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...

journal_title：Oncogene

authors： Joseph J,Radulovich N,Wang T,Raghavan V,Zhu CQ,Tsao MS

更新日期：2020-01-01 00:00:00

abstract：:Insights into the pathogenesis of human leukemia have relied heavily on studies of the identified chromosomal translocations found in this group of malignant diseases. Acquired, balanced translocations in acute myelogenous leukemia (AML) generally involve transcriptional regulatory genes, whereas in the myeloprolifera...

journal_title：Oncogene

authors： Nimer SD,Moore MA

更新日期：2004-05-24 00:00:00

abstract：:In this study, we show that the ETS transcription factor ER81 directly binds to and activates the promoter of the matrix metalloproteinase gene, MMP-1. Further, the oncoprotein HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription. The activation of ER81 by HER2/Neu is mediated by MAP kinases, which phosphory...

journal_title：Oncogene

authors： Bosc DG,Goueli BS,Janknecht R

更新日期：2001-09-27 00:00:00

abstract：:Microsatellite-stable, near-diploid (MSI-CIN-) colorectal carcinomas have been reported, but it is not clear as to whether these tumours form a discrete group or represent one end of the distribution of MSI-CIN+ cancers. In order to address this question, we screened 23 MSI-CIN- colorectal cancers for gains and losses...

journal_title：Oncogene

authors： Jones AM,Douglas EJ,Halford SE,Fiegler H,Gorman PA,Roylance RR,Carter NP,Tomlinson IP

更新日期：2005-01-06 00:00:00

abstract：:Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is noted for its transforming potential. Yet, it also acts as a cytostatic and growth-relenting factor in Burkitt's lymphoma (BL) cells. The underlying molecular mechanisms of the growth inhibitory property of LMP1 have remained largely unknown. In this...

journal_title：Oncogene

authors： Anastasiadou E,Boccellato F,Vincenti S,Rosato P,Bozzoni I,Frati L,Faggioni A,Presutti C,Trivedi P

更新日期：2010-03-04 00:00:00

abstract：:It has recently been shown that the high-risk human papillomavirus (HPV) E6 proteins can target the PDZ-domain containing proteins, Dlg, MUPP-1, MAGI-1 and hScrib for proteasome-mediated degradation. However, the E6 proteins from HPV-16 and HPV-18 (the two most common high-risk virus types) differ in their ability to ...

journal_title：Oncogene

authors： Thomas M,Glaunsinger B,Pim D,Javier R,Banks L

更新日期：2001-09-06 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) are the predominant excitatory neurotransmitter receptors in the mammalian brain. We found that among the three NMDARs examined (NMDAR1, NMDAR2A, NMDAR2B), only NMDAR2A was silenced in colorectal carcinoma (CRC) cell lines at basal line and reactivated by the demethylating agent...

journal_title：Oncogene

authors： Kim MS,Chang X,Nagpal JK,Yamashita K,Baek JH,Dasgupta S,Wu G,Osada M,Woo JH,Westra WH,Trink B,Ratovitski EA,Moon C,Sidransky D

更新日期：2008-03-27 00:00:00

abstract：:Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1) and MEN2 syndromes in humans, including medullary thyroid cancer (MTC). To study the genetic basis for these tumors, we microdissected MTC specimens or obtaine...

journal_title：Oncogene

authors： Coxon AB,Ward JM,Geradts J,Otterson GA,Zajac-Kaye M,Kaye FJ

更新日期：1998-09-24 00:00:00

abstract：:Protein-protein interaction can play an important role in the control of several biological events including gene transcription, replication and cell proliferation. E2F-1 is a DNA-binding transcription factor which, upon interaction with its target DNA sequence, induces expression of several S phase specific genes all...

journal_title：Oncogene

authors： Darbinian N,Gallia GL,Kundu M,Shcherbik N,Tretiakova A,Giordano A,Khalili K

更新日期：1999-11-04 00:00:00

abstract：:Provirus modifications which can occur in tumors may lead to tumor antigenic variants. To investigate this possibility we compared the restriction fragment length patterns of mouse mammary tumor virus (MMTV), murine leukemia virus and xenotropic and mink cell-focus inducing (MCF)-related sequences, using Southern blot...

journal_title：Oncogene

authors： Colombo MP,Ferrari G,Parmiani G,Wettstein PJ

更新日期：1988-04-01 00:00:00

abstract：:A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding muri...

journal_title：Oncogene

authors： Reynolds AB,Herbert L,Cleveland JL,Berg ST,Gaut JR

更新日期：1992-12-01 00:00:00

abstract：:Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaire...

journal_title：Oncogene

authors： Sari IN,Yang YG,Wijaya YT,Jun N,Lee S,Kim KS,Bajaj J,Oehler VG,Kim SH,Choi SY,Park SH,Kim DW,Reya T,Han J,Kwon HY

更新日期：2021-01-01 00:00:00

abstract：:DDB2, a gene mutated in XPE patients, is involved in global genomic repair especially the repair of cyclobutane pyrimidine dimers (CPDs), and is regulated by p53 in human cells. We show that DDB2 is expressed in mouse tissues and demonstrate, using primary mouse epithelial cells, that mouse DDB2 is regulated by E2F tr...

journal_title：Oncogene

authors： Prost S,Lu P,Caldwell H,Harrison D

更新日期：2007-05-24 00:00:00

abstract：:Experimental studies performed prior to 1990 led to the widely held belief that matrix metalloproteinases (MMPs) produced by cancer cells are of critical importance in tumor invasion and metastasis. Based on this evidence, the pharmaceutical industry produced several well tolerated, orally active MMP inhibitors (MMPIs...

journal_title：Oncogene

authors： Zucker S,Cao J,Chen WT

更新日期：2000-12-27 00:00:00

abstract：:We have isolated rat cDNAs that encode two related receptor-like tyrosine kinases. One of these receptors, TIE-1, is the rat homolog of a recently described human receptor-like kinase termed TIE (Partanen et al., 1992). The related TIE-2 receptor has the same organization of amino acid sequence motifs characteristic o...

journal_title：Oncogene

authors： Maisonpierre PC,Goldfarb M,Yancopoulos GD,Gao G

更新日期：1993-06-01 00:00:00

abstract：:A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance t...

journal_title：Oncogene

authors： Casazza A,Di Conza G,Wenes M,Finisguerra V,Deschoemaeker S,Mazzone M

更新日期：2014-04-03 00:00:00

abstract：:E1A of human adenovirus type 5 (Ad5) encodes proteins of 289 and 243 residues (289R and 243R) which differ only by the 46 amino acid CR3 region known to activate expression of certain cellular and early viral genes. E1A proteins also induce DNA synthesis and cell transformation, but as well can stimulate apoptosis. Tw...

journal_title：Oncogene

authors： Teodoro JG,Shore GC,Branton PE

更新日期：1995-08-03 00:00:00

abstract：:Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we have used small inter...

journal_title：Oncogene

authors： Rzymski T,Milani M,Pike L,Buffa F,Mellor HR,Winchester L,Pires I,Hammond E,Ragoussis I,Harris AL

更新日期：2010-08-05 00:00:00

abstract：:Oligodendroglioma is an important type of lower-grade glioma (LGG), which is a slowly progressing brain tumor. Many LGGs eventually transform into a more aggressive or malignant type. Enhanced angiogenesis is a characteristic of malignantly transformed oligodendroglioma (m-oligodendroglioma). However, the pathogenesis...

journal_title：Oncogene

authors： Qi L,Wang ZY,Shao XR,Li M,Chen SN,Liu XQ,Yan S,Zhang B,Zhang XD,Li X,Zhao W,Pan JA,Zhao B,Zhang XD

更新日期：2020-09-01 00:00:00

abstract：:Topors was identified recently as a human protein that binds to topoisomerase I and p53. Topors contains a highly conserved RING domain and localizes in promyelocytic leukemia nuclear bodies. Relatively little is known regarding topors expression patterns or function. We now demonstrate that topors mRNA and protein ar...

journal_title：Oncogene

authors： Saleem A,Dutta J,Malegaonkar D,Rasheed F,Rasheed Z,Rajendra R,Marshall H,Luo M,Li H,Rubin EH

更新日期：2004-07-08 00:00:00

abstract：:One of the hallmarks of malignancy is the polarization of tumor-associated macrophages (TAMs) from a pro-immune (M1-like) phenotype to an immune-suppressive (M2-like) phenotype. However, the molecular basis of the process is still unclear. MicroRNA (miRNA) comprises a group of small, non-coding RNAs that are broadly e...

journal_title：Oncogene

authors： Yang J,Zhang Z,Chen C,Liu Y,Si Q,Chuang TH,Li N,Gomez-Cabrero A,Reisfeld RA,Xiang R,Luo Y

更新日期：2014-06-05 00:00:00

abstract：:Small-molecule agonists at Toll-like receptor 7 (TLR7) and TLR8 have sparked a vivid interest in cancer research owing to their profound antitumoral activity. The lead compound of the imidazoquinoline family, imiquimod, is marketed as a topical formulation. It is efficacious against many primary skin tumors and cutane...

journal_title：Oncogene

authors： Schön MP,Schön M

更新日期：2008-01-07 00:00:00