Abstract：
:A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance to antitumor therapies. Nevertheless, how stromal components including blood and lymphatic endothelial cells, pericytes and fibroblasts, as well as hematopoietic cells, respond to low-oxygen tension in comparison with their normoxic counterparts has been a matter of investigation in the last few years only and, to date, this field of research remains poorly understood. In general, opposing phenotypes can arise from the same stromal component when embedded in different tumor microenvironments, and, vice versa, different stromal components can have opposite reaction to the same tumor microenvironment. In this article, we will discuss the emerging link between tumor stroma and hypoxia, and how this complexity is translated at the molecular level.
journal_name
Oncogenejournal_title
Oncogeneauthors
Casazza A,Di Conza G,Wenes M,Finisguerra V,Deschoemaeker S,Mazzone Mdoi
10.1038/onc.2013.121subject
Has Abstractpub_date
2014-04-03 00:00:00pages
1743-54issue
14eissn
0950-9232issn
1476-5594pii
onc2013121journal_volume
33pub_type
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