当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and compartmentalization of core binding factor beta.

Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and compartmentalization of core binding factor beta.

Abstract：

:Acute myeloid leukemia 1 (AML1) gene on chromosome 21 is involved in several chromosomal translocations, including t(8;21) and t(16;21), that produce chimeric fusion proteins AML1-eight twenty-one (ETO) and AML-myeloid transforming gene chromosome 16 (MTG16), which contribute to leukemogenesis. The molecular basis for the leukemogenic effects of these fusion proteins is incompletely understood. Using gel-shift assay, we showed that AML1-ETO and AML1-MTG16 bound to a series of AML1 consensus DNA-binding sites with different affinities. Using fluorescence recovery after photobleaching (FRAP), we demonstrated that a fusion of AML1 with ETO or MTG16 exhibits reduced intranuclear mobility compared with wild-type AML1 or either fusion partner. The dimerization domain (nervy homology region 2) of ETO is responsible for the reduced mobility of AML1-ETO. Dual FRAP studies revealed that CBFbeta colocalized with AML1-ETO within the nucleus, resulting in reduced mobility of CBFbeta. Therefore, AML1 fusion proteins may interfere with normal AML1 function due to aberrant nuclear dynamics, which leads to spatial and temporal sequestration of CBFbeta and perhaps other coregulators critical for myeloid differentiation.

journal_name

Oncogene

journal_title

Oncogene

authors

Qiu J,Wong J,Tweardy DJ,Dong S

doi

10.1038/sj.onc.1209431

subject

Has Abstract

pub_date

2006-06-29 00:00:00

pages

3982-93

issue

28

eissn

0950-9232

issn

1476-5594

pii

1209431

journal_volume

25

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells.

    abstract：:Nerve growth factor induces differentiation and survival of rat PC12 pheochromocytoma cells. The activation of the erk cascade has been implicated in transducing the multitude of signals induced by NGF. In order to explore the role of this signaling cascade in NGF mediated survival, differentiation and proliferation, ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202524

    authors： Klesse LJ,Meyers KA,Marshall CJ,Parada LF

    更新日期：1999-03-25 00:00:00

  • Smad3 regulates E-cadherin via miRNA-200 pathway.

    abstract：:To identify potential microRNA (miRNA) links between Smad3, a mediator of TGF-β (transforming growth factor-β) signaling, and E-cadherin, we characterized the miRNA profiles of two gastric cancer cell lines: SNU484-LPCX, which does not express Smad3, and SNU484-Smad3, in which Smad3 is overexpressed. We found that amo...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.484

    authors： Ahn SM,Cha JY,Kim J,Kim D,Trang HT,Kim YM,Cho YH,Park D,Hong S

    更新日期：2012-06-21 00:00:00

  • Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts.

    abstract：:Bcl-2 is a key inhibitor of a broad range of apoptotic pathways, yet neither the mechanism of action nor the role of Bcl-2 subcellular localization are well understood. The subcellular localization of Bcl-2 includes the mitochondrial membrane as well as the contiguous membrane of the endoplasmic reticulum and nuclear ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202716

    authors： Lee ST,Hoeflich KP,Wasfy GW,Woodgett JR,Leber B,Andrews DW,Hedley DW,Penn LZ

    更新日期：1999-06-10 00:00:00

  • Fibronectin induces cell proliferation and inhibits apoptosis in human bronchial epithelial cells: pro-oncogenic effects mediated by PI3-kinase and NF-kappa B.

    abstract：:The extracellular matrix glycoprotein, fibronectin, influences a variety of cellular functions including adhesion, migration, survival, differentiation, and growth. Fibronectin has also been shown to increase the migration and proliferation of human lung carcinoma cells. However, the role of fibronectin in controlling...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209460

    authors： Han SW,Roman J

    更新日期：2006-07-20 00:00:00

  • c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase.

    abstract：:The progression and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene. The underlying cause of this dysregulation, however, remains a subject of discussion, as the majority of cancer patients do not present with activating mutations in c-Met recept...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.586

    authors： Szabo R,Rasmussen AL,Moyer AB,Kosa P,Schafer JM,Molinolo AA,Gutkind JS,Bugge TH

    更新日期：2011-04-28 00:00:00

  • Regulation of Laloo by the Xenopus C-terminal Src kinase (Xcsk) during early vertebrate development.

    abstract：:Mesoderm formation in the frog, Xenopus laevis, is dependent on the activity of one or more members of the Src family kinases; the molecular interactions underlying this requirement are not well understood. The C-terminal Src Kinase (Csk) is a potent inhibitor of Src activity, and is required for normal mammalian deve...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204672

    authors： Song Y,Cohler AN,Weinstein DC

    更新日期：2001-08-23 00:00:00

  • Accelerated proliferation of myeloma cells by interleukin-6 cooperating with fibroblast growth factor receptor 3-mediated signals.

    abstract：:Interleukin-6 (IL-6) is a cytokine that regulates the proliferation of some tumor cells including multiple myeloma (MM). Ectopic expression of fibroblast growth factor receptor 3 (FGFR 3) associated with the chromosomal translocation, t(4;14)(p16.3;q32), is frequently found in MM, and therefore, has been implicated in...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208782

    authors： Ishikawa H,Tsuyama N,Liu S,Abroun S,Li FJ,Otsuyama K,Zheng X,Ma Z,Maki Y,Iqbal MS,Obata M,Kawano MM

    更新日期：2005-09-15 00:00:00

  • Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors.

    abstract：:Activation of the EGF receptor (c-erbB) tyrosine kinase has been implicated in tumorigenesis, either by overexpression of the normal receptor in the presence of EGF, or through expression of a truncated receptor lacking the EGF binding domain as in the viral oncogene v-erbB. Here, normal and truncated human EGF recept...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Haley JD,Hsuan JJ,Waterfield MD

    更新日期：1989-03-01 00:00:00

  • STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation.

    abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202694

    authors： Sachsenmaier C,Sadowski HB,Cooper JA

    更新日期：1999-06-17 00:00:00

  • Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation.

    abstract：:As tumors grow and invade beyond their homeostatic limits, the tumor cells are subjected to insufficient nutrient and oxygen supplies because of excessive demand for nutrition and oxygen, and insufficient vascularization. We therefore hypothesized that tolerance to nutrient deprivation as well as angiogenesis may be c...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205737

    authors： Kato K,Ogura T,Kishimoto A,Minegishi Y,Nakajima N,Miyazaki M,Esumi H

    更新日期：2002-09-05 00:00:00

  • RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789.

    abstract：:FGFR1 (fibroblast growth factor receptor 1) regulates many key cellular responses including proliferation, migration and differentiation through activation of signaling pathways. Irregularities in FGFR1 signaling have been implicated in several pathological conditions, including human cancer. In order to discover nove...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.425

    authors： Nadratowska-Wesolowska B,Haugsten EM,Zakrzewska M,Jakimowicz P,Zhen Y,Pajdzik D,Wesche J,Wiedlocha A

    更新日期：2014-10-02 00:00:00

  • The p53/p73 - p21CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells.

    abstract：:Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitosis leading to the generation of lagging chromosomes during anaphase as a major form of mitotic errors in human...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-01524-4

    authors： Schmidt AK,Pudelko K,Boekenkamp JE,Berger K,Kschischo M,Bastians H

    更新日期：2021-01-01 00:00:00

  • Notch tumor suppressor function.

    abstract：:Cancer development results from deregulated control of stem cell populations and alterations in their surrounding environment. Notch signaling is an important form of direct cell-cell communication involved in cell fate determination, stem cell potential and lineage commitment. The biological function of this pathway ...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2008.225

    authors： Dotto GP

    更新日期：2008-09-01 00:00:00

  • Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability.

    abstract：:The human c-rel gene (REL), encoding an NF-kappaB transcription factor, is amplified or mutated in several human B-cell lymphomas and can transform chicken lymphoid cells in vitro. We have previously shown that certain deletions of C-terminal transactivation sequences enhance REL's transforming ability in chicken sple...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208902

    authors： Starczynowski DT,Reynolds JG,Gilmore TD

    更新日期：2005-11-10 00:00:00

  • Human DF3/MUC1 carcinoma-associated protein functions as an oncogene.

    abstract：:The human DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed by most carcinomas of the breast and other epithelia. The contribution of MUC1 overexpression to the malignant phenotype is, however, not known. In the present studies, we have stably expressed MUC1 in rat 3Y1 fibroblasts. MUC1-positive cells were ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206732

    authors： Li Y,Liu D,Chen D,Kharbanda S,Kufe D

    更新日期：2003-09-04 00:00:00

  • PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.

    abstract：:Nuclear-enriched RNA-binding proteins (RBPs) are mainly involved in transcriptional regulation, which is a critical checkpoint to tune gene diversity and expression levels. We analyzed nuclear RBPs in human HCC tissues and matched normal control tissues. Based on the gene expression levels, PTBP3 was identified as top...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0416-8

    authors： Yang X,Qu S,Wang L,Zhang H,Yang Z,Wang J,Dai B,Tao K,Shang R,Liu Z,Li X,Zhang Z,Xia C,Ma B,Liu W,Li H,Dou K

    更新日期：2018-12-01 00:00:00

  • A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma.

    abstract：:Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, ne...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204723

    authors： Tanaka S,Sugimachi K,Saeki H,Kinoshita J,Ohga T,Shimada M,Maehara Y,Sugimachi K

    更新日期：2001-09-06 00:00:00

  • Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cells.

    abstract：:Constitutive NF-kappaB activity varies widely among cancer cell lines. In this report, we studied the expression and the role of different I kappaB inhibitors in adenocarcinoma cell lines. High constitutive NF-kappaB activity and low I kappaB-alpha expression was found in a number of these cell lines. Moreover, some o...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202599

    authors： Dejardin E,Deregowski V,Chapelier M,Jacobs N,Gielen J,Merville MP,Bours V

    更新日期：1999-04-22 00:00:00

  • Epstein-barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-kappaB.

    abstract：:Epstein-Barr virus (EBV) transforms resting primary human B lymphocytes into indefinitely proliferating lymphoblastoid cell lines in vitro and is associated with several human malignancies in vivo. Recombinant EBV genetic analyses combined with in vitro B lymphocyte transformation assays demonstrate that latent infect...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1203217

    authors： Cahir McFarland ED,Izumi KM,Mosialos G

    更新日期：1999-11-22 00:00:00

  • hPMC2 is required for recruiting an ERbeta coactivator complex to mediate transcriptional upregulation of NQO1 and protection against oxidative DNA damage by tamoxifen.

    abstract：:In the presence of ERbeta, trans-hydroxytamoxifen (TOT) protects cells against 17beta-estradiol (E(2))-induced oxidative DNA damage (ODD) and this correlates with increased expression of the antioxidative enzyme quinone reductase (QR). Here, we investigate the molecular mechanism responsible for ERbeta-mediated protec...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.235

    authors： Sripathy SP,Chaplin LJ,Gaikwad NW,Rogan EG,Montano MM

    更新日期：2008-10-23 00:00:00

  • ATF-2 controls transcription of Maspin and GADD45 alpha genes independently from p53 to suppress mammary tumors.

    abstract：:The activating transcription factor, ATF-2, is a target of p38 and JNK that are involved in stress-induced apoptosis. Heterozygous Atf-2 mutant (Atf-2+/-) mice are highly prone to mammary tumors. The apoptosis-regulated gene GADD45alpha and the breast cancer suppressor gene Maspin, both of which are known to be p53 ta...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210727

    authors： Maekawa T,Sano Y,Shinagawa T,Rahman Z,Sakuma T,Nomura S,Licht JD,Ishii S

    更新日期：2008-02-14 00:00:00

  • A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells.

    abstract：:A 1.26 kb murine cDNA having 31% homology with human ras and 55% homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily. Northern blot analysis indicates that the expression of the murine gene is restricted to the cells of hemopoiet...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Shirsat NV,Pignolo RJ,Kreider BL,Rovera G

    更新日期：1990-05-01 00:00:00

  • Na+,HCO3--cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice.

    abstract：:Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribution of the Na+,HCO3--cotransporter NBCn1 (Slc4a7) to intracellular a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0353-6

    authors： Lee S,Axelsen TV,Jessen N,Pedersen SF,Vahl P,Boedtkjer E

    更新日期：2018-10-01 00:00:00

  • Hyperthermic intraperitoneal chemotherapy leads to an anticancer immune response via exposure of cell surface heat shock protein 90.

    abstract：:The occurrence of peritoneal carcinomatosis is a major cause of treatment failure in colorectal cancer and is considered incurable. However, new therapeutic approaches have been proposed, including cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Although HIPEC has been effective ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2015.82

    authors： Zunino B,Rubio-Patiño C,Villa E,Meynet O,Proics E,Cornille A,Pommier S,Mondragón L,Chiche J,Bereder JM,Carles M,Ricci JE

    更新日期：2016-01-14 00:00:00

  • Random mutagenesis of PDZ(Omi) domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis.

    abstract：:Omi is a mammalian serine protease that is localized in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting with the X-chromosome linked inhibitor of apoptosis protein, as well as in a caspase-independent way that relies o...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206359

    authors： Junqueira D,Cilenti L,Musumeci L,Sedivy JM,Zervos AS

    更新日期：2003-05-08 00:00:00

  • Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.

    abstract：:The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small. There is a need to discover new potential actionable genetic lesions, to which end, non-conventional cancer pathways, such as RN...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2015.469

    authors： Anadón C,Guil S,Simó-Riudalbas L,Moutinho C,Setien F,Martínez-Cardús A,Moran S,Villanueva A,Calaf M,Vidal A,Lazo PA,Zondervan I,Savola S,Kohno T,Yokota J,Ribas de Pouplana L,Esteller M

    更新日期：2016-08-18 00:00:00

  • The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression.

    abstract：:The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely connected to therapy resistance in tumors harboring activating mutations in the NRF2 pathway. In melanoma, such mutations are rare, and it is unclear to what extent melanomas rely on NRF2. Here we show that NRF2 suppresses...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-01477-8

    authors： Jessen C,Kreß JKC,Baluapuri A,Hufnagel A,Schmitz W,Kneitz S,Roth S,Marquardt A,Appenzeller S,Ade CP,Glutsch V,Wobser M,Friedmann-Angeli JP,Mosteo L,Goding CR,Schilling B,Geissinger E,Wolf E,Meierjohann S

    更新日期：2020-10-01 00:00:00

  • Crosstalk between the human papillomavirus E2 transcriptional activator and the E6 oncoprotein.

    abstract：:Human papillomaviruses are the causative agents of cervical cancer. Previous studies have shown that loss of the viral E2 protein during malignant progression is an important feature of HPV-induced malignancy due to the resulting uncontrolled expression of the viral oncoproteins E6 and E7. We now show however that the...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208701

    authors： Grm HS,Massimi P,Gammoh N,Banks L

    更新日期：2005-08-04 00:00:00

  • FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.

    abstract：:T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is thought to have a pivotal role in the transformation of thymocytes and is as...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2015.481

    authors： Fleskens V,Mokry M,van der Leun AM,Huppelschoten S,Pals CE,Peeters J,Coenen S,Cardoso BA,Barata JT,van Loosdregt J,Coffer PJ

    更新日期：2016-08-04 00:00:00

  • Specific DNA binding by different classes of human p53 mutants.

    abstract：:The p53 protein is a multifunctional transcription factor which orchestrates cellular responses to DNA damage, so helping to conserve genomic stability. It may also regulate genes involved in intercellular signalling, such as thrombospondin, a negative regulator of angiogenesis and metastatic spread. Activation of p53...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Rolley N,Butcher S,Milner J

    更新日期：1995-08-17 00:00:00