Abstract:
:Cancer development results from deregulated control of stem cell populations and alterations in their surrounding environment. Notch signaling is an important form of direct cell-cell communication involved in cell fate determination, stem cell potential and lineage commitment. The biological function of this pathway is critically context dependent. Here we review the pro-differentiation role and tumor suppressing function of this pathway, as revealed by loss-of-function in keratinocytes and skin, downstream of p53 and in cross-connection with other determinants of stem cell potential and/or tumor formation, such as p63 and Rho/CDC42 effectors. The possibility that Notch signaling elicits a duality of signals, involved in growth/differentiation control and cell survival will be discussed, in the context of novel approaches for cancer therapy.
journal_name
Oncogenejournal_title
Oncogeneauthors
Dotto GPdoi
10.1038/onc.2008.225subject
Has Abstractpub_date
2008-09-01 00:00:00pages
5115-23issue
38eissn
0950-9232issn
1476-5594pii
onc2008225journal_volume
27pub_type
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