PML protein isoforms and the RBCC/TRIM motif.

abstract：:Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more...

journal_title：Oncogene

authors： Fessler E,Jansen M,De Sousa E Melo F,Zhao L,Prasetyanti PR,Rodermond H,Kandimalla R,Linnekamp JF,Franitza M,van Hooff SR,de Jong JH,Oppeneer SC,van Noesel CJ,Dekker E,Stassi G,Wang X,Medema JP,Vermeulen L

更新日期：2016-11-17 00:00:00

abstract：:Although TGF-beta1, a growth inhibitor, is known to also induce apoptosis, the molecular mechanism of this apoptosis is largely undefined. Here, we identify the mechanism of TGF-beta1-induced apoptosis in SNU-16 human gastric cancer cells. Cell cycle and TUNEL analysis showed that, upon TGF-beta1 treatment, cells were...

journal_title：Oncogene

authors： Kim SG,Kim SN,Jong HS,Kim NK,Hong SH,Kim SJ,Bang YJ

更新日期：2001-03-08 00:00:00

abstract：:Wilms tumor is one of the most frequent neoplasias in children. Our previous microarray screening in a large series of Wilms tumors revealed several candidate genes that are deregulated in advanced tumors and are part of the retinoic acid signaling pathway. To investigate whether retinoic acid could be employed as a n...

journal_title：Oncogene

authors： Zirn B,Samans B,Spangenberg C,Graf N,Eilers M,Gessler M

更新日期：2005-08-04 00:00:00

abstract：:Ultraviolet (UV) light is a potent mutagenic and genotoxic agent. Whereas DNA damage induced by UV light is known to be responsible for UV-induced genotoxicity, its role in triggering apoptosis is still unclear. We addressed this issue by comparing nucleotide excision repair (NER) deficient 27-1 and 43-3B Chinese hams...

journal_title：Oncogene

authors： Dunkern TR,Fritz G,Kaina B

更新日期：2001-09-20 00:00:00

abstract：:Melanoma dedifferentiation, characterized by the loss of MITF and MITF regulated genes and by upregulation of stemness markers as CD271, is implicated in resistance to chemotherapy, target therapy and immunotherapy. The identification of intrinsic mechanisms fostering melanoma dedifferentiation may provide actionable ...

journal_title：Oncogene

authors： Perotti V,Baldassari P,Molla A,Vegetti C,Bersani I,Maurichi A,Santinami M,Anichini A,Mortarini R

更新日期：2016-06-02 00:00:00

abstract：:A wealth of cytogenetic data has demonstrated that numerous somatic genetic changes are involved in the pathogenesis of human lung cancer. Despite the complexity of the genomic changes observed in these neoplasms, recurrent chromosomal patterns have emerged. In this review, we summarize chromosomal alterations identif...

journal_title：Oncogene

authors： Balsara BR,Testa JR

更新日期：2002-10-07 00:00:00

abstract：:Deleted in breast cancer-1 (DBC-1) was initially cloned from a homozygously deleted region in breast and other cancers on human chromosome 8p21, although no function is known for the protein product it encodes. We identified the generation of amino-terminally truncated versions of DBC-1 during tumor necrosis factor (T...

journal_title：Oncogene

authors： Sundararajan R,Chen G,Mukherjee C,White E

更新日期：2005-07-21 00:00:00

abstract：:Identification of prostate cancers at high risk of progression is difficult and a better understanding of how peptide growth factors influence cellular function might be useful. Fibroblast growth factors (FGFs) have been implicated in prostate cancer development. FGF8 was identified in the Shionogi mouse mammary carci...

journal_title：Oncogene

authors： Dorkin TJ,Robinson MC,Marsh C,Bjartell A,Neal DE,Leung HY

更新日期：1999-04-29 00:00:00

abstract：:We evaluated the effect of nitric oxide (NO) on vascular endothelial growth factor (VEGF) gene expression in human A-172 glioblastoma cells and human HepG2 hepatocellular carcinoma cells. The mRNA level of VEGF increased in response to S-Nitroso-N-acetyl-D,L-penicillamine (SNAP) in both cell lines, and increased in mR...

journal_title：Oncogene

authors： Chin K,Kurashima Y,Ogura T,Tajiri H,Yoshida S,Esumi H

更新日期：1997-07-24 00:00:00

abstract：:The autosomal dominantly inherited disease tuberous sclerosis (TSC) affects approximately 1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. TSC1, encoding hamartin, and TSC2, encoding tuberin are tumor suppressor genes responsible for TSC. Hamartin and tube...

journal_title：Oncogene

authors： Rosner M,Freilinger A,Hengstschläger M

更新日期：2007-01-25 00:00:00

abstract：:This study addresses the question of whether loss of p16INK4 expression contributes to the immortalization of human cells. In vitro immortalization usually proceeds through two phases. In the first phase (lifespan extension), cells continue proliferating and their telomeres continue shortening beyond the point at whic...

journal_title：Oncogene

authors： Noble JR,Rogan EM,Neumann AA,Maclean K,Bryan TM,Reddel RR

更新日期：1996-09-19 00:00:00

abstract：:Several motifs are conserved in the extracellular domain of the cloned chains of the recently described cytokine receptor superfamily. One of them, usually close to the transmembrane region, is the 'WS motif'. Its function remains unknown, but it has been recently shown that the integrity of this motif is essential fo...

journal_title：Oncogene

authors： Bénit L,Charon M,Cocault L,Wendling F,Gisselbrecht S

更新日期：1993-03-01 00:00:00

abstract：:Expression of constitutively activated M-Ras in normal murine bone-marrow cells was sufficient to induce the factor-independent, in vitro growth and differentiation of colonies of macrophages and neutrophils, and the generation of immortal lines of factor-independent mast cells, and, upon in vivo injection of the tran...

journal_title：Oncogene

authors： Guo X,Schrader KA,Xu Y,Schrader JW

更新日期：2005-03-31 00:00:00

abstract：:Radiation therapy (RT) is useful for selectively killing cancer cells. However, because high levels of ionizing radiation (IR) are toxic to normal cells, RT cannot be applied repeatedly to cancer patients. Therefore, novel chemicals that enhance the efficacy of chemoradiotherapy (CRT) would be valuable. Here, we repor...

journal_title：Oncogene

authors： Ohno S,Naito Y,Mukai S,Yabuta N,Nojima H

更新日期：2015-12-03 00:00:00

abstract：:The crizotinib-resistant ALK(F1174L) mutation arises de novo in neuroblastoma (NB) and is acquired in ALK translocation-driven cancers, lending impetus to the development of novel anaplastic lymphoma kinase (ALK) inhibitors with different modes of action. The diaminopyrimidine TAE684 and its derivative ceritinib (LDK3...

journal_title：Oncogene

authors： Debruyne DN,Bhatnagar N,Sharma B,Luther W,Moore NF,Cheung NK,Gray NS,George RE

更新日期：2016-07-14 00:00:00

abstract：:Microsatellite-stable, near-diploid (MSI-CIN-) colorectal carcinomas have been reported, but it is not clear as to whether these tumours form a discrete group or represent one end of the distribution of MSI-CIN+ cancers. In order to address this question, we screened 23 MSI-CIN- colorectal cancers for gains and losses...

journal_title：Oncogene

authors： Jones AM,Douglas EJ,Halford SE,Fiegler H,Gorman PA,Roylance RR,Carter NP,Tomlinson IP

更新日期：2005-01-06 00:00:00

abstract：:Since it is reported that adrenomedullin (AM) upregulated by hypoxia inhibits hypoxic cell death, we examined the effects of AM antagonist (AM C-terminal fragment; AM(22-52)) on the growth of pancreatic cancer cells. We, for the first time, demonstrated that AM antagonist significantly reduced the in vivo growth of th...

journal_title：Oncogene

authors： Ishikawa T,Chen J,Wang J,Okada F,Sugiyama T,Kobayashi T,Shindo M,Higashino F,Katoh H,Asaka M,Kondo T,Hosokawa M,Kobayashi M

更新日期：2003-02-27 00:00:00

abstract：:Tuberin is the protein product of the tuberous sclerosis-2 (TSC2) gene, which is associated with tuberous sclerosis (TSC), a human genetic syndrome characterized by the development of tumors in a variety of tissues. We have previously shown that tuberin is a widely expressed 180 kDa protein which exhibits specific GTP...

journal_title：Oncogene

authors： Wienecke R,Maize JC Jr,Shoarinejad F,Vass WC,Reed J,Bonifacino JS,Resau JH,de Gunzburg J,Yeung RS,DeClue JE

更新日期：1996-09-05 00:00:00

abstract：:CDX2 is a Drosophila caudal-related homeobox transcription factor that is important for the establishment and maintenance of intestinal epithelial cells. CDX2 is a marker of colon cancer, with strong staining in up to 90% of colonic adenocarcinomas. CDX2 heterozygous-null mice develop colonic neoplasms, which have sug...

journal_title：Oncogene

authors： Dang LH,Chen F,Ying C,Chun SY,Knock SA,Appelman HD,Dang DT

更新日期：2006-04-06 00:00:00

abstract：:Vinexin is an adaptor protein supposed to play pivotal roles in various cellular events such as cell adhesion, cytoskeletal organization, signaling and gene expression. Despite the possible importance, physiological functions and regulatory mechanisms of vinexin are largely unknown. In addition, although vinexin was r...

journal_title：Oncogene

authors： Mizutani K,Ito H,Iwamoto I,Morishita R,Deguchi T,Nozawa Y,Asano T,Nagata KI

更新日期：2007-11-01 00:00:00

abstract：:Activation of hypoxia-inducible factor (HIF) is due to loss of von Hippel-Lindau protein (pVHL) function in most clear cell renal cell carcinomas (ccRCCs). Here we describe a novel pVHL-independent mechanism of HIF regulation and identify nuclear factor (NF)-κB essential modulator (NEMO) as a hitherto unknown oncogeni...

journal_title：Oncogene

authors： Nowicka AM,Häuselmann I,Borsig L,Bolduan S,Schindler M,Schraml P,Heikenwalder M,Moch H

更新日期：2016-06-16 00:00:00

abstract：:The sirtuins (SIRT 1-7) comprise a family of NAD⁺-dependent protein-modifying enzymes with activities in lysine deacetylation, adenosinediphospho(ADP)-ribosylation, and/or deacylation. These enzymes are involved in the cell's stress response systems and in regulating gene expression, DNA damage repair, metabolism and ...

journal_title：Oncogene

authors： Roth M,Chen WY

更新日期：2014-03-27 00:00:00

abstract：:We have recently identified and cloned the gene for a cytosolic polypeptide, designated oncoprotein 18 (Op18), which is expressed in acute lymphocytic leukemia and some solid tumors including neuroblastoma. Op18 is phosphorylated upon treatment of lymphoid cells with phorbol myristate acetate. We have proposed that un...

journal_title：Oncogene

authors： Hailat N,Strahler J,Melhem R,Zhu XX,Brodeur G,Seeger RC,Reynolds CP,Hanash S

更新日期：1990-11-01 00:00:00

abstract：:The chromatin organizer SATB1 has been implicated in the development and progression of multiple cancers including breast and colorectal cancers. However, the regulation and role of SATB1 in colorectal cancers is poorly understood. Here, we demonstrate that expression of SATB1 is induced upon hyperactivation of Wnt/β-...

journal_title：Oncogene

authors： Mir R,Pradhan SJ,Patil P,Mulherkar R,Galande S

更新日期：2016-03-31 00:00:00

abstract：:Histone acetylation has a central role in establishing an active chromatin environment. The functional contribution of histone acetylation to chromatin transcription is accomplished by a dominant action of histone acetyltransferases over repressive histone-modifying activities at gene promoters; misregulation of these...

journal_title：Oncogene

authors： Heo K,Kim JS,Kim K,Kim H,Choi J,Yang K,An W

更新日期：2013-05-16 00:00:00

abstract：:The v-myb oncogene of the avian myeloblastosis virus encodes a nuclear protein, p48v-myb, which binds to DNA in a sequence-specific manner. We have used wild type and mutant forms of this protein expressed in E. coli to study the protein and DNA determinants for sequence-specific DNA-binding. We have shown that only t...

journal_title：Oncogene

authors： Garcia A,LaMontagne K,Reavis D,Stober-Grässer U,Lipsick JS

更新日期：1991-02-01 00:00:00

abstract：:Much evidence has been gathered in support of a critical role for p53 in the cellular response to DNA damage. p53 dysfunction is associated with progression and poor prognosis of many human cancers and with a high incidence of tumours in p53 knockout mice. The absence of a p53-dependent G1 arrest that facilitates DNA ...

journal_title：Oncogene

authors： Griffiths SD,Clarke AR,Healy LE,Ross G,Ford AM,Hooper ML,Wyllie AH,Greaves M

更新日期：1997-02-06 00:00:00

abstract：:The DCC (deleted in colorectal cancer) gene was originally identified as a candidate tumour suppressor gene in colon carcinogenesis on the basis of allelic losses in chromosome 18q.21 in 70% of colon cancers. Reverse transcriptase polymerase chain reaction (RT-PCR) of DCC mRNA suggests that DCC expression may also be ...

journal_title：Oncogene

authors： Gotley DC,Reeder JA,Fawcett J,Walsh MD,Bates P,Simmons DL,Antalis TM

更新日期：1996-08-15 00:00:00

abstract：:The functional inactivation of the tumor susceptibility gene tsg101 in mouse NIH3T3 cells leads to cell transformation and the formation of metastatic tumors in nude mice. We cloned, mapped and sequenced the mouse tsg101 gene and further identified a processed pseudogene that is 98% identical to the tsg101 cDNA. Based...

journal_title：Oncogene

authors： Wagner KU,Dierisseau P,Rucker EB 3rd,Robinson GW,Hennighausen L

更新日期：1998-11-26 00:00:00

abstract：:The release of cytochrome c from the intermembrane space of mitochondria into the cytosol is one of the critical events in apoptotic cell death. In the present study, it is shown that release of cytochrome c and apoptosis induced by tumor necrosis factor alpha (TNF) in HeLa cells can be inhibited by (i) overexpression...

journal_title：Oncogene

authors： Shchepina LA,Pletjushkina OY,Avetisyan AV,Bakeeva LE,Fetisova EK,Izyumov DS,Saprunova VB,Vyssokikh MY,Chernyak BV,Skulachev VP

更新日期：2002-11-21 00:00:00