Determinants of sequence-specific DNA-binding by p48v-myb.

abstract：:The natural phytoalexin resveratrol (3, 5, 4'-trihydroxystilbene) exhibits both chemopreventive and antitumor activities through a variety of mechanisms. We have shown previously that resveratrol-induced apoptosis of a human colon cancer cell line involved the redistribution of CD95 (Fas/Apo-1) into lipid rafts. Here,...

journal_title：Oncogene

authors： Delmas D,Rébé C,Micheau O,Athias A,Gambert P,Grazide S,Laurent G,Latruffe N,Solary E

更新日期：2004-11-25 00:00:00

abstract：:The HER-2/neu proto-oncogene is frequently amplified or overexpressed in many different types of human cancers, a phenomenon that has been shown to correlate with shorter survival time and lower survival rate in ovarian cancer patients. We previously reported that increased HER-2/neu expression led to more severe mali...

journal_title：Oncogene

authors： Yu D,Matin A,Xia W,Sorgi F,Huang L,Hung MC

更新日期：1995-10-05 00:00:00

abstract：:P63, a p53 family member, is expressed as TA and ΔN isoforms. Interestingly, both TAp63 and ΔNp63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for survival of some epithelial cell lineages, and lack of p63 leads to loss of epidermis and other epithelia in human...

journal_title：Oncogene

authors： Zhang Y,Yan W,Chen X

更新日期：2014-03-20 00:00:00

abstract：:This study addresses the question of whether loss of p16INK4 expression contributes to the immortalization of human cells. In vitro immortalization usually proceeds through two phases. In the first phase (lifespan extension), cells continue proliferating and their telomeres continue shortening beyond the point at whic...

journal_title：Oncogene

authors： Noble JR,Rogan EM,Neumann AA,Maclean K,Bryan TM,Reddel RR

更新日期：1996-09-19 00:00:00

abstract：:Evi5 is a common site of retroviral integration in T-cell lymphomas of AKXD mice. Mapping studies have localized Evi5 to a region approximately 18 kb upstream of another common viral integration site, Gfi1, on mouse chromosome 5 (Liao X, Jenkins NA and Copeland NG, (1995a). J. Virol., 69, 7132-7137). Gfi1 encodes a zi...

journal_title：Oncogene

authors： Liao X,Du Y,Morse HC 3rd,Jenkins NA,Copeland NG

更新日期：1997-03-06 00:00:00

abstract：:Uncontrolled growth and diffused invasion are major causes of mortality in patients with malignant gliomas. Nodal has been shown to have a central role in the tumorigenic signaling pathways of malignant melanoma. In this study, we show that grade IV human glioma cell lines expressed different levels of Nodal, parallel...

journal_title：Oncogene

authors： Lee CC,Jan HJ,Lai JH,Ma HI,Hueng DY,Lee YC,Cheng YY,Liu LW,Wei HW,Lee HM

更新日期：2010-05-27 00:00:00

abstract：:The v-Myb oncogene causes monoblastic leukemia and transforms only myelomonocytic cells in culture. The v-Myb protein is nuclear and binds to specific DNA sequences. To identify genes regulated by v-Myb, we utilized primary cells transformed by a retrovirus encoding a v-Myb-estrogen receptor (ER) fusion protein. The E...

journal_title：Oncogene

authors： Wang DM,Sevcikova S,Wen H,Roberts S,Lipsick JS

更新日期：2007-02-22 00:00:00

abstract：:Small-cell lung cancer (SCLC) is an aggressive, rapidly metastasizing neoplasm. The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is constitutively secreted by marrow stromal cells and plays a key role for homing of hematopoietic cells to the marrow. Here, we report that tumor cells from patients with SCLC ex...

journal_title：Oncogene

authors： Burger M,Glodek A,Hartmann T,Schmitt-Gräff A,Silberstein LE,Fujii N,Kipps TJ,Burger JA

更新日期：2003-11-06 00:00:00

abstract：:The most frequent genetic alterations described in neuroblastoma (NB) are amplification of MYCN oncogene and deletion of chromosome 1p, although somatic deletions have been demonstrated at other chromosomal intervals. Since loss of heterozygosity (LOH) at distal 4p has been observed in about 20-29% of neuroblastomas, ...

journal_title：Oncogene

authors： Perri P,Longo L,Cusano R,McConville CM,Rees SA,Devoto M,Conte M,Ferrara GB,Seri M,Romeo G,Tonini GP

更新日期：2002-11-28 00:00:00

abstract：:A wealth of cytogenetic data has demonstrated that numerous somatic genetic changes are involved in the pathogenesis of human lung cancer. Despite the complexity of the genomic changes observed in these neoplasms, recurrent chromosomal patterns have emerged. In this review, we summarize chromosomal alterations identif...

journal_title：Oncogene

authors： Balsara BR,Testa JR

更新日期：2002-10-07 00:00:00

abstract：:Osteopontin (OPN) is a phosphorylated glycoprotein that binds to alpha v-containing integrins and is important in malignant transformation and cancer. Previously, we have utilized suppressive subtractive hybridization between mRNAs isolated from the Rama 37 (R37) rat mammary cell line and a subclone rendered invasive ...

journal_title：Oncogene

authors： Kurisetty VV,Johnston PG,Johnston N,Erwin P,Crowe P,Fernig DG,Campbell FC,Anderson IP,Rudland PS,El-Tanani MK

更新日期：2008-12-04 00:00:00

abstract：:A limited number of adult stem cells (SCs) maintain the homoestasis of different tissues through the lifetime of the individual by generating differentiating daughters and renewing themselves. Errors in the SC division rate or in the fine balance between self-renewal and differentiation might result in tissue overgrow...

journal_title：Oncogene

authors： Januschke J,Gonzalez C

更新日期：2008-11-24 00:00:00

abstract：:Aberrant protein glycosylation could be a distinct surface-marker of cancer cells that influences cancer progression and metastasis because glycosylation can regulate membrane protein folding which alters receptor activation and changes epitope exposure for antibody (Ab) recognition. Carcinoembryonic antigen-related c...

journal_title：Oncogene

authors： Chiang WF,Cheng TM,Chang CC,Pan SH,Changou CA,Chang TH,Lee KH,Wu SY,Chen YF,Chuang KH,Shieh DB,Chen YL,Tu CC,Tsui WL,Wu MH

更新日期：2018-01-04 00:00:00

abstract：:Targeted therapeutics are potential therapeutic agents because of their selectivity and efficacy against tumors resistant to conventional therapy. The goal of this study was to determine the comparative activity of monovalent, engineered anti-Her2/neu immunotoxins fused to recombinant gelonin (rGel) to the activity of...

journal_title：Oncogene

authors： Cao Y,Marks JW,Liu Z,Cheung LH,Hittelman WN,Rosenblum MG

更新日期：2014-01-23 00:00:00

abstract：:The oncoprotein c-Myc contains two dimerization motifs- the helix-loop-helix (HLH) and the leucine zipper (LZ) - through which c-Myc specifically dimerizes with Max. We substituted regions of the c-Myc HLH and LZ motifs with the corresponding regions of structurally related proteins that do not interact with Max. Spec...

journal_title：Oncogene

authors： Davis LJ,Halazonetis TD

更新日期：1993-01-01 00:00:00

abstract：:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...

journal_title：Oncogene

authors： Olmeda D,Jordá M,Peinado H,Fabra A,Cano A

更新日期：2007-03-22 00:00:00

abstract：:Ras proteins activate Raf and PI-3 kinases, as well as exchange factors for RalA and RalB GTPases. Many previous studies have reported that the Ral-signaling cascade contributes positively to Ras-mediated oncogenesis. Here, using a bioengineered tissue model of early steps in Ras-induced human squamous cell carcinoma ...

journal_title：Oncogene

authors： Sowalsky AG,Alt-Holland A,Shamis Y,Garlick JA,Feig LA

更新日期：2010-01-07 00:00:00

abstract：:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Harkin DP

更新日期：2006-09-25 00:00:00

abstract：:Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we have used small inter...

journal_title：Oncogene

authors： Rzymski T,Milani M,Pike L,Buffa F,Mellor HR,Winchester L,Pires I,Hammond E,Ragoussis I,Harris AL

更新日期：2010-08-05 00:00:00

abstract：:Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive brea...

journal_title：Oncogene

authors： Walter M,Liang S,Ghosh S,Hornsby PJ,Li R

更新日期：2009-07-30 00:00:00

abstract：:The hepatitis B virus (HBV) X protein (pX) stimulates transcription regulated by cis-acting elements that control many viral and cellular genes, including the c-myc and the c-fos proto-oncogenes. Using several c-fos promoter deletion mutants, we found the serum-responsive element (SRE) located at -315, the modified TP...

journal_title：Oncogene

authors： Avantaggiati ML,Natoli G,Balsano C,Chirillo P,Artini M,De Marzio E,Collepardo D,Levrero M

更新日期：1993-06-01 00:00:00

abstract：:Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components regulating the CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-establishing cell cycle control through cyclin-dependent kinase (CDK) inhibition has therefore emerged as an attractive option in the development of targ...

journal_title：Oncogene

authors： Johnson J,Thijssen B,McDermott U,Garnett M,Wessels LF,Bernards R

更新日期：2016-09-15 00:00:00

abstract：:In search of human homologues of the anti-apoptotic protein Nr-13, we have characterized a human EST clone that potentially encodes a protein, which is the closest homologue of Nr-13 among the Bcl-2 family members, to date known, in humans. Phylogenetic analyses suggest Human nrh, Mouse diva/boo and Quail nr-13 to be ...

journal_title：Oncogene

authors： Aouacheria A,Arnaud E,Venet S,Lalle P,Gouy M,Rigal D,Gillet G

更新日期：2001-09-13 00:00:00

abstract：:The mechanism by which Bcl-2 inhibits apoptosis is unknown. The Bcl-2 protein is localized to intracellular membranes, including the endoplasmic reticulum (ER). The ER is the major intracellular reservoir of Ca2+ in non-muscle cells, sequestering Ca2+ for use in intracellular signaling, and is a prime target of oxidat...

journal_title：Oncogene

authors： Distelhorst CW,Lam M,McCormick TS

更新日期：1996-05-16 00:00:00

abstract：:beta-Catenin, a component of the Wnt signaling pathway, is a coactivator of human androgen receptor (hAR) transcriptional activity. Here, we show that Wnt signaling also influences androgen-mediated signaling through its ability to regulate hAR mRNA and protein in prostate cancer (PCa) cells. Three functional LEF-1/TC...

journal_title：Oncogene

authors： Yang X,Chen MW,Terry S,Vacherot F,Bemis DL,Capodice J,Kitajewski J,de la Taille A,Benson MC,Guo Y,Buttyan R

更新日期：2006-06-08 00:00:00

abstract：:The c-myc oncogene is the most extensively studied member of the myc gene family which now consists of three characterized members, namely the c-myc, N-myc and L-myc genes. These genes are often found amplified in cell lines from small cell carcinomas of the lung (SCLC). In this study the L-myc gene was examined in a ...

journal_title：Oncogene

authors： Saksela K

更新日期：1987-01-01 00:00:00

abstract：:Topors was identified recently as a human protein that binds to topoisomerase I and p53. Topors contains a highly conserved RING domain and localizes in promyelocytic leukemia nuclear bodies. Relatively little is known regarding topors expression patterns or function. We now demonstrate that topors mRNA and protein ar...

journal_title：Oncogene

authors： Saleem A,Dutta J,Malegaonkar D,Rasheed F,Rasheed Z,Rajendra R,Marshall H,Luo M,Li H,Rubin EH

更新日期：2004-07-08 00:00:00

abstract：:The RAF-mitogen-activated protein kinase kinase 1/2-extracellular signal-regulated kinase 1/2 (RAF-MEK1/2-ERK1/2) pathway is activated in many human tumours and can protect cells against growth factor deprivation; however, most such studies have relied upon overexpression of RAF or MEK constructs that are not found in...

journal_title：Oncogene

authors： Wickenden JA,Jin H,Johnson M,Gillings AS,Newson C,Austin M,Chell SD,Balmanno K,Pritchard CA,Cook SJ

更新日期：2008-12-04 00:00:00

abstract：:In the presence of ERbeta, trans-hydroxytamoxifen (TOT) protects cells against 17beta-estradiol (E(2))-induced oxidative DNA damage (ODD) and this correlates with increased expression of the antioxidative enzyme quinone reductase (QR). Here, we investigate the molecular mechanism responsible for ERbeta-mediated protec...

journal_title：Oncogene

authors： Sripathy SP,Chaplin LJ,Gaikwad NW,Rogan EG,Montano MM

更新日期：2008-10-23 00:00:00

abstract：:Recently, constitutive activation of JAK kinases (JAKs) and/or signal transducers and activators of transcription (STATs) has been reported in growing numbers of human cancer cells as well as oncogene-transformed cells. JAB/SOCS-1 has been shown to be an intrinsic JAK tyrosine kinase inhibitor and to suppress the cyto...

journal_title：Oncogene

authors： Iwamoto T,Senga T,Naito Y,Matsuda S,Miyake Y,Yoshimura A,Hamaguchi M

更新日期：2000-09-28 00:00:00