Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth.

abstract：:Castration-resistant prostate cancer (CRPC) continues to be a major clinical problem and the mechanisms behind it remain unclear. Thioredoxin domain-containing protein 5 (TXNDC5) is involved in protein folding and chaperone activity, and its overexpression has been reported in multiple malignancies. In the current stu...

journal_title：Oncogene

authors： Wang L,Song G,Chang X,Tan W,Pan J,Zhu X,Liu Z,Qi M,Yu J,Han B

更新日期：2015-09-03 00:00:00

abstract：:Mouse embryonic stem (ES) cells are known to express D-type cyclins at very low levels and these levels increase dramatically during in vitro and in vivo differentiation. Here, we investigate some of the signalling pathways regulating expression of cyclin D1 and progression to S phase, the Ras/Extracellular signal-reg...

journal_title：Oncogene

authors： Jirmanova L,Afanassieff M,Gobert-Gosse S,Markossian S,Savatier P

更新日期：2002-08-15 00:00:00

abstract：:Two alternatively spliced mouse lymphocyte and brain ltk cDNAs predict small transmembrane tyrosine kinases that use CUG translational start codons and that differ upstream of their transmembrane segment. A recently isolated human neuroblastoma ltk cDNA, in contrast, includes a regular AUG start codon and predicts a m...

journal_title：Oncogene

authors： Snijders AJ,Haase VH,Bernards A

更新日期：1993-01-01 00:00:00

abstract：:Rho small GTP-binding protein regulates various cell functions, such as formation of stress fibers and focal adhesions, cell motility, membrane ruffling, cytokinesis and smooth muscle contraction in mammalian cells and bud formation in the yeast Saccharomyces cerevisiae. As to the functioning sites of Rho in Saccharom...

journal_title：Oncogene

authors： Takaishi K,Sasaki T,Kameyama T,Tsukita S,Tsukita S,Takai Y

更新日期：1995-07-06 00:00:00

abstract：:Synemin (SYNM) is a type IV intermediate filament that has recently been shown to interact with the LIM domain protein zyxin, thereby possibly modulating cell adhesion and cell motility. Owing to this multiplicity of potential functions relevant to cancer development, we initiated a study to decipher SYNM expression a...

journal_title：Oncogene

authors： Noetzel E,Rose M,Sevinc E,Hilgers RD,Hartmann A,Naami A,Knüchel R,Dahl E

更新日期：2010-08-26 00:00:00

abstract：:Mouse embryonal carcinoma (EC) cells of the P19 line can be induced to differentiate into neurons, astrocytes and fibroblasts by exposure to retinoic acid (RA), whereas treatment of the EC cells with dimethyl sulfoxide (DMSO) leads to differentiation into mesodermal tissues, including cardiac and skeletal muscle. In R...

journal_title：Oncogene

authors： St-Arnaud R,Nepveu A,Marcu KB,McBurney MW

更新日期：1988-11-01 00:00:00

abstract：:RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas. We used RasGRP1 trans...

journal_title：Oncogene

authors： Klinger MB,Guilbault B,Goulding RE,Kay RJ

更新日期：2005-04-14 00:00:00

abstract：:Genetic mutations in BRCA1, which is crucial for the process of DNA repair and maintenance of genomic integrity, are known to increase markedly the risk of breast and ovarian cancers. Clinical genetic testing has been used to identify new BRCA1 variants; however, functional assessment and determination of their pathog...

journal_title：Oncogene

authors： Kweon J,Jang AH,Shin HR,See JE,Lee W,Lee JW,Chang S,Kim K,Kim Y

更新日期：2020-01-01 00:00:00

abstract：:FLT3 tyrosine kinase domain (TKD) mutations are detected in approximately 7% of acute myeloid leukemia patients, and suggested to correlate with poor prognosis and confer resistance to FLT3 inhibitors. To explore activation mechanism of FLT3 TKD mutation, we analysed critical tyrosine residues for the constitutive act...

journal_title：Oncogene

authors： Ishiko J,Mizuki M,Matsumura I,Shibayama H,Sugahara H,Scholz G,Serve H,Kanakura Y

更新日期：2005-12-08 00:00:00

abstract：:Treatment of mice with the carcinogen azoxymethane (AOM) induces a number of lesions in the colon, including hyperplastic lesions, as well adenomas and carcinomas in situ. Inbred strains of mice show different responses to AOM-induced carcinogenesis. A/J mice are highly susceptible and develop a greater number of hype...

journal_title：Oncogene

authors： Meunier C,Cai J,Fortin A,Kwan T,Marquis JF,Turbide C,Van Der Kraak L,Jothy S,Beauchemin N,Gros P

更新日期：2010-02-04 00:00:00

abstract：:Hepatocellular carcinoma (HCC) metastasis is largely responsible for HCC-associated recurrence and mortality. We aimed to identify metastasis-related long non-coding RNAs (lncRNAs) to understand the molecular mechanism of HCC metastasis. We first identified that miR-1258 was downregulated in HCC tissues both in The Ca...

journal_title：Oncogene

authors： Huang WJ,Tian XP,Bi SX,Zhang SR,He TS,Song LY,Yun JP,Zhou ZG,Yu RM,Li M

更新日期：2020-06-01 00:00:00

abstract：:While advances in laboratory automation has dramatically increased throughout of compound screening efforts, development of robust cell-based assays in relevant disease models remain resource-intensive and time-consuming, presenting a bottleneck to drug discovery campaigns. To address this issue, we present a modified...

journal_title：Oncogene

authors： Morris SM,Mhyre AJ,Carmack SS,Myers CH,Burns C,Ye W,Ferrer M,Olson JM,Klinghoffer RA

更新日期：2018-08-01 00:00:00

abstract：:An adenovirus mutant lacking the expression of the large E1B protein (DeltaE1B) has been reported to replicate selectively in cells lacking the expression of functionally wild-type (wt) p53. Based on these results the DeltaE1B or ONYX-015 virus has been proposed to be an oncolytic virus which might be useful to treat ...

journal_title：Oncogene

authors： Steegenga WT,Riteco N,Bos JL

更新日期：1999-09-09 00:00:00

abstract：:RAS-driven malignancies remain a major therapeutic challenge. The two-stage 7,12-dimethylbenz(a)anthracene (DMBA)/12-o-tetradecanoylphorbol-13-acetate (TPA) model of mouse skin carcinogenesis has been used to study mechanisms of epithelial tumor development by oncogenic Hras. We used mice with an Hras(G12V) knock-in a...

journal_title：Oncogene

authors： Chen X,Makarewicz JM,Knauf JA,Johnson LK,Fagin JA

更新日期：2014-11-20 00:00:00

abstract：:Exposure of cells to DNA damaging agents results in a G2 arrest. Exposure of HeLa cells to camptothecin, etoposide or nitrogen mustard for 1 h in S phase resulted in delayed expression of cyclin B1 mRNA during the G2 arrest. Initially the levels of cyclin B1 protein were low as well; however, with extended time the ce...

journal_title：Oncogene

authors： Maity A,Hwang A,Janss A,Phillips P,McKenna WG,Muschel RJ

更新日期：1996-10-17 00:00:00

abstract：:Mutant p53 proteins were shown to exert complex DNA-interactions in vitro, like binding to MAR-DNA, but so far it is unknown whether such interactions also occur in vivo. Therefore we analysed the binding of mutant (mut) p53 (Gly245-->Ser) in Onda 11 glioma cells to cellular DNA in vivo, using p53-specific chromatin i...

journal_title：Oncogene

authors： Koga H,Deppert W

更新日期：2000-08-24 00:00:00

abstract：:A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver h...

journal_title：Oncogene

authors： Rassoulzadegan M,Courtneidge SA,Loubière R,el Baze P,Cuzin F

更新日期：1990-10-01 00:00:00

abstract：:Despite the progress made in targeted anticancer therapies in recent years, challenges remain. The identification of new potential targets will ensure that the arsenal of cancer therapies continues to expand. FAM83B was recently discovered in a forward genetic screen for novel oncogenes that drive human mammary epithe...

journal_title：Oncogene

authors： Cipriano R,Bryson BL,Miskimen KL,Bartel CA,Hernandez-Sanchez W,Bruntz RC,Scott SA,Lindsley CW,Brown HA,Jackson MW

更新日期：2014-06-19 00:00:00

abstract：:A candidate gene (WT1) has recently been described for the 11p13 tumour-suppressor gene involved in the development of Wilms' tumour. This gene encodes a zinc finger protein which can bind to a specific DNA sequence. We have found a 226 base deletion in the mRNA from a unilateral Wilms' tumour, which would cause a fra...

journal_title：Oncogene

authors： Brown KW,Watson JE,Poirier V,Mott MG,Berry PJ,Maitland NJ

更新日期：1992-04-01 00:00:00

abstract：:Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor that catalyzes the de-phosphorylation of the AGC kinases, while p27 acts as a tumor suppressor that regulates cell cycle, apoptosis, and cell motility. Our previous studies have identified that PHLPP2 participates in in...

journal_title：Oncogene

authors： Peng M,Wang J,Zhang D,Jin H,Li J,Wu XR,Huang C

更新日期：2018-10-01 00:00:00

abstract：:p66(Shc), an isoform of Shc adaptor proteins, is shown to mediate various signals, including cellular stress. However, little is known about its involvement in carcinogenesis. We previously showed that p66(Shc) protein level is upregulated by steroid hormones in human carcinoma cells and is higher in prostate cancer (...

journal_title：Oncogene

authors： Veeramani S,Igawa T,Yuan TC,Lin FF,Lee MS,Lin JS,Johansson SL,Lin MF

更新日期：2005-11-03 00:00:00

abstract：:Inactivation of the tumor suppressor NF2/merlin underlies neurofibromatosis type 2 (NF2) and some sporadic tumors. Previous studies have established that merlin mediates contact inhibition of proliferation; however, the exact mechanisms remain obscure and multiple pathways have been implicated. We have previously repo...

journal_title：Oncogene

authors： Cui Y,Groth S,Troutman S,Carlstedt A,Sperka T,Riecken LB,Kissil JL,Jin H,Morrison H

更新日期：2019-09-01 00:00:00

abstract：:Neogenin is a member of the N-CAM family of cell adhesion molecules and is closely related to the DCC tumor suppressor gene product. Recently, it has been demonstrated that the DCC/Neogenin subfamily plays a key role in axonal guidance within the embryonic nervous system, however little is known about the function of ...

journal_title：Oncogene

authors： Keeling SL,Gad JM,Cooper HM

更新日期：1997-08-07 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a stable product, PTHrP1-17. PTHrP1-17 retains the ability to signal through PTH1R...

journal_title：Oncogene

authors： Frieling JS,Shay G,Izumi V,Aherne ST,Saul RG,Budzevich M,Koomen J,Lynch CC

更新日期：2017-08-01 00:00:00

abstract：:Cell cycle modulation of cyclin A expression is due to the periodic relief of a transcriptional repression mediated by a bipartite negative DNA regulatory region. The 5' element (Cell Cycle Responsive Element: CCRE; cell Cycle Dependent Element: CDE) is clearly occupied in a cyclic manner in vivo, whereas the 3' eleme...

journal_title：Oncogene

authors： Philips A,Chambeyron S,Lamb N,Vié A,Blanchard JM

更新日期：1999-11-04 00:00:00

abstract：:Understanding the molecular mechanisms that underlie the aggressive behavior and relapse of breast cancer may help in the development of novel therapeutic interventions. CUB-domain-containing protein 1 (CDCP1), a transmembrane adaptor protein, is highly maintained and required in the context of cellular metastatic pot...

journal_title：Oncogene

authors： Cui YH,Kim H,Lee M,Yi JM,Kim RK,Uddin N,Yoo KC,Kang JH,Choi MY,Cha HJ,Kwon OS,Bae IH,Kim MJ,Kaushik N,Lee SJ

更新日期：2018-10-01 00:00:00

abstract：:The mechanisms of ras activation by mutations in residue 61 and in the NKXD guanine nucleotide-binding consensus sequence (ras residues 116-119) have been evaluated. Weakly transforming mutations that either reduce intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activities (61P) or enhance guanine nucl...

journal_title：Oncogene

authors： Patel G,MacDonald MJ,Khosravi-Far R,Hisaka MM,Der CJ

更新日期：1992-02-01 00:00:00

abstract：:beta-Catenin, a component of the Wnt signaling pathway, is a coactivator of human androgen receptor (hAR) transcriptional activity. Here, we show that Wnt signaling also influences androgen-mediated signaling through its ability to regulate hAR mRNA and protein in prostate cancer (PCa) cells. Three functional LEF-1/TC...

journal_title：Oncogene

authors： Yang X,Chen MW,Terry S,Vacherot F,Bemis DL,Capodice J,Kitajewski J,de la Taille A,Benson MC,Guo Y,Buttyan R

更新日期：2006-06-08 00:00:00

abstract：:The short arm of chromosome 17 is one of the most frequently affected chromosomal regions in lung cancers, while there is solid evidence that the p53 gene at 17p13.1 is a target for frequent 17p deletions. In the present study, we re-evaluated 17p deletions in lung cancers by conducting a detailed analysis of the mini...

journal_title：Oncogene

authors： Konishi H,Takahashi T,Kozaki K,Yatabe Y,Mitsudomi T,Fujii Y,Sugiura T,Matsuda H,Takahashi T,Takahashi T

更新日期：1998-10-22 00:00:00

abstract：:High CD44 expression is associated with enhanced malignant potential in esophageal squamous cell carcinoma (ESCC), among the deadliest of all human carcinomas. Although alterations in autophagy and CD44 expression are associated with poor patient outcomes in various cancer types, the relationship between autophagy and...

journal_title：Oncogene

authors： Whelan KA,Chandramouleeswaran PM,Tanaka K,Natsuizaka M,Guha M,Srinivasan S,Darling DS,Kita Y,Natsugoe S,Winkler JD,Klein-Szanto AJ,Amaravadi RK,Avadhani NG,Rustgi AK,Nakagawa H

更新日期：2017-08-24 00:00:00