Abstract:
:We have recently identified and cloned the gene for a cytosolic polypeptide, designated oncoprotein 18 (Op18), which is expressed in acute lymphocytic leukemia and some solid tumors including neuroblastoma. Op18 is phosphorylated upon treatment of lymphoid cells with phorbol myristate acetate. We have proposed that unphosphorylated Op18 plays a role in cellular proliferation, and that its phosphorylated forms, namely Op18a and Op18b, are associated with diminished cell proliferation. In this study, we report that in neuroblastoma tumors, the phosphorylation of Op18 was substantially diminished with increasing N-myc gene copy number. Treatment of the neuroblastoma cell line SMS-KCNR, which contains 75 copies of the N-myc gene, with retinoic acid for ten days resulted in an increase in Op18 phosphorylation. Our findings provide evidence for distinct patterns of Op18 phosphorylation in neuroblastoma tumors with and without N-myc gene amplification.
journal_name
Oncogenejournal_title
Oncogeneauthors
Hailat N,Strahler J,Melhem R,Zhu XX,Brodeur G,Seeger RC,Reynolds CP,Hanash Ssubject
Has Abstractpub_date
1990-11-01 00:00:00pages
1615-8issue
11eissn
0950-9232issn
1476-5594journal_volume
5pub_type
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