Abstract:
:SPARC, also termed osteonectin, BM-40 and 43K protein, is an acidic, cysteine-rich component of the extracellular matrix that has been shown to be directly regulated by progesterone and dexamethasone and indirectly by cytokines. By RNA fingerprinting technique, we cloned a SPARC homolog from the normal human ovarian surface epithelial (HOSE) cells and demonstrated that it is expressed at high levels in the normal HOSE cells but at much lower levels in ovarian carcinoma cells in vitro and in vivo. Subsequently, we transfected the full length SPARC cDNA into an ovarian carcinoma cell line SKOV3 and showed that it reduced the growth rate of the cancer cell line in culture and reduced the cell's ability to induce tumours in nude mice. These results suggest that SPARC may play an important role in growth and and differentiation of the HOSE cells and support the hypothesis that SPARC functions as a tumor suppressor.
journal_name
Oncogenejournal_title
Oncogeneauthors
Mok SC,Chan WY,Wong KK,Muto MG,Berkowitz RSsubject
Has Abstractpub_date
1996-05-02 00:00:00pages
1895-901issue
9eissn
0950-9232issn
1476-5594journal_volume
12pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::We identified IFIX as a new member of the hematopoietic interferon (IFN)-inducible nuclear protein with the 200-amino-acid repeat (HIN-200) family. Six different alternatively spliced forms of mRNA are transcribed from the IFIX gene, which are predicted to encode six different isoforms of IFIX proteins (IFIXalpha1, al...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207592
更新日期:2004-06-03 00:00:00
abstract::Type I interferon (IFN) enhances the transcription of the tumor suppressor gene p53. To elucidate the molecular mechanism mediating IFN-induced apoptosis, we analysed programmed cell death in response to type I (IFNalpha) or type II (IFNgamma) treatment in relation to p53 status. In two cell lines (MCF-7, SKNSH), IFNa...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208204
更新日期:2005-01-20 00:00:00
abstract::Ewing sarcoma (ES) is an aggressive bone and soft tissue tumor of children and young adults in which finding effective new targeted therapies is imperative. Here, we report an in-depth preclinical study of the investigational cullin-RING ubiquitin ligase (CRL) inhibitor MLN4924 in ES, as we have recently demonstrated ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.153
更新日期:2013-03-14 00:00:00
abstract::The human MSH2/6 complex is essential for mismatch recognition during the repair of replication errors. Although mismatch repair components have been implicated in DNA homologous recombination repair, the exact function of hMSH2/6 in this pathway is unclear. Here, we show that the recombinant hMSH2/6 protein complex s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207462
更新日期:2004-05-06 00:00:00
abstract::Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon ti...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-11-16 00:00:00
abstract::The epidermal growth factor receptor (EGFR) is activated by a variety of ligands including EGF and transforming growth factor-alpha (TGFalpha), whereas no ligand for the homologous ErbB2 oncoprotein has yet been identified. Here we use both an ErbB2 phosphoantibody (aPY1222) and an activation-specific EGFR antibody to...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201595
更新日期:1997-10-01 00:00:00
abstract::Colon cancer is the most aggressive tumor in both men and women globally. As many the chemotherapeutic regimens have adverse side effects and contribute to the resistance and recurrence, therefore, finding novel therapeutic targets and developing effective agents are urgent. Based on the TCGA and GTEx database analysi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01467-w
更新日期:2020-10-01 00:00:00
abstract::Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, ne...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204723
更新日期:2001-09-06 00:00:00
abstract::The human c-abl oncogene gives rise to different mRNA transcripts which vary primarily in that they possess alternative first exons. In the present study, we present the sequence for the human c-abl 3' untranslated region (3'utr) and show that while human and murine c-abl cDNA sequences are generally homologous, human...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::The efficacy of anticancer therapy is limited by the development of drug resistance. While the role of p53 in the intrinsic sensitivity of human cancer cells to paclitaxel (PTX) remains controversial, its role in acquired paclitaxel resistance has never been addressed. In this study we examined the p53 status of three...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203642
更新日期:2000-06-22 00:00:00
abstract::Minichromosome maintenance (MCM) proteins 2-7 are important in DNA replication licensing. Functional roles beyond licensing are speculated. In addition, significances in medulloblastoma (MB) remain unclear. In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinica...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.287
更新日期:2010-10-07 00:00:00
abstract::The hyperactivated Wnt/β-catenin signaling acts as a switch to induce epithelial to mesenchymal transition and promote colorectal cancer. However, due to its essential role in gut homeostasis, therapeutic targeting of this pathway has proven challenging. Additionally, IL-6/Stat-3 signaling, activated by microbial tran...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.259
更新日期:2017-11-23 00:00:00
abstract::We have previously shown that transactivation by tumor suppressor protein p53 can be inhibited in vivo at elevated protein concentrations. In this study we characterize the structural requirements of this function. We show that oligomerization domain of p53 is involved in loss of transactivation at high protein concen...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201749
更新日期:1998-05-07 00:00:00
abstract::We have examined the possibility that the E7 proteins of the high-risk human papillomavirus (HPV) type 16 and 18 and the oncogenic adenovirus (Ad) type 12 E1A protein share the ability to down-regulate the expression of components of the antigen processing and presentation pathway, as a common strategy in the evasion ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203860
更新日期:2000-10-05 00:00:00
abstract::Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitosis leading to the generation of lagging chromosomes during anaphase as a major form of mitotic errors in human...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01524-4
更新日期:2021-01-01 00:00:00
abstract::Cortactin, a p80/85 protein first identified as a src kinase substrate, is thought to be involved in the signaling pathway of mitogenic receptors and adhesion molecules mediating cytoskeletal reorganization. The cortactin gene, EMS1, maps to chromosome 11q13, a region amplified in head and neck squamous cell carcinoma...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201850
更新日期:1998-06-25 00:00:00
abstract::Since defects in molecular mechanisms controlling DNA repair, cell cycle checkpoint and apoptosis could modify cellular sensitivity to DNA damaging agents, we have conducted a multiparametric molecular analysis for better understanding the regulation pathways leading to cell survival or cell death after irradiation. U...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203405
更新日期:2000-02-17 00:00:00
abstract::The tax gene product of the human T-cell leukemia virus type I (HTLV-I) induces the nuclear expression and biological function of the NF-kappa B/Rel family of host transcription factors although the underlying mechanism remains unclear. In the present study, we demonstrate that Tax-mediated activation of NF-kappa B/Re...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-09-07 00:00:00
abstract::Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects o...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2008.95
更新日期:2008-07-31 00:00:00
abstract::We have isolated mouse cDNA clones encoding Tyro 3, a receptor protein-tyrosine kinase (PTK) of the mammalin central nervous system (CNS). Expression of the Tyro 3 gene is strongly up-regulated in neurons of the mouse neocortex, cerebellum, and hippocampus after the day of birth, during periods of active synaptogenesi...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::A dual role of transforming growth factor β (TGF-β), to both suppress and promote tumor progression and metastasis, has been well established, but its molecular basis has remained elusive. In this review, we focus on Smad proteins, which are central mediators of the signal transduction of TGF-β family members. We desc...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2012.191
更新日期:2013-03-28 00:00:00
abstract::Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF superfamily. This subset, which also includes Fas ligand and TNF-alpha, can activate the extrinsic apoptotic cell death pathway on binding to cognate death...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2010.221
更新日期:2010-08-26 00:00:00
abstract::Knowledge of the type of biological reaction to chemotherapy is a prerequisite for its rational enhancement. We previously showed that irinotecan-induced DNA damage triggers in the HCT116p53(wt) colon carcinoma cell line a long-term cell cycle arrest and in HCT116p53(-/-) cells apoptosis (Magrini et al., 2002). To com...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209017
更新日期:2006-01-12 00:00:00
abstract::Cellular adhesion to extracellular matrix is a central phenomenon for the maintenance of tissue integrity and cellular movement. Collectively, these processes are regulated by a fine-tuned balance between the formation and loosening of adhesive contacts, a process involving integrins, and the elevation and diminution ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210883
更新日期:2008-04-10 00:00:00
abstract::Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding transcriptional respon...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.378
更新日期:2015-08-20 00:00:00
abstract::The acute contractile function of the heart is controlled by the effects of released nonepinephrine (NE) on cardiac adrenergic receptors. NE can also act in a more chronic fashion to induce cardiomyocyte growth, characterized by cell enlargement (hypertrophy), increased protein synthesis, alterations in gene expressio...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204275
更新日期:2001-03-26 00:00:00
abstract::Germline mutations in the tumor suppressor BRCA1 predispose women to breast and ovarian cancers. Current evidence demonstrates that mutations in BRCA1 do not directly result in tumor formation, but instead cause genetic instability, subjecting cells to high risks of malignant transformation. In an animal model in whic...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1203269
更新日期:2000-02-21 00:00:00
abstract::The nuclear transport receptor importin-β/karyopherin-β1 is overexpressed in cancers that display genomic instability. It is regarded as a promising cancer target and inhibitors are being developed. In addition to its role in nucleo-cytoplasmic transport, importin-β regulates mitosis, but the programmes and pathways i...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0989-x
更新日期:2020-01-01 00:00:00
abstract::The reciprocal chromosomal translocation t(4;11) is correlated with infant, childhood, adult and therapy-related high-risk acute leukemia. Here, we investigated the biological effects of MLL.AF4, AF4.MLL or the combination of both reciprocal fusion proteins in a conditional in vitro cell culture model system. Several ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210125
更新日期:2007-05-17 00:00:00
abstract::The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast cancer. ATM signalling is constitutively activated in early stages of diverse types of human malignancies and c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210885
更新日期:2008-04-10 00:00:00