The p53/p73 - p21CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells.

abstract：:Loss of the tumor suppressive effect of transforming growth factor-beta (TGF-beta) has been commonly found at later stages in carcinogenic progression. Although the genes encoding TGF-beta receptors and Smads have been found genetically altered in certain human cancers, no mutation in Smad3 has been observed. Therefor...

journal_title：Oncogene

authors： Han SU,Kim HT,Seong DH,Kim YS,Park YS,Bang YJ,Yang HK,Kim SJ

更新日期：2004-02-19 00:00:00

abstract：:Cancer cells can use a variety of metabolic substrates to fulfill the bioenergetic and biosynthetic needs of their oncogenic program. Besides bioenergetics, cancer cell metabolism also directly influences genetic, epigenetic and signaling events associated with tumor progression. Many cancer cells are addicted to glut...

journal_title：Oncogene

authors： Cacace A,Sboarina M,Vazeille T,Sonveaux P

更新日期：2017-04-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) interacts genetically with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to suppress early-onset T-lineage lymphomas in the mouse, but the underlying mechanisms have remained unknown. To address this question, we analyzed a series of lymphomas arising in PARP1(-/-)...

journal_title：Oncogene

authors： Rybanska I,Ishaq O,Chou J,Prakash M,Bakhsheshian J,Huso DL,Franco S

更新日期：2013-04-04 00:00:00

abstract：:This study examines whether the serine/threonine protein kinase, Akt, is involved in the crosstalk between the ErbB2 and estrogen receptor-alpha (ER-alpha) pathways. Treatment of MCF-7 cells with 10(-9) M heregulin-beta1 (HRG-beta1) resulted in a rapid phosphorylation of Akt and a 15-fold increase in Akt activity. Akt...

journal_title：Oncogene

authors： Stoica GE,Franke TF,Wellstein A,Morgan E,Czubayko F,List HJ,Reiter R,Martin MB,Stoica A

更新日期：2003-04-10 00:00:00

abstract：:The cancer-prone and premature aging disease Werner syndrome is due to loss of WRN gene function. Cells lacking WRN demonstrate genomic instability, including telomeric abnormalities and undergo premature senescence, suggesting defects in telomere metabolism. This notion is strongly supported by our finding of physica...

journal_title：Oncogene

authors： Machwe A,Xiao L,Orren DK

更新日期：2004-01-08 00:00:00

abstract：:Akt/PKB is a serine/threonine kinase that promotes tumor cell growth by phosphorylating transcription factors and cell cycle proteins. There is particular interest in finding tumor-specific substrates for Akt to understand how this protein functions in cancer and to provide new avenues for therapeutic targeting. Our l...

journal_title：Oncogene

authors： Sutherland BW,Kucab J,Wu J,Lee C,Cheang MC,Yorida E,Turbin D,Dedhar S,Nelson C,Pollak M,Leighton Grimes H,Miller K,Badve S,Huntsman D,Blake-Gilks C,Chen M,Pallen CJ,Dunn SE

更新日期：2005-06-16 00:00:00

abstract：:Checkpoint kinase 1 (CHK1) is a key component of the ATR (ataxia telangiectasia-mutated and Rad3-related)-dependent DNA damage response pathway that protect cells from replication stress, a cell intrinsic phenomenon enhanced by oncogenic transformation. Here, we show that CHK1 is overexpressed and hyperactivated in T-...

journal_title：Oncogene

authors： Sarmento LM,Póvoa V,Nascimento R,Real G,Antunes I,Martins LR,Moita C,Alves PM,Abecasis M,Moita LF,Parkhouse RM,Meijerink JP,Barata JT

更新日期：2015-06-04 00:00:00

abstract：:Tumor recurrence following treatment remains a major clinical challenge in oral cavity cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been considered as the driving force of tumor recurrence and metastasis. However, it still remains unclear whether targeting CSCs in oral cancer is a cl...

journal_title：Oncogene

authors： Hu J,Mirshahidi S,Simental A,Lee SC,De Andrade Filho PA,Peterson NR,Duerksen-Hughes P,Yuan X

更新日期：2019-07-01 00:00:00

abstract：:The p53 tumor suppressor gene continues to be distinguished as the most frequently mutated gene in human cancer; this gene can be found mutated in up to 50% of human tumors of diverse histological type. It is generally accepted that the ability of p53 to induce either growth arrest or programmed cell death in response...

journal_title：Oncogene

authors： Pietsch EC,Humbey O,Murphy ME

更新日期：2006-03-13 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and remains incurable with conventional chemotherapy treatment approaches. CLL as a disease entity is defined by a relatively parsimonious set of diagnostic criteria and therefore likely constitutes an umbrella term for multiple relate...

journal_title：Oncogene

authors： Malek SN

更新日期：2013-06-06 00:00:00

abstract：:MEK kinases (MEKKs) are serine-threonine kinases that regulate sequential protein phosphorylation pathways involving mitogen-activated protein kinases (MAPKs), including members of the Jun kinase (JNK) family. MEKK1 is a 196 kDa protein that when cleaved by caspase-3-like proteases generates an active COOH-terminal ki...

journal_title：Oncogene

authors： Widmann C,Johnson NL,Gardner AM,Smith RJ,Johnson GL

更新日期：1997-11-13 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare human tumor affecting the calcitonin-secreting c-cells of the thyroid. Here we report that two independent strains of transgenic mice expressing a Polyomavirus (Py) truncated middle-T antigen (deltaMT), consisting of the amino-terminal 304 amino acids, and the full length Py...

journal_title：Oncogene

authors： Felici A,Giorgio M,Krauzewicz N,Della Rocca C,Santoro M,Rovere P,Manni I,Amati P,Pozzi L

更新日期：1999-04-08 00:00:00

abstract：:We have sought to identify and isolate target genes for the zinc finger protein, EVI-1, which has been implicated in the genesis of myelogenous leukemia both in mouse and human. We have approached this with a two-step selection: we first selected for genomic fragments of mouse DNA that bind to the protein with high af...

journal_title：Oncogene

authors： Kim JH,Hui P,Yue D,Aycock J,Leclerc C,Bjoring AR,Perkins AS

更新日期：1998-09-24 00:00:00

abstract：:CD44 is a cell surface receptor for hyaluronate, a component of the extracellular matrix (ECM). Although CD44 has been implicated in tumor invasion and metastasis, the molecular mechanisms remain to be elucidated. Here we find that CD44 expressed in cancer cells is cleaved at the membrane-proximal region of the ectodo...

journal_title：Oncogene

authors： Okamoto I,Kawano Y,Tsuiki H,Sasaki J,Nakao M,Matsumoto M,Suga M,Ando M,Nakajima M,Saya H

更新日期：1999-02-18 00:00:00

abstract：:Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial for both normal cell migration and Src kinase-mediated metastasis of cancer cells. However, althoug...

journal_title：Oncogene

authors： Arpaia E,Blaser H,Quintela-Fandino M,Duncan G,Leong HS,Ablack A,Nambiar SC,Lind EF,Silvester J,Fleming CK,Rufini A,Tusche MW,Brüstle A,Ohashi PS,Lewis JD,Mak TW

更新日期：2012-02-16 00:00:00

abstract：:Prostate cancer is the most common malignancy of elderly men in the United States. Since there is no curative treatment for advanced prostate cancer, exploration of novel modalities of treatment is essential. Telomerase, a ribonucleoprotein, is detected in the vast majority of prostate cancer, but not in normal or ben...

journal_title：Oncogene

authors： Kondo Y,Koga S,Komata T,Kondo S

更新日期：2000-04-27 00:00:00

abstract：:A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver h...

journal_title：Oncogene

authors： Rassoulzadegan M,Courtneidge SA,Loubière R,el Baze P,Cuzin F

更新日期：1990-10-01 00:00:00

abstract：:PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein was originally discovered in patients suffering from acute promyelocytic leukaemia (APL). APL is associated with a reciprocal chromosomal translocation of chromosomes 15 and 17, which results in a fusion protein comprising PML and...

journal_title：Oncogene

authors： Jensen K,Shiels C,Freemont PS

更新日期：2001-10-29 00:00:00

abstract：:Accumulating evidences indicate that p120 catenin, a member of the E-cadherin (E-CD)/catenin adhesion complex, plays a role in tumor invasion. To establish the expression pattern of p120 in breast cancer, we analysed 326 breast tissue biopsies by tissue microarray. Most of the lobular tumors (88%) showed exclusive cyt...

journal_title：Oncogene

authors： Sarrió D,Pérez-Mies B,Hardisson D,Moreno-Bueno G,Suárez A,Cano A,Martín-Pérez J,Gamallo C,Palacios J

更新日期：2004-04-22 00:00:00

abstract：:To identify tyrosine kinases that may regulate regeneration of the mammalian intestinal epithelium, we amplified portions of the catalytic domains of protein kinases expressed in intestinal crypt cells, using the polymerase chain reaction technique with primers directed against two invariant amino acid sequence motifs...

journal_title：Oncogene

authors： Siyanova EY,Serfas MS,Mazo IA,Tyner AL

更新日期：1994-07-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with proper treatment. Antiangiogenic therapy is the most effective medical treatment for metastatic ccRCC. Thus, exploration of novel approaches t...

journal_title：Oncogene

authors： Li YL,Wu LW,Zeng LH,Zhang ZY,Wang W,Zhang C,Lin NM

更新日期：2020-09-01 00:00:00

abstract：:The oncoprotein c-Myc contains two dimerization motifs- the helix-loop-helix (HLH) and the leucine zipper (LZ) - through which c-Myc specifically dimerizes with Max. We substituted regions of the c-Myc HLH and LZ motifs with the corresponding regions of structurally related proteins that do not interact with Max. Spec...

journal_title：Oncogene

authors： Davis LJ,Halazonetis TD

更新日期：1993-01-01 00:00:00

abstract：:To ensure that their mRNAs are translated and that the viral proteins necessary for assembling the next generation of infectious progeny are produced, viruses must effectively seize control of the translational machinery within their host cells. In many cases, the ability to productively engage host translational comp...

journal_title：Oncogene

authors： Mohr I

更新日期：2005-11-21 00:00:00

abstract：:B-cell CLL/lymphoma 6 (BCL6) exerts oncogenic effects in several human hematopoietic malignancies including chronic myeloid leukemia (CML), where BCL6 expression was shown to be essential for CML stem cell survival and self-renewal during imatinib mesylate (IM) treatment. As several lines of evidence suggest that inte...

journal_title：Oncogene

authors： Madapura HS,Nagy N,Ujvari D,Kallas T,Kröhnke MCL,Amu S,Björkholm M,Stenke L,Mandal PK,McMurray JS,Keszei M,Westerberg LS,Cheng H,Xue F,Klein G,Klein E,Salamon D

更新日期：2017-08-10 00:00:00

abstract：:The Cancer Genome Atlas consortium brought us terabytes of information about genetic alterations in different types of human tumors. While many cancer-driver genes have been identified through these efforts, interrogating cancer genomes has also shed new light on tumor complexity. Mutations were found to vary tremendo...

journal_title：Oncogene

authors： Janiszewska M

更新日期：2020-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) as modulators of gene expression have been described to display both tumor-promoting and tumor-suppressive functions. Although their role has been studied in different tumor types, little is known about how they regulate nuclear factor κB (NF-κB) signaling in breast cancer. Here, we performed an unb...

journal_title：Oncogene

authors： Keklikoglou I,Koerner C,Schmidt C,Zhang JD,Heckmann D,Shavinskaya A,Allgayer H,Gückel B,Fehm T,Schneeweiss A,Sahin O,Wiemann S,Tschulena U

更新日期：2012-09-13 00:00:00

abstract：:We isolated three related cDNA clones from a mouse cerebellar library; the type I cDNA was identical to the gene encoding the apoptosis-associated tyrosine kinase (AATYK), whose expression in myeloid precursor cells is increased during growth arrest or apoptosis. Low levels of AATYK mRNA expression were seen in adult ...

journal_title：Oncogene

authors： Tomomura M,Fernandez-Gonzales A,Yano R,Yuzaki M

更新日期：2001-03-01 00:00:00

abstract：:Activating mutations of K-ras are frequent in colon tumors and aberrant crypt foci, and may play important roles in colon carcinogenesis. Here, we investigated the effects of a K-ras codon 12 mutation on inducible nitric oxide synthase (iNOS) expression. When rat intestinal epithelial cells (IEC-6) were transfected wi...

journal_title：Oncogene

authors： Takahashi M,Mutoh M,Shoji Y,Kamanaka Y,Naka M,Maruyama T,Sugimura T,Wakabayashi K

更新日期：2003-10-23 00:00:00

abstract：:Testicular germ cell tumours are classified into two major histological subgroups, seminomas and nonseminomas. All tumours display several recurrent chromosomal aberrations, but few target genes have been identified. Previous studies have shown that genome-wide hypermethylation of CpG islands is significantly more pre...

journal_title：Oncogene

authors： Smith-Sørensen B,Lind GE,Skotheim RI,Fosså SD,Fodstad Ø,Stenwig AE,Jakobsen KS,Lothe RA

更新日期：2002-12-12 00:00:00

abstract：:Our group recently identified Ras homolog member I (ARHI), a novel maternally imprinted tumor suppressor gene that encodes a 26 kDa GTP-binding protein with high homology to Ras and Rap. Unlike other Ras family members, ARHI exhibits several unusual structural and functional properties. ARHI contains a unique 34 amino...

journal_title：Oncogene

authors： Luo RZ,Fang X,Marquez R,Liu SY,Mills GB,Liao WS,Yu Y,Bast RC

更新日期：2003-05-15 00:00:00